vesiculobullous skin disease: Skin diseases characterized by local or general distributions of vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, distinguished by size (vesicles being less than 5–10 mm and bullae being larger than 5–10 mm). Vesiculobullous diseases are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous is sometimes used. (From Scientific American Medicine, 1990, and Wikipedia)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1960 |
4. Check minimum number of eventsNone |
1960 |
5. Include endpoints |
2125 |
6. Filter based on genotype QC (FinnGen only) |
2125 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
Bullous disorders
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17606 | 9615 | 7867 |
| Only index persons | 14671 | 8199 | 6472 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.28 | 0.22 |
| Only index persons | 0.28 | 0.30 | 0.25 |
| Median age at first event (years) | |||
| Whole population | 66.48 | 67.70 | 64.95 |
| Only index persons | 64.83 | 65.56 | 63.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2125 | 1145 | 980 |
| Unadjusted period prevalence (%) | 0.41 | 0.39 | 0.43 |
| Median age at first event (years) | 61.33 | 56.86 | 66.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1885
- Matched controls
- 18848
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L12.0
ICD-10 Finland
Bullous pemphigoid
3550.6
323.0
641
*
L13.0
ICD-10 Finland
Dermatitis herpetiformis
1682.9
323.0
497
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
11.0
323.0
718
995
J04BA02
ATC
dapsone; oral
144.7
249.7
262
21
L13.9
ICD-10 Finland
Bullous disorder, unspecified
184.0
247.8
255
16
K90.0
ICD-10 Finland
Coeliac disease
20.1
199.6
309
182
D07AD01
ATC
clobetasol; topical
5.5
178.8
635
1598
D07AC01
ATC
betamethasone; topical
4.1
175.6
1043
4379
L12.9
ICD-10 Finland
Pemphigoid, unspecified
457.5
170.6
168
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.8
162.7
662
1901
69399
ICD-8 Finland
Dermatitis herpetiformis
+∞
120.1
114
*
E0000UV
ATC
NA
3.2
119.4
1004
4989
H02AB06
ATC
prednisolone; systemic
3.1
116.6
1169
6519
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.1
97.8
443
1316
D07AC13
ATC
mometasone; topical
2.9
91.3
755
3513
L12.8
ICD-10 Finland
Other pemphigoid
855.2
84.2
82
*
TQW80
NOMESCO Finland
Local dermatologic skincare
8.7
74.8
168
209
E000001
ATC
NA
3.0
74.7
546
2283
L04AX01
ATC
azathioprine; systemic
6.6
70.9
193
320
D07AB02
ATC
hydrocortisone butyrate; topical
2.6
70.5
685
3383
L10.0
ICD-10 Finland
Pemphigus vulgaris
+∞
70.2
67
*
L12.1
ICD-10 Finland
Cicatricial pemphigoid
+∞
67.1
64
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
66.4
809
4477
135
Kela drug reimbursment
Pemphigus
+∞
66.0
63
*
L10.9
ICD-10 Finland
Pemphigus, unspecified
660.3
65.3
64
*
D07AB08
ATC
desonide; topical
3.6
63.9
326
1037
L13.8
ICD-10 Finland
Other specified bullous disorders
82.9
57.3
64
8
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.6
55.0
273
843
L11.1
ICD-10 Finland
Transient acantholytic dermatosis [Grover]
+∞
53.4
51
*
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.1
45.1
270
952
L12
ICD-10 Finland
Pemphigoid
85.6
45.1
50
6
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
43.7
647
3725
D07BC01
ATC
betamethasone and antiseptics; topical
2.8
42.0
315
1280
XQ848
NOMESCO Finland
Dermatological photography
6.0
40.6
117
207
R06AE07
ATC
cetirizine; oral
2.0
40.4
836
5459
ECA20
NOMESCO Finland
Biopsy of gingiva
11.0
35.8
69
65
L30.3
ICD-10 Finland
Infective dermatitis
5.1
35.1
115
237
L12.2
ICD-10 Finland
Chronic bullous disease of childhood
+∞
33.4
32
*
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.1
32.9
134
345
L29.9
ICD-10 Finland
Pruritus, unspecified
6.1
32.4
91
156
L10.2
ICD-10 Finland
Pemphigus foliaceus
+∞
31.3
30
*
J01DB01
ATC
cefalexin; oral
1.9
30.9
1509
12702
D07CC01
ATC
betamethasone and antibiotics; topical
2.4
29.5
289
1343
R06AE09
ATC
levocetirizine; oral
2.3
28.7
289
1359
6940A
ICD-9 Finland
Bullous dermatoses, Dermatitis herpetiformis
+∞
28.2
27
*
L10.8
ICD-10 Finland
Other pemphigus
+∞
27.1
26
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
27.0
336
1741
J01FF01
ATC
clindamycin; systemic
1.9
27.0
526
3244
D02AE01
ATC
carbamide; topical
3.0
26.9
164
579
E000002
ATC
NA
2.4
26.8
248
1119
L20.0
ICD-10 Finland
Besnier prurigo
3.3
26.6
140
445
A02BC02
ATC
pantoprazole; systemic
1.7
26.6
1201
9559
D02AX
ATC
Other emollients and protectives
4.1
26.1
104
262
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
25.4
852
6191
D09AB01
ATC
zinc bandage without supplements; topical
5.9
25.2
72
127
S97
ICPC
Chronic ulcer skin
3.0
24.5
150
529
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
17.6
24.4
38
22
L10.4
ICD-10 Finland
Pemphigus erythematosus
+∞
24.0
23
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.6
23.8
111
321
E000007
ATC
NA
3.1
23.8
136
459
S99
ICPC
Skin disease other
5.7
23.5
68
122
S29
ICPC
Skin symptom/complaint other
2.0
23.4
338
1853
S18
ICPC
Laceration/cut
1.7
23.2
791
5728
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.7
23.1
171
681
D07AA02
ATC
hydrocortisone; topical
2.1
23.0
280
1431
D07XC01
ATC
betamethasone, combinations; topical
2.2
22.9
253
1237
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.5
22.6
186
785
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
22.2
288
1508
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.1
22.2
131
450
A46
ICD-10 Finland
Erysipelas
2.0
22.2
299
1591
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.4
20.8
105
324
D05BB02
ATC
acitretin; oral
4.7
20.6
71
156
L30.0
ICD-10 Finland
Nummular dermatitis
3.4
19.6
99
306
L28.1
ICD-10 Finland
Prurigo nodularis
11.1
19.2
36
33
H02AB07
ATC
prednisone; oral
2.0
19.0
285
1577
A10AE04
ATC
insulin glargine; parenteral
2.2
18.9
195
922
XQ802
NOMESCO Finland
Epicutan test
3.5
18.5
89
265
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.7
18.4
435
2797
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.8
18.3
369
2259
R06AX27
ATC
desloratadine; oral
1.7
18.3
432
2777
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
17.5
291
1664
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
4.0
17.4
70
180
E000003
ATC
NA
3.0
17.3
104
362
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
17.2
340
2067
XQ800
NOMESCO Finland
Prick test
2.5
17.1
138
577
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
3.9
17.1
70
183
E000006
ATC
NA
2.4
17.0
151
662
EKA10
NOMESCO Finland
Biopsy of cheek
4.1
16.8
66
166
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
16.6
471
3174
L30.8
ICD-10 Finland
Other specified dermatitis
4.1
16.5
64
159
J01MA02
ATC
ciprofloxacin; systemic
1.5
16.5
723
5433
C03CA01
ATC
furosemide; systemic
1.6
16.1
611
4431
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
5.9
15.9
44
76
L29.8
ICD-10 Finland
Other pruritus
5.4
15.8
47
89
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.2
15.7
158
737
L11.0
ICD-10 Finland
Acquired keratosis follicularis
+∞
15.6
15
*
L10.1
ICD-10 Finland
Pemphigus vegetans
+∞
14.6
14
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.4
14.5
127
553
H02AB09
ATC
hydrocortisone; systemic
3.8
14.5
61
164
RD210
NOMESCO Finland
NA
4.7
14.5
49
107
S02
ICPC
Pruritus
3.0
14.3
83
285
SPAT1153
SPAT
Removal of sutures
1.5
14.2
570
4164
J01AA07
ATC
tetracycline; systemic
1.8
14.1
249
1449
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
4.4
14.0
50
116
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.6
13.7
100
396
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
13.6
424
2908
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.6
13.6
60
169
69400
ICD-8 Finland
Pemphigus, Vulgaris, vegetans, foliaceus
+∞
13.6
13
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.4
13.5
116
502
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
13.2
300
1890
SPAT1263
SPAT
Sampling
1.5
13.2
754
5916
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.8
13.1
246
1463
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
13.1
452
3179
L89
ICD-10 Finland
Decubitus ulcer and pressure area
4.0
13.1
51
129
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
12.9
368
2464
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.1
12.9
148
732
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.8
12.9
235
1381
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
2.9
12.7
75
262
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
3.1
12.7
70
234
N02BE01
ATC
paracetamol; systemic, rectal
1.5
12.6
1533
13917
L13.1
ICD-10 Finland
Subcorneal pustular dermatitis
+∞
12.5
12
*
L12.3
ICD-10 Finland
Acquired epidermolysis bullosa
130.8
12.4
13
*
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
12.4
607
4600
L04AA06
ATC
mycophenolic acid; systemic
4.1
12.4
47
116
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.5
12.4
97
401
103
Kela drug reimbursment
Diabetes, insulin-treated
1.5
12.1
478
3456
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
12.1
252
1546
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.2
12.0
125
592
L43.9
ICD-10 Finland
Lichen planus, unspecified
3.9
12.0
48
125
A10BH05
ATC
linagliptin; oral
2.4
12.0
103
448
WX002
NOMESCO Finland
Sedation and analgesia
1.6
11.9
349
2347
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.7
11.9
51
141
SPAT1229
SPAT
Assessment of need for aid
2.0
11.8
165
882
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
11.7
308
2013
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
11.7
208
1212
M05BA04
ATC
alendronic acid; oral
1.9
11.6
175
962
A10AA01
ATC
NA
3.5
11.6
53
154
H02AB04
ATC
methylprednisolone; systemic
1.7
11.6
261
1636
H13.3*L12.9
ICD-10 Finland
Ocular pemphigoid
+∞
11.5
11
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.8
11.4
188
1067
H04AA01
ATC
glucagon; nasal, parenteral
4.0
11.4
44
111
J01CF05
ATC
flucloxacillin; systemic
2.7
11.3
78
299
J01DA01
ATC
[U] cefalexin; systemic
1.4
11.3
1079
9216
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
1.9
11.3
176
983
R03AC02
ATC
salbutamol; inhalant
1.4
11.3
865
7106
C07AB07
ATC
bisoprolol; oral
1.4
11.2
866
7116
SBA00
NOMESCO Finland
Microbiological examinations
3.3
11.2
56
175
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
11.2
166
910
L04AD01
ATC
ciclosporin; systemic
3.7
11.2
48
133
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.5
11.1
421
3010
R60.0
ICD-10 Finland
Localized oedema
1.8
11.0
204
1203
R06AX13
ATC
loratadine; oral
1.7
11.0
235
1450
A10AE05
ATC
insulin detemir; parenteral
2.3
11.0
106
485
L51.9
ICD-10 Finland
Erythema multiforme, unspecified
12.0
10.8
19
16
R06.0
ICD-10 Finland
Dyspnoea
1.5
10.7
442
3213
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
10.6
710
5672
A28
ICPC
Limited function/disability NOS
1.6
10.6
299
1990
R53
ICD-10 Finland
Malaise and fatigue
1.5
10.5
358
2493
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
9.2
10.5
21
23
L43.8
ICD-10 Finland
Other lichen planus
3.7
10.5
45
125
L51.19
ICD-10 Finland
Other bullous erythema multiforme
110.6
10.4
11
*
L11.9
ICD-10 Finland
Acantholytic disorder, unspecified
+∞
10.4
10
*
R03BA01
ATC
beclometasone; inhalant
1.7
10.4
248
1576
SPAT1262
SPAT
Handing over of treatment supplies
1.6
10.3
321
2184
K90.9
ICD-10 Finland
Intestinal malabsorption, unspecified
10.6
10.3
19
18
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
10.0
665
5291
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
3.9
10.0
40
105
K12.10
ICD-10 Finland
Stomatitis NOS
6.1
10.0
26
43
A02BC03
ATC
lansoprazole; oral
1.4
10.0
511
3876
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
9.9
522
3979
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.5
9.9
75
307
N02AX02
ATC
tramadol; systemic, rectal
1.4
9.8
725
5873
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
9.6
540
4162
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
9.6
636
5049
B03BA03
ATC
hydroxocobalamin; parenteral
2.1
9.6
113
568
J45
ICD-10 Finland
Asthma
1.8
9.5
160
917
D05AX52
ATC
calcipotriol, combinations; topical
2.2
9.5
94
438
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
3.0
9.5
54
184
R03AC12
ATC
salmeterol; inhalant
2.2
9.5
91
418
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
4.6
9.4
31
68
69300
ICD-8 Finland
NA
+∞
9.4
9
*
M79.6
ICD-10 Finland
Pain in limb
1.4
9.3
573
4481
P01BA02
ATC
hydroxychloroquine; oral
1.9
9.3
141
778
L50.9
ICD-10 Finland
Urticaria, unspecified
2.8
9.3
59
218
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
2.7
9.2
60
226
SPAT1254
SPAT
Administration of medicine
1.6
9.1
274
1846
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
9.1
285
1941
S21
ICPC
Skin texture symptom/complaint
1.7
9.1
212
1342
K13.78
ICD-10 Finland
Other change in the oral mucosa
3.3
9.0
43
131
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.7
9.0
179
1080
A10AE06
ATC
insulin degludec; parenteral
2.9
8.9
52
182
R03BA02
ATC
budesonide; inhalant
1.5
8.9
283
1935
WX892
NOMESCO Finland
Monitored bed care
1.9
8.9
136
753
D07AC14
ATC
methylprednisolone aceponate; topical
2.2
8.9
87
402
S17
ICPC
Abrasion/scratch/blister
2.9
8.9
52
183
T90
ICPC
Diabetes non-insulin dependent
1.5
8.9
390
2861
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.9
8.8
139
777
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
8.8
534
4158
J01MA12
ATC
levofloxacin; systemic
1.5
8.8
311
2180
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.9
8.7
134
744
M04AA01
ATC
allopurinol; systemic
1.6
8.6
232
1520
R50.9
ICD-10 Finland
Fever, unspecified
1.6
8.6
230
1506
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.2
8.5
87
411
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.7
8.5
197
1244
N05BB01
ATC
hydroxyzine; systemic
2.0
8.5
111
581
L13
ICD-10 Finland
Other bullous disorders
20.1
8.5
12
6
A10AA02
ATC
NA
2.5
8.5
62
250
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
5.7
8.4
23
41
J02AC01
ATC
fluconazole; systemic
1.4
8.4
596
4761
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.0
8.4
107
557
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
2.8
8.4
53
195
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
2.8
8.2
52
191
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
8.2
1030
8972
L28.0
ICD-10 Finland
Lichen simplex chronicus
5.0
8.2
25
51
R11
ICD-10 Finland
Nausea and vomiting
1.8
8.2
132
746
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.3
8.2
39
120
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.6
8.2
56
217
B35.3
ICD-10 Finland
Tinea pedis
2.3
8.1
69
300
AA1AD
NOMESCO Finland
CT of head and brain
1.4
8.1
417
3145
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.7
8.1
154
919
WX110
NOMESCO Finland
Local anesthesy
1.3
8.1
1103
9717
D07XB05
ATC
dexamethasone, combinations; topical
2.6
8.1
57
226
L01.0
ICD-10 Finland
Impetigo [any organism] [any site]
3.9
8.0
31
80
R03BA05
ATC
fluticasone; inhalant
1.5
8.0
283
1980
J05AB01
ATC
aciclovir; systemic
1.5
8.0
332
2401
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.5
8.0
260
1787
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.8
7.9
126
710
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
7.9
270
1872
D64.9
ICD-10 Finland
Anaemia, unspecified
1.6
7.9
185
1172
J33.0
ICD-10 Finland
Polyp of nasal cavity
2.7
7.9
51
192
J01AA04
ATC
lymecycline; systemic
1.6
7.8
189
1205
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
7.8
287
2027
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.2
7.8
77
359
M81.4
ICD-10 Finland
Drug-induced osteoporosis
9.4
7.8
15
16
L01.1
ICD-10 Finland
Impetiginization of other dermatoses
7.0
7.8
18
26
ZX120
NOMESCO Finland
Intravenous
1.7
7.7
156
948
ZZA00
NOMESCO Finland
Split skin graft
2.4
7.7
60
250
Z01.8
ICD-10 Finland
Other specified special examinations
1.4
7.7
354
2616
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.5
7.6
229
1544
6BA02
NOMESCO Finland
NA
11.9
7.6
13
11
H3603, E103
ICD-10 Finland
NA
5.8
7.5
20
35
A07AA02
ATC
nystatin; oral
1.9
7.5
115
638
J05AB11
ATC
valaciclovir; oral
1.6
7.5
211
1398
D01AE15
ATC
terbinafine; topical
1.8
7.4
120
678
SPAT1301
SPAT
No procedures
1.3
7.4
550
4409
L43.1
ICD-10 Finland
Bullous lichen planus
13.4
7.4
12
9
WW200
NOMESCO Finland
Immunization
2.6
7.3
51
200
D01AC02
ATC
miconazole; topical
1.7
7.3
137
815
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
2.7
7.3
47
176
T89
ICPC
Diabetes insulin dependent
2.3
7.3
61
265
L10.3
ICD-10 Finland
Brazilian pemphigus [fogo selvagem]
+∞
7.3
7
*
I50.9
ICD-10 Finland
Heart failure, unspecified
1.5
7.3
260
1825
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
3.2
7.2
35
110
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
2.5
7.2
51
204
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
2.8
7.2
44
162
RS222
NOMESCO Finland
NA
3.8
7.2
28
74
R03DC03
ATC
montelukast; oral
1.5
7.1
234
1610
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.5
7.1
270
1917
B86
ICD-10 Finland
Scabies
3.7
7.1
29
80
N18.8
ICD-10 Finland
Other chronic renal failure
2.4
7.1
54
225
C08CA01
ATC
amlodipine; oral
1.3
7.1
615
5044
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
2.5
7.0
50
200
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.6
7.0
188
1231
A10BA02
ATC
metformin; oral
1.4
7.0
460
3613
UJF32
NOMESCO Finland
Coloscopy
1.4
7.0
431
3350
XQ845
NOMESCO Finland
Dermatoscopy
3.3
6.9
32
97
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
6.9
725
6099
SPAT1312
SPAT
General health counselling
1.3
6.9
505
4028
D11AX14
ATC
[U] tacrolimus; topical
7.5
6.9
15
20
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
2.9
6.9
40
141
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
3.6
6.9
29
82
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
6.9
548
4434
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
6.8
295
2146
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.3
6.8
58
255
R4180
NOMESCO Finland
Podiatric therapy
4.2
6.8
24
58
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
5.0
6.8
20
40
ZXA00
NOMESCO Finland
Right side
1.4
6.8
452
3555
L50.3
ICD-10 Finland
Dermatographic urticaria
3.5
6.8
29
83
N18.0
ICD-10 Finland
End-stage renal disease
3.9
6.8
26
68
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
2.7
6.8
44
167
R03BB04
ATC
tiotropium bromide; inhalant
1.6
6.8
170
1096
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.9
6.7
101
559
H3600, E103
ICD-10 Finland
NA
4.7
6.7
21
45
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.7
6.7
136
828
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.3
6.6
470
3731
S76
ICPC
Skin infection other
1.9
6.6
85
446
SPAT1310
SPAT
Counselling related to known health issue
1.3
6.6
513
4126
K11.70
ICD-10 Finland
Hypoptyalism
5.5
6.6
18
33
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.7
6.6
127
763
L04AA01
ATC
[U] ciclosporin; systemic
3.3
6.6
31
96
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.6
6.6
182
1203
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
6.6
469
3725
N02AA05
ATC
oxycodone; systemic
1.5
6.6
253
1802
K29.7
ICD-10 Finland
Gastritis, unspecified
2.2
6.6
62
287
N30.9
ICD-10 Finland
Cystitis, unspecified
1.9
6.6
94
512
D11AH01
ATC
tacrolimus; topical
4.8
6.5
20
42
ZXA10
NOMESCO Finland
Bilateral
1.4
6.5
317
2362
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
2.3
6.5
56
248
K59.09
ICD-10 Finland
Constipation, unspecified
1.8
6.5
107
613
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
3.1
6.5
32
103
ZXA05
NOMESCO Finland
Left side
1.4
6.4
421
3297
177
Kela drug reimbursment
Insulin glargine 300 U / ml
2.9
6.4
37
130
E66.9
ICD-10 Finland
Obesity, unspecified
2.4
6.4
49
204
A08
ICPC
Swelling
2.0
6.4
72
359
L08.0
ICD-10 Finland
Pyoderma
4.2
6.3
22
53
A01AB04
ATC
amphotericin B; local oral
1.9
6.3
86
463
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
6.3
687
5797
L10
ICD-10 Finland
Pemphigus
+∞
6.3
6
*
XF600
NOMESCO Finland
Bloodpressure measurement
1.8
6.2
108
627
J46
ICD-10 Finland
Status asthmaticus
2.4
6.2
51
220
A12AA04
ATC
calcium carbonate; oral
3.1
6.2
32
106
Z00.0
ICD-10 Finland
General medical examination
1.4
6.2
293
2169
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
5.0
6.2
18
36
N03AX16
ATC
pregabalin; oral
1.4
6.2
376
2909
L30.4
ICD-10 Finland
Erythema intertrigo
3.3
6.2
28
85
K12.18
ICD-10 Finland
Other forms of stomatitis
5.4
6.1
17
32
S01
ICPC
Pain/tenderness of skin
2.0
6.1
72
363
B81
ICPC
Anaemia vit B12/folate deficiency
2.1
6.1
66
324
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
2.1
6.1
64
311
J01AA02
ATC
doxycycline; systemic
1.3
6.1
1311
12036
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
2.5
6.1
44
178
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.6
6.1
154
994
L73.8
ICD-10 Finland
Other specified follicular disorders
4.7
6.1
19
41
R06AX12
ATC
terfenadine; oral
2.0
6.1
70
353
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
1.9
6.1
82
438
SPAT1211
SPAT
Application of soft bandage
1.6
6.1
146
934
H25.8
ICD-10 Finland
Other senile cataract
1.5
6.0
195
1336
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.6
6.0
160
1049
NHQ40
NOMESCO Finland
Amputation of toe
2.8
6.0
36
131
L73.9
ICD-10 Finland
Follicular disorder, unspecified
10.0
6.0
11
11
A41.9
ICD-10 Finland
Sepsis, unspecified
2.0
6.0
67
333
Mortality – FinRegistry
↥Association
Association between endpoint L12_BULLOUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_BULLOUS | 1.614 [1.43, 1.82] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.267 |
During the follow-up period (1.1.1998 — 31.12.2019), 2522 out of 7359 females with L12_BULLOUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_BULLOUS | 1.855 [1.6, 2.15] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 2107 out of 5767 males with L12_BULLOUS died.
Mortality risk
Mortality risk for people of age
years, who have L12_BULLOUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.124% | 0.413% |
| 5 | 0.867% | 2.001% |
| 10 | 2.293% | 4.857% |
| 15 | 4.463% | 8.924% |
| 20 | 7.786% | 14.77% |
Relationships between endpoints
↥Index endpoint: L12_BULLOUS – Bullous disorders
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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