Dermatitis herpetiformis

L12_DERMATHERP

dermatitis herpetiformis: Dermatitis herpetiformis (DH) is a chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. DH may also appear as a consequence of gluten intolerance.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L13.0 Hospital discharge: ICD-9 — 6940A\|6942 Hospital discharge: ICD-8 — 693 Cause of death: ICD-10 — L13.0 Cause of death: ICD-9 — 6940A\|6942 Cause of death: ICD-8 — 693 2 out of 7 registries used, show all original rules.	661
4. Check minimum number of events None	661
5. Include endpoints None	661
6. Filter based on genotype QC (FinnGen only)	661

Control definitions (FinnGen only)

Control exclude: L12_BULLOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L13
Name in latin: Dermatitis herpetiformis

NAME	L12_DERMATHERP
CONTROL_EXCLUDE	L12_BULLOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L130
HD_ICD_9	6940A\|6942
HD_ICD_8	693
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L130
COD_ICD_9	6940A\|6942
COD_ICD_8	693
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Dermatitis herpetiformis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	4875	2511	2338
Only index persons	4281	2269	2012
Unadjusted period prevalence (%)
Whole population	0.07	0.07	0.07
Only index persons	0.08	0.08	0.08
Median age at first event (years)
Whole population	45.74	45.97	45.38
Only index persons	44.15	44.66	43.57

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	661	378	283
Unadjusted period prevalence (%)	0.13	0.13	0.12
Median age at first event (years)	45.33	41.57	50.36

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
601: Matched controls
6010

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L13.0

ICD-10 Finland

Dermatitis herpetiformis

16384.0

323.0

492

K90.0

ICD-10 Finland

Coeliac disease

86.6

264.3

288

J04BA02

ATC

dapsone; oral

368.5

188.6

181

69399

ICD-8 Finland

Dermatitis herpetiformis

+∞

123.2

114

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

8.1

75.7

191

325

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

3.7

46.8

284

1165

D07AC01

ATC

betamethasone; topical

3.4

42.7

306

1404

L30.9

ICD-10 Finland

Dermatitis, unspecified

3.9

38.2

186

613

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

4.1

33.3

146

432

D07AC13

ATC

mometasone; topical

3.0

31.6

245

1119

E000001

ATC

3.3

30.1

189

741

D07AB02

ATC

hydrocortisone butyrate; topical

2.9

29.1

230

1050

6940A

ICD-9 Finland

Bullous dermatoses, Dermatitis herpetiformis

+∞

28.3

D07AB08

ATC

desonide; topical

4.1

25.0

107

304

E0000UV

ATC

2.4

23.1

285

1625

QCA99

NOMESCO Finland

Other local destruction of skin of upper limb

59.6

20.0

L20.0

ICD-10 Finland

Besnier prurigo

4.6

18.2

154

D07BA04

ATC

hydrocortisone and antiseptics; topical

3.3

17.7

321

D07CC01

ATC

betamethasone and antibiotics; topical

2.9

16.4

112

445

L12.0

ICD-10 Finland

Bullous pemphigoid

+∞

15.7

E000002

ATC

2.9

15.5

100

382

D07AD01

ATC

clobetasol; topical

2.6

15.2

125

553

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.1

14.7

218

1281

E000007

ATC

4.1

13.8

140

K90.9

ICD-10 Finland

Intestinal malabsorption, unspecified

29.1

13.0

H02AB06

ATC

prednisolone; systemic

1.9

12.6

293

2012

D07XB05

ATC

dexamethasone, combinations; topical

5.7

12.4

L13.9

ICD-10 Finland

Bullous disorder, unspecified

18.5

12.1

R06AE07

ATC

cetirizine; oral

1.8

11.6

272

1855

R06AE09

ATC

levocetirizine; oral

2.4

11.5

108

506

D07AA02

ATC

hydrocortisone; topical

2.4

10.8

458

RD210

NOMESCO Finland

6.9

10.8

R06AX13

ATC

loratadine; oral

2.3

10.7

101

476

D07BC01

ATC

betamethasone and antiseptics; topical

2.4

10.3

421

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

3.4

9.9

151

317

Kela drug reimbursment

Topical pimecrolimus and tacrolimus

8.9

9.8

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

2.5

9.5

309

69300

ICD-8 Finland

+∞

9.4

N05BB01

ATC

hydroxyzine; systemic

3.0

8.6

173

S02

ICPC

Pruritus

3.9

8.2

SPAT1263

SPAT

Sampling

1.7

8.1

254

1830

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.9

8.0

118

671

J05AB01

ATC

aciclovir; systemic

1.9

7.8

130

766

TQW80

NOMESCO Finland

Local dermatologic skincare

4.2

7.8

J01AA07

ATC

tetracycline; systemic

2.1

7.6

503

E000006

ATC

2.6

7.4

211

L13.1

ICD-10 Finland

Subcorneal pustular dermatitis

+∞

7.3

D11AX14

ATC

[U] tacrolimus; topical

20.3

7.1

D07CA01

ATC

hydrocortisone and antibiotics; topical

2.0

7.1

466

D01AC20

ATC

imidazoles/triazoles in combination with corticosteroids; topical

1.8

7.1

137

852

D07AC14

ATC

methylprednisolone aceponate; topical

3.3

7.1

108

D07XC01

ATC

betamethasone, combinations; topical

2.1

7.0

417

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

5.1

6.8

D11AH01

ATC

tacrolimus; topical

9.5

6.8

SPAT1249

SPAT

Treatment-related counselling outside office

1.6

6.8

232

1692

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.6

6.8

233

1698

J01DA01

ATC

[U] cefalexin; systemic

1.6

6.7

361

2940

D09AB01

ATC

zinc bandage without supplements; topical

4.3

6.7

WXQ27

NOMESCO Finland

UVB narrow spectrum light therapy

6.0

6.6

L30.3

ICD-10 Finland

Infective dermatitis

3.2

6.6

103

L29.9

ICD-10 Finland

Pruritus, unspecified

4.2

6.6

L08.8

ICD-10 Finland

Other specified local infections of skin and subcutaneous tissue

4.2

6.6

J45.0

ICD-10 Finland

Predominantly allergic asthma

2.4

6.5

226

L28.1

ICD-10 Finland

Prurigo nodularis

7.5

6.4

D02AX

ATC

Other emollients and protectives

3.3

6.1

Mortality – FinRegistry

↥

Association

Association between endpoint L12_DERMATHERP and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_DERMATHERP	0.983 [0.85, 1.14]	0.828
Birth year	0.994 [0.99, 1.0]	0.152

During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 1738 females with L12_DERMATHERP died.

Males

Parameter	HR [95% CI]	p-value
L12_DERMATHERP	0.935 [0.82, 1.07]	0.33
Birth year	0.988 [0.98, 1.0]	0.011

During the follow-up period (1.1.1998 — 31.12.2019), 281 out of 1496 males with L12_DERMATHERP died.

Mortality risk

Mortality risk for people of age

years, who have L12_DERMATHERP.

N-year risk	Females	Males
1	0.093%	0.172%
5	0.593%	1.034%
10	1.418%	2.787%
15	2.79%	5.294%
20	4.949%	8.632%

Relationships between endpoints

↥

Index endpoint: L12_DERMATHERP – Dermatitis herpetiformis

GWS hits: 3

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Dermatitis herpetiformis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints