Other and unspecified bullous disorders

L12_OTHERBULL

vesiculobullous skin disease: Skin diseases characterized by local or general distributions of vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, distinguished by size (vesicles being less than 5–10 mm and bullae being larger than 5–10 mm). Vesiculobullous diseases are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous is sometimes used. (From Scientific American Medicine, 1990, and Wikipedia)

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L13 Hospital discharge: ICD-9 — 694[8-9] Hospital discharge: ICD-8 — 69409 Hospital discharge: excluded ICD-10 — L13.0, L13.1 Cause of death: ICD-10 — L13 Cause of death: ICD-9 — 694[8-9] Cause of death: ICD-8 — 69409 Cause of death: excluded ICD-10 — L13.0, L13.1 2 out of 7 registries used, show all original rules.	342
4. Check minimum number of events None	342
5. Include endpoints None	342
6. Filter based on genotype QC (FinnGen only)	342

Control definitions (FinnGen only)

Control exclude: L12_BULLOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF6
Parent code in ICD-10: L10-L14
Name in latin: Aliae morbositates bullosae

NAME	L12_OTHERBULL
CONTROL_EXCLUDE	L12_BULLOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L13
HD_ICD_9	694[8-9]
HD_ICD_8	69409
HD_ICD_10_EXCL	L13[0-1]
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L13
COD_ICD_9	694[8-9]
COD_ICD_8	69409
COD_ICD_10_EXCL	L13[0-1]
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Other and unspecified bullous disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2861	1586	1258
Only index persons	2371	1363	1008
Unadjusted period prevalence (%)
Whole population	0.04	0.05	0.04
Only index persons	0.05	0.05	0.04
Median age at first event (years)
Whole population	55.73	56.47	54.87
Only index persons	56.95	56.76	57.21

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	342	207	135
Unadjusted period prevalence (%)	0.07	0.07	0.06
Median age at first event (years)	59.96	56.86	64.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
302: Matched controls
3019

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L13.9

ICD-10 Finland

Bullous disorder, unspecified

10684.7

298.3

236

L13.8

ICD-10 Finland

Other specified bullous disorders

665.8

57.6

L12.0

ICD-10 Finland

Bullous pemphigoid

+∞

49.3

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

8.4

38.7

154

L30.9

ICD-10 Finland

Dermatitis, unspecified

5.0

28.3

109

309

J04BA02

ATC

dapsone; oral

98.5

25.1

L13.0

ICD-10 Finland

Dermatitis herpetiformis

271.5

25.1

TQW80

NOMESCO Finland

Local dermatologic skincare

13.0

23.0

D07AC01

ATC

betamethasone; topical

3.5

22.6

150

664

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

4.9

21.6

199

L12.9

ICD-10 Finland

Pemphigoid, unspecified

+∞

16.8

D07AD01

ATC

clobetasol; topical

3.7

16.5

271

E0000UV

ATC

2.8

15.6

155

835

H02AB06

ATC

prednisolone; systemic

2.7

15.2

176

1034

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

7.2

15.2

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.6

12.5

124

644

SPAT1148

SPAT

Treatment of chronic ulcer or burn

3.4

12.5

224

D07AC13

ATC

mometasone; topical

2.6

12.3

110

539

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

3.9

12.0

148

D07AB08

ATC

desonide; topical

4.1

11.8

134

A46

ICD-10 Finland

Erysipelas

3.2

10.8

232

D07BA04

ATC

hydrocortisone and antiseptics; topical

3.5

10.6

164

S97

ICPC

Chronic ulcer skin

5.2

10.4

XQ802

NOMESCO Finland

Epicutan test

6.2

9.9

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

3.3

9.8

180

E000001

ATC

2.6

9.8

381

D07AB02

ATC

hydrocortisone butyrate; topical

2.4

9.7

105

557

S18

ICPC

Laceration/cut

2.2

9.7

143

874

J01FF01

ATC

clindamycin; systemic

2.4

9.7

103

542

J01DB01

ATC

cefalexin; oral

2.7

9.6

258

2078

R06AE07

ATC

cetirizine; oral

2.1

8.9

148

945

R50.9

ICD-10 Finland

Fever, unspecified

2.8

8.8

244

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

3.4

8.7

141

R06.0

ICD-10 Finland

Dyspnoea

2.4

8.7

446

J05AB11

ATC

valaciclovir; oral

3.0

8.7

201

I83.0

ICD-10 Finland

Varicose veins of lower extremities with ulcer

10.5

8.6

Z01.0

ICD-10 Finland

Examination of eyes and vision

2.6

8.3

306

D02AX

ATC

Other emollients and protectives

5.7

8.3

L30.3

ICD-10 Finland

Infective dermatitis

6.0

8.3

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

3.3

7.9

128

ZX120

NOMESCO Finland

Intravenous

3.1

7.8

158

XQ848

NOMESCO Finland

Dermatological photography

5.6

7.5

J01MA12

ATC

levofloxacin; systemic

2.5

7.5

309

L13

ICD-10 Finland

Other bullous disorders

82.0

7.4

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

2.9

7.4

170

S29

ICPC

Skin symptom/complaint other

2.5

7.3

279

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.0

7.3

141

930

A02BC02

ATC

pantoprazole; systemic

2.0

7.3

196

1463

C03CA01

ATC

furosemide; systemic

2.1

7.1

558

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

2.6

7.1

227

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

4.4

7.0

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

5.1

6.8

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

3.0

6.8

143

H3600, E103

ICD-10 Finland

17.2

6.8

L51.9

ICD-10 Finland

Erythema multiforme, unspecified

41.0

6.8

A10AE05

ATC

insulin detemir; parenteral

4.1

6.8

H02AB04

ATC

methylprednisolone; systemic

2.4

6.8

262

N02BE01

ATC

paracetamol; systemic, rectal

2.3

6.6

261

2219

D05BB02

ATC

acitretin; oral

7.1

6.6

H04.10

ICD-10 Finland

Dry eye syndrome

2.9

6.5

141

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

2.6

6.5

205

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

3.3

6.4

101

215

Kela drug reimbursment

Diabetes, non-insulin-treated

2.1

6.4

418

P01BA02

ATC

hydroxychloroquine; oral

3.1

6.3

123

L73.8

ICD-10 Finland

Other specified follicular disorders

27.3

6.3

QDA99

NOMESCO Finland

Other local destruction of skin of lower limb

27.3

6.3

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.8

6.2

158

Z3231

NOMESCO Finland

Registered nurse

2.0

6.1

547

ZY010

NOMESCO Finland

Hospital outpatient

3.7

6.1

H02AB09

ATC

hydrocortisone; systemic

5.8

6.1

J01MA02

ATC

ciprofloxacin; systemic

1.9

6.1

124

821

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.0

6.0

556

R21

ICD-10 Finland

Rash and other nonspecific skin eruption

4.1

6.0

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.3

6.0

304

Mortality – FinRegistry

↥

Association

Association between endpoint L12_OTHERBULL and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_OTHERBULL	1.902 [1.48, 2.45]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.074

During the follow-up period (1.1.1998 — 31.12.2019), 276 out of 1248 females with L12_OTHERBULL died.

Males

Parameter	HR [95% CI]	p-value
L12_OTHERBULL	2.2 [1.6, 3.02]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.001

During the follow-up period (1.1.1998 — 31.12.2019), 245 out of 961 males with L12_OTHERBULL died.

Mortality risk

Mortality risk for people of age

years, who have L12_OTHERBULL.

N-year risk	Females	Males
1	0.175%	0.288%
5	1.006%	2.259%
10	2.608%	6.262%
15	4.971%	11.153%
20	8.711%	18.21%

Relationships between endpoints

↥

Index endpoint: L12_OTHERBULL – Other and unspecified bullous disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other and unspecified bullous disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints