liver disease: A disease involving the liver.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
85 |
4. Check minimum number of eventsNone |
85 |
5. Include endpoints |
85 |
6. Filter based on genotype QC (FinnGen only) |
85 |
Control definitions (FinnGen only)
- Control exclude
- L12_BULLOUS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L10-L14
- Name in latin
- Aliae morbositates acantholyticae
Similar endpoints
↥List of similar endpoints to
Other acantholytic disorders
based on the number of shared cases.
Similar with more cases:
- Bullous disorders
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 473 | 161 | 310 |
| Only index persons | 425 | 134 | 291 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.00 | 0.01 |
| Only index persons | 0.01 | 0.00 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 71.40 | 69.04 | 72.62 |
| Only index persons | 70.72 | 67.25 | 72.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 85 | 26 | 59 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.03 |
| Median age at first event (years) | 70.06 | 64.92 | 72.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 78
- Matched controls
- 778
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L11.1
ICD-10 Finland
Transient acantholytic dermatosis [Grover]
+∞
61.9
51
*
D05BB02
ATC
acitretin; oral
132.2
19.6
20
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
12.8
17.3
33
42
L11.0
ICD-10 Finland
Acquired keratosis follicularis
+∞
16.2
15
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
8.3
14.4
37
76
E0000UV
ATC
NA
5.3
10.9
49
189
L11.9
ICD-10 Finland
Acantholytic disorder, unspecified
+∞
10.6
10
*
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
6.4
8.1
22
45
L82
ICD-10 Finland
Seborrhoeic keratosis
6.1
8.1
23
50
D07AC01
ATC
betamethasone; topical
3.6
6.6
41
183
D07AB02
ATC
hydrocortisone butyrate; topical
3.7
6.4
35
140
D07AD01
ATC
clobetasol; topical
4.8
6.4
22
59
D07AC13
ATC
mometasone; topical
3.6
6.3
35
143
XQ848
NOMESCO Finland
Dermatological photography
14.1
6.3
10
8
XQ845
NOMESCO Finland
Dermatoscopy
16.7
6.1
9
6
Mortality – FinRegistry
↥Association
Association between endpoint L12_ACANTHOLYTIC and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACANTHOLYTIC | 1.27 [0.84, 1.93] | 0.261 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 245 males with L12_ACANTHOLYTIC died.
Mortality risk
Mortality risk for people of age
years, who have L12_ACANTHOLYTIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.234% |
| 5 | No data | 1.37% |
| 10 | No data | 3.526% |
| 15 | No data | 6.809% |
| 20 | No data | 11.671% |
Relationships between endpoints
↥Index endpoint: L12_ACANTHOLYTIC – Other acantholytic disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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