subcorneal pustular dermatosis: a rare, benign, chronic relapsing sterile pustular eruption typically involving the flexural sites of the trunk and proximal extremities. It most commonly affects woman aged 40 years or older.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
850 |
4. Check minimum number of eventsNone |
850 |
5. Include endpoints |
984 |
6. Filter based on genotype QC (FinnGen only) |
984 |
Control definitions (FinnGen only)
- Control exclude
- L12_BULLOUS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L10-L14
- Name in latin
- Aliae morbositates bullosae
Similar endpoints
↥List of similar endpoints to
Other bullous disorders
based on the number of shared cases.
Similar with more cases:
- Bullous disorders
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7656 | 4036 | 3577 |
| Only index persons | 6569 | 3572 | 2997 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.12 | 0.10 |
| Only index persons | 0.12 | 0.13 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 48.42 | 48.66 | 48.09 |
| Only index persons | 47.51 | 47.64 | 47.37 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 984 | 570 | 414 |
| Unadjusted period prevalence (%) | 0.19 | 0.19 | 0.18 |
| Median age at first event (years) | 49.06 | 45.61 | 53.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 885
- Matched controls
- 8850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L13.0
ICD-10 Finland
Dermatitis herpetiformis
10090.7
323.0
494
*
L13.9
ICD-10 Finland
Bullous disorder, unspecified
802.0
252.7
237
*
K90.0
ICD-10 Finland
Coeliac disease
36.9
225.1
293
117
J04BA02
ATC
dapsone; oral
279.0
198.5
196
9
69399
ICD-8 Finland
Dermatitis herpetiformis
+∞
121.7
114
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.7
114.6
277
440
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.1
60.4
290
948
D07AC01
ATC
betamethasone; topical
3.3
60.2
443
2044
L12.0
ICD-10 Finland
Bullous pemphigoid
323.7
60.1
60
*
L13.8
ICD-10 Finland
Other specified bullous disorders
594.7
57.3
56
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.1
47.6
364
1645
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.0
46.3
211
638
E0000UV
ATC
NA
2.6
38.4
432
2386
D07AC13
ATC
mometasone; topical
2.7
37.2
343
1680
E000001
ATC
NA
3.0
36.5
265
1116
D07AB02
ATC
hydrocortisone butyrate; topical
2.6
33.6
328
1637
D07AD01
ATC
clobetasol; topical
2.9
28.3
202
824
6940A
ICD-9 Finland
Bullous dermatoses, Dermatitis herpetiformis
+∞
28.3
27
*
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.5
27.4
140
451
TQW80
NOMESCO Finland
Local dermatologic skincare
7.1
27.2
68
102
D07AB08
ATC
desonide; topical
3.3
26.7
149
512
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
53.5
22.2
26
5
H02AB06
ATC
prednisolone; systemic
2.0
21.9
457
3067
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
19.6
327
1984
E000002
ATC
NA
2.8
19.1
135
536
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.0
18.7
114
412
R06AE07
ATC
cetirizine; oral
1.9
18.6
410
2749
D07CC01
ATC
betamethasone and antibiotics; topical
2.6
18.5
148
635
L20.0
ICD-10 Finland
Besnier prurigo
3.6
18.4
87
261
D07BC01
ATC
betamethasone and antiseptics; topical
2.6
17.0
133
561
L12.9
ICD-10 Finland
Pemphigoid, unspecified
86.6
15.6
17
*
L30.3
ICD-10 Finland
Infective dermatitis
4.4
14.9
54
128
E000007
ATC
NA
3.5
14.9
71
215
D07AA02
ATC
hydrocortisone; topical
2.3
14.6
140
657
D02AX
ATC
Other emollients and protectives
4.4
13.5
49
117
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.4
13.4
66
206
R06AE09
ATC
levocetirizine; oral
2.2
12.9
146
736
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.3
12.8
64
202
K90.9
ICD-10 Finland
Intestinal malabsorption, unspecified
20.4
12.5
18
9
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
4.7
12.3
41
90
J01DB01
ATC
cefalexin; oral
1.8
12.2
703
6021
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.2
12.2
133
661
RD210
NOMESCO Finland
NA
5.6
11.9
34
63
XQ800
NOMESCO Finland
Prick test
2.7
11.6
79
306
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.5
11.5
94
403
L13.1
ICD-10 Finland
Subcorneal pustular dermatitis
121.5
11.4
12
*
J01FF01
ATC
clindamycin; systemic
1.8
11.1
246
1584
L29.9
ICD-10 Finland
Pruritus, unspecified
5.0
10.9
34
70
D07XC01
ATC
betamethasone, combinations; topical
2.1
10.5
123
628
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
10.0
174
1031
XQ848
NOMESCO Finland
Dermatological photography
3.9
9.8
39
103
D07XB05
ATC
dexamethasone, combinations; topical
4.2
9.7
36
89
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.8
9.6
31
67
R06AX13
ATC
loratadine; oral
2.0
9.5
137
757
69300
ICD-8 Finland
NA
+∞
9.4
9
*
J05AB01
ATC
aciclovir; systemic
1.8
9.4
183
1127
P01BA02
ATC
hydroxychloroquine; oral
2.4
9.1
79
349
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
9.1
105
532
S97
ICPC
Chronic ulcer skin
2.8
9.0
58
219
D09AB01
ATC
zinc bandage without supplements; topical
4.4
9.0
31
72
B03BA03
ATC
hydroxocobalamin; parenteral
2.8
8.9
57
215
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
8.9
358
2680
A46
ICD-10 Finland
Erysipelas
2.0
8.9
123
670
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
6.4
8.8
22
35
XQ802
NOMESCO Finland
Epicutan test
3.0
8.7
49
168
H3600, E103
ICD-10 Finland
NA
7.7
8.7
19
25
S29
ICPC
Skin symptom/complaint other
1.8
8.6
149
881
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.3
8.5
74
331
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.4
8.5
40
123
S99
ICPC
Skin disease other
4.9
8.4
26
54
D02AE01
ATC
carbamide; topical
2.4
8.4
69
297
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
2.1
8.4
92
458
L12.2
ICD-10 Finland
Chronic bullous disease of childhood
+∞
8.3
8
*
E000006
ATC
NA
2.4
8.3
70
308
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.9
8.2
122
683
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.2
8.2
83
396
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.1
8.2
44
149
L28.1
ICD-10 Finland
Prurigo nodularis
9.0
8.1
16
18
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
8.1
145
868
L51.9
ICD-10 Finland
Erythema multiforme, unspecified
22.2
8.0
11
5
A10AA01
ATC
NA
3.7
8.0
33
91
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
8.0
103
545
J01DA01
ATC
[U] cefalexin; systemic
1.5
8.0
528
4387
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
3.2
8.0
40
129
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.9
8.0
113
623
N05BB01
ATC
hydroxyzine; systemic
2.4
8.0
64
274
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
5.2
7.9
23
45
S02
ICPC
Pruritus
3.3
7.9
38
119
J01AA07
ATC
tetracycline; systemic
1.8
7.9
130
757
L04AD01
ATC
ciclosporin; systemic
4.5
7.8
26
59
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
9.5
7.8
15
16
D11AH01
ATC
tacrolimus; topical
9.5
7.8
15
16
R06AX27
ATC
desloratadine; oral
1.6
7.8
218
1482
J01CF05
ATC
flucloxacillin; systemic
3.1
7.7
41
138
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.8
7.7
49
184
J05AB11
ATC
valaciclovir; oral
1.9
7.7
111
616
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
7.7
331
2499
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.7
7.7
196
1298
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.0
7.6
41
140
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
7.6
182
1185
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
7.5
151
935
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.3
7.4
66
297
B81
ICPC
Anaemia vit B12/folate deficiency
3.2
7.4
37
120
135
Kela drug reimbursment
Pemphigus
+∞
7.3
7
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
7.3
330
2509
H04AA01
ATC
glucagon; nasal, parenteral
4.2
7.2
26
64
J01MA12
ATC
levofloxacin; systemic
1.7
7.2
153
962
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
7.2
254
1826
L13
ICD-10 Finland
Other bullous disorders
20.2
7.1
10
5
H02AB09
ATC
hydrocortisone; systemic
3.6
7.1
30
85
J01MA02
ATC
ciprofloxacin; systemic
1.5
7.1
316
2390
R06.0
ICD-10 Finland
Dyspnoea
1.6
7.0
207
1424
L04AX01
ATC
azathioprine; systemic
2.8
6.9
44
165
SPAT1263
SPAT
Sampling
1.5
6.9
349
2710
E000003
ATC
NA
2.6
6.9
49
198
ZY010
NOMESCO Finland
Hospital outpatient
2.6
6.9
48
191
S18
ICPC
Laceration/cut
1.5
6.9
345
2672
R50.9
ICD-10 Finland
Fever, unspecified
1.8
6.8
113
657
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
4.1
6.8
25
63
D05BB02
ATC
acitretin; oral
3.8
6.8
27
73
107
Kela drug reimbursment
Pernicious anaemia
4.0
6.7
25
64
R60.0
ICD-10 Finland
Localized oedema
1.9
6.6
91
495
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.5
6.5
28
81
L30.0
ICD-10 Finland
Nummular dermatitis
3.0
6.5
35
120
SPAT1099
SPAT
Measurement of blood pressure with Doppler ultrasound device
3.2
6.5
31
98
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.6
6.5
43
168
H02AB04
ATC
methylprednisolone; systemic
1.8
6.5
120
725
A02BC02
ATC
pantoprazole; systemic
1.4
6.4
533
4537
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
6.3
319
2461
N02BE01
ATC
paracetamol; systemic, rectal
1.5
6.3
721
6543
R03BA01
ATC
beclometasone; inhalant
1.7
6.3
118
715
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.2
6.2
58
270
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.1
6.2
65
319
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
3.5
6.1
26
75
A10AE05
ATC
insulin detemir; parenteral
2.4
6.1
49
210
ZX120
NOMESCO Finland
Intravenous
2.0
6.1
79
422
Mortality – FinRegistry
↥Association
Association between endpoint L12_BULLOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_BULLOTH | 1.288 [1.11, 1.49] | < 0.001 |
| Birth year | 1.001 [0.99, 1.01] | 0.879 |
During the follow-up period (1.1.1998 — 31.12.2019), 519 out of 2922 females with L12_BULLOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_BULLOTH | 1.22 [1.06, 1.4] | 0.006 |
| Birth year | 0.991 [0.98, 1.0] | 0.041 |
During the follow-up period (1.1.1998 — 31.12.2019), 526 out of 2437 males with L12_BULLOTH died.
Mortality risk
Mortality risk for people of age
years, who have L12_BULLOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.1% | 0.243% |
| 5 | 0.847% | 1.526% |
| 10 | 2.264% | 3.883% |
| 15 | 4.52% | 7.531% |
| 20 | 7.761% | 13.074% |
Relationships between endpoints
↥Index endpoint: L12_BULLOTH – Other bullous disorders
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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