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MS-disease / Multiple Sclerosis

DOID EFO PheWeb

G6_MS

multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G35
  • Hospital discharge: ICD-9 — 340
  • Hospital discharge: ICD-8 — 34099
  • Cause of death: ICD-10 — G35
  • Cause of death: ICD-9 — 340
  • Cause of death: ICD-8 — 34099
  • KELA reimbursements: KELA codes — 109

3 out of 7 registries used, show all original rules.

2533

4. Check minimum number of events

None

2533

5. Include endpoints

None

2533

6. Filter based on genotype QC (FinnGen only)

2409

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G35-G37
Name in latin Sclerosis multiplex

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19836 13288 6385
Only index persons 17256 11971 5285
Unadjusted prevalence (%)
Whole population 0.31 0.38 0.18
Only index persons 0.37 0.44 0.20
Median age at first event (years)
Whole population 39.19 38.69 40.18
Only index persons 38.41 38.12 39.08

-FinnGen-

Key figures

All Female Male
Number of individuals 2409 1819 590
Unadjusted prevalence (%) 0.68 0.79 0.32
Median age at first event (years) 38.05 36.86 41.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: G6_MS – MS-disease / Multiple Sclerosis

GWS hits: 9

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