Acute disseminated encephalitis/encephalomyelitis

G6_ADEM

acute disseminated encephalomyelitis: An encephalomyelitis characterized by inflammation located_in brain and located_in spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G04.0#
  • Hospital discharge: ICD-9 3235A
  • Hospital discharge: ICD-8 32300
  • Cause of death: ICD-10 G04.0#
  • Cause of death: ICD-9 3235A
  • Cause of death: ICD-8 32300

2 out of 7 registries used, show all original rules.

66

4. Check minimum number of events

None

66

5. Include endpoints

None

66

6. Filter based on genotype QC (FinnGen only)

66

Control definitions (FinnGen only)

Control exclude
G6_NEUINFL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G04
Name in latin
Encephalitis disseminata acuta

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
58
Matched controls
578
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
32300
ICD-8 Finland
Encephalitis, myelitis and encephalomyelitis, Encephalitis postinfectiosa
+∞
36.3
31
*
G04.0
ICD-10 Finland
Acute disseminated encephalitis
+∞
31.0
27
*
TAB00
NOMESCO Finland
Lumbar puncture
25.7
10.4
14
7
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
+∞
9.6
9
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
19.0
7.6
11
7
G40.9
ICD-10 Finland
Epilepsy, unspecified
19.7
7.0
10
6

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 676 304 364
Only index persons 537 257 280
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 21.71 24.51 18.75
Only index persons 20.47 23.38 17.79

-FinnGen-

Key figures

All Female Male
Number of individuals 66 40 26
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 25.74 24.83 27.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint G6_ADEM and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_ADEM.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: G6_ADEM – Acute disseminated encephalitis/encephalomyelitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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