info icon

Bacterial meningoencephalitis and meningomyelitis

G6_ENCEPHBACT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

42

4. Check minimum number of events

None

42

5. Include endpoints

None

42

6. Filter based on genotype QC (FinnGen only)

42

Control definitions (FinnGen only)

Control exclude
G6_NEUINFL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 433 195 233
Only index persons 332 153 179
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 49.00 50.72 47.75
Only index persons 46.58 47.45 45.85

-FinnGen-

Key figures

All Female Male
Number of individuals 42 26 16
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 52.85 50.42 56.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(36304419) Bacteria [Presence] in Urine
20
76
4.11
4.76
2.8
2.6
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
7
6
13.62
4.45
1.9
1.0
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
21
95
3.42
3.69
4.8
2.5
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
22
105
3.30
3.51
3.2
3.0
e6/l
20.6
46.5
0.54
16
70
(42870588) Differential panel, method unspecified - Blood
21
99
3.24
3.40
8.3
4.8
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
18
84
3.00
2.88
7.6
3.8
estimate
0.0
0.0
—
6
24
(3023368) Bacteria identified in Blood by Culture
18
88
2.83
2.61
6.3
4.1
—
—
—
0
0
(40761535) Cells panel - Urine sediment
9
27
3.95
2.57
6.2
2.6
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
16
75
2.83
2.49
7.2
3.2
—
—
—
0
0
(3005719) IgG [Mass/volume] in Serum or Plasma
7
18
4.44
2.37
5.0
1.3
g/l
9.7
10.4
—
7
18
(3026782) Osmolality of Urine
12
51
2.89
2.19
2.8
2.4
mosm/kgh2o
450.8
619.7
2.18
12
42
(3032080) INR in Blood by Coagulation assay
20
112
2.50
2.14
4.5
8.4
inr
1.0
1.2
—
8
36
(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma
8
26
3.55
2.14
2.9
2.1
pmol/l
4.1
4.4
—
8
20
(3015736) pH of Urine
22
129
2.48
2.14
6.2
3.0
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
17
89
2.53
2.08
4.0
3.1
—
—
—
0
0
(3000991) Gas panel - Venous blood
7
21
3.78
2.07
3.3
12.4
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
7
22
3.60
1.98
4.9
3.9
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
7
23
3.44
1.89
1.6
1.5
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
5
15
3.63
1.57
5.4
5.4
mmol/l
26.9
26.0
—
5
15
(3021601) Nitrite [Presence] in Urine by Test strip
23
158
2.01
1.35
7.2
4.3
estimate
0.0
0.0
—
7
25
(3033658) Prothrombin time (PT) actual/Normal
13
73
2.13
1.29
2.2
3.1
%
89.8
96.1
0.36
13
73
(3035350) Ketones [Presence] in Urine by Test strip
23
160
1.97
1.28
6.6
3.3
estimate
0.0
0.0
—
7
24
(3009261) Glucose [Presence] in Urine by Test strip
23
160
1.97
1.28
6.6
3.3
estimate
0.0
0.0
—
7
23
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
19
124
1.97
1.27
7.4
3.4
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
8
38
2.36
1.27
2.3
1.6
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
6
26
2.52
1.23
5.3
2.5
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
7
30
2.59
1.19
12.0
12.1
—
—
—
0
0
(3012544) pH of Venous blood
7
30
2.59
1.19
1.1
3.1
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
8
41
2.17
1.16
2.3
1.6
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
8
41
2.17
1.16
1.6
1.5
—
—
—
0
0
(3019060) Gas panel - Arterial blood
5
21
2.56
1.12
1.8
27.0
—
—
—
0
0
(3000492) Spirometry study
0
28
0.00
1.02
0.0
1.5
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
8
43
2.06
0.94
2.0
2.8
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
11
65
1.94
0.93
1.6
2.2
—
—
—
0
0
(3017732) Neutrophils [#/volume] in Blood
0
24
0.00
0.82
0.0
2.8
—
4.0
—
0
19
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
16
111
1.71
0.82
6.1
3.6
ng/l
25.8
22.2
—
10
68
(3019225) pH of Specimen
5
23
2.33
0.79
3.8
6.3
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
12
80
1.70
0.69
2.2
3.4
mg/l
9289.2
745.7
—
5
58
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
18
227
0.64
0.66
3.9
3.2
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
0
19
0.00
0.62
0.0
1.2
—
—
—
0
0
(3008898) HLA-B27 [Presence]
0
21
0.00
0.62
0.0
1.0
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
36
324
1.78
0.61
24.3
13.7
mg/l
23.6
22.0
0.13
31
244
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
9
59
1.67
0.60
2.8
1.6
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
18
139
1.52
0.57
4.9
4.5
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
26
299
0.66
0.55
22.3
16.1
%
39.2
39.9
0.33
17
228
(40768804) Tissue Pathology biopsy report
10
139
0.63
0.54
2.3
2.0
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
7
45
1.66
0.52
1.3
1.8
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
12
87
1.53
0.49
3.2
3.9
mg/mmol
1.2
6.5
—
5
56
(3037467) Urinalysis macro (dipstick) panel - Urine
27
235
1.42
0.42
7.6
3.9
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
10
72
1.51
0.41
7.0
4.2
—
—
—
0
0
(3002385) Erythrocyte distribution width [Ratio]
25
283
0.71
0.41
29.4
15.4
%
14.2
13.7
0.86
25
278
(3021960) Folate [Moles/volume] in Serum or Plasma
10
74
1.46
0.36
1.3
1.6
nmol/l
18.9
18.7
—
10
62
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
8
64
1.31
0.30
3.1
2.3
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
5
40
1.28
0.23
1.2
1.1
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
5
41
1.25
0.23
1.4
1.6
—
—
—
0
0
(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
0
11
0.00
0.21
0.0
1.4
—
101.8
—
0
11
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
3.4
—
16.8
—
0
10
(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay
0
10
0.00
0.21
0.0
1.6
—
3.6
—
0
10
(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
0
10
0.00
0.21
0.0
4.0
—
—
—
0
0
(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
0
10
0.00
0.21
0.0
1.5
—
202.3
—
0
10
(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method
0
13
0.00
0.21
0.0
1.5
—
3.1
—
0
6
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
6
51
1.21
0.20
1.7
1.4
—
—
—
0
0
(40768793) Breast Pathology biopsy report
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
11
91
1.28
0.20
2.8
2.2
—
—
—
0
0
(40758558) Short blood count panel - Blood
10
83
1.27
0.17
6.7
7.6
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
33
339
0.88
0.16
19.6
12.3
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
5
45
1.13
0.10
3.2
2.1
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
7
82
0.82
0.08
1.1
1.4
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
8
90
0.86
0.07
4.3
3.0
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
13
121
1.11
0.04
2.2
2.0
pmol/l
62.6
93.1
—
8
65
(1761868) Lipid panel - Serum or Plasma
10
107
0.91
0.02
2.2
2.6
—
—
—
0
0
(3044889) 12 lead EKG panel
23
227
1.03
0.00
5.4
3.3
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
6
64
0.93
0.00
2.2
1.7
—
—
—
0
0
(3013512) EKG study
7
75
0.92
0.00
2.0
3.6
—
—
—
0
0
(3007461) Platelets [#/volume] in Blood
36
359
1.02
0.00
31.6
20.0
e9/l
242.0
254.6
0.51
36
353
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay
0
5
0.00
0.00
0.0
4.6
—
8.7
—
0
5
(3008037) Lactate [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
3.9
—
1.7
—
0
8
(3035941) MCH [Entitic mass]
36
360
1.00
0.00
31.6
19.8
pg
29.8
30.3
0.90
36
355
(3043238) Trisomy 21 risk [Likelihood] in Fetus
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
87.5
—
0
5
(3023419) Bacteria identified in Sputum by Culture
0
6
0.00
0.00
0.0
3.5
—
—
—
0
0
(3041354) Potassium [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
3.5
—
4.0
—
0
8
(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.2
—
59.8
—
0
9
(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.5
—
11.2
—
0
6
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3026389) Candida sp identified in Specimen by Organism specific culture
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3024928) Oxygen saturation in Venous blood
0
6
0.00
0.00
0.0
4.7
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
3.9
—
7.2
—
0
8
(3047007) Chlamydophila sp Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
3.5
—
—
—
0
0
(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3026361) Erythrocytes [#/volume] in Blood
36
360
1.00
0.00
31.6
19.9
e12/l
4.4
4.5
1.06
36
351
(3010813) Leukocytes [#/volume] in Blood
36
360
1.00
0.00
31.7
19.9
e9/l
6.8
6.6
0.14
36
350
(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3032773) Endomysium IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3005033) Fetal Nuchal fold Thickness US
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3038177) Helicobacter pylori Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3009550) Parvovirus B19 IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(4268621)
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
7
71
0.98
0.00
3.1
4.9
ug/l
2.2
1.9
—
7
58
(3035285) Chloride [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
3.5
—
107.9
—
0
8
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
9
0.00
0.00
0.0
3.9
—
91.6
—
0
9
(3047352) Trisomy 18 risk [Likelihood] in Fetus
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(4306422)
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3000963) Hemoglobin [Mass/volume] in Blood
36
360
1.00
0.00
31.9
20.0
g/l
129.6
135.8
2.31
36
355
(3023420) DNA double strand Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
5
53
0.94
0.00
2.0
1.7
—
—
—
0
0
(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
5
53
0.94
0.00
3.2
2.2
—
—
—
0
0
(3024731) MCV [Entitic volume]
36
360
1.00
0.00
31.6
19.9
fl
89.8
90.8
0.62
36
355
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
3.0
—
4.2
—
0
6

Mortality – FinRegistry

Association

Association between endpoint G6_ENCEPHBACT and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
G6_ENCEPHBACT 2.668 [1.69, 4.2] < 0.001
Birth year 0.989 [0.98, 1.0] 0.035

During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 172 males with G6_ENCEPHBACT died.

Mortality risk

Mortality risk for people of age

years, who have G6_ENCEPHBACT.

N-year risk Females Males
1 No data 0.63%
5 No data 3.27%
10 No data 8.305%
15 No data 15.33%
20 No data 24.907%

Relationships between endpoints

Index endpoint: G6_ENCEPHBACT – Bacterial meningoencephalitis and meningomyelitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data