Other demyelinating diseases of the central nervous system

G6_OTHDEMYEL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G37
  • Hospital discharge: ICD-9 341[1-9]
  • Hospital discharge: ICD-8 3410[2-9]
  • Cause of death: ICD-10 G37
  • Cause of death: ICD-9 341[1-9]
  • Cause of death: ICD-8 3410[2-9]

2 out of 7 registries used, show all original rules.

1458

4. Check minimum number of events

None

1458

5. Include endpoints

None

1458

6. Filter based on genotype QC (FinnGen only)

1458

Control definitions (FinnGen only)

Control exclude
G6_DEMYEL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G35-G37
Name in latin
Alii morbi demyelinantes systematis nervosi centralis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8543 5445 3043
Only index persons 7717 5057 2660
Unadjusted period prevalence (%)
Whole population 0.13 0.16 0.09
Only index persons 0.16 0.19 0.10
Median age at first event (years)
Whole population 39.82 38.63 41.86
Only index persons 39.14 38.08 41.15

-FinnGen-

Key figures

All Female Male
Number of individuals 1458 1059 399
Unadjusted period prevalence (%) 0.31 0.36 0.18
Median age at first event (years) 39.28 37.77 43.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1322
Matched controls
13217
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
109
Kela drug reimbursment
Multiple sclerosis
+∞
323.0
659
*
TAB00
NOMESCO Finland
Lumbar puncture
27.7
323.0
500
284
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
+∞
323.0
1024
*
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
+∞
323.0
560
*
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
+∞
323.0
544
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
25.5
323.0
662
500
G35
ICD-10 Finland
Multiple sclerosis
10640.8
323.0
869
*
L03AB07
ATC
interferon beta-1a; parenteral
+∞
302.0
278
*
N86
ICPC
Multiple sclerosis
1074.9
275.2
260
*
L03AX13
ATC
glatiramer acetate; parenteral
+∞
244.6
227
*
H46
ICD-10 Finland
Optic neuritis
118.9
228.3
243
25
L04AX07
ATC
dimethyl fumarate; oral
+∞
207.9
194
*
L04AA31
ATC
teriflunomide; oral
+∞
180.4
169
*
164
Kela drug reimbursment
Fingolimod
+∞
170.6
160
*
353
Kela drug reimbursment
Cladribine and fingolimod
+∞
149.9
141
*
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
41.1
134.2
169
47
R20.2
ICD-10 Finland
Paraesthesia of skin
8.1
125.3
308
475
L03AB08
ATC
interferon beta-1b; parenteral
+∞
121.8
115
*
L04AA27
ATC
fingolimod; oral
+∞
118.6
112
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
7.5
117.2
306
513
N04BB01
ATC
amantadine; oral
38.9
117.0
149
43
N07XX09
ATC
[U] dimethyl fumarate; oral
+∞
116.4
110
*
G37.3
ICD-10 Finland
Acute transverse myelitis in demyelinating disease of central nervous system
+∞
107.8
102
*
M03BX01
ATC
baclofen; systemic
25.1
101.0
144
64
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
17.5
99.7
161
104
2AB04
NOMESCO Finland
NA
940.5
90.9
88
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
20.3
87.9
134
73
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
7.8
87.8
217
325
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.8
85.3
268
556
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
11.2
77.0
151
150
G36.9
ICD-10 Finland
Acute disseminated demyelination, unspecified
+∞
75.8
72
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.0
73.5
351
1107
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
23.9
69.5
100
45
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
13.2
67.2
121
100
XA800
NOMESCO Finland
Neuropsychological investigation
7.8
67.1
163
234
XCK00
NOMESCO Finland
Perimetry
6.8
63.6
171
284
XKD06
NOMESCO Finland
Physiologic investigation of micturition
11.9
59.9
113
103
L03AB13
ATC
peginterferon beta-1a; parenteral
+∞
58.8
56
*
G37.2
ICD-10 Finland
Central pontine myelinolysis
+∞
58.8
56
*
3419X
ICD-9 Finland
Other demyelinating diseases of central nervous system, Demyelinating disease of central nervous system, unspecified
+∞
54.6
52
*
G04BD12
ATC
mirabegron; oral
5.1
53.3
183
407
H53.2
ICD-10 Finland
Diplopia
9.5
51.4
109
124
ZX120
NOMESCO Finland
Intravenous
4.2
49.8
208
563
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
35.3
49.6
64
19
F02.89*G35
ICD-10 Finland
Dementia in multiple sclerosis
+∞
49.3
47
*
G37.8
ICD-10 Finland
Other specified demyelinating diseases of central nervous system
+∞
49.3
47
*
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
25.0
48.9
69
29
N03AX12
ATC
gabapentin; oral
3.2
47.6
294
1092
XKD00
NOMESCO Finland
Uroflowmetry
4.2
46.4
191
508
N06BA07
ATC
modafinil; oral
50.1
44.2
53
11
N03AE01
ATC
clonazepam; systemic
5.0
43.6
148
323
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
16.6
42.1
68
43
34109
ICD-8 Finland
Other demyelinating diseases of central nervous system, Unspecified
+∞
41.9
40
*
UKC02
NOMESCO Finland
Cystoscopy
3.5
41.3
214
691
G04BD09
ATC
trospium; oral
10.5
41.1
82
83
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
4.3
40.7
163
420
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
8.9
39.8
87
104
4AA23
NOMESCO Finland
NA
377.6
37.2
37
*
N03AX16
ATC
pregabalin; oral
2.4
35.9
365
1794
XKC03
NOMESCO Finland
Water cystometry
7.1
35.6
90
135
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.4
35.3
136
337
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
33.4
505
2970
3400A
ICD-9 Finland
Multiple sclerosis[SCLEROSIS MULTIPLEX (DISSEMINATA)]
+∞
31.4
30
*
L04AA40
ATC
cladribine; oral
+∞
31.4
30
*
R1250
NOMESCO Finland
Evaluation of functional capability
8.0
30.8
71
93
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.2
29.8
375
2013
G04BD08
ATC
solifenacin; oral
4.8
28.9
99
217
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
14.2
28.2
48
35
TKC22
NOMESCO Finland
Catheterisation instruction
10.6
28.1
55
54
L28
ICPC
Limited function/disability (L)
2.9
27.2
182
694
H53.1
ICD-10 Finland
Subjective visual disturbances
3.6
26.8
127
377
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
12.1
26.3
48
41
G36.0
ICD-10 Finland
Neuromyelitis optica [Devic]
+∞
26.1
25
*
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
6.9
25.5
65
99
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.5
25.4
127
393
R33
ICD-10 Finland
Retention of urine
4.7
24.9
88
199
N29
ICPC
Neurological sympt/complt other
9.0
24.9
53
61
G37.0
ICD-10 Finland
Diffuse sclerosis
+∞
24.0
23
*
H48.1*G35
ICD-10 Finland
Retrobulbar neuritis in multiple sclerosis
+∞
24.0
23
*
SPAT1229
SPAT
Assessment of need for aid
3.7
23.6
107
306
XCD10
NOMESCO Finland
Electrophysiological examination of eye
6.5
23.6
62
99
AA1AD
NOMESCO Finland
CT of head and brain
2.2
23.5
273
1392
L01BB04
ATC
cladribine; systemic
+∞
23.0
22
*
A02BC02
ATC
pantoprazole; systemic
1.8
22.3
811
6227
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
24.4
22.2
31
13
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
22.1
211
976
R35
ICD-10 Finland
Polyuria
4.0
22.0
92
245
G04BD04
ATC
oxybutynin; oral, transdermal
4.3
22.0
84
206
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.3
21.9
68
134
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.4
21.4
79
187
H02AB04
ATC
methylprednisolone; systemic
2.3
21.2
222
1071
XKD03
NOMESCO Finland
Urethral pressure profilometry
6.4
21.1
56
91
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.8
20.7
145
565
N32.83
ICD-10 Finland
Nozzle synergy in the bladder neck
30.6
20.6
27
9
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
4.8
20.6
70
153
N28
ICPC
Limited function/disability (N)
11.5
20.5
38
34
CS494
NOMESCO Finland
Other visual field testing
6.8
20.1
51
78
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
9.8
19.9
40
42
34099
ICD-8 Finland
Multiple sclerosis
+∞
19.8
19
*
G82.2
ICD-10 Finland
Paraplegia, unspecified
25.0
19.6
27
11
R42
ICD-10 Finland
Dizziness and giddiness
2.1
19.5
261
1402
N05CF01
ATC
zopiclone; oral
1.8
19.2
382
2385
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
20.4
19.1
28
14
N99
ICPC
Neurological disease other
12.0
18.8
34
29
4AA36
NOMESCO Finland
NA
+∞
18.8
18
*
34108
ICD-8 Finland
Other demyelinating diseases of central nervous system, Alii definiti
+∞
18.8
18
*
N06AX21
ATC
duloxetine; oral
2.3
18.5
184
864
TKC20
NOMESCO Finland
Catheterisation of bladder
3.5
18.4
87
258
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
30.5
18.4
24
8
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.4
18.2
89
271
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.5
18.0
156
684
G37.1
ICD-10 Finland
Central demyelination of corpus callosum
+∞
17.7
17
*
N03AF01
ATC
carbamazepine; oral, rectal
3.6
17.6
82
240
N06AX16
ATC
venlafaxine; oral
2.0
17.4
240
1301
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
12.2
17.4
31
26
G04BD07
ATC
tolterodine; oral
4.2
17.3
67
167
C10AC01
ATC
colestyramine; oral
4.6
17.3
61
139
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
11.3
17.3
32
29
J01EA01
ATC
trimethoprim; systemic
1.8
17.2
343
2132
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.2
16.8
90
294
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
91.2
16.6
18
*
L04AX01
ATC
azathioprine; systemic
3.2
16.3
87
283
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
12.4
15.9
28
23
R4110
NOMESCO Finland
Physiotherapy
1.8
15.7
323
2015
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.8
15.7
107
409
Z3231
NOMESCO Finland
Registered nurse
1.8
15.5
341
2173
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.1
15.4
87
293
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
5.7
15.2
43
77
Z3226
NOMESCO Finland
Physiotherapist
1.9
14.7
233
1326
G36.8
ICD-10 Finland
Other specified acute disseminated demyelination
+∞
14.6
14
*
N06AA09
ATC
amitriptyline; systemic
2.4
14.4
128
567
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
11.0
14.0
26
24
R4150
NOMESCO Finland
Neuropsychological rehabilitation
8.3
13.8
30
37
Z2445
NOMESCO Finland
Psychologist
3.0
13.8
81
283
SPAT1216
SPAT
Assessment of functional ability
2.2
13.8
146
706
R4120
NOMESCO Finland
Occupational therapy
2.7
13.5
95
370
SPAT1231
SPAT
Assessment of adjustments needed in living environment
7.5
13.5
31
42
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.7
13.1
92
359
G50.0
ICD-10 Finland
Trigeminal neuralgia
5.6
12.9
37
68
A28
ICPC
Limited function/disability NOS
2.3
12.7
115
516
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
12.6
265
1652
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
11.1
12.5
23
21
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.8
12.3
77
281
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
4.6
12.3
42
94
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
12.2
94
387
R39.1
ICD-10 Finland
Other difficulties with micturition
4.5
12.2
42
95
G04BD11
ATC
fesoterodine; oral
4.8
12.2
40
86
G61.0
ICD-10 Finland
Guillain-Barré syndrome
16.0
12.2
19
12
Z2446
NOMESCO Finland
Social worker
2.4
12.1
103
447
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
6.6
12.1
30
46
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.9
12.0
49
130
R51.80
ICD-10 Finland
Headache
1.8
12.0
228
1376
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
12.0
117
541
N30.0
ICD-10 Finland
Acute cystitis
1.9
12.0
181
1007
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
11.8
161
864
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
19.1
11.6
17
9
R20.1
ICD-10 Finland
Hypoaesthesia of skin
9.3
11.5
23
25
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.8
11.4
48
131
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
5.3
11.2
33
63
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
17.2
11.2
17
10
R27.0
ICD-10 Finland
Ataxia, unspecified
20.2
11.1
16
8
H30.2
ICD-10 Finland
Posterior cyclitis
15.6
10.8
17
11
G81.9
ICD-10 Finland
Hemiplegia, unspecified
6.8
10.7
26
39
H57.1
ICD-10 Finland
Ocular pain
3.2
10.7
55
177
H47.2
ICD-10 Finland
Optic atrophy
14.3
10.5
17
12
U13
ICPC
Bladder symptom/complaint other
3.7
10.5
45
126
G04.8
ICD-10 Finland
Other encephalitis, myelitis and encephalomyelitis
110.9
10.4
11
*
NA1CM
NOMESCO Finland
Cervical spine extensive MRI examination with 3 Tesla magnet
18.9
10.3
15
8
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
13.2
10.2
17
13
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
10.1
144
783
XCK10
NOMESCO Finland
Photography of fundus of eye
2.2
10.0
101
477
M03BX02
ATC
tizanidine; oral
1.5
9.9
826
7040
N03AF02
ATC
oxcarbazepine; oral
2.9
9.8
57
200
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.9
9.8
153
864
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
4.8
9.7
31
66
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
9.6
117
601
3773B
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[NEURITIS RETROBULBARIS]
100.7
9.4
10
*
36703
ICD-8 Finland
Inflammation of optic nerve and retina, Neuritis optica, retrobulbaris
100.7
9.4
10
*
H02AB06
ATC
prednisolone; systemic
1.5
9.4
536
4220
3418X
ICD-9 Finland
Other demyelinating diseases of central nervous system
+∞
9.4
9
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.1
9.3
50
167
A06AD11
ATC
lactulose; oral
2.0
9.3
124
658
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.5
9.2
72
298
R20.8
ICD-10 Finland
Other and unspecified disturbances of skin sensation
7.1
9.0
21
30
N18
ICPC
Paralysis/weakness
5.5
8.9
25
46
R52.2
ICD-10 Finland
Other chronic pain
3.0
8.7
50
173
6BA02
NOMESCO Finland
NA
14.1
8.7
14
10
WW400
NOMESCO Finland
Plasmaferesis
50.3
8.7
10
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
7.7
8.7
19
25
J01MA02
ATC
ciprofloxacin; systemic
1.5
8.6
406
3062
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
8.6
494
3879
SPAT1293
SPAT
Other function in accordance with rehabilitation guidance nomenclature
8.3
8.6
18
22
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.6
8.5
59
232
H53.4
ICD-10 Finland
Visual field defects
3.9
8.4
33
87
G37.5
ICD-10 Finland
Concentric sclerosis [Baló]
+∞
8.3
8
*
G96.9
ICD-10 Finland
Disorder of central nervous system, unspecified
+∞
8.3
8
*
RS221
NOMESCO Finland
NA
4.2
8.3
30
73
G04CA02
ATC
tamsulosin; oral
1.9
8.3
128
718
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
9.5
8.3
16
17
H25.8
ICD-10 Finland
Other senile cataract
2.6
8.2
57
225
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
7.6
8.2
18
24
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.9
8.1
114
619
H02AB07
ATC
prednisone; oral
1.7
8.1
162
989
R47.1
ICD-10 Finland
Dysarthria and anarthria
9.0
8.0
16
18
NA7CM
NOMESCO Finland
Spine and spinal cord extensive MRI examination with 3 Tesla magnet
22.2
8.0
11
5
119
Kela drug reimbursment
Trigeminal neuralgia or glossofaryngeusneuralgia
13.1
7.9
13
10
R20.0
ICD-10 Finland
Anaesthesia of skin
5.7
7.8
21
37
WX110
NOMESCO Finland
Local anesthesy
1.4
7.8
891
7858
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.5
7.8
34
98
XA402
NOMESCO Finland
ENMG
3.3
7.8
37
114
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
3.9
7.7
30
79
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.7
7.5
49
186
N06
ICPC
Sensation disturbance other
5.5
7.5
21
39
N06AB04
ATC
citalopram; systemic
1.5
7.5
261
1838
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
7.4
85
426
SPAT1167
SPAT
Insertion of urinary catheter
4.4
7.3
25
58
N02BE01
ATC
paracetamol; systemic, rectal
1.5
7.3
1052
9620
RS121
NOMESCO Finland
NA
6.9
7.3
17
25
H48.1
ICD-10 Finland
Retrobulbar neuritis in diseases classified elsewhere
+∞
7.3
7
*
SPAT1263
SPAT
Sampling
1.4
7.2
491
3940
Z43.5
ICD-10 Finland
Attention to cystostomy
15.8
7.2
11
7
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.5
7.2
32
94
H04.10
ICD-10 Finland
Dry eye syndrome
1.8
7.2
114
646
SPAT1262
SPAT
Handing over of treatment supplies
1.7
7.2
165
1046
R60.0
ICD-10 Finland
Localized oedema
1.9
7.2
102
555
Z2221
NOMESCO Finland
Medical doctor
1.4
7.2
345
2601
G95.9
ICD-10 Finland
Disease of spinal cord, unspecified
20.1
7.1
10
5
SPAT1301
SPAT
No procedures
1.4
7.1
332
2485
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.8
7.1
113
643
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
5.7
7.1
19
34
S97
ICPC
Chronic ulcer skin
2.8
7.1
45
167
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
7.1
99
536
U04
ICPC
Incontinence urine
2.8
6.9
42
154
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
4.3
6.9
24
57
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.9
6.8
97
530
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.2
6.8
67
315
R13
ICD-10 Finland
Dysphagia
2.2
6.8
67
316
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.6
6.7
160
1028
SAA03
NOMESCO Finland
Extended examination of mouth
1.4
6.6
490
3974
A06AC51
ATC
ispaghula, combinations; systemic
2.4
6.5
55
239
359
Kela drug reimbursment
Mirabegroni
10.1
6.5
12
12
RS222
NOMESCO Finland
NA
4.2
6.5
23
56
J05AB11
ATC
valaciclovir; oral
1.6
6.5
157
1011
M79.6
ICD-10 Finland
Pain in limb
1.4
6.5
397
3120
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.3
6.4
55
245
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
6.4
419
3328
R15
ICD-10 Finland
Faecal incontinence
3.2
6.4
31
99
G97.1
ICD-10 Finland
Other reaction to spinal and lumbar puncture
8.2
6.3
13
16
SPAT1325
SPAT
Vaccination
1.4
6.3
304
2284
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.6
6.3
26
73
XX1ZW
NOMESCO Finland
Very extensive written report from radiologist
9.3
6.3
12
13
R93.0
ICD-10 Finland
Abnormal findings on diagnostic imaging of skull and head, not elsewhere classified
18.1
6.3
9
5
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.4
6.2
51
221
5AB01
NOMESCO Finland
NA
26.8
6.2
8
*
Z73.6
ICD-10 Finland
Limitation of activities due to disability
7.1
6.2
14
20
J01CA08
ATC
pivmecillinam; oral
1.3
6.1
525
4346
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
6.1
288
2151
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
12.6
6.1
10
8
N04BC05
ATC
pramipexole; oral
2.1
6.1
67
332
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
6.0
204
1425
R53
ICD-10 Finland
Malaise and fatigue
1.5
6.0
223
1588
N04BD01
ATC
selegiline; oral
5.2
6.0
17
33

Mortality – FinRegistry

Association

Association between endpoint G6_OTHDEMYEL and mortality.

Females

Parameter HR [95% CI] p-value
G6_OTHDEMYEL 2.092 [1.77, 2.47] < 0.001
Birth year 0.994 [0.98, 1.0] 0.142

During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 4099 females with G6_OTHDEMYEL died.

Males

Parameter HR [95% CI] p-value
G6_OTHDEMYEL 2.444 [2.08, 2.87] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 304 out of 2166 males with G6_OTHDEMYEL died.

Mortality risk

Mortality risk for people of age

years, who have G6_OTHDEMYEL.

N-year risk Females Males
1 0.224% 0.37%
5 1.238% 2.478%
10 2.828% 5.803%
15 5.52% 11.151%
20 9.909% 18.746%

Relationships between endpoints

Index endpoint: G6_OTHDEMYEL – Other demyelinating diseases of the central nervous system

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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