autonomic nervous system disease: A disease involving the autonomic nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
779 |
4. Check minimum number of eventsNone |
779 |
5. Include endpoints |
801 |
6. Filter based on genotype QC (FinnGen only) |
801 |
Control definitions (FinnGen only)
- Control exclude
- G6_OTHNEU
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G90-G99
- Name in latin
- Morbositates systematis nervosi autonomici
Similar endpoints
↥List of similar endpoints to
Autonomic disorders
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6006 | 2906 | 3053 |
| Only index persons | 5139 | 2553 | 2586 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.09 |
| Only index persons | 0.10 | 0.09 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 56.80 | 57.86 | 55.60 |
| Only index persons | 55.36 | 56.45 | 54.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 801 | 429 | 372 |
| Unadjusted period prevalence (%) | 0.15 | 0.15 | 0.16 |
| Median age at first event (years) | 56.53 | 55.19 | 58.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 712
- Matched controls
- 7119
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G90.2
ICD-10 Finland
Horner syndrome
+∞
323.0
394
*
G90.0
ICD-10 Finland
Idiopathic peripheral autonomic neuropathy
+∞
115.9
108
*
G90.3
ICD-10 Finland
Multi-system degeneration
961.6
88.7
85
*
G90.9
ICD-10 Finland
Disorder of autonomic nervous system, unspecified
592.6
56.4
55
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
35.6
43.6
56
17
G90.8
ICD-10 Finland
Other disorders of autonomic nervous system
+∞
43.2
41
*
AA1AD
NOMESCO Finland
CT of head and brain
3.5
42.1
243
912
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
10.0
38.3
79
88
H02.4
ICD-10 Finland
Ptosis of eyelid
11.8
34.2
64
59
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.2
32.5
107
232
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
8.5
30.7
69
89
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
28.4
361
2102
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.6
27.7
102
248
H57.0
ICD-10 Finland
Anomalies of pupillary function
28.2
26.0
35
13
I67.0
ICD-10 Finland
Dissection of cerebral arteries, nonruptured
97.1
25.8
28
*
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
7.8
23.4
55
76
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
23.0
22
*
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
14.2
23.0
39
29
N03AX16
ATC
pregabalin; oral
2.5
22.2
211
1021
G20
ICD-10 Finland
Parkinson disease
7.1
22.1
55
83
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
118.7
21.7
23
*
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
+∞
20.9
20
*
H02AA02
ATC
fludrocortisone; oral
19.0
20.6
31
17
TAB00
NOMESCO Finland
Lumbar puncture
5.2
18.1
57
117
R51.80
ICD-10 Finland
Headache
2.8
18.0
125
497
R55
ICD-10 Finland
Syncope and collapse
3.1
18.0
106
379
G44.0
ICD-10 Finland
Cluster headache syndrome
17.1
18.0
28
17
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
17.8
17
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.9
17.7
59
129
R53
ICD-10 Finland
Malaise and fatigue
2.4
17.5
173
841
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.5
17.1
85
268
XCK00
NOMESCO Finland
Perimetry
3.9
17.0
73
204
G90.1
ICD-10 Finland
Familial dysautonomia [Riley-Day]
+∞
16.7
16
*
PA6CG
NOMESCO Finland
Extensive MRI examination of neck vasculature with high intensity magnet
28.3
16.6
22
8
I95.1
ICD-10 Finland
Orthostatic hypotension
6.6
16.3
42
67
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
+∞
15.7
15
*
R42
ICD-10 Finland
Dizziness and giddiness
2.3
15.6
168
847
N04BC05
ATC
pramipexole; oral
3.3
14.9
77
251
N87
ICPC
Parkinsonism
10.7
14.8
28
27
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.8
14.2
61
171
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
7.3
14.0
33
47
N03AX12
ATC
gabapentin; oral
2.4
13.9
124
567
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
5.0
13.5
43
90
Z3226
NOMESCO Finland
Physiotherapist
2.2
13.4
153
785
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.9
13.0
36
64
R4130
NOMESCO Finland
Speech therapy
7.2
13.0
31
45
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.1
13.0
73
252
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
12.5
12
*
G90.4
ICD-10 Finland
Autonomic dysreflexia
+∞
12.5
12
*
N02AX02
ATC
tramadol; systemic, rectal
1.8
12.5
302
2057
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.2
12.5
66
219
N06AX21
ATC
duloxetine; oral
2.6
12.2
96
409
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
12.2
125
609
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
21.7
12.0
17
8
R4110
NOMESCO Finland
Physiotherapy
1.9
12.0
198
1175
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
11.9
208
1262
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
11.8
116
554
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.3
11.8
61
199
R13
ICD-10 Finland
Dysphagia
3.3
11.7
60
194
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
11.6
126
630
ZXD05
NOMESCO Finland
Urgent procedure
1.9
11.5
227
1432
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
11.5
11
*
XA800
NOMESCO Finland
Neuropsychological investigation
4.2
11.4
43
108
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
11.3
276
1865
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
6.1
11.3
30
51
N28
ICPC
Limited function/disability (N)
7.8
11.2
25
33
N04BD01
ATC
selegiline; oral
7.6
11.0
25
34
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
3.4
11.0
54
170
J01MA02
ATC
ciprofloxacin; systemic
1.8
10.7
271
1850
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
7.5
10.5
24
33
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
10.4
95
436
R06.0
ICD-10 Finland
Dyspnoea
1.9
10.3
177
1057
PA7BD
NOMESCO Finland
CT angiography of neck and brain
9.8
10.3
20
21
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
11.5
10.1
18
16
M03BX01
ATC
baclofen; systemic
7.4
10.0
23
32
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.5
9.7
75
316
A28
ICPC
Limited function/disability NOS
2.1
9.7
110
558
XF606
NOMESCO Finland
Ortostatic test
15.3
9.5
15
10
N06AX16
ATC
venlafaxine; oral
2.2
9.5
99
484
C08DA01
ATC
verapamil; systemic
3.7
9.5
40
112
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.1
9.4
50
167
G99.2
ICD-10 Finland
Myelopathy in diseases classified elsewhere
+∞
9.4
9
*
3378X
ICD-9 Finland
Disorders of the autonomic nervous system[NEUROPATHIA AUTONOMICA PERIPHERICA ALIA DEFINITA]
+∞
9.4
9
*
PA6AD
NOMESCO Finland
CT of neck arteries
9.7
9.3
18
19
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
6.2
9.3
24
40
H02AB06
ATC
prednisolone; systemic
1.7
9.3
312
2284
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
9.2
119
638
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.6
9.2
65
260
R4120
NOMESCO Finland
Occupational therapy
2.9
9.2
57
210
N03AE01
ATC
clonazepam; systemic
2.9
9.2
54
194
N05AH04
ATC
quetiapine; oral
2.1
9.0
112
590
M03BX02
ATC
tizanidine; oral
1.6
8.9
407
3216
WX002
NOMESCO Finland
Sedation and analgesia
1.9
8.9
145
844
A02BC02
ATC
pantoprazole; systemic
1.6
8.9
433
3479
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
8.9
163
994
G93.3
ICD-10 Finland
Postviral fatigue syndrome
50.6
8.7
10
*
Z2445
NOMESCO Finland
Psychologist
3.7
8.7
37
105
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
3.4
8.7
40
121
A02BC05
ATC
esomeprazole; systemic
1.6
8.6
281
2025
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
8.6
146
864
R01AD08
ATC
fluticasone; nasal
1.8
8.6
190
1225
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
8.6
252
1766
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.9
8.6
127
717
N04BD02
ATC
rasagiline; oral
10.2
8.6
16
16
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
91.1
8.4
9
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
8.4
91
452
35800
ICD-8 Finland
Disease of peripheral autonomic nervous system, Syndroma Horner
+∞
8.3
8
*
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
+∞
8.3
8
*
G23.9
ICD-10 Finland
Degenerative disease of basal ganglia, unspecified
+∞
8.3
8
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.0
8.3
32
83
B01AA03
ATC
warfarin; systemic
1.8
8.1
139
827
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
11.9
8.1
14
12
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.5
8.1
62
261
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.4
8.0
70
315
Z3231
NOMESCO Finland
Registered nurse
1.7
7.9
188
1239
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
7.9
214
1464
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
9.5
7.8
15
16
H02AB07
ATC
prednisone; oral
2.0
7.8
107
587
A03FA01
ATC
metoclopramide; systemic, rectal
1.8
7.7
137
825
R52.2
ICD-10 Finland
Other chronic pain
3.8
7.6
31
85
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
4.6
7.6
25
56
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
7.6
177
1155
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.4
7.6
35
107
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
7.5
124
725
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
7.5
229
1611
XCK10
NOMESCO Finland
Photography of fundus of eye
2.2
7.4
75
361
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
7.4
259
1888
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
+∞
7.3
7
*
G23.3
ICD-10 Finland
Multiple system atrophy, cerebellar type [MSA-C]
+∞
7.3
7
*
N99
ICPC
Neurological disease other
6.3
7.3
18
29
N06AX11
ATC
mirtazapine; oral
1.6
7.3
207
1429
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
7.2
79
395
M79.6
ICD-10 Finland
Pain in limb
1.6
7.2
230
1635
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.3
7.2
67
311
M01AE03
ATC
ketoprofen; systemic, rectal
1.6
7.2
251
1822
Q13.2
ICD-10 Finland
Other congenital malformations of iris
30.3
7.2
9
*
N04BC04
ATC
ropinirole; oral
6.7
7.1
17
26
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
7.1
94
505
N02BE01
ATC
paracetamol; systemic, rectal
1.7
7.1
578
5127
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
7.0
141
879
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
7.0
88
466
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
7.0
103
579
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
7.0
85
442
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.9
6.9
41
149
J01FA06
ATC
roxithromycin; oral
1.6
6.9
257
1891
B01AC07
ATC
dipyridamole; systemic
3.7
6.9
28
77
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.0
6.9
85
446
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
6.9
297
2261
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.1
6.9
78
395
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
5.1
6.8
20
40
ZXA00
NOMESCO Finland
Right side
1.6
6.8
181
1220
193
Kela drug reimbursment
Rasagiline
11.1
6.8
12
11
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
6.2
6.8
17
28
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.4
6.8
57
253
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
6.8
194
1335
CBJ30
NOMESCO Finland
Plastic repair of levator aponeurosis of eyelid
16.9
6.8
10
6
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.5
6.7
29
85
R03AC02
ATC
salbutamol; inhalant
1.5
6.7
338
2662
B01AC04
ATC
clopidogrel; oral
2.0
6.7
87
468
Z3229
NOMESCO Finland
Other healthcare associate professional
2.2
6.6
65
308
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
6.6
188
1291
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.2
6.6
65
311
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
6.5
177
1202
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
5.1
6.5
19
38
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
2.2
6.5
67
326
L28
ICPC
Limited function/disability (L)
1.8
6.5
104
604
G99.2*M50.0
ICD-10 Finland
Cervical disc disorder with myelopathy
70.5
6.4
7
*
XX2CT
NOMESCO Finland
Other injection with CT guidance
70.5
6.4
7
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
7.5
6.4
14
19
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.5
6.4
49
208
Z2221
NOMESCO Finland
Medical doctor
1.6
6.3
187
1293
Z50.5
ICD-10 Finland
Speech therapy
5.6
6.3
17
31
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
4.6
6.3
20
44
G44.2
ICD-10 Finland
Tension-type headache
2.0
6.3
84
453
N06AB04
ATC
citalopram; systemic
1.7
6.3
139
890
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
9.4
6.3
12
13
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
9.4
6.3
12
13
N17
ICPC
Vertigo/dizziness
2.0
6.3
74
382
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.9
6.3
19
40
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
6.3
6
*
G93.0
ICD-10 Finland
Cerebral cysts
+∞
6.3
6
*
R50.9
ICD-10 Finland
Fever, unspecified
1.9
6.2
93
525
N18
ICPC
Paralysis/weakness
5.1
6.2
18
36
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.5
6.2
47
198
Z2446
NOMESCO Finland
Social worker
2.4
6.1
52
230
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
7.8
6.1
13
17
H53.1
ICD-10 Finland
Subjective visual disturbances
2.5
6.1
44
181
ZXA05
NOMESCO Finland
Left side
1.6
6.1
167
1131
N29
ICPC
Neurological sympt/complt other
5.0
6.1
18
37
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.4
6.1
47
201
Z73.6
ICD-10 Finland
Limitation of activities due to disability
8.7
6.1
12
14
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
6.8
6.1
14
21
ZXE00
NOMESCO Finland
One hour or less
1.5
6.0
263
1994
N03AX11
ATC
topiramate; oral
3.6
6.0
25
71
A02BC03
ATC
lansoprazole; oral
1.6
6.0
184
1283
N02AA05
ATC
oxycodone; systemic
1.8
6.0
95
548
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
4.6
6.0
19
42
ZXA10
NOMESCO Finland
Bilateral
1.7
6.0
127
801
Mortality – FinRegistry
↥Association
Association between endpoint G6_AUTONOM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_AUTONOM | 2.775 [2.37, 3.25] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.162 |
During the follow-up period (1.1.1998 — 31.12.2019), 671 out of 2348 females with G6_AUTONOM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_AUTONOM | 2.517 [2.17, 2.92] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 798 out of 2520 males with G6_AUTONOM died.
Mortality risk
Mortality risk for people of age
years, who have G6_AUTONOM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.269% | 0.529% |
| 5 | 1.548% | 2.991% |
| 10 | 3.906% | 7.184% |
| 15 | 7.323% | 13.304% |
| 20 | 12.638% | 22.103% |
Relationships between endpoints
↥Index endpoint: G6_AUTONOM – Autonomic disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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