No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
121 |
4. Check minimum number of eventsNone |
121 |
5. Include endpointsNone |
121 |
6. Filter based on genotype QC (FinnGen only) |
121 |
Control definitions (FinnGen only)
- Control exclude
- G6_AUTONOM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G90
- Name in latin
- Neuropathia autonomica peripherica idiopathica
Similar endpoints
↥List of similar endpoints to
Idiopathic peripheral autonomic neuropathy
based on the number of shared cases.
Similar with more cases:
- Autonomic disorders
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 941 | 432 | 497 |
| Only index persons | 774 | 372 | 402 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 57.97 | 60.25 | 55.86 |
| Only index persons | 55.19 | 57.82 | 52.76 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 121 | 61 | 60 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 62.44 | 59.91 | 65.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 109
- Matched controls
- 1087
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G90.0
ICD-10 Finland
Idiopathic peripheral autonomic neuropathy
+∞
154.2
108
*
R55
ICD-10 Finland
Syncope and collapse
11.2
21.3
44
62
I49.5
ICD-10 Finland
Sick sinus syndrome
19.3
12.2
18
11
AA1AD
NOMESCO Finland
CT of head and brain
3.8
8.6
44
165
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.7
7.7
19
33
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
8.7
6.9
14
18
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
5.6
6.1
17
35
Mortality – FinRegistry
↥Association
Association between endpoint G6_IDIOAUT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_IDIOAUT | 2.777 [2.01, 3.83] | < 0.001 |
| Birth year | 0.994 [0.98, 1.01] | 0.307 |
During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 349 females with G6_IDIOAUT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_IDIOAUT | 1.888 [1.43, 2.49] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 150 out of 429 males with G6_IDIOAUT died.
Mortality risk
Mortality risk for people of age
years, who have G6_IDIOAUT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.284% | 0.399% |
| 5 | 1.651% | 2.298% |
| 10 | 4.088% | 5.4% |
| 15 | 7.869% | 10.144% |
| 20 | 13.603% | 17.063% |
Relationships between endpoints
↥Index endpoint: G6_IDIOAUT – Idiopathic peripheral autonomic neuropathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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