autonomic nervous system disease: A disease involving the autonomic nervous system.
Other and unspecified disorders of autonomic nervous system
DOID EFO Endpoint Browser PheWeb
G6_AUTOTHUNS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
137 |
4. Check minimum number of eventsNone |
137 |
5. Include endpointsNone |
137 |
6. Filter based on genotype QC (FinnGen only) |
137 |
Control definitions (FinnGen only)
- Control exclude
- G6_AUTONOM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified disorders of autonomic nervous system
based on the number of shared cases.
Similar with more cases:
- Autonomic disorders
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1130 | 550 | 569 |
| Only index persons | 923 | 477 | 446 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 50.73 | 48.91 | 52.18 |
| Only index persons | 48.28 | 47.06 | 49.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 137 | 80 | 57 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 48.53 | 46.05 | 52.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 110
- Matched controls
- 1102
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G90.9
ICD-10 Finland
Disorder of autonomic nervous system, unspecified
+∞
63.9
55
*
G90.8
ICD-10 Finland
Other disorders of autonomic nervous system
+∞
46.1
41
*
3378X
ICD-9 Finland
Disorders of the autonomic nervous system[NEUROPATHIA AUTONOMICA PERIPHERICA ALIA DEFINITA]
+∞
9.5
9
*
N03AX16
ATC
pregabalin; oral
4.2
9.4
41
136
R53
ICD-10 Finland
Malaise and fatigue
3.9
8.2
38
131
Z01.8
ICD-10 Finland
Other specified special examinations
3.7
7.2
35
124
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.1
6.4
25
73
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
19.4
6.4
9
5
N06AX21
ATC
duloxetine; oral
4.7
6.3
21
52
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
8.5
6.3
13
17
G90.0
ICD-10 Finland
Idiopathic peripheral autonomic neuropathy
+∞
6.3
6
*
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
4.3
6.1
22
60
I20.90
ICD-10 Finland
Angina pectoris, unspecified
16.2
6.0
9
6
U09.9
ICD-10 Finland
Post COVID-19 condition, unspecified
16.2
6.0
9
6
Mortality – FinRegistry
↥Association
Association between endpoint G6_AUTOTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_AUTOTHUNS | 2.676 [1.8, 3.98] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.258 |
During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 362 females with G6_AUTOTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_AUTOTHUNS | 2.681 [2.0, 3.6] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 159 out of 402 males with G6_AUTOTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_AUTOTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.252% | 0.419% |
| 5 | 1.563% | 3.014% |
| 10 | 3.867% | 7.291% |
| 15 | 7.165% | 13.851% |
| 20 | 12.414% | 22.741% |
Relationships between endpoints
↥Index endpoint: G6_AUTOTHUNS – Other and unspecified disorders of autonomic nervous system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data