Horner syndrome

G6_HORNER

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G90.2 Hospital discharge: ICD-8 — 35800 Cause of death: ICD-10 — G90.2 Cause of death: ICD-8 — 35800 2 out of 7 registries used, show all original rules.	438
4. Check minimum number of events None	438
5. Include endpoints None	438
6. Filter based on genotype QC (FinnGen only)	438

Control definitions (FinnGen only)

Control exclude: G6_AUTONOM

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G90
Name in latin: Syndroma Horner

NAME	G6_HORNER
CONTROL_EXCLUDE	G6_AUTONOM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G902
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	35800
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G902
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	35800
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Horner syndrome based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2743	1372	1366
Only index persons	2515	1258	1257
Unadjusted period prevalence (%)
Whole population	0.04	0.04	0.04
Only index persons	0.05	0.05	0.05
Median age at first event (years)
Whole population	52.54	54.09	50.94
Only index persons	52.78	54.46	51.10

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	438	242	196
Unadjusted period prevalence (%)	0.08	0.08	0.09
Median age at first event (years)	55.53	55.55	55.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
401: Matched controls
4010

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G90.2

ICD-10 Finland

Horner syndrome

+∞

323.0

394

H02.4

ICD-10 Finland

Ptosis of eyelid

13.6

34.0

PA6BD

NOMESCO Finland

Extensive CT of neck arteries

9.3

29.2

H57.0

ICD-10 Finland

Anomalies of pupillary function

59.7

28.6

I67.0

ICD-10 Finland

Dissection of cerebral arteries, nonruptured

96.3

25.0

AA1AD

NOMESCO Finland

CT of head and brain

3.4

24.7

148

582

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.8

21.0

222

1239

I65.2

ICD-10 Finland

Occlusion and stenosis of carotid artery

14.1

20.6

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

4.8

19.1

160

PA6CG

NOMESCO Finland

Extensive MRI examination of neck vasculature with high intensity magnet

30.0

15.3

G44.0

ICD-10 Finland

Cluster headache syndrome

21.1

15.3

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

3.9

13.6

166

XCK00

NOMESCO Finland

Perimetry

4.3

13.0

125

XCK10

NOMESCO Finland

Photography of fundus of eye

3.4

12.6

206

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

8.3

11.5

CBJ40

NOMESCO Finland

Resection of levator muscle of eyelid

16.1

10.9

Z01.0

ICD-10 Finland

Examination of eyes and vision

2.6

10.6

363

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

5.8

9.8

B01AA03

ATC

warfarin; systemic

2.3

9.4

451

N03AX16

ATC

pregabalin; oral

2.2

9.2

114

624

PA6BG

NOMESCO Finland

MRI examination of neck vasculature with high intensity magnet

19.1

9.0

I63.2

ICD-10 Finland

Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries

19.1

9.0

35800

ICD-8 Finland

Disease of peripheral autonomic nervous system, Syndroma Horner

+∞

8.4

R51.80

ICD-10 Finland

Headache

2.4

8.2

319

N06AX21

ATC

duloxetine; oral

2.8

8.2

210

TAB00

NOMESCO Finland

Lumbar puncture

4.3

8.2

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

3.5

7.6

108

NA1CG

NOMESCO Finland

Cervical spine extensive MRI examination with high intensity magnet

9.1

7.6

N02AX02

ATC

tramadol; systemic, rectal

1.8

7.6

182

1259

WX002

NOMESCO Finland

Sedation and analgesia

2.1

7.5

497

PA6AD

NOMESCO Finland

CT of neck arteries

7.9

7.5

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

3.4

7.4

110

XCW99

NOMESCO Finland

Other investigative procedure of eye

2.6

7.4

227

PA7BD

NOMESCO Finland

CT angiography of neck and brain

7.5

7.3

Q13.2

ICD-10 Finland

Other congenital malformations of iris

30.6

7.2

C08DA01

ATC

verapamil; systemic

3.8

7.1

R42

ICD-10 Finland

Dizziness and giddiness

2.1

7.0

506

N02BE01

ATC

paracetamol; systemic, rectal

2.0

6.7

340

2943

CA1CG

NOMESCO Finland

Eye and orbita extensive MRI examination with high intensity magnet

12.5

6.6

N02CC01

ATC

sumatriptan; nasal, systemic, rectal

2.4

6.5

242

NAG40

NOMESCO Finland

Anterior fusion of cervical spine without fixation

4.8

6.5

CBJ41

NOMESCO Finland

Shortening of superior tarsal muscle (Müller's muscle)

70.9

6.4

ZXA10

NOMESCO Finland

Bilateral

2.1

6.4

440

AA1DM

NOMESCO Finland

Very extensive MRI examination of brain with 3 Tesla magnet

11.3

6.3

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

3.1

6.3

113

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

3.1

6.3

108

WX110

NOMESCO Finland

Local anesthesy

1.7

6.1

269

2181

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

3.2

6.0

Mortality – FinRegistry

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Association

Association between endpoint G6_HORNER and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_HORNER	1.65 [1.36, 2.0]	< 0.001
Birth year	0.998 [0.99, 1.01]	0.712

During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 1204 females with G6_HORNER died.

Males

Parameter	HR [95% CI]	p-value
G6_HORNER	1.362 [1.12, 1.65]	0.002
Birth year	0.988 [0.98, 1.0]	0.016

During the follow-up period (1.1.1998 — 31.12.2019), 172 out of 1188 males with G6_HORNER died.

Mortality risk

Mortality risk for people of age

years, who have G6_HORNER.

N-year risk	Females	Males
1	0.154%	0.27%
5	0.995%	1.74%
10	2.61%	4.415%
15	5.056%	8.223%
20	9.002%	13.224%

Relationships between endpoints

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Index endpoint: G6_HORNER – Horner syndrome

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Horner syndrome

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints