Inflammatory diseases of the central nervous system

G6_NEUINFL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G00-G09
  • Cause of death: ICD-10 G00-G09

2 out of 7 registries used, show all original rules.

2063

4. Check minimum number of events

None

2063

5. Include endpoints

3025

6. Filter based on genotype QC (FinnGen only)

2913

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 30865 14355 16249
Only index persons 25199 12176 13023
Unadjusted period prevalence (%)
Whole population 0.43 0.41 0.45
Only index persons 0.47 0.45 0.50
Median age at first event (years)
Whole population 36.98 38.34 35.46
Only index persons 33.30 35.46 31.28

-FinnGen-

Key figures

All Female Male
Number of individuals 2913 1565 1348
Unadjusted period prevalence (%) 0.64 0.61 0.68
Median age at first event (years) 40.43 36.25 45.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
3024
Matched controls
30239
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
32099
ICD-8 Finland
Meningitis, With no organism specified as cause
+∞
323.0
335
*
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
+∞
323.0
406
*
G03.9
ICD-10 Finland
Meningitis, unspecified
3967.1
323.0
362
*
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
2682.2
269.7
257
*
TAB00
NOMESCO Finland
Lumbar puncture
11.1
262.0
528
564
32088
ICD-8 Finland
Meningitis, Alia definita
+∞
189.6
180
*
G06.1
ICD-10 Finland
Intraspinal abscess and granuloma
1829.0
172.5
166
*
A87.9
ICD-10 Finland
Viral meningitis, unspecified
32.9
159.7
212
69
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.2
151.1
520
1162
AA1AD
NOMESCO Finland
CT of head and brain
3.1
136.1
965
4001
G06.0
ICD-10 Finland
Intracranial abscess and granuloma
1335.0
132.3
128
*
A86
ICD-10 Finland
Unspecified viral encephalitis
35.9
120.9
157
46
G05.1*B00.4
ICD-10 Finland
Herpesviral meningoencephalitis
+∞
109.0
104
*
32000
ICD-8 Finland
Meningitis, H. influenzae
+∞
105.8
101
*
32309
ICD-8 Finland
Encephalitis, myelitis and encephalomyelitis, Unspecified
+∞
103.7
99
*
G01*A69.2
ICD-10 Finland
Meningitis (in) Lyme disease
+∞
95.3
91
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.3
91.9
231
337
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.9
89.7
314
694
G04.8
ICD-10 Finland
Other encephalitis, myelitis and encephalomyelitis
+∞
89.0
85
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.0
85.2
569
2169
3229X
ICD-9 Finland
Meningitis of unspecified cause, Meningitis, unspecified
+∞
82.7
79
*
G00.1
ICD-10 Finland
Pneumococcal meningitis
+∞
81.6
78
*
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
78.5
75
*
R51.80
ICD-10 Finland
Headache
2.8
78.2
602
2498
N03AX14
ATC
levetiracetam; systemic
7.2
78.1
197
288
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
77.1
581
2378
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.0
74.4
215
378
XA800
NOMESCO Finland
Neuropsychological investigation
4.9
70.7
244
528
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
60.8
1290
8415
5AB01
NOMESCO Finland
NA
69.4
59.4
68
10
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.1
59.1
357
1249
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
8.6
58.4
131
159
R50.9
ICD-10 Finland
Fever, unspecified
2.5
58.1
521
2320
G09
ICD-10 Finland
Sequelae of inflammatory diseases of central nervous system
+∞
55.4
53
*
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
11.2
54.4
105
97
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.8
53.2
371
1423
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
14.7
52.9
90
63
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
52.4
677
3583
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
6.5
52.1
141
227
N03AF02
ATC
oxcarbazepine; oral
5.1
51.1
168
343
ZXD05
NOMESCO Finland
Urgent procedure
1.9
51.0
995
6186
N03AX16
ATC
pregabalin; oral
2.0
48.0
739
4185
G05.1
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere
+∞
47.0
45
*
G06.2
ICD-10 Finland
Extradural and subdural abscess, unspecified
+∞
47.0
45
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
6.4
47.0
128
208
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.3
46.1
248
794
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
9.2
45.1
96
107
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
44.9
524
2629
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
6.1
44.9
127
217
G05.8*M32.1
ICD-10 Finland
Encephalitis in systemic lupus erythematosus
+∞
43.8
42
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.8
43.0
307
1187
G05.1*J09
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis in influenza caused by certain identified influenza viruses
+∞
42.8
41
*
N03AX12
ATC
gabapentin; oral
2.2
41.6
492
2478
G01*A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
40.7
39
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.2
40.1
220
714
G03.0
ICD-10 Finland
Nonpyogenic meningitis
+∞
39.7
38
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
39.3
504
2623
N03AG01
ATC
valproic acid; systemic, rectal
3.0
37.3
235
838
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.7
37.2
110
199
N71
ICPC
Meningitis/encephalitis
131.6
36.8
39
*
G03.8
ICD-10 Finland
Meningitis due to other specified causes
+∞
36.5
35
*
B00.4
ICD-10 Finland
Herpesviral encephalitis
361.5
36.0
36
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
35.4
658
3930
AAF00
NOMESCO Finland
Ventriculostomy
12.6
34.5
62
50
G05.1*B01.1
ICD-10 Finland
Varicella encephalitis
+∞
34.4
33
*
ZX120
NOMESCO Finland
Intravenous
2.4
34.2
315
1397
N03AX18
ATC
lacosamide; systemic
11.2
34.2
65
59
H02AB06
ATC
prednisolone; systemic
1.6
33.7
1317
9777
M46.3
ICD-10 Finland
Infection of intervertebral disc (pyogenic)
25.1
33.6
47
19
M46.4
ICD-10 Finland
Discitis, unspecified
18.2
33.6
52
29
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
5.8
33.4
97
172
N03AB02
ATC
phenytoin; systemic
8.2
33.0
75
94
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
5.5
32.8
99
184
32300
ICD-8 Finland
Encephalitis, myelitis and encephalomyelitis, Encephalitis postinfectiosa
+∞
32.3
31
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.2
32.2
126
309
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
7.8
30.4
71
93
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
31.2
30.3
40
13
G05.1*B02.0
ICD-10 Finland
Zoster encephalitis
+∞
30.3
29
*
TKC20
NOMESCO Finland
Catheterisation of bladder
2.6
29.9
228
914
G03.1
ICD-10 Finland
Chronic meningitis
+∞
29.2
28
*
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
10.4
28.9
57
56
N02AX02
ATC
tramadol; systemic, rectal
1.6
28.8
1153
8505
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
14.8
28.7
48
33
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
28.4
819
5543
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
28.3
772
5144
G00.2
ICD-10 Finland
Streptococcal meningitis
+∞
28.2
27
*
AAM00
NOMESCO Finland
Puncture and evacuation of intracerebral abscess
+∞
28.2
27
*
G04.0
ICD-10 Finland
Acute disseminated encephalitis
+∞
28.2
27
*
J01MA12
ATC
levofloxacin; systemic
1.9
28.1
506
2961
J01FF01
ATC
clindamycin; systemic
1.7
28.1
777
5195
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
28.1
994
7096
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
27.7
359
1857
L28
ICPC
Limited function/disability (L)
1.9
26.9
411
2266
H02AB07
ATC
prednisone; oral
1.9
26.5
411
2279
A41.9
ICD-10 Finland
Sepsis, unspecified
3.5
26.4
127
373
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
26.3
398
2185
A28
ICPC
Limited function/disability NOS
2.0
26.2
371
1983
G02.0*B02.1
ICD-10 Finland
Zoster meningitis
+∞
26.1
25
*
3238B
ICD-9 Finland
Encephalitis, myelitis and encephalomyelitis, Other causes of encephalitis[ENCEPHALITIS (MYELITIS,ENCEPHALOMYELITIS) VIROSA]
+∞
26.1
25
*
Z3231
NOMESCO Finland
Registered nurse
1.6
25.7
766
5208
N03AF01
ATC
carbamazepine; oral, rectal
2.7
25.6
184
712
G91.0
ICD-10 Finland
Communicating hydrocephalus
12.3
25.5
46
38
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
4.2
25.3
97
234
G02.0
ICD-10 Finland
Meningitis in viral diseases classified elsewhere
+∞
25.0
24
*
G00.3
ICD-10 Finland
Staphylococcal meningitis
+∞
25.0
24
*
G00.8
ICD-10 Finland
Other bacterial meningitis
+∞
25.0
24
*
R4120
NOMESCO Finland
Occupational therapy
2.4
24.7
214
918
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.2
24.6
265
1263
J01DB01
ATC
cefalexin; oral
1.6
24.6
2340
20693
N02AA05
ATC
oxycodone; systemic
1.9
24.6
378
2086
N02BE01
ATC
paracetamol; systemic, rectal
1.6
24.5
2413
21511
JN4BD
NOMESCO Finland
Extensive body CT
2.1
24.1
303
1541
R42
ICD-10 Finland
Dizziness and giddiness
1.7
24.1
567
3600
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
8.4
24.1
53
64
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.7
23.9
174
678
H02AB09
ATC
hydrocortisone; systemic
4.2
23.9
93
228
WX892
NOMESCO Finland
Monitored bed care
2.3
23.8
229
1033
B94.1
ICD-10 Finland
Sequelae of viral encephalitis
241.8
23.7
24
*
Z2445
NOMESCO Finland
Psychologist
2.9
23.6
151
542
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
23.5
488
2978
SPAT1255
SPAT
Intravenous administration of medicine
2.4
23.5
209
910
N06AA09
ATC
amitriptyline; systemic
2.1
23.3
276
1370
A02BC02
ATC
pantoprazole; systemic
1.5
23.3
1736
14441
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
36.6
23.0
29
8
3209X
ICD-9 Finland
Bacterial meningitis, Meningitis due to unspecified bacterium
+∞
22.9
22
*
N05CF01
ATC
zopiclone; oral
1.6
22.9
831
5905
J04AB02
ATC
rifampicin; systemic
5.6
22.6
66
119
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.9
22.3
143
513
J05AB11
ATC
valaciclovir; oral
1.9
22.3
367
2072
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
5.0
22.2
72
147
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
22.2
222
1024
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
21.5
22.1
32
15
R4150
NOMESCO Finland
Neuropsychological rehabilitation
7.1
22.1
54
77
R4110
NOMESCO Finland
Physiotherapy
1.6
22.1
721
4982
R51
ICD-10 Finland
Headache
2.5
22.0
173
705
AAM30
NOMESCO Finland
Evacuation of epidural or subdural empyema
+∞
21.9
21
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
6.6
21.8
56
86
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.0
21.7
287
1490
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.7
21.6
149
562
G91.1
ICD-10 Finland
Obstructive hydrocephalus
15.4
21.5
35
23
183
Kela drug reimbursment
Lamotrigin and topiramate
6.2
21.5
58
95
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
6.8
21.3
54
81
A69.2
ICD-10 Finland
Lyme disease
2.6
21.3
157
614
WX882
NOMESCO Finland
High dependency care
3.4
21.2
105
317
G51.0
ICD-10 Finland
Bell palsy
3.7
21.1
94
261
G02.0*B01.0
ICD-10 Finland
Varicella meningitis
+∞
20.9
20
*
N05BA09
ATC
clobazam; oral
9.1
20.6
43
48
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
30.2
20.5
27
9
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.7
20.3
140
527
N05BA01
ATC
diazepam; systemic, rectal
1.8
20.1
364
2118
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
6.6
19.9
51
78
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
11.3
19.9
37
33
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
7.6
19.8
46
61
32400
ICD-8 Finland
Late effects of intracranial abscess or pyogenic infection, Hydrocephalus acquisitus
+∞
19.8
19
*
G01*A32.1
ICD-10 Finland
Listerial meningitis
+∞
19.8
19
*
G05.1*J10.8
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis in influenza caused by other identified influenza virus
+∞
19.8
19
*
G04.2
ICD-10 Finland
Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified
+∞
19.8
19
*
G01
ICD-10 Finland
Meningitis in bacterial diseases classified elsewhere
+∞
19.8
19
*
J01MA02
ATC
ciprofloxacin; systemic
1.5
19.8
1006
7655
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
7.3
19.7
47
65
G35
ICD-10 Finland
Multiple sclerosis
4.2
19.7
75
181
N03AX09
ATC
lamotrigine; oral
2.5
19.6
157
644
Z3226
NOMESCO Finland
Physiotherapist
1.7
19.6
506
3278
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.3
19.4
98
301
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.1
19.2
229
1139
R33
ICD-10 Finland
Retention of urine
2.2
18.9
194
902
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
18.9
1413
11551
N01
ICPC
Headache
1.9
18.9
291
1603
L04AX01
ATC
azathioprine; systemic
2.5
18.8
150
616
G02.0*A87.0
ICD-10 Finland
Enteroviral meningitis
+∞
18.8
18
*
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
18.7
457
2912
6BA02
NOMESCO Finland
NA
11.1
18.7
35
32
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
23.8
18.6
26
11
XA400
NOMESCO Finland
EEG
9.0
18.6
39
44
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
18.5
503
3299
C03CA01
ATC
furosemide; systemic
1.5
18.5
647
4522
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.1
18.4
225
1133
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
18.3
939
7129
N99
ICPC
Neurological disease other
5.4
18.3
55
104
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
18.1
715
5130
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
7.1
18.1
44
63
N03AE01
ATC
clonazepam; systemic
2.3
18.0
170
760
R53
ICD-10 Finland
Malaise and fatigue
1.6
18.0
532
3564
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
7.0
17.9
44
64
M03BX01
ATC
baclofen; systemic
4.3
17.9
67
160
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.2
17.9
180
833
A87.8
ICD-10 Finland
Other viral meningitis
+∞
17.7
17
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.9
17.6
290
1632
WX704
NOMESCO Finland
Intubation
2.1
17.6
204
1006
N28
ICPC
Limited function/disability (N)
4.7
17.5
60
131
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
4.1
17.5
68
168
N18
ICPC
Paralysis/weakness
4.4
17.3
62
142
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.7
17.0
117
442
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.0
16.9
227
1186
G44.2
ICD-10 Finland
Tension-type headache
1.7
16.9
351
2129
N05AH04
ATC
quetiapine; oral
1.6
16.9
449
2924
F05.9
ICD-10 Finland
Delirium, unspecified
4.0
16.7
67
171
32010
ICD-8 Finland
Meningitis, Pneumococcus
+∞
16.7
16
*
G03.2
ICD-10 Finland
Benign recurrent meningitis [Mollaret]
+∞
16.7
16
*
G05.1*A85.0
ICD-10 Finland
Encephalitis, myelitis or encephalomyelitis (in) enteroviral
+∞
16.7
16
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
16.6
422
2711
J05AB01
ATC
aciclovir; systemic
1.6
16.5
543
3726
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.0
16.3
224
1179
N03AX11
ATC
topiramate; oral
3.1
16.2
89
292
AAA10
NOMESCO Finland
Biopsy through craniotomy
47.8
16.0
19
*
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
21.1
16.0
23
11
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
15.9
559
3894
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
4.4
15.8
57
132
ZXC95
NOMESCO Finland
Use of surgical navigator
5.0
15.8
50
101
ZXD35
NOMESCO Finland
Usual procedure
2.7
15.8
111
427
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
3.3
15.7
79
243
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
15.7
297
1750
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
15.6
528
3642
2AB04
NOMESCO Finland
NA
13.0
15.6
27
21
Z2221
NOMESCO Finland
Medical doctor
1.5
15.6
731
5413
AAM10
NOMESCO Finland
Excision of intracerebral abscess
+∞
15.6
15
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
15.6
260
1470
NAS20
NOMESCO Finland
Incision and debridement of infection of vertebra, unspecified
160.8
15.5
16
*
A06AD11
ATC
lactulose; oral
1.7
15.3
346
2146
G82.2
ICD-10 Finland
Paraplegia, unspecified
12.4
15.3
27
22
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
4.3
15.3
56
132
J01AA02
ATC
doxycycline; systemic
1.4
15.2
2108
18849
N29
ICPC
Neurological sympt/complt other
3.8
15.2
65
176
Z2446
NOMESCO Finland
Social worker
2.0
15.2
197
1015
R41.0
ICD-10 Finland
Disorientation, unspecified
2.9
15.2
94
334
R20.2
ICD-10 Finland
Paraesthesia of skin
2.1
15.2
177
872
H53.2
ICD-10 Finland
Diplopia
2.8
15.1
98
358
WX730
NOMESCO Finland
Conventional respirator
3.8
15.1
63
167
L04AA06
ATC
mycophenolic acid; systemic
3.5
15.0
70
204
J01DA01
ATC
[U] cefalexin; systemic
1.4
14.9
1695
14641
N06AX21
ATC
duloxetine; oral
1.8
14.9
284
1678
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
15.1
14.9
24
16
109
Kela drug reimbursment
Multiple sclerosis
4.8
14.8
49
104
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.0
14.7
199
1042
WX872
NOMESCO Finland
Intensive care
2.3
14.6
142
645
3200A
ICD-9 Finland
Bacterial meningitis, Haemophilus meningitis
+∞
14.6
14
*
A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
14.6
14
*
0499X
ICD-9 Finland
Other non-arthropod-borne viral diseases of central nervous system, Unspecified non-arthropod-borne viral diseases of central nervous system
11.9
14.5
26
22
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
14.2
14.5
24
17
R11
ICD-10 Finland
Nausea and vomiting
1.9
14.5
212
1145
ZXA00
NOMESCO Finland
Right side
1.5
14.4
651
4777
N05BA04
ATC
oxazepam; oral
1.5
14.4
625
4548
P01BA02
ATC
hydroxychloroquine; oral
1.9
14.4
217
1185
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
5.2
14.4
44
86
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.6
14.3
409
2704
G40.10
ICD-10 Finland
Simple partial seizures
6.3
14.2
37
59
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
22.4
14.2
20
9
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.7
14.0
278
1662
B01AB05
ATC
enoxaparin; parenteral
1.4
13.9
717
5393
XKD06
NOMESCO Finland
Physiologic investigation of micturition
2.8
13.9
88
318
UKC02
NOMESCO Finland
Cystoscopy
1.6
13.9
365
2359
N73
ICPC
Neurological infection other
30.2
13.9
18
6
M05BA04
ATC
alendronic acid; oral
2.0
13.9
189
995
N06AX11
ATC
mirtazapine; oral
1.4
13.8
804
6185
R03AC02
ATC
salbutamol; inhalant
1.3
13.8
1363
11453
AAK00
NOMESCO Finland
Cranioplasty
17.6
13.8
21
12
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
23.9
13.8
19
8
N05CD07
ATC
temazepam; oral
1.7
13.8
289
1757
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.9
13.7
196
1051
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
13.7
249
1449
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
13.7
728
5511
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
13.6
242
1398
S18
ICPC
Laceration/cut
1.4
13.6
1014
8141
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.6
13.6
335
2130
G00.0
ICD-10 Finland
Haemophilus meningitis
+∞
13.5
13
*
32308
ICD-8 Finland
Encephalitis, myelitis and encephalomyelitis, Alia definita
+∞
13.5
13
*
R4130
NOMESCO Finland
Speech therapy
3.1
13.5
73
238
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
4.3
13.5
49
115
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.1
13.5
151
731
ZXE20
NOMESCO Finland
More than three and less than five hours
1.6
13.4
336
2146
ZXY02
NOMESCO Finland
Neuropsychologist
6.2
13.3
35
57
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
11.5
13.3
24
21
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
13.2
1196
9891
G41.9
ICD-10 Finland
Status epilepticus, unspecified
6.7
13.2
33
50
WW400
NOMESCO Finland
Plasmaferesis
13.8
13.2
22
16
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.0
13.2
171
880
SPAT1254
SPAT
Administration of medicine
1.6
13.2
363
2376
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
7.6
13.1
30
40
A02BC01
ATC
omeprazole; systemic
1.4
13.1
682
5132
NA1DG
NOMESCO Finland
Cervical spine very extensive MRI examination with high intensity magnet
15.1
13.1
21
14
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.0
13.0
176
922
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
6.2
13.0
34
55
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.6
13.0
323
2058
G63.0*A69.2
ICD-10 Finland
Polyneuropathy (in) Lyme disease
28.5
12.9
17
6
R60.0
ICD-10 Finland
Localized oedema
1.7
12.9
260
1560
WX110
NOMESCO Finland
Local anesthesy
1.3
12.9
1873
16616
04599
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Aseptic meningitis, unspecified
14.1
12.7
21
15
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
3.6
12.7
56
157
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.1
12.6
147
727
H47.1
ICD-10 Finland
Papilloedema, unspecified
6.2
12.6
33
54
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
6.1
12.4
33
55
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.9
12.3
175
937
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.3
12.3
110
481
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.7
12.3
286
1791
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
12.2
557
4075
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.0
12.2
161
835
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.6
12.2
310
1987
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
12.1
235
1392
G81.9
ICD-10 Finland
Hemiplegia, unspecified
4.5
12.1
42
95
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
12.1
950
7659
ZXD10
NOMESCO Finland
Scheduled procedure
1.4
12.0
953
7685
AWC00
NOMESCO Finland
Reoperation of nervous system because of deep wound infection in the nervous system
18.1
12.0
18
10
N30.0
ICD-10 Finland
Acute cystitis
1.6
12.0
324
2109
B34.9
ICD-10 Finland
Viral infection, unspecified
2.7
12.0
83
317
G37.3
ICD-10 Finland
Acute transverse myelitis in demyelinating disease of central nervous system
21.4
12.0
17
8
N06AX16
ATC
venlafaxine; oral
1.6
11.9
354
2358
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.1
11.9
140
697
G40
ICD-10 Finland
Epilepsy
4.5
11.8
41
93
ZXA05
NOMESCO Finland
Left side
1.4
11.8
597
4457
J01CF05
ATC
flucloxacillin; systemic
2.3
11.7
102
443
P01AB01
ATC
metronidazole; oral, rectal
1.3
11.7
975
7921
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
5.5
11.6
33
60
A32.7
ICD-10 Finland
Listerial sepsis
65.2
11.6
13
*
XF600
NOMESCO Finland
Bloodpressure measurement
1.9
11.5
160
846
XCK00
NOMESCO Finland
Perimetry
1.9
11.5
162
861
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.1
11.5
128
621
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.1
11.5
125
600
B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
11.5
11
*
3201A
ICD-9 Finland
Bacterial meningitis, Pneumococcal meningitis
+∞
11.5
11
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
5.7
11.5
32
57
G73.7*M32.1
ICD-10 Finland
Myopathy in systemic lupus erythematosus
120.4
11.4
12
*
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
2.9
11.4
69
245
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
4.6
11.4
38
83
D64.9
ICD-10 Finland
Anaemia, unspecified
1.7
11.3
223
1332
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
35.1
11.3
14
*
Z3229
NOMESCO Finland
Other healthcare associate professional
1.8
11.2
213
1254
G41.0
ICD-10 Finland
Grand mal status epilepticus
12.7
11.1
19
15
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.6
11.1
270
1711
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
4.6
11.1
37
81
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.3
11.0
99
435
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
8.6
11.0
23
27
M54.5
ICD-10 Finland
Low back pain
1.3
11.0
817
6510
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
13.9
11.0
18
13
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
2.4
10.9
93
399
SPAT1234
SPAT
Support of social functional capacity
2.1
10.9
119
576
H53.4
ICD-10 Finland
Visual field defects
3.3
10.8
54
168
G40.89
ICD-10 Finland
Other epilepsy
6.9
10.8
26
38
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
15.5
10.8
17
11
G82.5
ICD-10 Finland
Tetraplegia, unspecified
15.5
10.8
17
11
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
4.0
10.8
42
107
G61.0
ICD-10 Finland
Guillain-Barré syndrome
10.6
10.8
20
19
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
10.7
926
7542
101
Kela drug reimbursment
Anterior pituitary hypofunction
5.6
10.7
30
54
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.7
10.7
215
1291
NA1AD
NOMESCO Finland
Cervical spine CT examination
2.2
10.6
100
453
M03BC01
ATC
orphenadrine (citrate); systemic
1.4
10.6
592
4492
Z71.8
ICD-10 Finland
Other specified counselling
1.4
10.5
601
4575
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
10.5
617
4721
J01CA04
ATC
amoxicillin; systemic
1.3
10.5
2240
20648
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
3.6
10.5
46
130
B02.1
ICD-10 Finland
Zoster meningitis
110.4
10.4
11
*
32200
ICD-8 Finland
Intracranial and intraspinal abscess, Intracerebralis
+∞
10.4
10
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
1.9
10.4
153
828
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
4.3
10.4
37
87
120
Kela drug reimbursment
Hypogammaglobulinaemia
12.1
10.3
18
15
ZXE00
NOMESCO Finland
One hour or less
1.3
10.3
990
8177
AA1AA
NOMESCO Finland
Head X-ray examination
4.5
10.2
35
79
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.5
10.2
380
2664
X58
ICD-10 Finland
Exposure to other specified factors
1.5
10.2
339
2318
A02BC03
ATC
lansoprazole; oral
1.4
10.2
683
5341
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
11.3
10.0
18
16
A02BC05
ATC
esomeprazole; systemic
1.3
10.0
997
8266
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
9.1
10.0
20
22
A03FA01
ATC
metoclopramide; systemic, rectal
1.4
10.0
470
3450
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.5
9.9
303
2029
J01MA14
ATC
moxifloxacin; systemic
1.7
9.9
216
1330
R1260
NOMESCO Finland
Evaluation of communicative skills
3.4
9.9
46
137
AAF15
NOMESCO Finland
Ventriculoatrial shunt
12.2
9.8
17
14
H02AB04
ATC
methylprednisolone; systemic
1.5
9.8
352
2446
A46
ICD-10 Finland
Erysipelas
1.5
9.8
318
2162
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
2.9
9.8
57
197
G50.0
ICD-10 Finland
Trigeminal neuralgia
3.1
9.8
52
170
G91.8
ICD-10 Finland
Other hydrocephalus
20.1
9.8
14
7
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.3
9.8
805
6493
R47.0
ICD-10 Finland
Dysphasia and aphasia
4.1
9.7
36
88
F07.1
ICD-10 Finland
Postencephalitic syndrome
55.2
9.6
11
*
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.8
9.6
160
903
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
1.9
9.6
145
794
B18.2
ICD-10 Finland
Chronic viral hepatitis C
3.5
9.6
43
124
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.0
9.6
116
584
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
4.0
9.5
36
90
N03AX22
ATC
perampanel; oral
15.1
9.5
15
10
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.3
9.5
708
5626
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.6
9.4
257
1676
N05CD08
ATC
midazolam; nasal, systemic
2.8
9.4
59
213
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
7.5
9.4
21
28
23810
ICD-8 Finland
Neoplasm of unspecified nature of eye, brain and other parts of nervous system, Brain
+∞
9.4
9
*
3240A
ICD-9 Finland
Intracranial and intraspinal abscess, Intracranial abscess
+∞
9.4
9
*
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
6.2
9.4
24
39
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
21.7
9.3
13
6
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
9.3
299
2028
J02AC01
ATC
fluconazole; systemic
1.3
9.3
951
7898
WX002
NOMESCO Finland
Sedation and analgesia
1.4
9.3
462
3423
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.6
9.3
251
1634
H02AB02
ATC
dexamethasone; systemic
1.6
9.3
221
1392
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.3
9.2
85
381
L89
ICD-10 Finland
Decubitus ulcer and pressure area
3.3
9.2
45
139
B99
ICD-10 Finland
Other and unspecified infectious diseases
2.8
9.2
56
201
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
2.6
9.2
64
249
M01AE02
ATC
naproxen; oral, rectal
1.3
9.2
1469
12912
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
6.0
9.2
24
40
N05AX08
ATC
risperidone; systemic
1.7
9.2
188
1136
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
1.7
9.1
191
1162
SPAT1216
SPAT
Assessment of functional ability
1.5
9.1
331
2304
R06.0
ICD-10 Finland
Dyspnoea
1.4
9.1
556
4270
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.0
9.1
113
577
B02.8
ICD-10 Finland
Zoster with other complications
6.7
9.1
22
33
H53.1
ICD-10 Finland
Subjective visual disturbances
1.9
9.0
140
773
L04AA01
ATC
[U] ciclosporin; systemic
3.3
9.0
44
136
J01FA06
ATC
roxithromycin; oral
1.3
9.0
994
8331
102
Kela drug reimbursment
Diabetes insipidus
10.0
9.0
17
17
G43.9
ICD-10 Finland
Migraine, unspecified
1.8
9.0
142
792
N07BA03
ATC
varenicline; oral
1.9
9.0
130
703
A04
ICPC
Weakness/tiredness general
1.5
9.0
302
2070
M79.6
ICD-10 Finland
Pain in limb
1.3
9.0
843
6912
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
2.1
8.9
93
441
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
1.8
8.9
163
951
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
3.5
8.9
40
116
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.8
8.9
150
854
J01FA10
ATC
azithromycin; systemic
1.3
8.9
1514
13392
C07AB07
ATC
bisoprolol; oral
1.3
8.8
1052
8901
K90
ICPC
Stroke/cerebrovascular accident
2.5
8.8
65
262
SPAT1167
SPAT
Insertion of urinary catheter
2.4
8.8
73
312
C01CA24
ATC
epinephrine; parenteral
1.8
8.7
151
868
EBA15
NOMESCO Finland
Extraction of large number of teeth
2.1
8.7
97
475
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.5
8.7
273
1839
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
2.4
8.7
68
283
A87.0
ICD-10 Finland
Enteroviral meningitis
50.1
8.7
10
*
B01AA03
ATC
warfarin; systemic
1.4
8.7
409
3000
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
8.6
921
7675
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
1.7
8.6
164
972
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
2.3
8.6
78
348
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.8
8.6
155
903
S06.0
ICD-10 Finland
Concussion
1.6
8.6
248
1643
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
3.0
8.6
46
153
G44.8
ICD-10 Finland
Other specified headache syndromes
3.4
8.6
39
115
E23.00
ICD-10 Finland
Panhypopituitarism
6.9
8.5
20
29
5CM18
NOMESCO Finland
NA
6.9
8.5
20
29
JN4AD
NOMESCO Finland
Body CT examination
1.7
8.5
163
967
3451A
ICD-9 Finland
Epilepsy, Generalised convulsive epilepsy
10.0
8.5
16
16
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
8.5
1013
8561
ADB00
NOMESCO Finland
Implantation of vagus nerve stimulating device
20.1
8.5
12
6
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
1.9
8.4
124
676
F11.22
ICD-10 Finland
Addiction-induced dependence is currently independent but uses substitute intermittent medication
5.4
8.4
24
45
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
4.0
8.4
32
81
UJF32
NOMESCO Finland
Coloscopy
1.3
8.4
577
4510
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
1.9
8.4
118
633
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.5
8.4
337
2396
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
2.8
8.4
50
178
G05.1*J11.8
ICD-10 Finland
Encephalitis, myelitis or encephalomyelitis in suspected influenza
+∞
8.3
8
*
A03
ICPC
Fever
1.4
8.3
387
2834
TPX10
NOMESCO Finland
Implantation of vascular injection port
2.3
8.3
73
321
XKC03
NOMESCO Finland
Water cystometry
2.3
8.3
71
310
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.6
8.3
225
1468
R03BA05
ATC
fluticasone; inhalant
1.4
8.3
427
3183
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
1.9
8.2
112
593
ZXE30
NOMESCO Finland
More than five and less than seven hours
1.9
8.2
118
638
J01EA01
ATC
trimethoprim; systemic
1.3
8.2
571
4474
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
5.1
8.1
24
47
N07
ICPC
Convulsion/seizure
7.5
8.1
18
24
S97
ICPC
Chronic ulcer skin
1.9
8.1
121
661
W19
ICD-10 Finland
Unspecified fall
1.6
8.1
214
1386
A40.8
ICD-10 Finland
Other streptococcal sepsis
4.3
8.1
28
65
B02.0
ICD-10 Finland
Zoster encephalitis
17.2
8.1
12
7
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
1.9
8.1
107
563
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.0
8.0
93
461
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.7
8.0
178
1100
T78.4
ICD-10 Finland
Allergy, unspecified
1.9
8.0
114
612
SPAT1215
SPAT
Assessment of need for medical rehabilitation
1.9
8.0
108
572
SPAT1229
SPAT
Assessment of need for aid
1.7
8.0
166
1009
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.4
7.9
404
3004
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
1.7
7.9
149
881
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.2
7.9
74
337
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.7
7.9
155
925
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
2.3
7.9
68
298
N02CA01
ATC
dihydroergotamine; nasal, systemic
6.6
7.9
19
29
G95.9
ICD-10 Finland
Disease of spinal cord, unspecified
13.0
7.9
13
10
M00.0
ICD-10 Finland
Staphylococcal arthritis and polyarthritis
13.0
7.9
13
10
M03BX02
ATC
tizanidine; oral
1.2
7.9
1596
14322
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.0
7.8
101
526
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.0
7.8
98
503
N03AX23
ATC
brivaracetam; systemic
10.8
7.8
14
13
AAG00
NOMESCO Finland
Stereotactic intracranial biopsy
9.4
7.8
15
16
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
1.6
7.7
216
1417
J01.1
ICD-10 Finland
Acute frontal sinusitis
2.9
7.7
45
158
H47.2
ICD-10 Finland
Optic atrophy
5.9
7.7
20
34
N06AB04
ATC
citalopram; systemic
1.3
7.6
506
3929
Y89.9
ICD-10 Finland
Sequelae of unspecified external cause
3.8
7.6
30
79
R40.2
ICD-10 Finland
Coma, unspecified
3.8
7.6
30
79
SPAT1231
SPAT
Assessment of adjustments needed in living environment
2.8
7.6
45
160
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.2
7.6
27
65
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.6
7.6
172
1071
GBB00
NOMESCO Finland
Tracheostomy
3.3
7.6
36
111
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
3.6
7.5
32
90
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
2.4
7.5
59
245
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
10.0
7.5
14
14
R55
ICD-10 Finland
Syncope and collapse
1.5
7.5
230
1544
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
4.3
7.5
26
61
A29
ICPC
General symptom/complaint other
1.5
7.5
240
1628
R1250
NOMESCO Finland
Evaluation of functional capability
2.5
7.4
56
230
B94.80
ICD-10 Finland
Late effects of bacterial meningitis
80.3
7.4
8
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
1.7
7.4
132
769
R52.2
ICD-10 Finland
Other chronic pain
2.1
7.4
80
389
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
6.5
7.4
18
28
J01XX08
ATC
linezolid; systemic
5.0
7.4
22
44
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.3
7.4
502
3915
A41.8
ICD-10 Finland
Other specified sepsis
2.9
7.4
41
141
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
7.7
7.4
16
21
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
1.9
7.4
95
495
N05AH03
ATC
olanzapine; systemic
1.7
7.4
147
886
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
1.8
7.3
129
747
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
7.3
1216
10639
G36.9
ICD-10 Finland
Acute disseminated demyelination, unspecified
8.4
7.3
15
18
G08
ICD-10 Finland
Intracranial and intraspinal phlebitis and thrombophlebitis
+∞
7.3
7
*
32401
ICD-8 Finland
Late effects of intracranial abscess or pyogenic infection, Status postencephaliticus
+∞
7.3
7
*
I60.5
ICD-10 Finland
Subarachnoid haemorrhage from vertebral artery
+∞
7.3
7
*
79199
ICD-8 Finland
Headache
2.9
7.3
42
146
J96.0
ICD-10 Finland
Acute respiratory failure
3.2
7.3
35
109
N02AC04
ATC
dextropropoxyphene; oral
2.1
7.3
77
372
XKD03
NOMESCO Finland
Urethral pressure profilometry
2.5
7.2
54
219
NA7DM
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with 3 Tesla magnet
15.8
7.2
11
7
D33.30
ICD-10 Finland
Acoustic neuroma
5.8
7.2
19
33
WW200
NOMESCO Finland
Immunization
2.2
7.2
73
343
C71.10
ICD-10 Finland
Malignant tumor in frontal lobe without histology
7.3
7.2
16
22
L29
ICPC
Musculoskeletal sympt/complt other
1.7
7.2
155
954
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
7.2
440
3379
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
2.0
7.2
91
471
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
3.7
7.1
29
79
NA7CM
NOMESCO Finland
Spine and spinal cord extensive MRI examination with 3 Tesla magnet
20.1
7.1
10
5
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.3
7.1
646
5248
G93.4
ICD-10 Finland
Encephalopathy, unspecified
7.9
7.1
15
19
M46.2
ICD-10 Finland
Osteomyelitis of vertebra
12.0
7.1
12
10
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.6
7.1
159
990
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
5.3
7.1
20
38
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
1.8
7.0
114
644
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
1.6
7.0
157
977
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.4
7.0
305
2204
WX722
NOMESCO Finland
PEEP
1.8
7.0
106
588
R35
ICD-10 Finland
Polyuria
1.7
7.0
136
812
XKD00
NOMESCO Finland
Uroflowmetry
1.4
6.9
318
2322
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1.6
6.9
172
1099
M48.0
ICD-10 Finland
Spinal stenosis
1.5
6.9
245
1701
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.6
6.9
183
1190
XX1XW
NOMESCO Finland
Extensive written report from radiologist
2.4
6.9
53
221
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
4.6
6.9
22
48
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
3.5
6.9
30
87
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
3.6
6.9
29
82
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.5
6.8
269
1906
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.4
6.8
304
2205
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.0
6.8
78
390
A85.8
ICD-10 Finland
Other specified viral encephalitis
40.1
6.8
8
*
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
40.1
6.8
8
*
R07.3
ICD-10 Finland
Other chest pain
1.5
6.8
196
1299
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.6
6.8
184
1203
EBA00
NOMESCO Finland
Extraction of tooth
1.3
6.7
785
6576
ABE50
NOMESCO Finland
Occipitocervical decompression
16.7
6.7
10
6
I60.6
ICD-10 Finland
Subarachnoid haemorrhage from other intracranial arteries
16.7
6.7
10
6
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.3
6.7
566
4546
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
6.7
79
397
U04
ICPC
Incontinence urine
1.9
6.7
90
478
06599
ICD-8 Finland
Viral encephalitis, unspecified
22.6
6.7
9
*
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
2.2
6.6
65
305
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
2.2
6.6
64
296
A04AA01
ATC
ondansetron; systemic, rectal
1.7
6.6
138
844
UJF30
NOMESCO Finland
Ileoscopy through colon
1.5
6.6
209
1416
K08.3
ICD-10 Finland
Retained dental root
1.6
6.6
159
1011
Z43.0
ICD-10 Finland
Attention to tracheostomy
12.3
6.6
11
9
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.4
6.6
398
3046
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.6
6.6
144
890
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
1.7
6.5
139
852
G41.2
ICD-10 Finland
Complex partial status epilepticus
8.7
6.5
13
15
ZZC00
NOMESCO Finland
Graft of fascia
10.0
6.5
12
12
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
1.6
6.5
152
958
N06AB03
ATC
fluoxetine; oral
1.4
6.5
277
1994
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
2.7
6.5
42
158
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
1.9
6.5
86
455
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
6.5
1104
9646
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
1.9
6.5
88
470
G83.4
ICD-10 Finland
Cauda equina syndrome
5.3
6.5
18
34
B01AB10
ATC
tinzaparin; parenteral
1.7
6.4
133
809
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
1.8
6.4
112
646
AAE05
NOMESCO Finland
Nasoendoscopic closure of cerebrospinal fluid fistula
70.0
6.4
7
*
G43.3
ICD-10 Finland
Complicated migraine
2.6
6.4
42
160
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
1.9
6.4
85
447
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.5
6.4
230
1602
G97.1
ICD-10 Finland
Other reaction to spinal and lumbar puncture
7.4
6.4
14
19
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.5
6.4
244
1721
S29
ICPC
Skin symptom/complaint other
1.4
6.4
348
2616
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
3.2
6.4
30
93
RS221
NOMESCO Finland
NA
2.5
6.4
46
186
ZY010
NOMESCO Finland
Hospital outpatient
1.7
6.4
119
706
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.0
6.4
74
370
XLA10
NOMESCO Finland
NA
1.8
6.3
102
574
A40.1
ICD-10 Finland
Sepsis due to streptococcus, group B
11.0
6.3
11
10
G61.9
ICD-10 Finland
Inflammatory polyneuropathy, unspecified
11.0
6.3
11
10
G40.11
ICD-10 Finland
Simple partial epileptic seizure that develops into a complex partial seizure
11.0
6.3
11
10
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
11.0
6.3
11
10
G40.1
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
5.5
6.3
17
31
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.4
6.3
274
1983
G04BD04
ATC
oxybutynin; oral, transdermal
1.8
6.3
109
631
K59.0
ICD-10 Finland
Constipation
1.7
6.3
118
701
L08
ICPC
Shoulder symptom/complaint
1.3
6.3
401
3095
121
Kela drug reimbursment
Severe hypofunction of sexual glands
2.5
6.3
45
181
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
2.7
6.3
41
156
G05.0*A17.8
ICD-10 Finland
Tuberculous meningoencephalitis
+∞
6.3
6
*
B01.1
ICD-10 Finland
Varicella encephalitis
+∞
6.3
6
*
3238X
ICD-9 Finland
Encephalitis, myelitis and encephalomyelitis, Other causes of encephalitis[ENCEPHALITIS (MYELITIS, ENCEPHALOMYELITIS) ALIA DEF]
+∞
6.3
6
*
N16.4*M32.1
ICD-10 Finland
Renal tubulo-interstitial disorders in systemic lupus erythematosus
+∞
6.3
6
*
32408
ICD-8 Finland
Late effects of intracranial abscess or pyogenic infection, Alia definitae
+∞
6.3
6
*
N05AA02
ATC
levomepromazine; systemic
1.8
6.2
94
521
2133
FHL
Suntin revisio
26.7
6.2
8
*
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
3.0
6.2
33
112
F05.8
ICD-10 Finland
Other delirium
4.1
6.2
22
54
SPAT1262
SPAT
Handing over of treatment supplies
1.3
6.2
382
2932
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.3
6.2
530
4265
N06AB10
ATC
escitalopram; oral
1.3
6.2
471
3731
ZXA10
NOMESCO Finland
Bilateral
1.3
6.2
407
3157
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
1.6
6.1
137
854
A07AA02
ATC
nystatin; oral
1.7
6.1
125
757
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.3
6.1
379
2911
T91.3
ICD-10 Finland
Sequelae of injury of spinal cord
5.3
6.1
17
32
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
1.8
6.1
106
614
R01AD08
ATC
fluticasone; nasal
1.3
6.1
669
5554
C71.20
ICD-10 Finland
Malignant tumor in temporal lobe without histology
7.7
6.1
13
17
NA1CM
NOMESCO Finland
Cervical spine extensive MRI examination with 3 Tesla magnet
7.7
6.1
13
17
PA2KT
NOMESCO Finland
Endovascular closure of brain aneurysm
7.7
6.1
13
17
A02BA02
ATC
ranitidine; systemic
1.3
6.1
422
3294
S01.0
ICD-10 Finland
Open wound of scalp
1.6
6.1
157
1013
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
1.9
6.1
87
473
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.3
6.1
433
3395
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
2.5
6.1
44
178
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
2.6
6.1
40
153
A10AE04
ATC
insulin glargine; parenteral
1.5
6.1
203
1390
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.5
6.1
190
1285
M32
ICD-10 Finland
Systemic lupus erythematosus
12.5
6.1
10
8
SPAT1211
SPAT
Application of soft bandage
1.5
6.1
197
1344
K91
ICPC
Cerebrovascular disease
2.9
6.0
33
114
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
1.7
6.0
112
660

Mortality – FinRegistry

Association

Association between endpoint G6_NEUINFL and mortality.

Females

Parameter HR [95% CI] p-value
G6_NEUINFL 2.497 [2.2, 2.84] < 0.001
Birth year 0.996 [0.99, 1.0] 0.389

During the follow-up period (1.1.1998 — 31.12.2019), 1652 out of 7552 females with G6_NEUINFL died.

Males

Parameter HR [95% CI] p-value
G6_NEUINFL 2.74 [2.21, 3.4] < 0.001
Birth year 0.983 [0.92, 1.05] 0.626

During the follow-up period (1.1.1998 — 31.12.2019), 1966 out of 7915 males with G6_NEUINFL died.

Mortality risk

Mortality risk for people of age

years, who have G6_NEUINFL.

N-year risk Females Males
1 0.258% 0.562%
5 1.414% 2.811%
10 3.869% 6.966%
15 7.369% 13.161%
20 13.182% 21.618%

Relationships between endpoints

Index endpoint: G6_NEUINFL – Inflammatory diseases of the central nervous system

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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