Risteys · G6

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G06, G07, G07A06.6, G07A17.1, G07A17.8, G07A54.8, G07B65.9 Hospital discharge: ICD-9 — 324 Hospital discharge: ICD-8 — 322 Cause of death: ICD-10 — G06, G07, G07A06.6, G07A17.1, G07A17.8, G07A54.8, G07B65.9 Cause of death: ICD-9 — 324 Cause of death: ICD-8 — 322 2 out of 7 registries used, show all original rules.	388
4. Check minimum number of events None	388
5. Include endpoints None	388
6. Filter based on genotype QC (FinnGen only)	388

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3266	1188	2050
Only index persons	2599	978	1621
Unadjusted period prevalence (%)
Whole population	0.05	0.03	0.06
Only index persons	0.05	0.04	0.06
Median age at first event (years)
Whole population	56.24	57.43	55.51
Only index persons	55.94	56.94	55.33

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	388	155	233
Unadjusted period prevalence (%)	0.08	0.05	0.10
Median age at first event (years)	59.25	56.49	61.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
352: Matched controls
3520

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G06.1

ICD-10 Finland

Intraspinal abscess and granuloma

+∞

191.7

166

G06.0

ICD-10 Finland

Intracranial abscess and granuloma

+∞

143.9

128

A41.0

ICD-10 Finland

Sepsis due to Staphylococcus aureus

42.2

75.5

G06.2

ICD-10 Finland

Extradural and subdural abscess, unspecified

+∞

48.0

J04AB02

ATC

rifampicin; systemic

43.5

40.0

M46.3

ICD-10 Finland

Infection of intervertebral disc (pyogenic)

118.8

39.7

A49.9

ICD-10 Finland

Bacterial infection, unspecified

7.0

36.7

101

192

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

9.2

36.0

109

M46.4

ICD-10 Finland

Discitis, unspecified

62.4

34.0

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

12.9

31.4

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

4.9

30.7

118

328

AAM00

NOMESCO Finland

Puncture and evacuation of intracerebral abscess

+∞

28.5

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

4.6

28.5

116

339

NA3DG

NOMESCO Finland

Lumbar spine very extensive MRI examination with high intensity magnet

51.8

28.0

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

4.6

27.8

113

328

AA1CD

NOMESCO Finland

Very extensive CT of head and brain

24.9

25.8

AA1AD

NOMESCO Finland

CT of head and brain

3.7

24.9

137

516

WX408

NOMESCO Finland

General anesthesy, balanced

3.5

24.5

148

599

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

6.1

24.1

137

JN4BD

NOMESCO Finland

Extensive body CT

4.8

23.2

223

J01FF01

ATC

clindamycin; systemic

3.4

23.1

150

636

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

11.5

21.8

N03AX14

ATC

levetiracetam; systemic

12.8

21.3

AAM30

NOMESCO Finland

Evacuation of epidural or subdural empyema

+∞

21.0

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

7.7

21.0

B18.2

ICD-10 Finland

Chronic viral hepatitis C

44.7

20.7

NA1CG

NOMESCO Finland

Cervical spine extensive MRI examination with high intensity magnet

17.1

19.2

FM1BE

NOMESCO Finland

Cardiac ultrasound examination through oesophagus

5.3

19.1

137

AA1BD

NOMESCO Finland

Extensive CT of head and brain

11.0

18.9

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.8

18.9

196

1093

NA7DG

NOMESCO Finland

Spine and spinal cord very extensive MRI examination with high intensity magnet

15.5

18.5

N02AA05

ATC

oxycodone; systemic

3.7

17.7

293

NA7CG

NOMESCO Finland

Spine and spinal cord extensive MRI examination with high intensity magnet

18.2

17.7

TPH04

NOMESCO Finland

Cathetrisation of vein

3.2

17.3

109

434

R4110

NOMESCO Finland

Physiotherapy

3.0

17.1

128

570

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

9.8

16.9

182

Kela drug reimbursment

Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide

13.7

16.5

J01CF05

ATC

flucloxacillin; systemic

8.1

16.4

TPH30

NOMESCO Finland

Insertion of central venous catheter through periferal vein

12.6

15.9

AAM10

NOMESCO Finland

Excision of intracerebral abscess

+∞

15.7

R50.9

ICD-10 Finland

Fever, unspecified

3.4

15.1

283

G40.29

ICD-10 Finland

Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures

11.1

14.5

A41.9

ICD-10 Finland

Sepsis, unspecified

6.8

14.2

TKC20

NOMESCO Finland

Catheterisation of bladder

4.7

14.1

116

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

5.3

14.1

NA2BG

NOMESCO Finland

Thoracal spine MRI examination with high intensity magnet

11.6

13.7

NAS20

NOMESCO Finland

Incision and debridement of infection of vertebra, unspecified

+∞

13.6

J01MA12

ATC

levofloxacin; systemic

2.9

13.6

396

N03AX16

ATC

pregabalin; oral

2.7

13.1

110

513

G40.9

ICD-10 Finland

Epilepsy, unspecified

7.5

12.9

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

2.9

12.8

349

N02AX02

ATC

tramadol; systemic, rectal

2.3

12.6

173

1039

L28

ICPC

Limited function/disability (L)

3.0

12.1

288

NA1DG

NOMESCO Finland

Cervical spine very extensive MRI examination with high intensity magnet

31.2

11.7

G09

ICD-10 Finland

Sequelae of inflammatory diseases of central nervous system

+∞

11.5

T36

ICD-10 Finland

Poisoning by systemic antibiotics

6.5

11.3

G40.22

ICD-10 Finland

Complex partial epileptic seizure with secondary generalization

13.3

11.3

WX892

NOMESCO Finland

Monitored bed care

4.1

11.2

118

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

3.4

10.8

183

ZXM00

NOMESCO Finland

Intraoperative use of ultrasonographic imaging

18.6

10.8

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.0

10.7

257

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

2.2

10.6

150

893

WX110

NOMESCO Finland

Local anesthesy

2.2

10.6

248

1835

AAK00

NOMESCO Finland

Cranioplasty

113.3

10.5

AWC00

NOMESCO Finland

Reoperation of nervous system because of deep wound infection in the nervous system

113.3

10.5

G00.9

ICD-10 Finland

Bacterial meningitis, unspecified

+∞

10.5

32200

ICD-8 Finland

Intracranial and intraspinal abscess, Intracerebralis

+∞

10.5

N03AX18

ATC

lacosamide; systemic

19.5

10.3

ZXC95

NOMESCO Finland

Use of surgical navigator

13.7

10.3

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

3.8

10.1

129

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.4

10.1

470

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

3.2

10.1

197

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

3.3

10.1

175

A46

ICD-10 Finland

Erysipelas

2.9

10.0

267

NA2CG

NOMESCO Finland

Thoracal spine extensive MRI examination with high intensity magnet

15.6

9.6

I33.0

ICD-10 Finland

Acute and subacute infective endocarditis

15.6

9.6

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

3.5

9.5

142

M46.2

ICD-10 Finland

Osteomyelitis of vertebra

+∞

9.4

3240A

ICD-9 Finland

Intracranial and intraspinal abscess, Intracranial abscess

+∞

9.4

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

4.0

9.4

100

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

2.9

9.2

227

F11.22

ICD-10 Finland

Addiction-induced dependence is currently independent but uses substitute intermittent medication

37.7

9.1

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

3.1

9.0

176

X69

ICD-10 Finland

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

7.1

9.0

X59

ICD-10 Finland

Exposure to unspecified factor

2.4

8.9

379

XF400

NOMESCO Finland

ECG with 12 standard connections

2.6

8.8

322

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.4

8.8

425

R4120

NOMESCO Finland

Occupational therapy

3.8

8.7

102

A40.8

ICD-10 Finland

Other streptococcal sepsis

10.4

8.6

N03AB02

ATC

phenytoin; systemic

16.8

8.6

AA1DM

NOMESCO Finland

Very extensive MRI examination of brain with 3 Tesla magnet

16.8

8.6

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

3.1

8.6

177

EBA15

NOMESCO Finland

Extraction of large number of teeth

4.6

8.5

QX2XE

NOMESCO Finland

Ultrsound examination of soft tissue not elsewhere classified

7.0

8.5

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

3.1

8.5

165

F11.29

ICD-10 Finland

Addiction caused by opiates UNS

+∞

8.4

AAG00

NOMESCO Finland

Stereotactic intracranial biopsy

+∞

8.4

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

3.7

8.3

106

ABC60

NOMESCO Finland

Decompression of cervical spinal cord

14.9

8.3

A41.5

ICD-10 Finland

Sepsis due to other Gram-negative organisms

5.5

8.2

XA800

NOMESCO Finland

Neuropsychological investigation

4.7

7.9

IAZ97

NOMESCO Finland

Psychiatric consultation in another specialty

13.4

7.9

ZXA00

NOMESCO Finland

Right side

2.1

7.9

107

609

WX882

NOMESCO Finland

High dependency care

6.2

7.8

N02BE01

ATC

paracetamol; systemic, rectal

2.3

7.8

300

2529

P19

ICPC

Drug abuse

15.5

7.8

AWB00

NOMESCO Finland

Reoperation for superficial infection in surgery of the nervous system

46.0

7.7

G95.8

ICD-10 Finland

Other specified diseases of spinal cord

46.0

7.7

F15.1

ICD-10 Finland

Mental and behavioural disorders due to use of other stimulants, including caffeine, harmful use

46.0

7.7

A41.8

ICD-10 Finland

Other specified sepsis

7.0

7.7

EBA10

NOMESCO Finland

Surgical removal of tooth

2.9

7.7

184

A28

ICPC

Limited function/disability NOS

2.5

7.7

296

AAA10

NOMESCO Finland

Biopsy through craniotomy

25.6

7.6

M00.0

ICD-10 Finland

Staphylococcal arthritis and polyarthritis

25.6

7.6

N05BA01

ATC

diazepam; systemic, rectal

2.5

7.5

267

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

4.4

7.5

AAD10

NOMESCO Finland

Evacuation of chronic subdural haematoma

9.7

7.3

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

2.7

7.3

214

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

4.6

7.3

WX872

NOMESCO Finland

Intensive care

3.5

7.2

F19.1

ICD-10 Finland

Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use

30.7

7.2

F11.25

ICD-10 Finland

Relationship caused by opiates continuously used

30.7

7.2

Z72.2

ICD-10 Finland

Drug use

20.5

7.2

S06.5

ICD-10 Finland

Traumatic subdural haemorrhage

4.9

7.2

SPAT1255

SPAT

Intravenous administration of medicine

3.1

7.1

132

B01AB05

ATC

enoxaparin; parenteral

2.0

7.1

111

663

F10.29

ICD-10 Finland

Addiction caused by alcohol UNS

6.6

7.0

A04.7

ICD-10 Finland

Enterocolitis due to Clostridium difficile

6.1

7.0

N03AF01

ATC

carbamazepine; oral, rectal

4.3

6.8

M54.5

ICD-10 Finland

Low back pain

1.9

6.8

117

724

T91.3

ICD-10 Finland

Sequelae of injury of spinal cord

40.9

6.8

J01XX08

ATC

linezolid; systemic

17.1

6.8

M79.6

ICD-10 Finland

Pain in limb

1.9

6.8

115

708

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

4.8

6.7

NK5AT

NOMESCO Finland

Joint injection with ultrasound guidance not elsewhere classified

23.0

6.7

N03AX12

ATC

gabapentin; oral

2.3

6.7

296

WX002

NOMESCO Finland

Sedation and analgesia

2.1

6.7

413

R60.0

ICD-10 Finland

Localized oedema

2.8

6.7

162

TPH07

NOMESCO Finland

Cathetrisation of artery

2.6

6.6

208

R56.8

ICD-10 Finland

Other and unspecified convulsions

3.9

6.6

F10.24

ICD-10 Finland

Alcohol depence active use

9.0

6.6

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

3.4

6.6

C03CA01

ATC

furosemide; systemic

1.9

6.5

110

674

G40.10

ICD-10 Finland

Simple partial seizures

14.7

6.4

M54.9

ICD-10 Finland

Dorsalgia, unspecified

2.7

6.4

178

F10.25

ICD-10 Finland

Alcohol dependence continuous use

6.8

6.4

Z46.3

ICD-10 Finland

Fitting and adjustment of dental prosthetic device

8.4

6.4

K90

ICPC

Stroke/cerebrovascular accident

6.2

6.4

A06AD11

ATC

lactulose; oral

2.4

6.3

254

F19.29

ICD-10 Finland

Addiction caused by several drugs in combination and by other psychoactive substances UNS

18.4

6.3

J01DB01

ATC

cefalexin; oral

1.9

6.3

282

2375

F11.24

ICD-10 Finland

Addiction-induced dependence caused by opiates active addiction

+∞

6.3

D43.2

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Brain, unspecified

+∞

6.3

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.8

6.2

163

1152

TPX10

NOMESCO Finland

Implantation of vascular injection port

4.8

6.2

L02.4

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle of limb

4.8

6.2

H02AB07

ATC

prednisone; oral

2.3

6.2

277

P15

ICPC

Chronic alcohol abuse

5.4

6.1

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

3.0

6.1

120

N18

ICPC

Paralysis/weakness

6.2

6.1

R33

ICD-10 Finland

Retention of urine

2.8

6.0

146

Mortality – FinRegistry

↥

Association

Association between endpoint G6_CNSABSC and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_CNSABSC	2.858 [2.2, 3.71]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.345

During the follow-up period (1.1.1998 — 31.12.2019), 249 out of 827 females with G6_CNSABSC died.

Males

Parameter	HR [95% CI]	p-value
G6_CNSABSC	3.057 [2.48, 3.77]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 456 out of 1360 males with G6_CNSABSC died.

Mortality risk

Mortality risk for people of age

years, who have G6_CNSABSC.

N-year risk	Females	Males
1	0.342%	0.607%
5	2.032%	3.043%
10	4.479%	7.957%
15	7.857%	15.197%
20	13.336%	24.356%

Relationships between endpoints

↥

Index endpoint: G6_CNSABSC – Intracranial and intraspinal abscess and granuloma

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	G6_CNSABSC
CONTROL_EXCLUDE	G6_NEUINFL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G06\|G07
HD_ICD_9	324
HD_ICD_8	322
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G06\|G07
COD_ICD_9	324
COD_ICD_8	322
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Intracranial and intraspinal abscess and granuloma

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints