No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
8809 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
4123 |
6. Filter based on genotype QC (FinnGen only) |
4123 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Graves disease, strict definition
based on the number of shared cases.
Similar with more cases:
- Carbimazole or st.post thyroidectomy, condition for graves disease
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 23064 | 18836 | 4057 |
| Only index persons | 22484 | 18513 | 3971 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.46 | 0.54 | 0.11 |
| Only index persons | 0.59 | 0.68 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 49.31 | 49.21 | 50.36 |
| Only index persons | 49.26 | 49.12 | 49.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4123 | 3491 | 632 |
| Unadjusted period prevalence (%) | 1.05 | 1.19 | 0.28 |
| Median age at first event (years) | 49.40 | 48.66 | 53.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3572
- Matched controls
- 35718
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
BAA60
NOMESCO Finland
Total thyroidectomy
54.3
323.0
1079
282
H03AA01
ATC
levothyroxine sodium; systemic
12.3
323.0
2558
6060
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
117.7
323.0
1687
270
C07AA05
ATC
propranolol; systemic
5.8
323.0
1706
4837
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
10985.0
323.0
3521
182
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
45.5
323.0
675
182
H03BB01
ATC
carbimazole; oral
4425.3
323.0
3487
361
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
63.4
323.0
440
79
104
Kela drug reimbursment
Thyroid insufficiency
9.0
323.0
952
1388
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
104.9
323.0
602
69
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
234.5
323.0
469
23
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
32.4
266.9
357
122
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
32.6
225.0
300
100
T85
ICPC
Hyperthyroidism/thyrotoxicosis
54.7
184.8
221
43
C07AB07
ATC
bisoprolol; oral
2.9
184.5
1786
9273
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
185.0
169.4
176
10
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
14.4
168.6
295
222
H062, E050
ICD-10 Finland
NA
396.5
153.4
153
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.8
116.9
424
975
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.3
113.3
1675
10004
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
103.7
1327
7304
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
7.9
89.2
212
282
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
35.2
81.5
106
31
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
34.5
79.6
104
31
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
45.4
75.5
93
21
T86
ICPC
Hypothyroidism/myxoedema
4.6
74.3
277
646
E05.89
ICD-10 Finland
Other thyrotoxicosis
40.1
71.3
90
23
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
16.3
69.6
114
72
H03BA02
ATC
propylthiouracil; oral
132.3
61.0
65
5
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
22.3
59.4
87
40
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.4
59.1
229
553
E05.5
ICD-10 Finland
Thyroid crisis or storm
280.4
54.3
55
*
H05.2
ICD-10 Finland
Exophthalmic conditions
24.0
46.3
66
28
CA1AD
NOMESCO Finland
Orbita CT
40.6
44.8
56
14
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.2
44.6
536
2702
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
11.1
40.0
77
71
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
25.4
39.3
55
22
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.6
39.2
186
537
E03
ICD-10 Finland
Other hypothyroidism
2.7
39.2
293
1155
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
5.6
39.1
117
214
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
5.4
36.4
113
216
A11CC03
ATC
alfacalcidol; systemic
5.4
35.5
109
206
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
340.3
34.0
34
*
ZXA10
NOMESCO Finland
Bilateral
1.8
31.3
603
3601
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
28.8
879
5988
E83.51
ICD-10 Finland
Hypocalcemia
10.5
27.7
54
52
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
60.5
26.0
30
5
106
Kela drug reimbursment
Hypoparathyroidism
14.5
25.6
43
30
H53.2
ICD-10 Finland
Diplopia
3.5
25.6
124
366
H02AB06
ATC
prednisolone; systemic
1.4
23.7
1497
11889
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
23.7
369
2033
CAC44
NOMESCO Finland
Combined decompression of orbit
231.4
22.6
23
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
4.3
21.8
81
190
E06.3
ICD-10 Finland
Autoimmune thyroiditis
6.1
21.6
59
98
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.6
21.3
162
645
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
+∞
20.8
20
*
CAC20
NOMESCO Finland
Lateral decompression of orbit
+∞
20.8
20
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
20.3
716
4993
C07AB02
ATC
metoprolol; systemic
1.6
20.1
522
3367
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
20.0
504
3227
XCK00
NOMESCO Finland
Perimetry
2.2
19.8
213
1010
H50.2
ICD-10 Finland
Vertical strabismus
5.3
18.5
56
106
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
14.2
18.5
31
22
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.8
18.5
317
1802
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
16.6
17.8
28
17
A11CC02
ATC
dihydrotachysterol; oral
15.4
16.2
26
17
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.1
16.0
86
278
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
15.7
379
2390
CA1BD
NOMESCO Finland
Extensive orbita CT
33.5
15.7
20
6
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
3.9
15.7
65
171
R00.2
ICD-10 Finland
Palpitations
1.8
15.5
253
1414
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
20.1
15.1
22
11
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
15.1
1137
9108
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
14.0
15.0
25
18
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
4.4
14.6
52
119
WX402
NOMESCO Finland
General anaesthesia
1.5
14.0
514
3588
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
14.7
13.6
22
15
E50.0
ICD-10 Finland
Vitamin A deficiency with conjunctival xerosis
+∞
13.5
13
*
ZX120
NOMESCO Finland
Intravenous
1.7
13.1
266
1595
K90.0
ICD-10 Finland
Coeliac disease
2.4
13.0
106
442
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
14.1
12.7
21
15
H02AB07
ATC
prednisone; oral
1.5
12.6
422
2883
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
2.6
12.1
86
334
H50.8
ICD-10 Finland
Other specified strabismus
13.4
11.9
20
15
H50.6
ICD-10 Finland
Mechanical strabismus
22.9
11.6
16
7
TPH04
NOMESCO Finland
Cathetrisation of vein
1.4
11.5
549
4036
2AB04
NOMESCO Finland
NA
7.5
11.4
26
35
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
2.1
11.3
126
611
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
6.2
11.2
29
47
WF099
NOMESCO Finland
Other radiotherapy
5.2
10.4
31
60
N07BA03
ATC
varenicline; oral
1.8
10.3
161
891
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
2.3
10.0
90
396
E05.3
ICD-10 Finland
Thyrotoxicosis from ectopic thyroid tissue
40.2
10.0
12
*
E06.9
ICD-10 Finland
Thyroiditis, unspecified
4.9
9.9
31
64
N02BE01
ATC
paracetamol; systemic, rectal
1.3
9.6
2858
26904
K04
ICPC
Palpitations/awareness of heart
1.8
9.4
153
857
A02BC02
ATC
pantoprazole; systemic
1.2
9.3
1980
17841
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
8.7
9.3
19
22
E89.1
ICD-10 Finland
Postprocedural hypoinsulinaemia
18.6
8.9
13
7
H50.0
ICD-10 Finland
Convergent concomitant strabismus
4.0
8.9
34
86
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
8.6
1227
10532
E06.1
ICD-10 Finland
Subacute thyroiditis
3.7
8.6
36
99
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
27.6
8.5
11
*
WX110
NOMESCO Finland
Local anesthesy
1.2
8.5
2277
20950
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
1.9
8.4
124
674
G73.0*E05.9
ICD-10 Finland
Myasthenic syndromes in thyrotoxicosis [hyperthyroidism]
90.3
8.4
9
*
TFP20
NOMESCO Finland
Cardiodefibrillation
1.8
8.1
123
679
K80
ICPC
Cardiac arrhythmia NOS
1.6
8.0
188
1179
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
4.6
8.0
26
57
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
4.1
8.0
29
71
XCK10
NOMESCO Finland
Photography of fundus of eye
1.6
7.8
225
1483
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
7.7
447
3387
CEC00
NOMESCO Finland
Recession of extraocular muscle
4.2
7.7
27
64
E20.8
ICD-10 Finland
Other hypoparathyroidism
18.4
7.6
11
6
M14.5*E05.9
ICD-10 Finland
Arthropathy in thyrotoxicosis [hyperthyroidism]
80.2
7.4
8
*
A04
ICPC
Weakness/tiredness general
1.4
7.3
337
2458
H04AA01
ATC
glucagon; nasal, parenteral
2.1
7.2
74
351
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
15.8
7.2
11
7
UDQ12
NOMESCO Finland
Flexible laryngoscopy
1.7
7.1
143
863
R63.4
ICD-10 Finland
Abnormal weight loss
2.1
7.1
73
349
Z50.5
ICD-10 Finland
Speech therapy
3.0
7.0
38
129
SGA01
NOMESCO Finland
Tooth opening as first aid
1.3
6.7
489
3843
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
1.6
6.7
144
887
8341/3-C73.9
ICD-O-3
Papillary microcarcinoma of thyroid gland
10.0
6.5
12
12
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
1.9
6.5
84
437
B01AA03
ATC
warfarin; systemic
1.4
6.4
310
2281
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.3
6.4
469
3688
CKC12
NOMESCO Finland
Photocoagulation of retina
1.8
6.3
99
554
CE2W4
NOMESCO Finland
Eye movement mapping
9.3
6.3
12
13
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
6.3
1756
15986
E8901, E050
ICD-10 Finland
NA
+∞
6.2
6
*
E50.9
ICD-10 Finland
Vitamin A deficiency, unspecified
+∞
6.2
6
*
O992, E050
ICD-10 Finland
NA
+∞
6.2
6
*
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
7.0
6.2
14
20
T89
ICPC
Diabetes insulin dependent
1.8
6.1
99
562
WX290
NOMESCO Finland
Other blockade of nerve
1.2
6.1
1439
12889
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
8.6
6.0
12
14
CEW99
NOMESCO Finland
Other operation on extraocular muscle
8.6
6.0
12
14
E10
ICD-10 Finland
Type 1 diabetes mellitus
2.2
6.0
56
257
GB1AA
NOMESCO Finland
Tracheal X-ray examination
10.0
6.0
11
11
Mortality – FinRegistry
↥Association
Association between endpoint E4_GRAVES_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GRAVES_STRICT | 1.07 [0.94, 1.22] | 0.294 |
| Birth year | 0.992 [0.98, 1.0] | 0.082 |
During the follow-up period (1.1.1998 — 31.12.2019), 1142 out of 16342 females with E4_GRAVES_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GRAVES_STRICT | 1.036 [0.89, 1.21] | 0.654 |
| Birth year | 0.991 [0.98, 1.0] | 0.053 |
During the follow-up period (1.1.1998 — 31.12.2019), 345 out of 3489 males with E4_GRAVES_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have E4_GRAVES_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.062% | 0.176% |
| 5 | 0.599% | 1.156% |
| 10 | 1.414% | 3.262% |
| 15 | 2.705% | 6.508% |
| 20 | 4.747% | 11.059% |
Relationships between endpoints
↥Index endpoint: E4_GRAVES_STRICT – Graves disease, strict definition
GWS hits: 21
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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