No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
912 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
894 |
4. Check minimum number of eventsNone |
894 |
5. Include endpointsNone |
894 |
6. Filter based on genotype QC (FinnGen only) |
894 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Graves ophthalmopathy
based on the number of shared cases.
Similar with more cases:
- Disorders of lacrimal system and orbit in diseases classified elsewhere
- Disorders of orbit
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Disorders of eyelid, lacrimal system and orbit
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4440 | 3590 | 832 |
| Only index persons | 4309 | 3510 | 799 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.02 |
| Only index persons | 0.11 | 0.13 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 50.59 | 50.50 | 51.24 |
| Only index persons | 50.44 | 50.39 | 50.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 894 | 733 | 161 |
| Unadjusted period prevalence (%) | 0.22 | 0.25 | 0.07 |
| Median age at first event (years) | 51.25 | 50.65 | 54.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 792
- Matched controls
- 7920
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03BB01
ATC
carbimazole; oral
189.7
323.0
627
155
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
87.1
323.0
416
99
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
323.0
676
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
504.4
323.0
691
106
H03AA01
ATC
levothyroxine sodium; systemic
21.1
297.0
652
1431
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
3124.0
261.4
238
*
BAA60
NOMESCO Finland
Total thyroidectomy
50.0
229.0
277
84
H062, E050
ICD-10 Finland
NA
+∞
213.4
195
*
104
Kela drug reimbursment
Thyroid insufficiency
12.8
155.0
307
374
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
40.7
154.4
195
63
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
7.3
137.0
608
2474
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
+∞
119.9
112
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
45.4
97.6
120
31
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.8
92.1
472
1865
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
54.2
90.9
108
23
C07AA05
ATC
propranolol; systemic
5.0
84.2
344
1045
H05.2
ICD-10 Finland
Exophthalmic conditions
160.5
82.8
86
6
H53.2
ICD-10 Finland
Diplopia
18.6
81.6
129
82
H50.2
ICD-10 Finland
Vertical strabismus
43.0
63.0
78
20
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
43.4
60.7
75
19
H02AB06
ATC
prednisolone; systemic
3.2
53.3
503
2774
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.0
51.7
186
456
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
+∞
50.6
48
*
XCK00
NOMESCO Finland
Perimetry
6.2
49.0
142
268
ZX120
NOMESCO Finland
Intravenous
4.5
39.7
157
415
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.4
37.7
216
783
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.9
36.5
109
210
CEC00
NOMESCO Finland
Recession of extraocular muscle
61.6
35.5
41
7
CAC44
NOMESCO Finland
Combined decompression of orbit
+∞
34.6
33
*
CA1AD
NOMESCO Finland
Orbita CT
79.8
34.1
38
5
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
340.6
33.1
33
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
14.7
32.6
55
40
H50.0
ICD-10 Finland
Convergent concomitant strabismus
40.9
31.5
39
10
H50.6
ICD-10 Finland
Mechanical strabismus
161.0
29.9
31
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
11.1
29.7
57
55
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.2
28.4
173
639
ZXA10
NOMESCO Finland
Bilateral
2.8
27.9
215
930
H50.8
ICD-10 Finland
Other specified strabismus
103.8
27.8
30
*
A02BC02
ATC
pantoprazole; systemic
2.4
27.5
579
4204
E03.89
ICD-10 Finland
Other specified hypothyroidism
5.9
27.1
79
147
T85
ICPC
Hyperthyroidism/thyrotoxicosis
28.9
26.9
36
13
H04.10
ICD-10 Finland
Dry eye syndrome
3.3
26.8
149
516
CAC20
NOMESCO Finland
Lateral decompression of orbit
+∞
26.2
25
*
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
+∞
26.2
25
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
25.8
216
975
WF099
NOMESCO Finland
Other radiotherapy
26.1
25.5
35
14
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
69.7
23.9
27
*
C07AB07
ATC
bisoprolol; oral
2.2
23.8
384
2387
XCD10
NOMESCO Finland
Electrophysiological examination of eye
7.4
23.6
57
82
T86
ICPC
Hypothyroidism/myxoedema
4.9
22.7
77
170
H02AB07
ATC
prednisone; oral
2.8
21.8
162
674
2AB04
NOMESCO Finland
NA
44.7
21.5
26
6
E03
ICD-10 Finland
Other hypothyroidism
3.8
20.4
90
257
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.1
20.3
122
440
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
49.4
20.2
24
5
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
9.6
18.3
37
40
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
53.8
18.0
21
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
4.7
17.8
61
137
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
17.4
324
2053
XCK10
NOMESCO Finland
Photography of fundus of eye
3.0
17.1
106
389
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
5.2
17.0
53
107
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
26.2
17.0
23
9
Z3231
NOMESCO Finland
Registered nurse
2.1
16.5
242
1389
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.3
16.3
50
99
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
16.3
245
1418
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
21.5
16.0
23
11
E05.5
ICD-10 Finland
Thyroid crisis or storm
61.3
15.8
18
*
CEW99
NOMESCO Finland
Other operation on extraocular muscle
34.1
15.8
20
6
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
13.3
15.8
27
21
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
163.1
15.5
16
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
14.8
335
2239
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
152.7
14.5
15
*
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
27.7
14.3
19
7
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.9
13.9
88
328
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
13.5
335
2288
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
9.3
13.3
27
30
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
40.8
13.2
16
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
3.2
12.5
66
217
A11CC03
ATC
alfacalcidol; systemic
6.1
12.4
33
56
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
6.5
12.2
31
49
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
10.3
12.0
23
23
E05.89
ICD-10 Finland
Other thyrotoxicosis
21.7
12.0
17
8
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.8
12.0
276
1824
CS494
NOMESCO Finland
Other visual field testing
5.6
11.9
34
63
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.1
11.8
67
231
N05CF01
ATC
zopiclone; oral
1.8
11.7
270
1783
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
5.0
11.4
36
75
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
35.6
11.3
14
*
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
28.4
10.7
14
5
1XC02
NOMESCO Finland
NA
11.4
10.6
19
17
WF002
NOMESCO Finland
Radical radiotherapy
3.8
10.1
42
115
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
17.0
9.9
15
9
106
Kela drug reimbursment
Hypoparathyroidism
17.0
9.9
15
9
H57.1
ICD-10 Finland
Ocular pain
3.7
9.9
42
118
H03BA02
ATC
propylthiouracil; oral
26.4
9.8
13
5
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.0
9.8
137
756
CE2W4
NOMESCO Finland
Eye movement mapping
22.0
9.4
13
6
S01GX01
ATC
cromoglicic acid; ophthalmic
1.8
9.3
180
1111
A11CC02
ATC
dihydrotachysterol; oral
24.3
8.9
12
5
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
8.3
8.6
18
22
Z3229
NOMESCO Finland
Other healthcare associate professional
2.4
8.6
74
330
WX002
NOMESCO Finland
Sedation and analgesia
1.8
8.5
159
965
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
8.0
8.4
18
23
S01KA02
ATC
hypromellose; ophthalmic
4.7
8.4
27
59
ZX050
NOMESCO Finland
Stereotactic radiotherapy
14.7
8.2
13
9
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
7.6
8.2
18
24
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
9.0
8.1
16
18
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
8.6
7.8
16
19
H02AB09
ATC
hydrocortisone; systemic
4.3
7.7
27
65
WX402
NOMESCO Finland
General anaesthesia
1.8
7.6
137
820
CA1BD
NOMESCO Finland
Extensive orbita CT
25.3
7.6
10
*
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
25.3
7.6
10
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.4
7.4
61
268
E50.0
ICD-10 Finland
Vitamin A deficiency with conjunctival xerosis
+∞
7.3
7
*
ZXE00
NOMESCO Finland
One hour or less
1.5
7.2
302
2272
XCH00
NOMESCO Finland
Eye pressure measurement
3.1
7.1
36
118
ZXC95
NOMESCO Finland
Use of surgical navigator
6.1
7.1
18
30
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
12.2
7.1
12
10
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
6.9
91
489
H50.52
ICD-10 Finland
Exophoria
6.8
6.8
16
24
Z2221
NOMESCO Finland
Medical doctor
1.6
6.8
216
1516
CD2S4
NOMESCO Finland
Photography of eye
11.1
6.8
12
11
ZXD20
NOMESCO Finland
Day surgery
1.9
6.8
103
584
WX140
NOMESCO Finland
Parabulbar anesthesy
3.0
6.7
36
124
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
6.6
172
1147
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
3.9
6.6
25
65
ZX090
NOMESCO Finland
Other technic of radiotherapy
3.4
6.5
29
87
XX3DW
NOMESCO Finland
Time consuming IT work
2.0
6.4
82
436
CBK99
NOMESCO Finland
Other operation for retraction of eyelid
70.4
6.4
7
*
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
14.4
6.4
10
7
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.8
6.3
37
134
G73.0*E05.9
ICD-10 Finland
Myasthenic syndromes in thyrotoxicosis [hyperthyroidism]
+∞
6.3
6
*
H50.9
ICD-10 Finland
Strabismus, unspecified
26.9
6.2
8
*
ZXA00
NOMESCO Finland
Right side
1.6
6.2
194
1357
Z3226
NOMESCO Finland
Physiotherapist
1.7
6.1
135
859
H01CB02
ATC
octreotide; parenteral
12.6
6.1
10
8
H11.1
ICD-10 Finland
Conjunctival degenerations and deposits
8.7
6.1
12
14
Mortality – FinRegistry
↥Association
Association between endpoint GRAVES_OPHT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GRAVES_OPHT | 0.959 [0.83, 1.1] | 0.558 |
| Birth year | 0.994 [0.99, 1.0] | 0.163 |
During the follow-up period (1.1.1998 — 31.12.2019), 269 out of 3299 females with GRAVES_OPHT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GRAVES_OPHT | 0.932 [0.75, 1.16] | 0.532 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 762 males with GRAVES_OPHT died.
Mortality risk
Mortality risk for people of age
years, who have GRAVES_OPHT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | 0.178% |
| 5 | 0.592% | 1.02% |
| 10 | 1.423% | 2.475% |
| 15 | 2.785% | 4.756% |
| 20 | 4.852% | 8.199% |
Relationships between endpoints
↥Index endpoint: GRAVES_OPHT – Graves ophthalmopathy
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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