info icon

Carbimazole or st.post thyroidectomy, condition for graves disease

GRAVES_COND

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Operations: NOMESCO codes ^BAA60
  • Medicine purchases: ATC H03BB01

2 out of 7 registries used, show all original rules.

7979

4. Check minimum number of events

Min. number of events 3
7979

5. Include endpoints

None

7979

6. Filter based on genotype QC (FinnGen only)

7679

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 7679 6132 1547
Unadjusted period prevalence (%) 2.08 2.41 0.78
Median age at first event (years) 53.72 52.25 59.55

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
7979
Matched controls
79788
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
15.1
323.0
1534
1241
EP1AE
NOMESCO Finland
Neck ultrasound examination
10.5
323.0
1587
1835
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
98.2
323.0
1319
161
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
177.2
323.0
483
29
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
16.7
323.0
639
413
BAA60
NOMESCO Finland
Total thyroidectomy
+∞
323.0
4087
*
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
105.8
323.0
918
98
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
55.1
323.0
910
186
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
149.5
323.0
3621
441
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
323.0
3609
17944
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
11.3
323.0
671
645
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
40.5
323.0
573
152
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
87.7
323.0
2609
440
C07AA05
ATC
propranolol; systemic
3.4
323.0
2659
10186
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
19.8
323.0
635
347
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
103.5
323.0
1693
207
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
82.9
323.0
1098
153
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
85.1
323.0
472
59
H03BB01
ATC
carbimazole; oral
279.7
323.0
5163
520
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
75.0
323.0
804
119
H03AA01
ATC
levothyroxine sodium; systemic
16.3
323.0
6066
12988
104
Kela drug reimbursment
Thyroid insufficiency
17.5
323.0
3154
2879
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
13.2
279.3
508
409
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
93.6
275.5
306
34
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
13.3
259.5
470
374
JN5AQ
NOMESCO Finland
SPECT of thyroid metastasis with low-dose CT
275.7
235.8
240
9
T85
ICPC
Hyperthyroidism/thyrotoxicosis
35.9
233.0
304
88
4CJ01
NOMESCO Finland
NA
172.9
224.2
235
14
C07AB07
ATC
bisoprolol; oral
2.1
220.6
3746
23269
E05.89
ICD-10 Finland
Other thyrotoxicosis
96.8
220.5
244
26
A11CC03
ATC
alfacalcidol; systemic
9.5
204.7
440
489
ZX114
NOMESCO Finland
Intramuscular
11.2
188.6
369
343
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
179.9
2457
13533
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
17.2
167.2
271
163
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
44.0
165.2
206
48
T86
ICPC
Hypothyroidism/myxoedema
4.5
162.6
617
1450
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
73.4
157.3
180
25
BA1NN
NOMESCO Finland
I-131 dose capsel measurement
137.7
151.8
162
12
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
150.8
3119
19955
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.7
149.5
540
1204
C73.99
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland), other or unspecified histology
47.8
145.2
178
38
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.1
144.5
2036
11162
H062, E050
ICD-10 Finland
NA
141.8
143.7
153
11
E83.51
ICD-10 Finland
Hypocalcemia
21.2
140.4
211
102
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
14.2
138.7
242
175
ZXA10
NOMESCO Finland
Bilateral
2.1
128.6
1657
8671
C73
ICD-10 Finland
Malignant neoplasm of thyroid gland
38.9
128.4
164
43
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.4
126.9
1281
5973
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
58.3
125.9
149
26
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
38.9
125.3
160
42
106
Kela drug reimbursment
Hypoparathyroidism
27.0
119.7
167
63
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
21.0
119.0
179
87
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
21.7
115.5
172
81
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
6.6
112.6
303
474
E03
ICD-10 Finland
Other hypothyroidism
2.9
101.3
688
2545
WX402
NOMESCO Finland
General anaesthesia
2.0
95.4
1452
8017
C01BD01
ATC
amiodarone; systemic
5.3
94.3
303
591
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
32.3
91.1
121
38
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
88.8
3066
21946
T71
ICPC
Malignant neoplasm thyroid
68.1
87.6
101
15
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
82.5
3255
23986
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
74.3
1063
5674
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.4
74.0
382
1162
A11CC02
ATC
dihydrotachysterol; oral
25.1
73.4
104
42
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
15.9
68.4
113
72
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.6
66.8
510
2012
8341/3-C73.9
ICD-O-3
Papillary microcarcinoma of thyroid gland
83.1
66.0
74
9
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
4.6
64.3
235
527
E05.5
ICD-10 Finland
Thyroid crisis or storm
315.3
61.4
62
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
61.0
2954
22345
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
5.8
59.9
177
313
Z51.88
ICD-10 Finland
Other specified medical care
4.6
58.6
213
475
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
12.5
58.0
106
86
T81
ICPC
Goitre
12.7
57.4
104
83
H03BA02
ATC
propylthiouracil; oral
42.1
57.0
71
17
N02BE01
ATC
paracetamol; systemic, rectal
1.6
56.2
6657
60455
PJ3AT
NOMESCO Finland
Cytology of lymphnode with ultrasound guidance
5.3
55.0
173
330
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
53.6
1177
7220
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
46.8
53.3
65
14
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
46.6
1410
9426
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
4.7
46.5
164
356
8340/3-C73.9
ICD-O-3
Papillary carcinoma, follicular variant of thyroid gland
100.6
45.8
50
5
TFP20
NOMESCO Finland
Cardiodefibrillation
2.3
45.5
447
2009
E06.3
ICD-10 Finland
Autoimmune thyroiditis
6.4
44.6
120
189
ZXE00
NOMESCO Finland
One hour or less
1.4
42.6
2915
23129
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
5.8
42.4
123
214
E04.8
ICD-10 Finland
Other specified nontoxic goitre
11.0
42.1
81
74
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
7.1
41.5
104
149
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
2.6
41.3
312
1220
EP2AT
NOMESCO Finland
Neck soft tissue cytology with ultrasound guidance
14.8
41.0
69
47
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
39.9
1532
10794
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
6.6
39.6
104
159
C07AB02
ATC
metoprolol; systemic
1.6
39.5
1260
8500
PJD91
NOMESCO Finland
Excision of lymph nodes in neck, 1 to 2 areas in total
35.9
39.0
50
14
8330/3-C73.9
ICD-O-3
Follicular carcinoma, NOS, of thyroid gland
22.1
37.8
55
25
WX704
NOMESCO Finland
Intubation
2.0
37.6
535
2817
H05.2
ICD-10 Finland
Exophthalmic conditions
11.4
37.5
71
63
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
4.8
36.0
124
264
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
35.9
646
3692
CA1AD
NOMESCO Finland
Orbita CT
15.4
35.1
58
38
207
Kela drug reimbursment
Chronic arrhythmias
1.7
34.9
769
4685
H02AB06
ATC
prednisolone; systemic
1.3
33.3
3297
27466
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
3.9
33.1
138
354
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
44.6
32.7
40
9
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
32.0
2312
18279
JN5SN
NOMESCO Finland
NA
61.9
32.0
37
6
DQE10
NOMESCO Finland
Injection of foreign material into vocal cord
11.6
31.7
59
51
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.6
31.6
1005
6739
E06.9
ICD-10 Finland
Thyroiditis, unspecified
8.3
31.3
70
85
E06.4
ICD-10 Finland
Drug-induced thyroiditis
53.1
31.3
37
7
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
31.2
729
4511
E20.8
ICD-10 Finland
Other hypoparathyroidism
22.1
30.4
44
20
Z2221
NOMESCO Finland
Medical doctor
1.4
30.0
1986
15440
R49.08
ICD-10 Finland
Other specified dysphonia
2.8
29.7
198
720
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
4.9
28.7
95
195
BA1AQ
NOMESCO Finland
Thyroid SPECT with low dose CT
150.5
28.6
30
*
C73.94
ICD-10 Finland
Medullary thyroid carcinoma (thyroid)
43.9
28.6
35
8
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
16.8
28.3
45
27
B01AA03
ATC
warfarin; systemic
1.5
27.7
962
6572
J01DB01
ATC
cefalexin; oral
1.3
27.4
6097
56372
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
18.3
27.3
42
23
GB1AA
NOMESCO Finland
Tracheal X-ray examination
19.6
27.3
41
21
E04
ICD-10 Finland
Other nontoxic goitre
7.8
27.3
63
81
A12AA04
ATC
calcium carbonate; oral
3.7
27.3
121
329
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
4.8
27.3
92
193
Z3226
NOMESCO Finland
Physiotherapist
1.5
27.2
1224
8839
WZC30
NOMESCO Finland
Teaching
1.6
26.8
848
5667
C01AA05
ATC
digoxin; systemic
2.0
26.1
359
1863
R00.2
ICD-10 Finland
Palpitations
1.7
25.5
527
3143
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.1
25.2
293
1421
T72
ICPC
Benign neoplasm thyroid
10.5
25.2
49
47
C07AA07
ATC
sotalol; systemic
2.4
24.9
226
977
B01AB05
ATC
enoxaparin; parenteral
1.3
24.5
1975
15752
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.6
24.2
708
4641
WX110
NOMESCO Finland
Local anesthesy
1.3
24.1
5024
45485
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
2.8
24.1
156
560
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
23.9
1197
8802
BAA99
NOMESCO Finland
Other operation on thyroid gland
22.8
23.8
34
15
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
33.4
23.3
30
9
R4110
NOMESCO Finland
Physiotherapy
1.3
23.3
1704
13372
E06.1
ICD-10 Finland
Subacute thyroiditis
4.4
23.0
84
192
C03CA01
ATC
furosemide; systemic
1.4
22.9
1451
11116
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.0
22.9
312
1614
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.5
22.8
758
5120
Z3231
NOMESCO Finland
Registered nurse
1.3
22.8
1762
13937
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
3.4
22.7
112
333
TFP35
NOMESCO Finland
Electroanatomical mapping
3.4
22.6
110
324
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
7.3
22.6
54
74
WB223
NOMESCO Finland
Demanding adjuvant hormone therapy of malignancy
7.1
22.5
55
78
A02BC02
ATC
pantoprazole; systemic
1.3
22.3
4570
41072
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
22.3
917
6485
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.5
21.8
939
6696
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.6
21.7
616
4004
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
7.6
21.5
50
66
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
1.9
21.2
320
1721
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
5.6
21.2
62
112
TFP34
NOMESCO Finland
Electrophysiological investigation
2.4
21.0
187
805
E8901, C7391
ICD-10 Finland
NA
210.5
20.6
21
*
BWD00
NOMESCO Finland
Reoperation for deep haemorrhage in endocrine surgery
18.3
20.4
31
17
XF404
NOMESCO Finland
Ambulatory ECG
1.6
20.3
536
3415
GD6AD
NOMESCO Finland
CT of chest and neck
8.5
20.3
44
52
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.3
20.1
1570
12399
R03AC02
ATC
salbutamol; inhalant
1.2
20.1
3750
33139
PJD51
NOMESCO Finland
Block dissection of cervical lymph nodes
17.3
20.0
31
18
CAC44
NOMESCO Finland
Combined decompression of orbit
57.6
19.9
23
*
R4130
NOMESCO Finland
Speech therapy
2.6
19.8
144
556
H50.2
ICD-10 Finland
Vertical strabismus
4.7
19.8
67
143
GD1AD
NOMESCO Finland
Thorax CT examination
2.0
19.7
241
1197
I50.9
ICD-10 Finland
Heart failure, unspecified
1.6
19.5
561
3656
WW200
NOMESCO Finland
Immunization
2.3
19.4
181
795
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
5.8
19.4
55
96
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.4
18.8
1001
7419
GD6BD
NOMESCO Finland
Extensive CT of chest and neck
9.1
18.8
39
43
BA2MN
NOMESCO Finland
Thyroid radiation dose measurement during isotope therapy
+∞
18.8
18
*
R13
ICD-10 Finland
Dysphagia
1.7
18.7
381
2261
WX725
NOMESCO Finland
Noninvasive ventilation
1.9
18.7
287
1554
A02BC05
ATC
esomeprazole; systemic
1.3
18.6
2766
23744
XX9AQ
NOMESCO Finland
Supplementary SPECT-CT or additional scan
8.7
18.3
39
45
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
2.0
18.2
229
1148
K80
ICPC
Cardiac arrhythmia NOS
1.6
17.9
435
2715
WA039
NOMESCO Finland
Radiotherapy with free isotopes
+∞
17.7
17
*
XX1MN
NOMESCO Finland
Isotope examination with measurement
66.7
17.7
20
*
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
3.3
17.6
89
272
8345/3-C73.9
ICD-O-3
Medullary thyroid carcinoma of thyroid gland
180.3
17.5
18
*
R06.0
ICD-10 Finland
Dyspnoea
1.3
17.4
1497
11964
I47.2
ICD-10 Finland
Ventricular tachycardia
2.6
17.4
128
499
I10
ICD-10 Finland
Essential (primary) hypertension
1.2
17.3
3398
30005
WX002
NOMESCO Finland
Sedation and analgesia
1.3
17.2
1207
9352
Z50.5
ICD-10 Finland
Speech therapy
2.9
17.1
104
359
ZX120
NOMESCO Finland
Intravenous
1.5
16.8
571
3870
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
1.8
16.8
297
1689
C73.93
ICD-10 Finland
Anaplastic thyroid carcinoma (thyroid)
35.1
16.6
21
6
E89.1
ICD-10 Finland
Postprocedural hypoinsulinaemia
27.6
16.5
22
8
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
40.1
16.3
20
5
I42.0
ICD-10 Finland
Dilated cardiomyopathy
2.5
16.1
130
533
C01BC04
ATC
flecainide; systemic
2.0
15.7
195
976
R53
ICD-10 Finland
Malaise and fatigue
1.3
15.7
1265
9998
CAC20
NOMESCO Finland
Lateral decompression of orbit
33.4
15.7
20
6
H53.2
ICD-10 Finland
Diplopia
2.0
15.3
191
960
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
2.1
15.1
165
785
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
2.9
15.1
93
327
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
15.0
1779
14784
ZXE30
NOMESCO Finland
More than five and less than seven hours
1.8
14.9
268
1532
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
8.9
14.9
31
35
H02AB07
ATC
prednisone; oral
1.4
14.6
893
6759
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.4
14.5
612
4340
J01AA02
ATC
doxycycline; systemic
1.2
14.4
5680
53362
R21
ICPC
Throat symptom/complaint
1.3
14.3
1311
10540
E07.89
ICD-10 Finland
Other specified disorders of thyroid
10.4
14.2
27
26
WX892
NOMESCO Finland
Monitored bed care
1.6
13.9
389
2522
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
1.7
13.8
291
1745
XCD10
NOMESCO Finland
Electrophysiological examination of eye
2.1
13.8
150
713
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
2.9
13.7
82
285
B01AF02
ATC
apixaban; oral
1.5
13.7
452
3045
K04
ICPC
Palpitations/awareness of heart
1.6
13.7
318
1961
AQ2
HP
Electrophysiological electroanatomical examination
4.7
13.6
45
96
R49.01
ICD-10 Finland
Functional dysphonia
1.9
13.5
202
1086
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.4
13.5
718
5313
G73.0*E05.9
ICD-10 Finland
Myasthenic syndromes in thyrotoxicosis [hyperthyroidism]
140.2
13.4
14
*
BA1AN
NOMESCO Finland
Thyroid gland isotope imaging
140.2
13.4
14
*
XCK00
NOMESCO Finland
Perimetry
1.6
13.4
379
2461
A04
ICPC
Weakness/tiredness general
1.4
13.3
748
5589
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
5.9
13.2
36
61
198
Kela drug reimbursment
Sorafenib
10.4
13.2
25
24
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.5
13.1
420
2806
E50.0
ICD-10 Finland
Vitamin A deficiency with conjunctival xerosis
50.1
12.8
15
*
R01AD09
ATC
mometasone; nasal
1.2
12.8
3170
28354
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
1.8
12.6
234
1352
M14.5*E05.9
ICD-10 Finland
Arthropathy in thyrotoxicosis [hyperthyroidism]
70.0
12.6
14
*
TFP47
NOMESCO Finland
Ablation or modification of the AV-node
5.3
12.5
37
70
GAB20
NOMESCO Finland
Median sternotomy
17.3
12.5
19
11
1AB01
NOMESCO Finland
NA
130.2
12.4
13
*
EP1AE
SPAT
NA
2.4
12.4
104
440
AR6
HP
Catheter ablation of arrhythmia, target: atrial fibrillation
4.7
12.4
41
88
ZSB00
NOMESCO Finland
Procedure related to previous procedure classified in chapter B
11.6
12.3
22
19
J01FA10
ATC
azithromycin; systemic
1.2
12.3
4197
38577
J37.0
ICD-10 Finland
Chronic laryngitis
1.8
12.1
196
1086
H50.6
ICD-10 Finland
Mechanical strabismus
21.3
12.0
17
8
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
11.9
3470
31421
E05.3
ICD-10 Finland
Thyrotoxicosis from ectopic thyroid tissue
46.7
11.9
14
*
ZXA00
NOMESCO Finland
Right side
1.2
11.9
1604
13487
J45.9
ICD-10 Finland
Asthma, unspecified
1.3
11.7
1060
8486
XCK10
NOMESCO Finland
Photography of fundus of eye
1.4
11.6
525
3771
Z01.7
ICD-10 Finland
Laboratory examination
1.4
11.5
654
4892
E06.0
ICD-10 Finland
Acute thyroiditis
6.1
11.5
30
49
2AB04
NOMESCO Finland
NA
6.1
11.5
30
49
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
6.9
11.3
27
39
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.3
11.2
944
7486
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
12.7
11.1
19
15
201
Kela drug reimbursment
Chronic cardiac insufficiency
1.8
11.1
180
1000
R07.4
ICD-10 Finland
Chest pain, unspecified
1.2
11.0
1546
13039
XF600
NOMESCO Finland
Bloodpressure measurement
1.5
10.9
331
2188
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
1.8
10.7
173
958
CA1BD
NOMESCO Finland
Extensive orbita CT
10.5
10.7
20
19
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.2
10.7
2616
23258
WX320
NOMESCO Finland
Spinalanesthesy
1.2
10.7
1365
11388
A02BC01
ATC
omeprazole; systemic
1.2
10.6
1673
14270
J01FA06
ATC
roxithromycin; oral
1.2
10.6
2715
24237
K02.1
ICD-10 Finland
Caries of dentine
1.2
10.6
3892
35794
C09AA05
ATC
ramipril; oral
1.3
10.6
1188
9768
C03DA01
ATC
spironolactone; oral
1.4
10.6
513
3731
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
10.5
3799
34883
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
4.2
10.5
38
90
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.5
10.5
372
2546
ZXA05
NOMESCO Finland
Left side
1.2
10.4
1478
12468
8000/3-C73.9
ICD-O-3
Neoplasm, malignant of thyroid gland
110.1
10.4
11
*
E20.9
ICD-10 Finland
Hypoparathyroidism, unspecified
7.7
10.3
23
30
SPAT1249
SPAT
Treatment-related counselling outside office
1.2
10.3
2626
23410
323
Kela drug reimbursment
Sorafenib
16.0
10.3
16
10
N05CF01
ATC
zopiclone; oral
1.2
10.3
1946
16896
I50.1
ICD-10 Finland
Left ventricular failure
1.8
10.1
168
943
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.2
10.1
2068
18086
R07.0
ICD-10 Finland
Pain in throat
1.5
10.1
374
2586
R01AD08
ATC
fluticasone; nasal
1.2
10.1
1907
16554
J01FA09
ATC
clarithromycin; systemic
1.2
10.0
2108
18474
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.5
10.0
380
2642
R49.8
ICD-10 Finland
Other and unspecified voice disturbances
2.5
9.9
76
309
B01AB04
ATC
dalteparin; parenteral
1.6
9.9
255
1619
K78
ICPC
Atrial fibrillation/flutter
1.5
9.9
309
2059
Z71.8
ICD-10 Finland
Other specified counselling
1.2
9.9
1503
12765
1508
Kela drug reimbursment
Lenvatinib
26.0
9.8
13
5
XF402
NOMESCO Finland
ECG with work load test
1.4
9.8
557
4166
EP1AT
NOMESCO Finland
Punction of soft tissue of neck with ultrasound guidance
13.4
9.6
16
12
E83.50
ICD-10 Finland
Hypercalcemia
2.4
9.6
77
321
S04
ICPC
Lump/swelling localized
1.4
9.6
521
3868
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
2.9
9.5
56
195
QX4AT
NOMESCO Finland
Ultrsound guided needle biopsy of skin
4.2
9.4
34
81
PJD99
NOMESCO Finland
Excision of other lymph nodes
7.5
9.4
21
28
N02AX02
ATC
tramadol; systemic, rectal
1.2
9.3
2595
23256
342
Kela drug reimbursment
Dronedarone
3.1
9.3
49
159
8290/3-C73.9
ICD-O-3
Oxyphilic adenocarcinoma of thyroid gland
21.7
9.3
13
6
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.2
9.3
2348
20878
C739
ICD-10 Finland
NA
8.7
9.3
19
22
L01XE05
ATC
[U] sorafenib; oral
10.6
9.3
17
16
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
9.3
2958
26802
M79.6
ICD-10 Finland
Pain in limb
1.2
9.2
2308
20500
A60
ICPC
General and Unspecified, Result test/procedure
1.6
9.2
246
1579
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.5
9.2
352
2449
M03BC51
ATC
orphenadrine, combinations; systemic
1.2
9.2
1862
16247
C08CA01
ATC
amlodipine; oral
1.2
9.2
1853
16158
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.4
9.1
488
3610
L28
ICPC
Limited function/disability (L)
1.3
9.1
811
6472
J02AC01
ATC
fluconazole; systemic
1.2
9.1
3068
27909
WX290
NOMESCO Finland
Other blockade of nerve
1.2
9.1
2951
26769
C03AA03
ATC
hydrochlorothiazide; oral
1.4
9.0
493
3662
1CX08
NOMESCO Finland
NA
4.7
9.0
29
62
130
Kela drug reimbursment
Malignant tumour
1.4
9.0
353
2472
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.2
9.0
3017
27428
E21.0
ICD-10 Finland
Primary hyperparathyroidism
2.1
9.0
94
446
R02
ICPC
Shortness of breath/dyspnoea
1.3
8.9
664
5173
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.3
8.9
892
7221
3019
Kela drug reimbursment
Lenvatinib
24.0
8.9
12
5
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
4.0
8.9
34
86
R03BA02
ATC
budesonide; inhalant
1.2
8.7
1084
9009
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.3
8.6
521
3934
M01AB05
ATC
diclofenac; systemic, rectal
1.2
8.6
4639
43599
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.2
8.5
1840
16122
E06
ICD-10 Finland
Thyroiditis
6.9
8.5
20
29
I47.9
ICD-10 Finland
Paroxysmal tachycardia, unspecified
2.0
8.5
98
485
E03.4
ICD-10 Finland
Atrophy of thyroid (acquired)
20.0
8.5
12
6
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
20.0
8.5
12
6
J02.9
ICD-10 Finland
Acute pharyngitis, unspecified
1.5
8.4
248
1633
R49.03
ICD-10 Finland
Atrophic dysphonia
2.6
8.4
56
213
XX3DW
NOMESCO Finland
Time consuming IT work
1.3
8.4
539
4110
AA1AD
NOMESCO Finland
CT of head and brain
1.2
8.4
1241
10502
F29
ICPC
Eye symptom/complaint other
1.4
8.3
460
3426
H50.8
ICD-10 Finland
Other specified strabismus
6.7
8.3
20
30
T15
ICPC
THYROID LUMP/MASS
6.7
8.3
20
30
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
3.5
8.3
36
102
RL210
NOMESCO Finland
NA
3.3
8.3
39
118
A10AE04
ATC
insulin glargine; parenteral
1.4
8.3
435
3214
WX720
NOMESCO Finland
Own respiration
1.6
8.2
197
1233
UDQ02
NOMESCO Finland
Direct laryngoscopy
2.7
8.2
53
197
RP210
NOMESCO Finland
NA
4.7
8.2
26
55
E89.9
ICD-10 Finland
Postprocedural endocrine and metabolic disorder, unspecified
14.5
8.2
13
9
ZXB10
NOMESCO Finland
Medial
3.2
8.1
40
125
ZYC06
NOMESCO Finland
Real-time text-based remote transaction
5.1
8.1
24
47
WF099
NOMESCO Finland
Other radiotherapy
3.1
8.1
41
131
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.2
8.1
995
8255
ENB50
NOMESCO Finland
Excision of cyst or fistula of thyroglossic duct
8.1
8.1
17
21
J01CA04
ATC
amoxicillin; systemic
1.2
8.1
5893
56489
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
2.8
8.0
49
177
M01AE01
ATC
ibuprofen; systemic, rectal
1.2
8.0
6751
65470
A98
ICPC
Health maint/preventive medicine
1.3
8.0
7515
73764
I49.3
ICD-10 Finland
Ventricular premature depolarization
1.4
8.0
355
2545
R06AE07
ATC
cetirizine; oral
1.1
8.0
3056
27977
K90.0
ICD-10 Finland
Coeliac disease
1.7
7.9
166
1005
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.4
7.9
411
3029
ZXE40
NOMESCO Finland
More than seven and less than nine hours
1.9
7.9
114
612
ZXD05
NOMESCO Finland
Urgent procedure
1.2
7.9
1903
16814
LCA06
NOMESCO Finland
Biopsy of endometrium
1.2
7.9
860
7037
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.3
7.9
749
6028
E06.5
ICD-10 Finland
Other chronic thyroiditis
13.0
7.9
13
10
DQE20
NOMESCO Finland
Implantation of foreign material in vocal chord
13.0
7.9
13
10
UGC12
NOMESCO Finland
Flexible bronchoscopy
1.4
7.9
331
2351
A08
ICPC
Swelling
1.6
7.9
209
1346
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.4
7.8
443
3312
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
1.4
7.8
376
2736
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.2
7.8
1005
8379
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
3.0
7.8
42
141
TBA20
NOMESCO Finland
Aspiration cytology of thyroid gland
9.4
7.8
15
16
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
1.5
7.7
232
1537
M03BX02
ATC
tizanidine; oral
1.1
7.7
4409
41455
N07BB01
ATC
disulfiram; oral
0.5
7.7
73
1352
R60.0
ICD-10 Finland
Localized oedema
1.3
7.6
573
4471
I48.1
ICD-10 Finland
Persistent atrial fibrillation
1.9
7.6
108
579
S18
ICPC
Laceration/cut
1.2
7.6
2494
22555
M02AA07
ATC
piroxicam; topical
1.2
7.6
2268
20376
BBA20
NOMESCO Finland
Exploration of parathyroid gland
3.8
7.5
30
80
FPG30
NOMESCO Finland
Implantation of cardioverter-defibrillator with ventricular electrode
3.8
7.5
30
80
A29
ICPC
General symptom/complaint other
1.3
7.5
586
4599
R05FA02
ATC
opium derivatives and expectorants; systemic
1.1
7.5
2637
23961
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
1.3
7.5
749
6066
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
2.8
7.5
44
155
R60.9
ICD-10 Finland
Oedema, unspecified
1.5
7.5
240
1616
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.2
7.5
849
6978
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
3.1
7.5
39
128
Z01.9
ICD-10 Finland
Special examination, unspecified
1.4
7.5
302
2132
J01DA01
ATC
[U] cefalexin; systemic
1.1
7.4
4348
40890
T89
ICPC
Diabetes insulin dependent
1.6
7.4
184
1167
A02BC03
ATC
lansoprazole; oral
1.2
7.4
1763
15550
R2110
NOMESCO Finland
Giving the first information
1.3
7.4
453
3435
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
1.5
7.4
219
1447
EP1DM
NOMESCO Finland
Very extensive MRI examination of soft tissue of neck with 3 Tesla magnet
7.6
7.4
16
21
JN5AN
NOMESCO Finland
Total body isotope imaging
7.6
7.4
16
21
C75
ICD-10 Finland
Malignant neoplasm of other endocrine glands and related structures
+∞
7.3
7
*
R03BB04
ATC
tiotropium bromide; inhalant
1.3
7.3
437
3304
BA2AT
NOMESCO Finland
Biopsy of thyroid with ultrasound quidance
6.8
7.3
17
25
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
4.9
7.3
22
45
CEC00
NOMESCO Finland
Recession of extraocular muscle
3.4
7.3
32
93
T99
ICPC
Endocr/metab/nutrit disease other
2.0
7.2
84
419
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.3
7.2
494
3806
O90.5
ICD-10 Finland
Postpartum thyroiditis
15.7
7.2
11
7
G47.3
ICD-10 Finland
Sleep apnoea
1.2
7.2
1077
9112
SPAT1262
SPAT
Handing over of treatment supplies
1.2
7.2
924
7699
SPAT1097
SPAT
Recording of ECG
1.2
7.2
769
6278
D11.0
ICD-10 Finland
Benign neoplasm: Parotid gland
2.0
7.2
87
439
H57.1
ICD-10 Finland
Ocular pain
1.6
7.1
179
1140
J01MA02
ATC
ciprofloxacin; systemic
1.2
7.1
2241
20188
AQ1
HP
Conventional electrophysiological examination
2.2
7.1
65
292
H50.0
ICD-10 Finland
Convergent concomitant strabismus
2.9
7.0
39
134
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
2.7
7.0
43
157
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.1
7.0
3248
30033
C09DX04
ATC
valsartan and sacubitril; oral
3.1
6.9
35
113
I50.0
ICD-10 Finland
Congestive heart failure
1.5
6.9
240
1644
H02AB09
ATC
hydrocortisone; systemic
1.7
6.9
121
699
L01
ICPC
Neck symptom/complaint
1.2
6.9
812
6707
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.2
6.8
1613
14209
EP1CM
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with 3 Tesla magnet
4.8
6.8
21
44
WF002
NOMESCO Finland
Radical radiotherapy
1.6
6.8
180
1160
M01AE03
ATC
ketoprofen; systemic, rectal
1.1
6.8
2339
21195
SGA02
NOMESCO Finland
Opening and dilatation of root canal of tooth
1.3
6.8
693
5628
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
1.4
6.8
313
2265
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.3
6.8
682
5529
8020/3-C73.9
ICD-O-3
Carcinoma, undifferentiated, NOS, of thyroid gland
40.0
6.8
8
*
L01XE29
ATC
[U] lenvatinib; oral
40.0
6.8
8
*
8010/3-C73.9
ICD-O-3
Carcinoma, NOS, of thyroid gland
40.0
6.8
8
*
BWA00
NOMESCO Finland
Repair of wound dehiscence in endocrine surgery
40.0
6.8
8
*
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
1.7
6.7
137
826
ARB
HP
Catheter ablation of arrhythmia: Cutiing or modification of the AV node
7.2
6.7
15
21
UJC01
NOMESCO Finland
Scopy of lower throat
2.4
6.7
52
218
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.2
6.7
1333
11577
ZXD20
NOMESCO Finland
Day surgery
1.2
6.7
764
6284
P01AB01
ATC
metronidazole; oral, rectal
1.1
6.7
2714
24865
SPAT1263
SPAT
Sampling
1.1
6.6
2716
24889
I49.0
ICD-10 Finland
Ventricular fibrillation and flutter
2.7
6.6
43
161
N02AJ06
ATC
codeine and paracetamol; systemic
1.1
6.6
2321
21046
C01BD07
ATC
dronedarone; oral
2.9
6.6
38
132
BAA30
NOMESCO Finland
Excision of thyroid isthmus
5.9
6.6
17
29
SAA01
NOMESCO Finland
Simple examination of mouth
1.1
6.6
4976
47387
7AX01
NOMESCO Finland
NA
12.2
6.6
11
9
C09CA01
ATC
losartan; oral
1.2
6.5
1253
10842
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
10.0
6.5
12
12
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
1.6
6.5
153
957
A91
ICPC
Abnormal result investigation NOS
1.5
6.5
213
1444
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.2
6.5
1412
12355
E10
ICD-10 Finland
Type 1 diabetes mellitus
1.9
6.5
92
494
R06AX27
ATC
desloratadine; oral
1.2
6.5
1797
16022
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
1.6
6.5
167
1073
R42
ICD-10 Finland
Dizziness and giddiness
1.2
6.4
1199
10347
J38.3
ICD-10 Finland
Other diseases of vocal cords
2.2
6.4
58
259
FPE96
NOMESCO Finland
Other implantation or replacement of transvenous cardiac pacemaker
3.7
6.4
26
71
E05.81
ICD-10 Finland
Overproduction of thyroid-stimulating hormone
69.9
6.4
7
*
SPAT1336
SPAT
Request for examination
1.5
6.4
194
1291
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.3
6.4
376
2836
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
7.4
6.4
14
19
J01FF01
ATC
clindamycin; systemic
1.2
6.4
1613
14277
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.3
6.4
599
4819
SPAT1153
SPAT
Removal of sutures
1.2
6.4
1860
16644
N05BA04
ATC
oxazepam; oral
1.2
6.4
1518
13377
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.2
6.3
1090
9346
JN4AD
NOMESCO Finland
Body CT examination
1.4
6.3
349
2610
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
1.4
6.3
354
2650
E07
ICD-10 Finland
Other disorders of thyroid
18.0
6.3
9
5
8510/3-C73.9
ICD-O-3
Medullary carcinoma, NOS, of thyroid gland
18.0
6.3
9
5
O992, E050
ICD-10 Finland
NA
+∞
6.2
6
*
E8901, E050
ICD-10 Finland
NA
+∞
6.2
6
*
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.2
6.2
1589
14069
M03BC01
ATC
orphenadrine (citrate); systemic
1.2
6.2
1499
13215
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
7.0
6.2
14
20
A02BA02
ATC
ranitidine; systemic
1.2
6.2
1092
9382
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.2
6.2
1616
14342
R01AD12
ATC
fluticasone furoate; nasal
1.1
6.2
1964
17677
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
1.6
6.1
138
858
C08DB01
ATC
diltiazem; oral
1.5
6.1
203
1381
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
2.3
6.1
53
232
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
1.5
6.1
201
1365
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
1.6
6.1
155
990
I50
ICD-10 Finland
Heart failure
1.7
6.1
110
642
SPAT1342
SPAT
Referral to specialised care
2.1
6.1
66
322
Q18.0
ICD-10 Finland
Sinus, fistula and cyst of branchial cleft
3.3
6.0
28
86
BB1BQ
NOMESCO Finland
Extensive scintigraphy of parathyroid gland, 2 isotopes, SPECT and low-dose CT
3.3
6.0
27
81
R05
ICPC
Cough
1.2
6.0
1332
11663
N01
ICPC
Headache
1.3
6.0
570
4592
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
2.1
6.0
60
281

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: GRAVES_COND – Carbimazole or st.post thyroidectomy, condition for graves disease

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).