Graves disease: Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland ( hyperthyroidism ).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy , antithyroid drugs, and/or thyroid surgery.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
6220 |
4. Check minimum number of eventsNone |
6220 |
5. Include endpointsNone |
6220 |
6. Filter based on genotype QC (FinnGen only) |
6220 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Thyreotoxicosis cum struma diffusa
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis with diffuse goitre
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 38371 | 31186 | 6900 |
| Only index persons | 35764 | 29429 | 6335 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.76 | 0.89 | 0.19 |
| Only index persons | 0.93 | 1.08 | 0.24 |
| Median age at first event (years) | |||
| Whole population | 49.44 | 49.13 | 51.36 |
| Only index persons | 48.69 | 48.33 | 50.36 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6220 | 5214 | 1006 |
| Unadjusted period prevalence (%) | 1.56 | 1.78 | 0.44 |
| Median age at first event (years) | 49.24 | 48.24 | 54.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 5573
- Matched controls
- 55738
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
444.6
323.0
740
19
104
Kela drug reimbursment
Thyroid insufficiency
2104.3
323.0
1524
10
T86
ICPC
Hypothyroidism/myxoedema
83.7
323.0
446
58
H03AA01
ATC
levothyroxine sodium; systemic
178.1
323.0
3871
700
E03.89
ICD-10 Finland
Other specified hypothyroidism
237.3
323.0
397
18
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
323.0
592
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
4503599627370496.0
323.0
5146
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
100.3
323.0
1081
133
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
2418.0
323.0
2288
16
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
8534.3
323.0
752
*
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
4035.9
323.0
387
*
H03BB01
ATC
carbimazole; oral
5082.5
323.0
4396
39
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
2364.7
323.0
764
*
C07AA05
ATC
propranolol; systemic
5.0
323.0
2279
6805
BAA60
NOMESCO Finland
Total thyroidectomy
1113.0
323.0
1080
12
E03
ICD-10 Finland
Other hypothyroidism
74.9
323.0
499
73
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
827.5
323.0
457
6
T85
ICPC
Hyperthyroidism/thyrotoxicosis
182.1
265.9
277
16
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
31.9
265.2
356
119
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
239.3
228
*
C07AB07
ATC
bisoprolol; oral
2.6
234.6
2699
14873
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
29.6
223.8
306
109
H062, E050
ICD-10 Finland
NA
+∞
204.4
195
*
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
+∞
194.9
186
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.0
189.0
557
1005
24209
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffuse NUD
+∞
184.4
176
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
143.5
182.6
194
14
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
+∞
168.6
161
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
34.5
166.6
219
66
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
81.1
166.5
188
24
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.1
146.6
2553
15925
24200
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffusa et exophthalmo. Morbus Basedowi
+∞
145.4
139
*
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
138.1
132
*
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
126.5
121
*
H03BA02
ATC
propylthiouracil; oral
+∞
118.1
113
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
117.6
1975
11810
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
37.2
107.2
138
38
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
+∞
97.1
93
*
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
244.1
93.9
96
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
14.7
93.3
160
112
E06.3
ICD-10 Finland
Autoimmune thyroiditis
64.9
87.9
102
16
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
105.1
85.1
93
9
H05.2
ICD-10 Finland
Exophthalmic conditions
47.9
81.1
99
21
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
15.6
79.8
133
87
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
66.0
78.7
91
14
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.4
74.3
287
684
E05.5
ICD-10 Finland
Thyroid crisis or storm
+∞
72.0
69
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
110.1
70.0
76
7
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
62.6
60
*
H02AB06
ATC
prednisolone; systemic
1.6
59.4
2426
18099
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
+∞
57.4
55
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
16.3
57.0
93
58
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
56.3
54
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
11.5
55.3
105
93
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
6.7
54.0
142
217
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
38.2
53.5
68
18
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
21.4
50.0
74
35
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
+∞
49.0
47
*
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
49.0
47
*
CA1AD
NOMESCO Finland
Orbita CT
30.3
47.1
63
21
H53.2
ICD-10 Finland
Diplopia
3.8
45.7
200
535
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
451.3
45.3
45
*
A11CC03
ATC
alfacalcidol; systemic
5.1
45.3
148
297
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
+∞
44.8
43
*
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
44.6
577
2956
H50.2
ICD-10 Finland
Vertical strabismus
9.4
43.4
91
98
C07AB02
ATC
metoprolol; systemic
1.8
42.7
893
5431
106
Kela drug reimbursment
Hypoparathyroidism
43.7
42.2
52
12
E06.9
ICD-10 Finland
Thyroiditis, unspecified
46.7
41.9
51
11
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
41.3
811
4827
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
37.5
1294
9001
ZXA10
NOMESCO Finland
Bilateral
1.7
35.5
902
5780
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.8
35.1
230
830
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.8
34.6
719
4339
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.9
34.5
510
2738
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
+∞
34.4
33
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
32.3
31
*
CAC44
NOMESCO Finland
Combined decompression of orbit
+∞
32.3
31
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
30.3
1837
14283
E83.51
ICD-10 Finland
Hypocalcemia
10.3
30.3
60
59
24220
ICD-8 Finland
Thyrotoxicosis with or without goitre, Thyrotoxicosis without mention of goitre
+∞
30.2
29
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.3
29.8
157
490
XCK00
NOMESCO Finland
Perimetry
2.1
29.0
330
1591
24210
ICD-8 Finland
Thyrotoxicosis with or without goitre, Toxic nodular goitre
28.0
28.8
39
14
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.5
27.8
235
983
H04AA01
ATC
glucagon; nasal, parenteral
3.4
27.6
136
404
TFP20
NOMESCO Finland
Cardiodefibrillation
2.3
27.1
257
1141
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
26.9
925
6361
T89
ICPC
Diabetes insulin dependent
2.7
26.2
188
717
A11CC02
ATC
dihydrotachysterol; oral
36.9
26.1
33
9
R00.2
ICD-10 Finland
Palpitations
1.9
25.8
381
2042
H50.6
ICD-10 Finland
Mechanical strabismus
73.0
25.8
29
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
25.7
1057
7558
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
135.6
25.6
27
*
H02AB07
ATC
prednisone; oral
1.6
24.9
677
4386
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
24.5
1944
15695
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
2.6
24.1
177
687
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
2.7
23.6
162
604
H02AB09
ATC
hydrocortisone; systemic
3.4
23.4
115
342
E05.3
ICD-10 Finland
Thyrotoxicosis from ectopic thyroid tissue
+∞
22.9
22
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.0
22.7
132
443
CAC20
NOMESCO Finland
Lateral decompression of orbit
120.5
22.6
24
*
C07AA07
ATC
sotalol; systemic
2.8
22.4
146
529
H50.8
ICD-10 Finland
Other specified strabismus
21.4
22.1
32
15
C01BD01
ATC
amiodarone; systemic
3.3
22.0
111
337
A02BC02
ATC
pantoprazole; systemic
1.3
21.7
3149
27675
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.1
21.2
117
380
K90.0
ICD-10 Finland
Coeliac disease
2.5
21.1
165
664
CEC00
NOMESCO Finland
Recession of extraocular muscle
8.7
21.0
45
52
C03CA01
ATC
furosemide; systemic
1.5
21.0
944
6843
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.0
20.9
291
1523
ZX120
NOMESCO Finland
Intravenous
1.7
20.9
424
2524
A10AA02
ATC
NA
2.6
20.6
151
585
N02BE01
ATC
paracetamol; systemic, rectal
1.4
20.6
4466
41502
A10AA01
ATC
NA
2.7
19.8
134
495
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
19.3
1217
9378
A10AE04
ATC
insulin glargine; parenteral
1.8
19.3
336
1909
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
8.7
18.8
40
46
R53
ICD-10 Finland
Malaise and fatigue
1.4
18.7
890
6510
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
23.7
18.6
26
11
A10AE05
ATC
insulin detemir; parenteral
2.1
18.6
215
1045
K29.4
ICD-10 Finland
Chronic atrophic gastritis
3.6
18.5
84
236
207
Kela drug reimbursment
Chronic arrhythmias
1.7
18.4
439
2739
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
18.3
776
5544
H3600, E103
ICD-10 Finland
NA
4.3
18.3
68
160
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
+∞
17.7
17
*
R06.0
ICD-10 Finland
Dyspnoea
1.4
17.5
1009
7637
XCK10
NOMESCO Finland
Photography of fundus of eye
1.7
17.2
381
2328
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
12.6
17.1
30
24
CA1BD
NOMESCO Finland
Extensive orbita CT
31.5
17.0
22
7
B01AA03
ATC
warfarin; systemic
1.5
16.9
602
4146
K04
ICPC
Palpitations/awareness of heart
1.9
16.8
242
1287
E06.0
ICD-10 Finland
Acute thyroiditis
63.5
16.7
19
*
E89.9
ICD-10 Finland
Postprocedural endocrine and metabolic disorder, unspecified
+∞
16.7
16
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
3.1
16.6
91
297
WX110
NOMESCO Finland
Local anesthesy
1.3
16.4
3484
31590
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
2.8
16.1
104
377
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.8
16.1
284
1620
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
24.5
16.0
22
9
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.5
15.8
507
3407
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
60.2
15.7
18
*
M14.5*E03.9
ICD-10 Finland
Arthropathy in hypothyroidism (E00-E03+)
+∞
15.6
15
*
E06.4
ICD-10 Finland
Drug-induced thyroiditis
+∞
15.6
15
*
H50.0
ICD-10 Finland
Convergent concomitant strabismus
5.3
15.5
47
90
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.5
15.5
642
4561
B03BA03
ATC
hydroxocobalamin; parenteral
2.0
15.4
200
1022
107
Kela drug reimbursment
Pernicious anaemia
3.1
14.9
81
264
E89.1
ICD-10 Finland
Postprocedural hypoinsulinaemia
56.8
14.8
17
*
2AB04
NOMESCO Finland
NA
8.2
14.7
32
39
Z01.8
ICD-10 Finland
Other specified special examinations
1.4
14.6
916
7010
G73.0*E05.9
ICD-10 Finland
Myasthenic syndromes in thyrotoxicosis [hyperthyroidism]
+∞
14.6
14
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.5
14.5
594
4205
E20.8
ICD-10 Finland
Other hypoparathyroidism
150.4
14.5
15
*
WF099
NOMESCO Finland
Other radiotherapy
5.5
14.4
42
77
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
7.3
14.4
34
47
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
14.2
1352
11017
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.6
14.2
410
2690
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
14.1
1046
8225
A04
ICPC
Weakness/tiredness general
1.5
13.9
534
3732
SPAT1097
SPAT
Recording of ECG
1.5
13.8
558
3943
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
5.0
13.8
43
86
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
11.4
13.8
25
22
K80
ICPC
Cardiac arrhythmia NOS
1.7
13.7
300
1830
C01AA05
ATC
digoxin; systemic
1.9
13.6
211
1154
E50.0
ICD-10 Finland
Vitamin A deficiency with conjunctival xerosis
75.3
13.6
15
*
6481B
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Thyroid dysfunction[HYPOTHYREOSIS IN GRAVIDITATE]
140.3
13.4
14
*
J01DB01
ATC
cefalexin; oral
1.3
13.3
4157
38896
SPAT1263
SPAT
Sampling
1.3
13.3
1973
16968
SPAT1262
SPAT
Handing over of treatment supplies
1.4
13.3
648
4745
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
13.2
2706
24126
CEW99
NOMESCO Finland
Other operation on extraocular muscle
13.8
13.2
22
16
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
1.6
13.1
327
2064
J01AA02
ATC
doxycycline; systemic
1.3
13.1
3941
36666
I50.9
ICD-10 Finland
Heart failure, unspecified
1.6
12.7
345
2223
N05CF01
ATC
zopiclone; oral
1.3
12.7
1348
11116
H3601, E103
ICD-10 Finland
NA
4.3
12.7
46
108
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.4
12.7
738
5572
24400
ICD-8 Finland
Myxoedema, (hypothyreosis) post therapiam
+∞
12.5
12
*
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
2.6
12.4
87
334
A10AE06
ATC
insulin degludec; parenteral
2.3
12.4
115
511
R03AC02
ATC
salbutamol; inhalant
1.2
12.4
2553
22715
WX402
NOMESCO Finland
General anaesthesia
1.4
12.3
738
5594
E07.89
ICD-10 Finland
Other specified disorders of thyroid
37.6
12.2
15
*
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
37.6
12.2
15
*
A02BC01
ATC
omeprazole; systemic
1.3
12.1
1153
9363
N05BA04
ATC
oxazepam; oral
1.3
12.0
1097
8858
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
3.9
12.0
48
124
R01AD08
ATC
fluticasone; nasal
1.3
11.9
1349
11199
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.5
11.7
352
2329
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.2
11.7
1668
14234
A02BC05
ATC
esomeprazole; systemic
1.2
11.7
1819
15672
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
65.1
11.6
13
*
177
Kela drug reimbursment
Insulin glargine 300 U / ml
2.6
11.5
80
305
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
4.7
11.5
38
82
M14.5*E05.9
ICD-10 Finland
Arthropathy in thyrotoxicosis [hyperthyroidism]
+∞
11.5
11
*
E03.8
ICD-10 Finland
Other specified hypothyroidism
+∞
11.5
11
*
GB1AA
NOMESCO Finland
Tracheal X-ray examination
120.2
11.4
12
*
K02.1
ICD-10 Finland
Caries of dentine
1.2
11.4
2767
24952
SGA01
NOMESCO Finland
Tooth opening as first aid
1.3
11.1
718
5505
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
12.7
11.1
19
15
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
7.1
11.0
26
37
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
3.0
11.0
60
199
UDQ12
NOMESCO Finland
Flexible laryngoscopy
1.7
10.9
207
1214
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
3.7
10.8
46
126
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
3.3
10.7
52
159
105
Kela drug reimbursment
Adrenal cortical hypofunction
10.0
10.5
20
20
R50.9
ICD-10 Finland
Fever, unspecified
1.4
10.5
522
3834
H03BB02
ATC
thiamazole; oral
110.2
10.4
11
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
2.6
10.2
72
278
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
3.2
10.1
51
160
N07BA03
ATC
varenicline; oral
1.7
10.1
223
1366
8341/3-C73.9
ICD-O-3
Papillary microcarcinoma of thyroid gland
40.1
10.0
12
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
1.7
9.8
219
1343
SPAT1301
SPAT
No procedures
1.2
9.8
1315
11098
E23.05
ICD-10 Finland
Lack of TSH
26.0
9.8
13
5
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
5.4
9.8
28
52
J45.9
ICD-10 Finland
Asthma, unspecified
1.3
9.7
723
5663
I10
ICD-10 Finland
Essential (primary) hypertension
1.2
9.6
2153
19149
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
3.8
9.6
39
104
2504
FHL
Unilateral resection or enucleation
9.1
9.5
19
21
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.4
9.5
426
3072
E05.81
ICD-10 Finland
Overproduction of thyroid-stimulating hormone
100.2
9.4
10
*
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
9.4
2314
20748
N05CF02
ATC
zolpidem; oral
1.3
9.4
789
6284
A29
ICPC
General symptom/complaint other
1.4
9.4
411
2948
E05.8
ICD-10 Finland
Other thyrotoxicosis
+∞
9.4
9
*
2440A
ICD-9 Finland
Acquired hypothyroidism, Postsurgical hypothyroidism
+∞
9.4
9
*
8340/3-C73.9
ICD-O-3
Papillary carcinoma, follicular variant of thyroid gland
+∞
9.4
9
*
24110
ICD-8 Finland
Non-toxic nodular goitre, Sporadic
+∞
9.4
9
*
B01AF02
ATC
apixaban; oral
1.5
9.4
273
1798
J01CA04
ATC
amoxicillin; systemic
1.2
9.3
4160
39401
SAA01
NOMESCO Finland
Simple examination of mouth
1.2
9.3
3544
33055
J01FA10
ATC
azithromycin; systemic
1.2
9.2
2938
26946
C01BC04
ATC
flecainide; systemic
2.0
9.2
108
537
XF600
NOMESCO Finland
Bloodpressure measurement
1.6
9.2
227
1434
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.3
9.2
1002
8252
B81
ICPC
Anaemia vit B12/folate deficiency
1.9
9.1
121
631
TFP34
NOMESCO Finland
Electrophysiological investigation
2.0
9.0
108
543
N02AX02
ATC
tramadol; systemic, rectal
1.2
9.0
1734
15178
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.5
8.8
286
1930
XF404
NOMESCO Finland
Ambulatory ECG
1.5
8.8
316
2181
XF400
NOMESCO Finland
ECG with 12 standard connections
1.3
8.8
556
4249
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
1.7
8.8
180
1083
A60
ICPC
General and Unspecified, Result test/procedure
1.7
8.7
171
1014
R06AE07
ATC
cetirizine; oral
1.2
8.7
2143
19177
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
2.1
8.6
91
434
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.5
8.6
279
1885
E04.8
ICD-10 Finland
Other specified nontoxic goitre
16.3
8.5
13
8
L28
ICPC
Limited function/disability (L)
1.3
8.4
542
4150
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
5.1
8.4
25
49
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.2
8.4
993
8249
E06.5
ICD-10 Finland
Other chronic thyroiditis
+∞
8.3
8
*
O992, E050
ICD-10 Finland
NA
+∞
8.3
8
*
2441A
ICD-9 Finland
Acquired hypothyroidism, Other postablative hypothyroidism
+∞
8.3
8
*
BA1NN
NOMESCO Finland
I-131 dose capsel measurement
+∞
8.3
8
*
2506
FHL
Thyroidectomy
+∞
8.3
8
*
WX290
NOMESCO Finland
Other blockade of nerve
1.2
8.3
2107
18875
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
1.5
8.3
262
1758
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.4
8.3
409
3002
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.2
8.3
1801
15917
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.2
8.2
2079
18613
B01AB05
ATC
enoxaparin; parenteral
1.2
8.2
1234
10512
J01FA06
ATC
roxithromycin; oral
1.2
8.2
1860
16496
J01DA01
ATC
[U] cefalexin; systemic
1.2
8.1
3063
28361
M79.0
ICD-10 Finland
Rheumatism, unspecified
1.7
8.1
155
916
R63.4
ICD-10 Finland
Abnormal weight loss
1.9
8.1
121
660
G47.3
ICD-10 Finland
Sleep apnoea
1.3
8.0
692
5529
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.2
8.0
1174
9978
A50
ICPC
General and Unspecified, Medication/prescr/renewal
1.9
8.0
117
636
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.2
8.0
937
7769
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
1.7
8.0
164
991
R11
ICD-10 Finland
Nausea and vomiting
1.4
7.9
308
2163
N06AX21
ATC
duloxetine; oral
1.4
7.9
447
3354
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
1.7
7.9
154
915
WZC30
NOMESCO Finland
Teaching
1.3
7.8
485
3693
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
2.1
7.8
83
397
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
3.6
7.8
33
92
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.3
7.8
687
5498
TFP47
NOMESCO Finland
Ablation or modification of the AV-node
4.6
7.8
25
54
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.3
7.8
781
6359
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.2
7.7
1431
12439
CKC12
NOMESCO Finland
Photocoagulation of retina
1.7
7.7
144
842
H36.00
ICD-10 Finland
Diabetic background retinopathy
2.7
7.7
50
187
TBA20
NOMESCO Finland
Aspiration cytology of thyroid gland
45.0
7.7
9
*
4CJ01
NOMESCO Finland
NA
45.0
7.7
9
*
-60
ICPC
Result test/procedure
1.5
7.6
232
1548
R05
ICPC
Cough
1.2
7.6
955
7973
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.4
7.6
392
2897
O90.5
ICD-10 Finland
Postpartum thyroiditis
25.0
7.6
10
*
J01FA09
ATC
clarithromycin; systemic
1.2
7.5
1455
12702
R01AD09
ATC
mometasone; nasal
1.2
7.5
2173
19642
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.3
7.4
585
4614
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.2
7.4
1517
13301
BWD00
NOMESCO Finland
Reoperation for deep haemorrhage in endocrine surgery
80.2
7.4
8
*
Z50.5
ICD-10 Finland
Speech therapy
2.7
7.4
48
180
SPAT1283
SPAT
Restricted health certificate
1.2
7.4
848
7007
A09
ICPC
Sweating problem
2.6
7.4
49
187
T81
ICPC
Goitre
6.0
7.4
19
32
R49.08
ICD-10 Finland
Other specified dysphonia
2.0
7.3
91
466
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
3.1
7.3
38
125
3762A
ICD-9 Finland
Disorders of the orbit, Endocrine exophthalmos
+∞
7.3
7
*
E03.4
ICD-10 Finland
Atrophy of thyroid (acquired)
+∞
7.3
7
*
M03BX02
ATC
tizanidine; oral
1.2
7.3
3069
28555
M54.5
ICD-10 Finland
Low back pain
1.2
7.3
1474
12907
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
3.5
7.2
31
88
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
1.6
7.2
173
1088
C08CA01
ATC
amlodipine; oral
1.2
7.2
1190
10219
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.3
7.1
514
4004
A98
ICPC
Health maint/preventive medicine
1.4
7.1
5252
51428
M25.5
ICD-10 Finland
Pain in joint
1.2
7.1
1272
11009
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
7.1
2107
19054
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.3
7.1
615
4915
AR6
HP
Catheter ablation of arrhythmia, target: atrial fibrillation
5.3
7.1
20
38
R60.0
ICD-10 Finland
Localized oedema
1.4
7.0
377
2807
D01
ICPC
Abdominal pain/cramps general
1.3
7.0
438
3341
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
3.2
7.0
34
107
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.5
7.0
240
1645
C01BD07
ATC
dronedarone; oral
3.8
6.9
27
71
H57.1
ICD-10 Finland
Ocular pain
1.7
6.9
128
753
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.3
6.9
605
4842
H02AB04
ATC
methylprednisolone; systemic
1.3
6.8
583
4646
F29
ICPC
Eye symptom/complaint other
1.4
6.8
318
2312
J02AC01
ATC
fluconazole; systemic
1.2
6.8
2179
19801
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
6.8
2371
21695
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.2
6.8
2766
25607
A12AA04
ATC
calcium carbonate; oral
2.5
6.7
49
198
C03DA01
ATC
spironolactone; oral
1.4
6.7
308
2232
H01.0
ICD-10 Finland
Blepharitis
1.5
6.6
214
1450
R03BB04
ATC
tiotropium bromide; inhalant
1.4
6.5
292
2111
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.2
6.5
1787
16033
-50
ICPC
Medication/prescr/renewal
1.6
6.5
144
889
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.4
6.5
268
1908
M01AH01
ATC
celecoxib; oral (coxibs)
1.2
6.5
723
5957
R60.9
ICD-10 Finland
Oedema, unspecified
1.6
6.4
157
996
R21
ICPC
Throat symptom/complaint
1.2
6.4
908
7668
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.2
6.4
1135
9801
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
1.7
6.4
113
655
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.2
6.4
1118
9641
E89
ICD-10 Finland
Postprocedural endocrine and metabolic disorders, not elsewhere classified
69.9
6.4
7
*
C73
ICD-10 Finland
Malignant neoplasm of thyroid gland
69.9
6.4
7
*
342
Kela drug reimbursment
Dronedarone
3.3
6.4
29
87
N06AX11
ATC
mirtazapine; oral
1.2
6.4
1344
11789
P06
ICPC
Sleep disturbance
1.3
6.4
369
2781
XCH00
NOMESCO Finland
Eye pressure measurement
1.7
6.3
136
832
RP210
NOMESCO Finland
NA
6.5
6.3
15
23
A99
ICPC
Disease/condition unspecnature/site
1.4
6.3
277
1992
C10AA03
ATC
pravastatin; oral
1.5
6.3
197
1322
-34
ICPC
Blood test
1.7
6.3
115
672
R01AD12
ATC
fluticasone furoate; nasal
1.2
6.3
1398
12317
T08
ICPC
Weight loss
2.3
6.3
52
225
CE2W4
NOMESCO Finland
Eye movement mapping
5.5
6.3
17
31
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.3
6.3
495
3908
K78
ICPC
Atrial fibrillation/flutter
1.5
6.3
189
1262
E50.9
ICD-10 Finland
Vitamin A deficiency, unspecified
18.0
6.3
9
5
JN5AQ
NOMESCO Finland
SPECT of thyroid metastasis with low-dose CT
+∞
6.2
6
*
E8901, E050
ICD-10 Finland
NA
+∞
6.2
6
*
BA1AN
NOMESCO Finland
Thyroid gland isotope imaging
+∞
6.2
6
*
2410A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic uninodular goitre
+∞
6.2
6
*
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.2
6.2
757
6290
103
Kela drug reimbursment
Diabetes, insulin-treated
1.2
6.2
817
6850
N03AX12
ATC
gabapentin; oral
1.3
6.2
593
4795
L04
ICPC
Chest symptom/complaint
1.5
6.2
215
1477
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
2.4
6.2
46
189
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.2
6.2
748
6215
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.2
6.2
2490
22967
J01MA12
ATC
levofloxacin; systemic
1.3
6.2
633
5160
G44.2
ICD-10 Finland
Tension-type headache
1.3
6.2
575
4635
CS494
NOMESCO Finland
Other visual field testing
1.9
6.1
79
411
SPAT1312
SPAT
General health counselling
1.2
6.1
1379
12161
M01AE03
ATC
ketoprofen; systemic, rectal
1.2
6.1
1575
14044
H50.52
ICD-10 Finland
Exophoria
2.4
6.1
47
196
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.2
6.1
1715
15404
AA1AD
NOMESCO Finland
CT of head and brain
1.2
6.0
788
6604
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXGOITDIF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXGOITDIF | 1.072 [0.97, 1.19] | 0.195 |
| Birth year | 0.998 [0.99, 1.01] | 0.668 |
During the follow-up period (1.1.1998 — 31.12.2019), 2220 out of 23978 females with E4_THYTOXGOITDIF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXGOITDIF | 1.256 [1.11, 1.42] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 772 out of 5286 males with E4_THYTOXGOITDIF died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYTOXGOITDIF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.133% | 0.248% |
| 5 | 0.717% | 1.366% |
| 10 | 1.728% | 3.515% |
| 15 | 3.315% | 6.757% |
| 20 | 5.89% | 11.323% |
Relationships between endpoints
↥Index endpoint: E4_THYTOXGOITDIF – Thyrotoxicosis with diffuse goitre
GWS hits: 30
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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