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Other disorders of thyroid

DIS_THYROID_OTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

472

6. Filter based on genotype QC (FinnGen only)

472

Control definitions (FinnGen only)

Control exclude
THYROID_DISORDER_IBD

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 472 389 83
Unadjusted period prevalence (%) 0.12 0.13 0.04
Median age at first event (years) 43.99 42.16 52.59

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
401
Matched controls
4011
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
1274.9
173.6
157
*
24599
ICD-8 Finland
Thyroiditis, Unspecified
+∞
138.8
125
*
E07.89
ICD-10 Finland
Other specified disorders of thyroid
+∞
74.3
69
*
H03AA01
ATC
levothyroxine sodium; systemic
4.9
45.4
198
662
104
Kela drug reimbursment
Thyroid insufficiency
6.9
32.9
89
160
H03BB01
ATC
carbimazole; oral
74.8
25.1
28
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
116.0
20.8
22
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
7.5
19.2
46
68
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.7
18.1
89
290
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
94.0
16.7
18
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
8.7
16.7
36
45
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
166.1
15.6
16
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
7.4
13.9
33
48
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
9.0
13.5
28
33
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
8.4
12.5
27
34
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
13.0
12.3
21
17
BAA60
NOMESCO Finland
Total thyroidectomy
9.7
12.2
24
26
E07.81
ICD-10 Finland
Pituitary thyroxin resistence
+∞
10.5
10
*
E07.82
ICD-10 Finland
Disorder of thyroid function caused by general disease state
+∞
10.5
10
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
10.5
10
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
12.6
9.9
17
14
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.9
9.2
38
106
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
16.0
9.1
14
9
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
8.4
8
*
2469X
ICD-9 Finland
Other disorders of thyroid, Unspecified disorder of thyroid
+∞
8.4
8
*
E07.8
ICD-10 Finland
Other specified disorders of thyroid
+∞
8.4
8
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
+∞
7.3
7
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
7.2
7.1
16
23
T86
ICPC
Hypothyroidism/myxoedema
3.8
6.9
28
78
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
40.7
6.8
8
*
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
6.4
6.5
16
26
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
6.4
151
1025
24210
ICD-8 Finland
Thyrotoxicosis with or without goitre, Toxic nodular goitre
+∞
6.3
6
*
E07.80
ICD-10 Finland
Pituitary thyroxin resistence
+∞
6.3
6
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
6.1
120
764
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
6.2
6.0
15
25

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: DIS_THYROID_OTH – Other disorders of thyroid

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).