Disorder of thyroid, unspecified

E4_THYROIDNASOTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

461

4. Check minimum number of events

None

461

5. Include endpoints

None

461

6. Filter based on genotype QC (FinnGen only)

461

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3547 2760 749
Only index persons 2885 2275 610
Unadjusted period prevalence (%)
Whole population 0.07 0.08 0.02
Only index persons 0.07 0.08 0.02
Median age at first event (years)
Whole population 47.04 46.23 49.67
Only index persons 43.39 42.46 46.83

-FinnGen-

Key figures

All Female Male
Number of individuals 461 379 82
Unadjusted period prevalence (%) 0.11 0.13 0.04
Median age at first event (years) 43.64 41.67 52.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
392
Matched controls
3921
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
2601.8
175.9
157
*
H03AA01
ATC
levothyroxine sodium; systemic
71.9
171.5
193
52
24599
ICD-8 Finland
Thyroiditis, Unspecified
+∞
139.0
125
*
104
Kela drug reimbursment
Thyroid insufficiency
1094.6
91.7
86
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
159.0
84.9
87
7
E07.89
ICD-10 Finland
Other specified disorders of thyroid
+∞
74.4
69
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
173.1
44.8
46
*
E03
ICD-10 Finland
Other hypothyroidism
179.6
32.2
33
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
65.8
31.6
36
6
E03.89
ICD-10 Finland
Other specified hypothyroidism
119.7
31.2
33
*
H03BB01
ATC
carbimazole; oral
289.8
27.1
27
*
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
289.8
27.1
27
*
BAA60
NOMESCO Finland
Total thyroidectomy
243.6
22.9
23
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
22.1
21
*
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
33.3
21.8
28
9
T86
ICPC
Hypothyroidism/myxoedema
39.6
21.0
26
7
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
+∞
21.0
20
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
17.8
17
*
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
+∞
15.7
15
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
51.8
12.9
15
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.4
12.7
38
76
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
22.1
12.1
17
8
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
18.5
10.8
16
9
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
112.9
10.5
11
*
E07.81
ICD-10 Finland
Pituitary thyroxin resistence
+∞
10.5
10
*
E07.82
ICD-10 Finland
Disorder of thyroid function caused by general disease state
+∞
10.5
10
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
+∞
10.5
10
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
10.5
10
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
16.6
10.4
16
10
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
33.5
10.4
13
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
9.4
9
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
8.4
8
*
2469X
ICD-9 Finland
Other disorders of thyroid, Unspecified disorder of thyroid
+∞
8.4
8
*
E07.8
ICD-10 Finland
Other specified disorders of thyroid
+∞
8.4
8
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
81.6
7.4
8
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
+∞
7.3
7
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
30.6
7.2
9
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
6.6
117
724
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
6.4
147
991
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
6.3
147
992
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
+∞
6.3
6
*
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
+∞
6.3
6
*
E07.80
ICD-10 Finland
Pituitary thyroxin resistence
+∞
6.3
6
*
24210
ICD-8 Finland
Thyrotoxicosis with or without goitre, Toxic nodular goitre
+∞
6.3
6
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.8
6.2
122
777

Mortality – FinRegistry

Association

Association between endpoint E4_THYROIDNASOTH and mortality.

Females

Parameter HR [95% CI] p-value
E4_THYROIDNASOTH 1.444 [1.16, 1.8] 0.001
Birth year 0.993 [0.98, 1.0] 0.115

During the follow-up period (1.1.1998 — 31.12.2019), 162 out of 1145 females with E4_THYROIDNASOTH died.

Males

Parameter HR [95% CI] p-value
E4_THYROIDNASOTH 0.919 [0.68, 1.25] 0.585
Birth year 0.988 [0.98, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 391 males with E4_THYROIDNASOTH died.

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDNASOTH.

N-year risk Females Males
1 0.15% 0.156%
5 0.893% 1.064%
10 2.105% 2.826%
15 3.935% 5.346%
20 6.989% 8.95%

Relationships between endpoints

Index endpoint: E4_THYROIDNASOTH – Disorder of thyroid, unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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