thyroid carcinoma: A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1213 |
4. Check minimum number of eventsNone |
1213 |
5. Include endpointsNone |
1213 |
6. Filter based on genotype QC (FinnGen only) |
1213 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D10-D36
- Name in latin
- Neoplasma benignum glandulae thyreoideae
Similar endpoints
↥List of similar endpoints to
Benign neoplasm of thyroid gland
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm of thyroid gland
- Benign neoplasms
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7907 | 6229 | 1639 |
| Only index persons | 7326 | 5875 | 1451 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.18 | 0.05 |
| Only index persons | 0.18 | 0.22 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 51.68 | 50.47 | 56.14 |
| Only index persons | 50.64 | 49.65 | 54.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1213 | 936 | 277 |
| Unadjusted period prevalence (%) | 0.27 | 0.32 | 0.12 |
| Median age at first event (years) | 51.45 | 49.43 | 58.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1088
- Matched controls
- 10879
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
11426.5
323.0
883
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
79.2
323.0
477
106
2260A
ICD-9 Finland
Benign neoplasm of thyroid gland[NEOPLASMA BENIGNUM GLANDULAE THYREOIDEAE]
+∞
214.9
199
*
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
52.7
189.8
227
54
H03AA01
ATC
levothyroxine sodium; systemic
4.6
115.3
554
1984
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
18.5
89.2
141
87
2504
FHL
Unilateral resection or enucleation
36.6
86.9
112
34
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
22.8
79.9
117
57
104
Kela drug reimbursment
Thyroid insufficiency
5.8
77.6
247
527
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
8.5
75.6
176
242
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
16.2
74.2
123
85
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.5
64.8
181
322
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
20.1
63.1
96
52
BAA60
NOMESCO Finland
Total thyroidectomy
10.8
57.7
115
118
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
9.7
54.3
114
129
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
12.3
47.7
88
77
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
13.1
34.9
62
50
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
10.7
34.3
67
66
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
70.0
30.0
34
5
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
48.5
27.6
33
7
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
9.3
25.7
54
61
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.5
21.3
190
858
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
26.1
20.5
28
11
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
11.2
20.3
38
35
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
10.6
20.2
39
38
C73.99
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland), other or unspecified histology
26.6
19.2
26
10
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
14.0
17.8
30
22
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
4.0
17.1
70
185
8330/3-C73.9
ICD-O-3
Follicular carcinoma, NOS, of thyroid gland
64.4
16.8
19
*
BAA30
NOMESCO Finland
Excision of thyroid isthmus
45.7
15.1
18
*
C73
ICD-10 Finland
Malignant neoplasm of thyroid gland
13.4
12.5
21
16
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
5.8
10.9
30
53
JN5AQ
NOMESCO Finland
SPECT of thyroid metastasis with low-dose CT
18.0
10.7
16
9
E03
ICD-10 Finland
Other hypothyroidism
2.5
10.6
86
365
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
10.3
386
2824
E83.51
ICD-10 Finland
Hypocalcemia
11.5
9.6
17
15
2506
FHL
Thyroidectomy
11.5
9.6
17
15
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
30.3
9.4
12
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.5
9.3
73
307
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
9.3
234
1538
T86
ICPC
Hypothyroidism/myxoedema
2.7
9.0
61
236
106
Kela drug reimbursment
Hypoparathyroidism
12.7
8.9
15
12
R13
ICD-10 Finland
Dysphagia
2.3
8.6
75
334
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
8.4
288
2044
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
12.9
8.4
14
11
A02BC05
ATC
esomeprazole; systemic
1.5
8.3
427
3312
A11CC03
ATC
alfacalcidol; systemic
4.1
8.1
30
75
D35.1
ICD-10 Finland
Benign neoplasm: Parathyroid gland
22.2
8.0
11
5
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
7.7
382
2926
WZC30
NOMESCO Finland
Teaching
1.8
7.6
139
829
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
7.3
234
1625
T72
ICPC
Benign neoplasm thyroid
10.9
7.3
13
12
Z00.0
ICD-10 Finland
General medical examination
1.6
7.2
185
1219
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
8.8
7.1
14
16
ZX114
NOMESCO Finland
Intramuscular
3.9
7.0
27
71
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
5.9
6.6
17
29
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
4.6
6.6
21
46
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
12.3
6.6
11
9
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
6.4
103
587
8340/3-C73.9
ICD-O-3
Papillary carcinoma, follicular variant of thyroid gland
70.2
6.4
7
*
R01AD09
ATC
mometasone; nasal
1.4
6.4
458
3733
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
6.3
289
2167
T71
ICPC
Malignant neoplasm thyroid
18.1
6.3
9
5
D44
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of endocrine glands
+∞
6.3
6
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
6.1
351
2743
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_THYROID and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_THYROID | 0.943 [0.83, 1.06] | 0.343 |
| Birth year | 0.993 [0.98, 1.0] | 0.136 |
During the follow-up period (1.1.1998 — 31.12.2019), 416 out of 3924 females with CD2_BENIGN_THYROID died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_THYROID | 1.195 [1.01, 1.42] | 0.042 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 240 out of 1134 males with CD2_BENIGN_THYROID died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_THYROID.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.091% | 0.186% |
| 5 | 0.58% | 1.233% |
| 10 | 1.361% | 3.105% |
| 15 | 2.586% | 5.841% |
| 20 | 4.419% | 10.295% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_THYROID – Benign neoplasm of thyroid gland
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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