Nontoxic diffuse goitre

E4_GOITREDIFF

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E04.0
  • Hospital discharge: ICD-9 2400
  • Hospital discharge: ICD-8 240
  • Cause of death: ICD-10 E04.0
  • Cause of death: ICD-9 2400
  • Cause of death: ICD-8 240

2 out of 7 registries used, show all original rules.

1189

4. Check minimum number of events

None

1189

5. Include endpoints

None

1189

6. Filter based on genotype QC (FinnGen only)

1189

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E04
Name in latin
Struma atoxica diffusa

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8966 7514 1404
Only index persons 7805 6684 1121
Unadjusted period prevalence (%)
Whole population 0.19 0.22 0.04
Only index persons 0.22 0.25 0.04
Median age at first event (years)
Whole population 54.97 54.35 58.33
Only index persons 53.79 53.13 57.68

-FinnGen-

Key figures

All Female Male
Number of individuals 1189 1003 186
Unadjusted period prevalence (%) 0.30 0.34 0.08
Median age at first event (years) 52.77 51.70 58.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1045
Matched controls
10450
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
298.0
323.0
368
19
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
4503599627370496.0
323.0
871
*
H03AA01
ATC
levothyroxine sodium; systemic
92.4
323.0
571
134
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
279.3
274.8
270
13
104
Kela drug reimbursment
Thyroid insufficiency
616.4
252.1
240
5
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
130.1
206.4
217
21
BAA60
NOMESCO Finland
Total thyroidectomy
2234.4
188.4
177
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
101.5
176.4
191
23
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
162.6
136.0
141
10
24099
ICD-8 Finland
Simple goitre, Unspecified
+∞
120.2
113
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
580.0
107.8
105
*
H03BB01
ATC
carbimazole; oral
104.4
87.6
95
10
E03
ICD-10 Finland
Other hypothyroidism
57.0
75.5
89
17
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
69.6
66
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
245.9
68.1
69
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
178.7
64.8
67
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
326.1
61.0
61
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
44.0
53.5
66
16
EP1AE
NOMESCO Finland
Neck ultrasound examination
7.0
49.6
130
209
T86
ICPC
Hypothyroidism/myxoedema
56.8
46.0
54
10
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
467.1
45.6
45
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
44.1
42
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
+∞
43.0
41
*
E04.8
ICD-10 Finland
Other specified nontoxic goitre
81.0
35.1
39
5
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
19.2
34.7
53
29
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
+∞
34.6
33
*
2504
FHL
Unilateral resection or enucleation
337.2
33.1
33
*
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
54.7
31.5
37
7
2400A
ICD-9 Finland
Simple and unspecified goitre, Goitre, specified as simple
+∞
30.4
29
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
11.1
30.3
58
55
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
+∞
27.2
26
*
E04
ICD-10 Finland
Other nontoxic goitre
53.1
26.3
31
6
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
22.6
24.4
35
16
24010
ICD-8 Finland
Simple goitre, Sporadic
+∞
23.0
22
*
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
122.7
22.7
24
*
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
20.9
20
*
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
19.8
19
*
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
203.6
19.6
20
*
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
+∞
18.8
18
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
193.3
18.6
19
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
96.7
17.6
19
*
E06.3
ICD-10 Finland
Autoimmune thyroiditis
91.5
16.6
18
*
T81
ICPC
Goitre
86.4
15.6
17
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.4
14.7
73
227
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
13.6
13
*
2411A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic multinodular goitre
+∞
13.6
13
*
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
141.7
13.5
14
*
106
Kela drug reimbursment
Hypoparathyroidism
131.5
12.5
13
*
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
13.4
12.5
21
16
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
11.7
276
1801
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
+∞
11.5
11
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
11.5
11
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
8.0
11.4
25
32
N02BE01
ATC
paracetamol; systemic, rectal
1.8
11.2
897
8040
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
60.6
10.6
12
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
10.6
217
1349
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
10.5
386
2822
A11CC03
ATC
alfacalcidol; systemic
5.7
10.5
29
52
GB1AA
NOMESCO Finland
Tracheal X-ray examination
111.1
10.4
11
*
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
+∞
10.4
10
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
9.4
181
1101
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
+∞
9.4
9
*
R42
ICD-10 Finland
Dizziness and giddiness
1.7
9.3
221
1429
BA1AE
SPAT
NA
10.8
9.3
17
16
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
9.2
382
2853
R06.0
ICD-10 Finland
Dyspnoea
1.6
8.9
246
1659
R13
ICD-10 Finland
Dysphagia
2.5
8.8
69
288
XA402
NOMESCO Finland
ENMG
3.9
8.8
35
93
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
7.3
8.8
20
28
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
3.1
8.7
46
153
M01AE02
ATC
naproxen; oral, rectal
1.5
8.6
560
4587
8330/3-C73.9
ICD-O-3
Follicular carcinoma, NOS, of thyroid gland
+∞
8.3
8
*
24000
ICD-8 Finland
Simple goitre, Endemic
+∞
8.3
8
*
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
8.3
8
*
A11CC02
ATC
dihydrotachysterol; oral
33.6
8.1
10
*
L03
ICPC
Low back symptom/complaint
1.6
8.0
239
1644
A02BC02
ATC
pantoprazole; systemic
1.5
7.8
644
5489
A03FA02
ATC
cisapride; oral, rectal
2.1
7.6
85
424
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
7.5
294
2148
A02BC05
ATC
esomeprazole; systemic
1.5
7.5
397
3092
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
80.6
7.4
8
*
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
6.0
7.4
19
32
E83.51
ICD-10 Finland
Hypocalcemia
13.5
7.4
12
9
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
7.3
7
*
19399
ICD-8 Finland
Malignant neoplasm of thyroid gland
+∞
7.3
7
*
N02AX02
ATC
tramadol; systemic, rectal
1.4
7.2
402
3156
C07AB07
ATC
bisoprolol; oral
1.4
7.2
440
3515
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
7.1
123
721
M01AX17
ATC
nimesulide; oral
1.5
7.1
254
1810
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
20.2
7.1
10
5
N03AX16
ATC
pregabalin; oral
1.5
7.1
234
1642
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
6.7
515
4273
R00.2
ICD-10 Finland
Palpitations
2.1
6.6
75
376
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
6.6
338
2597
XG410
NOMESCO Finland
Flow-volume spirometry
2.6
6.5
44
173
E06
ICD-10 Finland
Thyroiditis
70.2
6.4
7
*
G44.2
ICD-10 Finland
Tension-type headache
1.7
6.3
135
843
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
6.3
162
1066
ZXA00
NOMESCO Finland
Right side
1.5
6.3
272
2018
ZSB00
NOMESCO Finland
Procedure related to previous procedure classified in chapter B
+∞
6.3
6
*
TBA20
NOMESCO Finland
Aspiration cytology of thyroid gland
+∞
6.3
6
*
24599
ICD-8 Finland
Thyroiditis, Unspecified
+∞
6.3
6
*
24110
ICD-8 Finland
Non-toxic nodular goitre, Sporadic
+∞
6.3
6
*
E07.89
ICD-10 Finland
Other specified disorders of thyroid
+∞
6.3
6
*
2410A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic uninodular goitre
+∞
6.3
6
*
BAA30
NOMESCO Finland
Excision of thyroid isthmus
+∞
6.3
6
*
UJC01
NOMESCO Finland
Scopy of lower throat
6.3
6.2
15
24
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
6.1
445
3632
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.7
6.0
113
679

Mortality – FinRegistry

Association

Association between endpoint E4_GOITREDIFF and mortality.

Females

Parameter HR [95% CI] p-value
E4_GOITREDIFF 1.08 [0.97, 1.2] 0.166
Birth year 0.994 [0.99, 1.0] 0.153

During the follow-up period (1.1.1998 — 31.12.2019), 753 out of 4980 females with E4_GOITREDIFF died.

Males

Parameter HR [95% CI] p-value
E4_GOITREDIFF 1.199 [1.0, 1.44] 0.05
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 221 out of 886 males with E4_GOITREDIFF died.

Mortality risk

Mortality risk for people of age

years, who have E4_GOITREDIFF.

N-year risk Females Males
1 0.093% 0.187%
5 0.582% 1.244%
10 1.489% 3.239%
15 2.926% 5.961%
20 5.264% 10.079%

Relationships between endpoints

Index endpoint: E4_GOITREDIFF – Nontoxic diffuse goitre

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data