Benign neoplasm of other and unspecified female genital organs

CD2_BENIGN_FEMALE_GEN_OTH

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D28 Cause of death: ICD-10 — D28 2 out of 7 registries used, show all original rules.	986
4. Check minimum number of events None	986
5. Include endpoints CD2_BENIGN_VAGINA CD2_BENIGN_VULVA CD2_BENIGN_UTERINE_TUBES_LIGAMENTS CD2_BENIGN_FEMALE_GEN_NOS	1601
6. Filter based on genotype QC (FinnGen only)	1601

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 2
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D10-D36
Name in latin: Neoplasmata benigna organorum genitalium femininorum aliorum et non specificatorum

NAME	CD2_BENIGN_FEMALE_GEN_OTH
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE	CD2_BENIGN_VAGINA\|CD2_BENIGN_VULVA\|CD2_BENIGN_UTERINE_TUBES_LIGAMENTS\|CD2_BENIGN_FEMALE_GEN_NOS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D28
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D28
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm of other and unspecified female genital organs based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	11216	11216	-
Only index persons	10243	10243	-
Unadjusted period prevalence (%)
Whole population	0.32	0.32	-
Only index persons	0.38	0.38	-
Median age at first event (years)
Whole population	-	41.94	-
Only index persons	-	40.87	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	1601	1601	-
Unadjusted period prevalence (%)	0.55	0.55	-
Median age at first event (years)	41.01	41.01	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1436: Matched controls
14359

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D28.0

ICD-10 Finland

Benign neoplasm: Vulva

+∞

323.0

459

D28.1

ICD-10 Finland

Benign neoplasm: Vagina

3157.8

290.6

271

LFB10

NOMESCO Finland

Excision of lesion of vulva or perineum

37.9

153.5

197

22120

ICD-8 Finland

Benign neoplasm of other female genital organs, Vulva

+∞

129.1

122

22101

ICD-8 Finland

Benign neoplasm of other female genital organs, Fallopian tube and broad ligament

+∞

107.7

102

22110

ICD-8 Finland

Benign neoplasm of other female genital organs, Vagina

+∞

97.0

D28.2

ICD-10 Finland

Benign neoplasm: Uterine tubes and ligaments

+∞

76.8

LEB10

NOMESCO Finland

Excision of lesion of vagina

36.2

75.9

2210A

ICD-9 Finland

Benign neoplasm of other female genital organs, Fallopian tube and uterine ligaments

+∞

57.7

D28.9

ICD-10 Finland

Benign neoplasm: Female genital organ, unspecified

569.4

56.0

22121

ICD-8 Finland

+∞

51.4

22122

ICD-8 Finland

+∞

50.3

D28.7

ICD-10 Finland

Benign neoplasm: Other specified female genital organs

+∞

37.7

22199

ICD-8 Finland

Benign neoplasm of other female genital organs, Unspecified site

+∞

29.3

Z09.0

ICD-10 Finland

Follow-up examination after surgery for other conditions

2.7

28.6

217

890

2211A

ICD-9 Finland

Benign neoplasm of other female genital organs, Vagina

+∞

28.2

LFB20

NOMESCO Finland

Destruction of lesion of vulva or perineum

10.5

25.1

LFB00

NOMESCO Finland

Biopsy of vulva or perineum

4.2

24.2

238

22111

ICD-8 Finland

+∞

16.7

LX1AE

NOMESCO Finland

Gynecological ultrasound examination as part of clinical examination

1.9

12.7

196

1097

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.5

12.6

518

3843

N75.0

ICD-10 Finland

Cyst of Bartholin gland

6.2

12.6

8412

FHL

Vaginal tumor removal

37.9

12.2

N83.2

ICD-10 Finland

Other and unspecified ovarian cysts

1.9

12.1

201

1155

G03CA03

ATC

estradiol; nasal, systemic, rectal, transdermal, vaginal

1.5

11.7

938

8008

LEB00

NOMESCO Finland

Biopsy of vagina

3.7

11.6

134

LEB20

NOMESCO Finland

Marsupialisation of vaginal cyst

21.6

10.7

LC2BE

NOMESCO Finland

Transvaginal ultrasound examination of uterus, parametria and lower abdomen

1.5

10.7

495

3742

N90.7

ICD-10 Finland

Vulvar cyst

10.1

10.5

2218X

ICD-9 Finland

Benign neoplasm of other female genital organs, Other specified sites of female genital organs

+∞

9.4

UKC02

NOMESCO Finland

Cystoscopy

1.8

9.0

156

906

8206

FHL

Removal of the parovarial cyst

50.3

8.7

8473

FHL

Guinea pig or gland excision

9.0

8.5

J01DA01

ATC

[U] cefalexin; systemic

1.4

8.4

870

7535

R01AD09

ATC

mometasone; nasal

1.4

8.2

636

5229

J02AC01

ATC

fluconazole; systemic

1.4

8.1

688

5749

62212

ICD-8 Finland

Infective diseases of uterus (except cervix), vagina and vulva, Bartholinitis acuta

9.0

8.0

JN2DG

NOMESCO Finland

Very extensive MRI examination of lower part of abdoment with high intensity magnet

4.8

7.9

M25.5

ICD-10 Finland

Pain in joint

1.4

7.9

406

3096

D82

ICPC

Teeth/gum disease

1.4

7.6

456

3576

X01

ICPC

Genital pain female

5.8

7.5

M54.5

ICD-10 Finland

Low back pain

1.4

7.5

448

3503

ULA02

NOMESCO Finland

Kolposcopy

1.7

7.4

161

1006

N39.3

ICD-10 Finland

Stress incontinence

1.7

7.1

149

917

121

Kela drug reimbursment

Severe hypofunction of sexual glands

2.9

7.1

144

J01DB01

ATC

cefalexin; oral

1.4

7.1

1122

10283

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

1.5

7.0

312

2305

J01AA02

ATC

doxycycline; systemic

1.4

7.0

1106

10117

M01AE02

ATC

naproxen; oral, rectal

1.3

6.9

780

6747

N36.1

ICD-10 Finland

Urethral diverticulum

13.8

6.9

N02AX02

ATC

tramadol; systemic, rectal

1.4

6.9

536

4374

2200A

ICD-9 Finland

Benign neoplasm of ovary[NEOPLASMA BENIGNUM OVARII]

3.4

6.7

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.4

6.6

412

3235

8204

FHL

Salpingo-oophorectomy

3.0

6.6

124

N02BE01

ATC

paracetamol; systemic, rectal

1.5

6.6

1228

11492

21899

ICD-8 Finland

Uterine fibroma

1.9

6.6

501

LCD00

NOMESCO Finland

Hysterectomy

1.8

6.4

549

Z01.4

ICD-10 Finland

Gynaecological examination (general)(routine)

1.4

6.4

282

2079

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.3

6.4

693

5929

A02BC02

ATC

pantoprazole; systemic

1.3

6.3

897

7981

S18

ICPC

Laceration/cut

1.3

6.3

534

4399

R03AC02

ATC

salbutamol; inhalant

1.3

6.3

727

6274

N89.9

ICD-10 Finland

Noninflammatory disorder of vagina, unspecified

7.1

6.2

E000001

ATC

1.5

6.2

261

1906

LAC31

NOMESCO Finland

Laparoscopic excision of paraovarian cyst

12.6

6.1

LEB30

NOMESCO Finland

Destruction of lesion of vaginal mucosa

5.2

6.0

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.3

6.0

523

4320

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_FEMALE_GEN_OTH and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_FEMALE_GEN_OTH	1.037 [0.92, 1.17]	0.546
Birth year	0.991 [0.98, 1.0]	0.056

During the follow-up period (1.1.1998 — 31.12.2019), 555 out of 5027 females with CD2_BENIGN_FEMALE_GEN_OTH died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_FEMALE_GEN_OTH.

N-year risk	Females	Males
1	0.103%	No data
5	0.612%	No data
10	1.446%	No data
15	2.636%	No data
20	4.381%	No data

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_FEMALE_GEN_OTH – Benign neoplasm of other and unspecified female genital organs

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm of other and unspecified female genital organs

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints