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This is a non-core endpoint: only basic statistics are computed.

Benign neoplasm: Vagina

CD2_BENIGN_VULVA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D28.1&
  • Hospital discharge: ICD-9 2211
  • Hospital discharge: ICD-8 2211
  • Cause of death: ICD-10 D28.1&
  • Cause of death: ICD-9 2211
  • Cause of death: ICD-8 2211

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D28
Name in latin
Neoplasma benignum vaginae

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 456 456 -
Unadjusted period prevalence (%) 0.16 0.16 -
Median age at first event (years) 41.63 41.63 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
407
Matched controls
4069
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D28.1
ICD-10 Finland
Benign neoplasm: Vagina
9986.6
323.0
271
*
22110
ICD-8 Finland
Benign neoplasm of other female genital organs, Vagina
+∞
100.2
92
*
LEB10
NOMESCO Finland
Excision of lesion of vagina
194.5
90.3
91
6
115
Kela drug reimbursment
Breast cancer
+∞
44.6
42
*
PJA12
NOMESCO Finland
Sentinel node biopsy
127.2
33.2
35
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
30.6
29
*
2211A
ICD-9 Finland
Benign neoplasm of other female genital organs, Vagina
+∞
28.5
27
*
H02AB02
ATC
dexamethasone; systemic
28.8
23.9
32
12
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
20.0
19
*
A04AA02
ATC
granisetron; systemic, transdermal
209.7
19.7
20
*
HAC20
NOMESCO Finland
Total mastectomy
209.7
19.7
20
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
18.9
18
*
L02BA01
ATC
tamoxifen; oral
198.7
18.7
19
*
L02BG04
ATC
letrozole; oral
13.5
16.9
29
23
22111
ICD-8 Finland
NA
+∞
16.8
16
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
16.8
16
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
16.8
16
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
15.7
15
*
C50.99
ICD-10 Finland
Breast, unspecified
+∞
15.7
15
*
HAB40
NOMESCO Finland
Wedge excision of mammary gland
29.9
15.3
20
7
LEB00
NOMESCO Finland
Biopsy of vagina
9.5
15.2
31
35
LEB20
NOMESCO Finland
Marsupialisation of vaginal cyst
+∞
14.7
14
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
14.7
14
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
13.6
13
*
8412
FHL
Vaginal tumor removal
144.6
13.5
14
*
L02BG03
ATC
anastrozole; oral
+∞
11.5
11
*
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
11.5
11
*
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
+∞
11.5
11
*
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
+∞
11.5
11
*
8500/3-C50.4
ICD-O-3
Infiltrating duct carcinoma, NOS, of upper-outer quadrant of breast
+∞
11.5
11
*
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
3.1
11.5
66
238
A03FA01
ATC
metoclopramide; systemic, rectal
2.7
11.3
85
364
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
112.8
10.5
11
*
C50
ICD-10 Finland
Malignant neoplasm of breast
+∞
10.5
10
*
L02BG06
ATC
exemestane; oral
+∞
10.5
10
*
HA1AA
NOMESCO Finland
X-ray mammography
4.5
10.1
35
83
N89.8
ICD-10 Finland
Other specified noninflammatory disorders of vagina
18.1
9.5
14
8
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
+∞
9.4
9
*
UKC02
NOMESCO Finland
Cystoscopy
2.9
9.0
56
213
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
51.1
8.7
10
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.1
8.7
124
713
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
16.7
8.6
13
8
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
+∞
8.4
8
*
130
Kela drug reimbursment
Malignant tumour
+∞
8.4
8
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
8.4
8
*
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
+∞
8.4
8
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
8.4
8
*
HAE20
NOMESCO Finland
Reconstruction of areola and mamilla using graft or flap
+∞
8.4
8
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
+∞
8.4
8
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
8.4
8
*
LEB30
NOMESCO Finland
Destruction of lesion of vaginal mucosa
14.9
8.2
13
9
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
34.1
8.1
10
*
XX3DW
NOMESCO Finland
Time consuming IT work
4.2
7.5
27
67
TQW20
NOMESCO Finland
Tatoe
81.5
7.4
8
*
X76
ICPC
Malignant neoplasm breast female
+∞
7.3
7
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
7.3
7
*
C50.42
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, lobular tumor
+∞
7.3
7
*
N36.1
ICD-10 Finland
Urethral diverticulum
30.6
7.2
9
*
JN4AD
NOMESCO Finland
Body CT examination
5.0
6.9
21
44
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.8
6.9
152
1011
SPAT1153
SPAT
Removal of sutures
1.9
6.9
128
804
N89.9
ICD-10 Finland
Noninflammatory disorder of vagina, unspecified
17.0
6.8
10
6
C50.49
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology
+∞
6.3
6
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
6.3
6
*
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
+∞
6.3
6
*
LCD00
NOMESCO Finland
Hysterectomy
3.0
6.2
35
125

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_BENIGN_VULVA_EXALLC – Benign neoplasm: Vagina

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).