Congenital hydrocephalus

Q17_CONGEN_HYDROCEPHALUS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — Q03 Hospital discharge: ICD-9 — 7423 Hospital discharge: ICD-8 — 742 Cause of death: ICD-10 — Q03 Cause of death: ICD-9 — 7423 Cause of death: ICD-8 — 742 2 out of 7 registries used, show all original rules.	148
4. Check minimum number of events None	148
5. Include endpoints None	148
6. Filter based on genotype QC (FinnGen only)	148

Control definitions (FinnGen only)

Control exclude: Q17_CONGEN_MALFO_NERVOUS_SYSTEM

Extra metadata

Level in the ICD hierarchy: 3
Special: Q17_HCCONG
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: Q00-Q07
Name in latin: Hydrocephalia congenita

NAME	Q17_CONGEN_HYDROCEPHALUS
CONTROL_EXCLUDE	Q17_CONGEN_MALFO_NERVOUS_SYSTEM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	Q03
HD_ICD_9	7423
HD_ICD_8	742
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	Q03
COD_ICD_9	7423
COD_ICD_8	742
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Congenital hydrocephalus based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2458	1124	1328
Only index persons	1790	813	977
Unadjusted period prevalence (%)
Whole population	0.03	0.03	0.04
Only index persons	0.03	0.03	0.04
Median age at first event (years)
Whole population	3.23	3.70	2.57
Only index persons	3.93	5.20	2.87

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	148	74	74
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	10.18	12.76	7.61

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
135: Matched controls
1347

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

AAF20

NOMESCO Finland

Revision of shunt of ventricle of brain

+∞

45.4

G91.1

ICD-10 Finland

Obstructive hydrocephalus

+∞

39.5

Q03.9

ICD-10 Finland

Congenital hydrocephalus, unspecified

+∞

38.4

7423A

ICD-9 Finland

Other congenital anomalies of nervous system, Congenital hydrocephalus

+∞

32.6

74200

ICD-8 Finland

Congenital hydrocephalus, Communicans

+∞

31.5

G91.9

ICD-10 Finland

Hydrocephalus, unspecified

191.0

30.0

Q03.0

ICD-10 Finland

Malformations of aqueduct of Sylvius

+∞

29.2

74209

ICD-8 Finland

Congenital hydrocephalus, Unspecified

+∞

25.9

G91.0

ICD-10 Finland

Communicating hydrocephalus

+∞

25.9

2133

FHL

Suntin revisio

+∞

23.6

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

14.3

19.6

AA7AA

NOMESCO Finland

Liquor cerebri shunt X-ray examinatin without contrast

205.9

18.0

T85.0

ICD-10 Finland

Mechanical complication of ventricular intracranial (communicating) shunt

+∞

17.0

AAF25

NOMESCO Finland

Removal of shunt of ventricle of brain

+∞

17.0

2132

FHL

Ventricular operators sunt

+∞

15.9

AAF05

NOMESCO Finland

Ventriculoperitoneal shunt

64.3

15.2

G40.9

ICD-10 Finland

Epilepsy, unspecified

18.2

15.1

3313A

ICD-9 Finland

Other cerebral degenerations, Communicating hydrocephalus

+∞

13.8

G91.2

ICD-10 Finland

Normal-pressure hydrocephalus

+∞

12.7

AAF99

NOMESCO Finland

Other shunt operation on ventricle of brain or intracerebral cyst

+∞

12.7

H47.2

ICD-10 Finland

Optic atrophy

142.7

12.7

AA1AA

NOMESCO Finland

Head X-ray examination

130.7

11.6

74201

ICD-8 Finland

Congenital hydrocephalus, Non communicans

+∞

10.5

G91.8

ICD-10 Finland

Other hydrocephalus

+∞

10.5

Q03.1

ICD-10 Finland

Atresia of foramina of Magendie and Luschka

+∞

10.5

74210

ICD-8 Finland

+∞

10.5

AA1AD

NOMESCO Finland

CT of head and brain

4.4

10.2

117

182

Kela drug reimbursment

Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide

18.5

10.1

G40.20

ICD-10 Finland

Complex partial seizures with only alteration of consciousness

59.4

9.8

AAF00

NOMESCO Finland

Ventriculostomy

107.2

9.5

3314A

ICD-9 Finland

Other cerebral degenerations, Obstructive hydrocephalus

+∞

9.5

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

6.3

9.0

183

Kela drug reimbursment

Lamotrigin and topiramate

23.7

8.2

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

5.4

8.0

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

8.9

7.9

N03AF02

ATC

oxcarbazepine; oral

9.2

7.5

7410D

ICD-9 Finland

Spina bifida, With hydrocephalus[SPINA BIFIDA APERTA CUM HYDROCEPHALO REG LUMBALIS]

+∞

7.4

AAF15

NOMESCO Finland

Ventriculoatrial shunt

+∞

7.4

Q03.88

ICD-10 Finland

Other congenital hydrocephalus

+∞

7.4

XCK00

NOMESCO Finland

Perimetry

7.7

7.2

Y83.1

ICD-10 Finland

Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

42.2

6.8

R51.80

ICD-10 Finland

Headache

3.5

6.6

110

H53.4

ICD-10 Finland

Visual field defects

19.1

6.4

Q05.2

ICD-10 Finland

Lumbar spina bifida with hydrocephalus

+∞

6.3

2139

FHL

Other measure in this category

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

19.63

7.72

2.9

1.3

—

(3016018) Differential panel - Cerebral spinal fluid

8.38

4.11

3.4

4.3

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

10.41

4.05

3.7

2.6

umol/l

66.9

52.9

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

10.41

4.05

1.3

mmol/l

1.7

1.5

—

(3044290) Cell count panel - Cerebral spinal fluid

4.05

3.58

3.2

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

386

1.88

3.32

6.7

7.5

mmol/l

1.2

1.07

354

(3007853) Bacteria identified in Skin by Aerobe culture

114

2.32

3.16

1.5

1.7

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

418

1.83

3.14

6.2

8.4

mmol/l

1.2

0.48

359

(46235355) HIV 1 and 2 tests - Meaningful Use set

378

0.43

3.06

2.7

2.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.38

2.89

6.6

6.7

—

(3019832) Treponema pallidum Ab [Presence] in Serum

210

0.35

2.83

3.0

1.8

—

(1761868) Lipid panel - Serum or Plasma

462

0.51

2.59

2.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

2.28

0.0

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

1025

0.62

2.14

3.4

3.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

2.10

0.0

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

2.10

0.0

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

2.09

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

2.09

0.0

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

302

1.65

1.95

2.4

—

(3003694) ABO and Rh group [Type] in Blood

335

0.53

1.85

1.5

—

(3035637) Corticotropin [Mass/volume] in Plasma

3.63

1.85

1.3

1.2

—

(3023368) Bacteria identified in Blood by Culture

229

1.69

1.85

2.4

4.5

—

(3020891) Body temperature

2.76

1.75

2.9

5.5

—

(3005033) Fetal Nuchal fold Thickness US

0.00

1.74

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

1.74

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

1.74

0.0

1.3

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

1.73

0.0

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

293

0.53

1.72

1.2

1.7

—

(3026008) Bacteria identified in Urine by Culture

262

1.61

1.64

3.6

2.7

—

(3032080) INR in Blood by Coagulation assay

346

1.53

1.52

4.2

6.3

inr

1.2

1.1

0.22

104

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

475

1.48

1.51

3.7

4.3

—

(3003396) Base excess in Arterial blood by calculation

1.89

1.50

8.2

12.0

mmol/l

0.8

1.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.31

1.50

14.9

8.8

mmol/l

24.9

24.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

281

0.55

1.49

2.9

2.2

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

286

1.55

1.47

3.4

2.1

u/l

338.1

249.4

0.21

275

(3023410) Appearance of Cerebral spinal fluid

3.20

1.45

4.8

4.4

—

(3015736) pH of Urine

414

1.48

1.43

3.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

253

0.55

1.41

2.7

2.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

220

1.58

1.39

2.2

2.5

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.21

1.37

11.6

18.7

—

(1616796) Gas panel - Central venous blood

3.01

1.37

1.2

1.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

157

0.48

1.34

1.5

1.7

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

320

1.48

1.31

2.6

3.4

mmol/l

2.4

0.39

281

(3019150) Specific gravity of Urine by Refractometry

251

1.52

1.27

3.5

3.1

kg/l

1.0

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

217

1.54

1.25

1.7

1.8

mg/l

3.0

3.1

0.04

185

(42870588) Differential panel, method unspecified - Blood

351

1.45

1.23

4.6

7.2

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

397

1.43

1.23

2.6

2.4

nmol/l

69.5

71.9

0.26

363

(3012544) pH of Venous blood

1.83

1.17

3.8

5.9

—

(3007566) Smooth muscle Ab [Titer] in Serum

0.00

1.17

0.0

1.2

—

66.0

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

318

1.45

1.16

1.7

pmol/l

97.5

97.6

0.01

163

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.55

1.16

1.4

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

331

0.64

1.16

1.8

1.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

630

1.39

1.15

9.5

10.4

e9/l

4.4

4.0

0.57

559

(3034770) Mitochondria Ab [Titer] in Serum

0.00

1.15

0.0

1.2

—

(3019060) Gas panel - Arterial blood

1.93

1.10

6.0

12.7

—

(3042936) Bacteria identified in Isolate by Culture

130

1.62

1.09

2.2

2.4

—

(40768804) Tissue Pathology biopsy report

393

0.67

1.09

1.4

1.8

—

(40761535) Cells panel - Urine sediment

1.86

1.08

3.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

209

0.59

1.03

1.3

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

220

1.46

0.98

4.3

3.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

339

1.38

0.94

2.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

226

0.63

0.92

1.9

1.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

305

0.67

0.92

1.2

1.3

u/ml

0.9

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.71

0.91

3.3

3.5

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.63

0.88

3.8

7.8

mmol/l

105.1

104.0

0.45

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

111

0.52

0.87

1.2

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.82

0.86

1.9

1.7

—

(3018418) pH of Serum or Plasma

253

1.39

0.85

2.5

3.7

7.4

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.78

0.84

10.4

10.3

1.4

1.7

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.85

0.80

1.0

1.4

—

(40768793) Breast Pathology biopsy report

0.00

0.80

0.0

1.2

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.77

0.0

1.6

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

2.12

0.75

1.0

1.1

—

0.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.88

0.74

1.1

2.6

65.8

54.7

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.03

0.73

1.2

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.79

0.72

1.4

3.1

1.1

1.7

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.79

0.72

1.4

1.3

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

1.95

0.71

1.0

1.2

—

2.6

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.59

0.71

2.4

2.7

mmol/l

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

271

1.33

0.69

3.6

3.2

estimate

0.0

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.88

0.69

1.2

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.56

0.68

1.2

iu/ml

67.0

236.8

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

499

1.27

0.67

2.6

2.4

ug/l

71.5

96.6

1.23

465

(3009542) Hematocrit [Volume Fraction] of Blood

124

1171

1.36

0.66

15.6

12.1

41.6

41.3

0.23

976

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

882

0.80

0.65

2.9

u/l

62.8

41.6

0.56

849

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

137

0.63

0.64

4.6

1.8

—

(3022313) Gas panel - Capillary blood

1.63

0.62

12.5

4.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.60

0.0

2.9

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.60

0.0

4.5

—

1.8

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.60

0.0

1.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.59

0.0

1.5

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.58

0.57

4.0

3.4

pmol/l

5.0

4.7

—

(3022621) pH of Urine by Test strip

1.48

0.57

2.6

2.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.65

0.56

2.2

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.65

0.56

1.2

4.8

104.0

92.3

—

(3044889) 12 lead EKG panel

695

1.22

0.56

2.8

3.1

—

(3019225) pH of Specimen

1.50

0.52

4.0

5.6

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.52

0.52

2.2

2.6

—

(3000991) Gas panel - Venous blood

1.53

0.51

10.2

9.4

—

(3022145) Colonoscopy Study observation

106

0.64

0.51

1.0

1.3

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.58

0.49

11.7

10.5

0.8

0.7

—

(36660697) Celiac disease serology panel - Serum

117

0.67

0.48

1.0

1.1

—

(3025941) Bacteria identified in Stool by Culture

0.57

0.47

1.0

1.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

420

1.21

0.46

3.5

3.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

139

1.34

0.46

3.3

2.8

e6/l

2.5

2.6

—

(3035350) Ketones [Presence] in Urine by Test strip

527

1.20

0.46

3.7

3.2

estimate

0.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.58

0.42

1.8

1.4

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.41

0.0

1.3

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.41

0.0

1.5

—

(3000492) Spirometry study

137

0.71

0.41

1.6

1.4

—

(3009261) Glucose [Presence] in Urine by Test strip

532

1.18

0.41

3.8

3.2

estimate

0.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.41

0.0

1.8

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.41

0.0

1.5

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.41

0.0

1.8

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.41

0.0

1.8

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.41

0.0

1.8

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.4

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.40

0.0

1.4

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.40

0.0

1.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.7

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.40

0.0

3.9

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.7

—

(3021601) Nitrite [Presence] in Urine by Test strip

523

1.18

0.40

5.3

4.5

estimate

0.0

—

101

(3003338) MCHC [Mass/volume]

115

1098

1.21

0.39

17.5

14.0

g/l

334.4

334.6

0.10

115

1091

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.39

0.39

1.6

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.39

0.0

4.8

—

0.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.39

0.0

2.8

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.39

0.0

4.8

—

0.0

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.39

0.0

4.8

—

0.0

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

115

0.68

0.38

4.6

1.7

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

144

1.28

0.37

3.4

2.7

e6/l

1.2

0.9

0.23

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.64

0.37

1.2

1.0

—

(3045414) Leukocytes [Presence] in Urine

1.48

0.36

1.3

—

(3019198) Lymphocytes [#/volume] in Blood

566

1.16

0.36

5.0

6.9

e9/l

2.0

1.9

0.40

515

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.41

0.35

1.2

1.1

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

102

970

1.17

0.34

4.0

4.4

mmol/mol

36.9

38.3

0.84

924

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.29

0.30

1.7

2.0

ng/l

32.6

113.2

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

193

0.81

0.28

1.3

1.2

iu/ml

64.8

28.7

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.29

0.28

3.9

ng/l

29.9

66.0

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.24

0.27

37.6

3.8

kpa

5.1

—

(3002179) Metamyelocytes/100 leukocytes in Blood

1.20

0.27

2.3

3.8

—

0.7

—

(3005322) IgE [Units/volume] in Serum or Plasma

0.67

0.26

1.2

u/ml

72.2

136.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

151

1.22

0.26

2.4

1.9

—

(3030467) Casts [#/volume] in Urine by Automated count

257

1.16

0.24

3.1

2.6

e6/l

0.1

0.3

1.98

190

(40768797) Stomach Pathology biopsy report

136

0.79

0.24

1.1

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

860

1.12

0.23

3.5

3.6

pmol/l

15.1

14.5

1.18

797

(3037467) Urinalysis macro (dipstick) panel - Urine

741

1.11

0.22

3.8

—

(3006315) Basophils [#/volume] in Blood

553

1.11

0.21

5.4

6.8

e9/l

0.0

0.10

499

(3001604) Monocytes [#/volume] in Blood

553

1.11

0.21

5.1

6.8

e9/l

0.6

0.5

0.42

497

(3015171) Extractable nuclear Ab [Units/volume] in Serum

1.20

0.21

2.0

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

134

0.81

0.21

1.5

1.8

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.0

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

2.6

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3015183) Erythrocyte sedimentation rate

0.00

0.21

0.0

1.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

0.9

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

3.6

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

8.9

—

0.6

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

153.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

100

1035

0.90

0.21

9.6

ml/min/173m2

101.3

92.3

3.96

820

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(40758558) Short blood count panel - Blood

270

1.14

0.21

7.7

8.4

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

0.21

0.0

2.2

—

7.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

280

0.87

0.21

1.6

1.4

g/l

1.9

2.2

0.47

176

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

108

1046

1.12

0.21

4.3

4.1

mu/l

1.9

1.8

0.52

971

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

232

1.15

0.20

1.9

2.2

mg/l

0.9

1.2

0.20

169

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.20

0.0

1.4

—

(3002256) Pathology report gross observation

109

1.21

0.19

1.2

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

109

1.21

0.19

3.4

3.3

30.4

30.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

195

1.15

0.19

1.5

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

321

1.12

0.18

2.5

2.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.17

0.18

1.4

1.2

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

1.15

0.18

1.9

1.6

mu/l

297.7

314.4

—

(3000494) Fungus identified in Specimen by Culture

119

0.83

0.16

1.5

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.13

0.15

1.2

1.3

—

26.8

—

(3018095) Leukocytes [#/volume] in Urine

344

1.10

0.15

4.0

3.4

e6/l

22.9

41.1

0.52

234

(3013115) Eosinophils [#/volume] in Blood

571

1.09

0.15

6.0

7.3

e9/l

0.2

0.06

520

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.80

0.15

1.1

1.5

—

(36304419) Bacteria [Presence] in Urine

258

1.11

0.13

3.2

2.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

339

0.93

0.10

2.5

3.1

ng/l

18.6

18.3

0.02

184

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

105

1069

0.94

0.09

3.6

mmol/l

5.5

5.7

1.70

994

(3028300) Cannabinoids [Presence] in Urine

112

0.89

0.07

1.1

1.6

—

(3027008) Opiates [Presence] in Urine

112

0.89

0.07

1.1

1.6

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.83

0.07

1.0

1.3

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.06

0.07

2.3

2.5

—

27.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

132

0.90

0.07

1.1

1.6

—

(3016879) Cocaine [Presence] in Urine

103

0.87

0.06

1.1

1.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

112

1134

0.95

0.06

3.6

3.8

mmol/l

3.0

2.9

0.52

101

1071

(3013512) EKG study

238

1.06

0.05

3.3

3.1

—

(3021960) Folate [Moles/volume] in Serum or Plasma

199

1.06

0.05

1.2

1.4

nmol/l

17.7

21.4

0.61

165

(3002582) Erythrocytes [#/volume] in Urine

299

1.05

0.04

3.4

2.6

e6/l

18.4

243.9

0.53

229

(21494755) Public health laboratory ask at order entry panel

199

0.95

0.03

1.2

1.3

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

106

1069

0.97

0.02

2.8

3.3

mmol/l

1.4

1.3

0.64

1007

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

121

1202

1.04

0.02

13.0

11.2

mg/l

22.5

21.2

0.21

877

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

103

1.07

0.02

2.9

1.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

103

1.07

0.02

2.2

1.6

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

113

1122

1.03

0.02

3.4

3.5

mmol/l

4.7

0.07

102

1064

(40760892) CBC W Ordered Manual Differential panel - Blood

257

0.97

0.01

4.8

4.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

111

1116

0.98

0.00

3.4

3.5

mmol/l

1.4

1.29

100

1056

(3024731) MCV [Entitic volume]

136

1361

0.99

0.00

19.4

15.9

89.1

89.9

1.26

136

1339

(3021589) Normoblasts [#/volume] in Blood

492

0.99

0.00

6.3

9.1

e9/l

0.0

0.00

406

(3013707) Erythrocyte sedimentation rate by Westergren method

812

0.99

0.00

3.8

3.6

mm/h

9.5

8.9

0.22

751

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

185

1.03

0.00

3.1

2.6

ng/l

11.3

116.8

—

107

(3000764) Benzodiazepines [Presence] in Urine

112

0.98

0.00

1.1

1.6

—

(3027944) Amphetamines [Presence] in Urine

112

0.98

0.00

1.1

1.6

—

(3000963) Hemoglobin [Mass/volume] in Blood

136

1362

0.98

0.00

19.9

16.0

g/l

138.7

139.0

0.08

136

1339

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

178

1.01

0.00

4.4

3.8

21.5

21.7

—

(40761511) CBC panel - Blood by Automated count

127

1265

1.03

0.00

12.8

9.6

—

(3021440) Promyelocytes/100 leukocytes in Blood

1.02

0.00

3.0

3.8

—

0.3

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.4

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

0.92

0.00

2.4

2.8

g/l

0.2

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.02

0.00

1.6

1.4

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

2.0

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.1

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.4

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.7

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.8

—

29.9

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.6

—

133.4

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(723474) SARS-CoV-2 (COVID-19) IgG Ab [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(4146454)

0.00

0.0

2.6

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.3

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

3.1

—

18.8

—

(3001186) Copper [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

19.0

—

(3032352) Blasts [#/volume] in Cerebral spinal fluid

0.00

0.0

7.0

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.3

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

2.0

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

2.7

—

(3010503) CD19 cells [#/volume] in Blood

0.00

0.0

1.5

—

0.1

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3016616) Dehydroepiandrosterone sulfate (DHEA-S) [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

7.4

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3028707) Methadone [Presence] in Urine by Screen method

0.98

0.00

1.2

1.6

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(4035726)

0.86

0.00

1.3

1.4

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.0

—

33.4

—

(40768446) Kidney Pathology biopsy report

0.00

0.0

1.8

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.1

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.02

0.00

2.5

1.7

ug/l

8.7

4.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.7

—

1154.6

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.7

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1398.6

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.89

0.00

1.2

1.4

—

(3025159) Blasts/100 leukocytes in Blood

0.88

0.00

3.3

3.7

—

0.5

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.3

—

11.1

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.1

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.88

0.00

2.1

1.9

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.6

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(4133840)

0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.3

—

5.9

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.3

—

(3035941) MCH [Entitic mass]

136

1360

1.00

0.00

19.4

15.9

29.8

30.2

1.42

136

1338

(3034426) Prothrombin time (PT)

0.00

0.0

1.5

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

8.7

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

1.4

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.3

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.6

—

(3010375) cycloSPORINE [Mass/volume] in Blood

0.00

0.0

48.1

—

105.7

—

(40761536) Microorganisms panel - Urine sediment

0.91

0.00

5.0

2.8

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.5

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

1.3

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.8

—

23.6

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.5

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

0.0

2.1

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.3

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.3

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.7

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.3

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

1.4

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint Q17_CONGEN_HYDROCEPHALUS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have Q17_CONGEN_HYDROCEPHALUS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: Q17_CONGEN_HYDROCEPHALUS – Congenital hydrocephalus

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Congenital hydrocephalus

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints