Rheumatoid arthritis

M13_RHEUMA

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M05, M06
  • Hospital discharge: ICD-9 7140A|7140B|7241|7142
  • Hospital discharge: ICD-8 712[1-3]
  • Cause of death: ICD-10 M05, M06
  • Cause of death: ICD-9 7140A|7140B|7241|7142
  • Cause of death: ICD-8 712[1-3]

2 out of 7 registries used, show all original rules.

14002

4. Check minimum number of events

None

14002

5. Include endpoints

None

14002

6. Filter based on genotype QC (FinnGen only)

13620

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Rheumatoid arthritis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 122129 82772 38172
Only index persons 94097 65400 28697
Unadjusted prevalence (%)
Whole population 1.95 2.37 1.07
Only index persons 2.01 2.40 1.10
Median age at first event (years)
Whole population 56.51 56.02 57.52
Only index persons 54.66 54.03 56.10

-FinnGen-

Key figures

All Female Male
Number of individuals 13620 9151 4469
Unadjusted prevalence (%) 3.48 3.97 2.46
Median age at first event (years) 53.25 51.29 57.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: M13_RHEUMA – Rheumatoid arthritis

GWS hits: 25

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