Seropositive rheumatoid arthritis, strict definition

RHEUMA_SEROPOS_STRICT

Felty's syndrome: Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • RHEUMA_SEROPOS_OTH_ICD10
10701

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • KELA reimbursements: KELA codes ANY
  • KELA reimbursements: ICD-10 M05

1 out of 7 registries used, show all original rules.

5569

4. Check minimum number of events

None

5569

5. Include endpoints

None

5569

6. Filter based on genotype QC (FinnGen only)

5426

Control definitions (FinnGen only)

Control conditions not RHEUMA_SEROPOS_OTH_ICD10

Extra metadata

First used in FinnGen datafreeze DF3

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 31325 21200 9976
Only index persons 29603 20324 9279
Unadjusted period prevalence (%)
Whole population 0.50 0.61 0.28
Only index persons 0.62 0.75 0.35
Median age at first event (years)
Whole population 59.60 59.01 60.86
Only index persons 59.06 58.50 60.29

-FinnGen-

Key figures

All Female Male
Number of individuals 5426 3764 1662
Unadjusted period prevalence (%) 1.28 1.48 0.83
Median age at first event (years) 56.76 55.05 60.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: RHEUMA_SEROPOS_STRICT – Seropositive rheumatoid arthritis, strict definition

GWS hits: 15

loading spinner Loading Relationships table