This is a non-core endpoint: only basic statistics are computed.

Other transepidermal elimination disorders

L12_TRANSEPIELINAS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L87.8, L87.9 Cause of death: ICD-10 — L87.8, L87.9 2 out of 7 registries used, show all original rules.	12
4. Check minimum number of events None	12
5. Include endpoints None	12
6. Filter based on genotype QC (FinnGen only)	12

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	L12_TRANSEPIELINAS
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L87[8-9]
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L87[8-9]
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other transepidermal elimination disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	105	63	40
Only index persons	85	54	31
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	61.71	66.52	53.43
Only index persons	56.34	59.52	50.79

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	12	9	-
Unadjusted period prevalence (%)	0.00	0.00	-
Median age at first event (years)	52.75	57.59	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

9.60

2.96

2.2

1.2

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

+∞

1.75

9.3

7.9

u/l

75.6

80.9

0.26

(3030467) Casts [#/volume] in Urine by Automated count

4.39

1.70

3.8

2.6

e6/l

0.1

0.2

—

(3044640) Blood type and Crossmatch panel - Blood

4.16

1.62

1.7

2.3

—

(3013707) Erythrocyte sedimentation rate by Westergren method

+∞

1.45

4.2

3.7

mm/h

12.9

11.3

0.19

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

3.75

1.37

2.4

1.8

mg/l

1.4

2.0

—

(3015736) pH of Urine

3.23

1.24

5.1

2.6

—

(3003694) ABO and Rh group [Type] in Blood

3.33

1.23

1.2

1.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

2.73

0.99

5.3

2.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

2.99

0.97

9.9

3.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

+∞

0.92

5.2

5.1

mu/l

1.2

1.8

2.49

(3033658) Prothrombin time (PT) actual/Normal

2.98

0.89

2.8

3.5

89.0

99.2

—

(36304419) Bacteria [Presence] in Urine

2.83

0.87

4.4

2.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

2.44

0.79

11.6

3.6

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

2.33

0.76

5.6

1.9

ng/l

3260.8

330.0

—

(1761868) Lipid panel - Serum or Plasma

2.32

0.71

4.0

3.0

—

(40758558) Short blood count panel - Blood

2.23

0.53

2.4

7.2

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

1.92

0.46

5.3

2.9

nmol/l

75.2

72.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.00

0.44

0.0

1.4

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

0.44

0.0

4.6

—

35.3

—

(3019225) pH of Specimen

0.00

0.22

0.0

5.7

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.22

0.0

1.6

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.22

0.0

2.5

—

(4035726)

0.00

0.22

0.0

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.00

0.22

0.0

5.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

107

+∞

0.22

6.2

4.5

mmol/l

4.3

4.8

0.75

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

0.00

0.22

0.0

4.3

—

22.2

—

(40761511) CBC panel - Blood by Automated count

114

+∞

0.00

47.4

12.3

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

114

+∞

0.00

15.8

10.2

u/l

27.3

25.8

0.10

109

(3020564) Creatinine [Moles/volume] in Serum or Plasma

114

+∞

0.00

48.0

14.1

umol/l

104.0

70.3

0.38

114

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.7

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

111

+∞

0.00

7.7

5.1

mmol/l

2.4

2.9

1.65

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

0.2

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

1.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.0

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(1002224) Polysomnography panel

0.00

0.0

1.3

—

(4094501)

0.00

0.0

1.3

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.0

1.6

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.2

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

11.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.0

1.7

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

67.4

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.0

1.1

—

(3000492) Spirometry study

0.00

0.0

1.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_TRANSEPIELINAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_TRANSEPIELINAS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_TRANSEPIELINAS – Other transepidermal elimination disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other transepidermal elimination disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints