This is a non-core endpoint: only basic statistics are computed.
Transepidermal elimination disorders
L12_TRANSEPIDERMELIMINATION
skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
46 |
6. Filter based on genotype QC (FinnGen only) |
43 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L80-L99
- Name in latin
- Perturbationes eliminationis transepidermalis
Similar endpoints
↥List of similar endpoints to
Transepidermal elimination disorders
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 466 | 280 | 178 |
| Only index persons | 395 | 249 | 146 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 56.95 | 57.00 | 56.49 |
| Only index persons | 55.30 | 55.34 | 55.24 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 43 | 28 | 15 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 54.14 | 54.53 | 53.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
Mortality – FinRegistry
↥Association
Association between endpoint L12_TRANSEPIDERMELIMINATION and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_TRANSEPIDERMELIMINATION | 1.881 [1.35, 2.62] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.06 |
During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 259 females with L12_TRANSEPIDERMELIMINATION died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_TRANSEPIDERMELIMINATION | 2.845 [1.63, 4.95] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 149 males with L12_TRANSEPIDERMELIMINATION died.
Mortality risk
Mortality risk for people of age
years, who have L12_TRANSEPIDERMELIMINATION.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.202% | 0.466% |
| 5 | 0.896% | 2.788% |
| 10 | 2.435% | 7.127% |
| 15 | 4.718% | 13.85% |
| 20 | 8.183% | 22.8% |
Relationships between endpoints
↥Index endpoint: L12_TRANSEPIDERMELIMINATION – Transepidermal elimination disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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