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Genitourinary diseases

N14_GENITOURINARY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N00-N99
  • Hospital discharge: ICD-9 5[8-9]|6[0-2]
  • Hospital discharge: ICD-8 5[8-9]|6[0-2]
  • Cause of death: ICD-10 N00-N99
  • Cause of death: ICD-9 5[8-9]|6[0-2]
  • Cause of death: ICD-8 5[8-9]|6[0-2]

2 out of 7 registries used, show all original rules.

255084

4. Check minimum number of events

None

255084

5. Include endpoints

268301

6. Filter based on genotype QC (FinnGen only)

257656

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
1
First used in FinnGen datafreeze
DF10

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 257656 177222 80434
Unadjusted period prevalence (%) 60.49 69.60 40.40
Median age at first event (years) 46.70 40.04 61.37

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
144
Matched controls
879
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
+∞
28.6
32
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
11.1
19.9
44
33
N47
ICD-10 Finland
Redundant prepuce, phimosis and paraphimosis
27.3
14.9
23
6
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
+∞
14.8
17
*
N30.0
ICD-10 Finland
Acute cystitis
+∞
14.8
17
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
36.8
14.5
21
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
123.5
14.5
18
*
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
12.1
13.7
28
17
L04AD01
ATC
ciclosporin; systemic
19.4
13.0
22
8
Z94.0
ICD-10 Finland
Kidney transplant status
57.9
12.7
17
*
H02AB09
ATC
hydrocortisone; systemic
7.8
12.6
33
32
N48.1
ICD-10 Finland
Balanoposthitis
6.6
12.1
36
42
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
+∞
12.1
14
*
N18.8
ICD-10 Finland
Other chronic renal failure
+∞
12.1
14
*
A11CC03
ATC
alfacalcidol; systemic
16.3
11.7
21
9
127
Kela drug reimbursment
Transplant complication
17.3
11.4
20
8
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
11.2
13
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
93.2
11.0
14
*
H02AB04
ATC
methylprednisolone; systemic
15.4
11.0
20
9
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
23.1
10.7
17
5
L04AA06
ATC
mycophenolic acid; systemic
23.1
10.7
17
5
B03XA01
ATC
erythropoietin; parenteral
+∞
10.4
12
*
KC1JB
NOMESCO Finland
Miktiocystography with X-ray
16.7
8.6
15
6
KAS20
NOMESCO Finland
Allogenic transplantation of kidney from living donor
+∞
8.6
10
*
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
+∞
8.6
10
*
KAC00
NOMESCO Finland
Nephrectomy
+∞
8.6
10
*
N04.80
ICD-10 Finland
Congenital nephrotic syndrome of the Finnish type
+∞
8.6
10
*
137
Kela drug reimbursment
Uraemia requiring dialysis
+∞
8.6
10
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
+∞
8.6
10
*
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
7.0
8.6
23
23
A12AA04
ATC
calcium carbonate; oral
39.3
8.5
12
*
XKD00
NOMESCO Finland
Uroflowmetry
6.6
7.9
22
23
K06.18
ICD-10 Finland
Another gingival hyperplasia
26.2
7.9
12
*
KGH10
NOMESCO Finland
Operation for phimosis
+∞
7.7
9
*
Z49.2
ICD-10 Finland
Other dialysis
+∞
7.7
9
*
TK820
NOMESCO Finland
Peritoneal dialysis
+∞
7.7
9
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
+∞
7.7
9
*
C08CA01
ATC
amlodipine; oral
9.7
7.4
16
11
ZYB02
NOMESCO Finland
Outreach service at unit of another specialty
9.7
7.4
16
11
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
8.2
7.2
17
14
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
6.8
7.1
19
19
TK800
NOMESCO Finland
Hemodialysis
32.3
6.9
10
*
N18.0
ICD-10 Finland
End-stage renal disease
+∞
6.9
8
*
N04.9
ICD-10 Finland
Nephrotic syndrome, unspecified
+∞
6.9
8
*
U14
ICPC
Kidney symptom/complaint
57.8
6.8
9
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
6.7
6.4
17
17
4AA09
NOMESCO Finland
NA
28.8
6.1
9
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
8.4
6.1
14
11

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: N14_GENITOURINARY – Genitourinary diseases

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).