This is a non-core endpoint: only basic statistics are computed.

Reactive perforating collagenosis

L12_REACPERFCOLLAG

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L87.1 Cause of death: ICD-10 — L87.1 2 out of 7 registries used, show all original rules.	15
4. Check minimum number of events None	15
5. Include endpoints None	15
6. Filter based on genotype QC (FinnGen only)	15

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L87
Name in latin: Collagenosis perforans reactiva

NAME	L12_REACPERFCOLLAG
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L871
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L871
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Reactive perforating collagenosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	107	75	30
Only index persons	87	64	23
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	55.07	53.85	57.15
Only index persons	52.73	52.42	53.62

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	15	10	5
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	53.74	54.40	52.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

8.65

2.58

3.0

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

6.20

2.12

1.8

1.9

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

5.65

2.00

2.2

1.9

—

(3023368) Bacteria identified in Blood by Culture

4.32

1.95

7.4

5.2

—

(40758558) Short blood count panel - Blood

3.77

1.72

11.0

5.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

4.05

1.71

2.5

1.7

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

3.58

1.68

6.0

3.0

ug/l

170.4

82.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

3.64

1.55

2.7

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

3.30

1.41

3.0

3.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.63

1.41

2.6

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.00

1.37

0.0

3.0

—

(3044640) Blood type and Crossmatch panel - Blood

2.96

1.24

3.4

3.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

3.04

1.19

15.0

3.4

—

(42870588) Differential panel, method unspecified - Blood

2.75

1.17

15.9

3.7

—

(40768797) Stomach Pathology biopsy report

3.01

1.09

1.8

1.1

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

2.76

1.04

5.5

1.9

u/l

276.0

121.3

—

(3026008) Bacteria identified in Urine by Culture

2.65

1.01

2.5

2.8

—

(3013512) EKG study

2.54

0.98

1.7

2.2

—

(40768804) Tissue Pathology biopsy report

2.41

0.82

3.3

2.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

2.17

0.81

2.1

3.1

mmol/l

2.3

2.4

—

(3044889) 12 lead EKG panel

2.05

0.55

3.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.99

0.50

4.4

2.2

—

(3000494) Fungus identified in Specimen by Culture

0.00

0.44

0.0

2.9

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.43

0.0

1.4

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

1.74

0.41

26.9

15.7

mmol/l

1.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.50

0.25

4.5

7.6

—

(3000492) Spirometry study

0.00

0.22

0.0

1.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.22

0.0

1.2

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.22

0.0

2.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

1.29

0.11

4.4

3.7

pmol/l

15.4

14.5

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

0.81

0.10

4.0

3.2

u/l

44.4

61.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3047181) Lactate [Moles/volume] in Blood

0.00

0.0

98.4

—

1.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.5

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.0

2.0

—

21.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.8

—

21.8

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.3

—

30.2

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

0.00

0.0

97.4

—

0.7

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.0

3.2

—

0.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_REACPERFCOLLAG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_REACPERFCOLLAG.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_REACPERFCOLLAG – Reactive perforating collagenosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Reactive perforating collagenosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints