bullous pemphigoid: Bullous pemphigoid (BP) is the most common form of autoimmune bullous dermatosis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
280 |
4. Check minimum number of eventsNone |
280 |
5. Include endpointsNone |
280 |
6. Filter based on genotype QC (FinnGen only) |
280 |
Control definitions (FinnGen only)
- Control exclude
- L12_BULLOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF6
Similar endpoints
↥List of similar endpoints to
Other and unspecified pemphigoid
based on the number of shared cases.
Similar with more cases:
- Pemphigoid
- Bullous disorders
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Diseases of the skin and subcutaneous tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2871 | 1684 | 1154 |
| Only index persons | 2032 | 1255 | 777 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 75.93 | 76.22 | 75.54 |
| Only index persons | 75.51 | 76.02 | 74.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 280 | 158 | 122 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 72.29 | 70.58 | 74.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 239
- Matched controls
- 2392
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L12.9
ICD-10 Finland
Pemphigoid, unspecified
+∞
171.1
143
*
L12.0
ICD-10 Finland
Bullous pemphigoid
2669.9
146.9
127
*
L12.8
ICD-10 Finland
Other pemphigoid
+∞
89.3
80
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
14.0
55.8
106
128
D07AD01
ATC
clobetasol; topical
10.1
49.5
116
203
D07AC01
ATC
betamethasone; topical
7.8
47.1
164
522
H02AB06
ATC
prednisolone; systemic
8.8
46.4
197
829
135
Kela drug reimbursment
Pemphigus
+∞
45.3
42
*
L04AX01
ATC
azathioprine; systemic
23.5
40.0
58
32
J04BA02
ATC
dapsone; oral
92.0
29.6
32
*
L12.1
ICD-10 Finland
Cicatricial pemphigoid
+∞
27.6
26
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.4
25.0
89
237
E0000UV
ATC
NA
3.9
22.0
140
634
TQW80
NOMESCO Finland
Local dermatologic skincare
19.6
20.7
31
18
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
7.0
18.9
49
85
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.4
17.9
132
637
D07AC13
ATC
mometasone; topical
3.5
17.4
109
462
XQ848
NOMESCO Finland
Dermatological photography
19.3
17.4
26
15
ECA20
NOMESCO Finland
Biopsy of gingiva
26.7
16.3
22
9
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
16.3
15.7
25
17
EKA10
NOMESCO Finland
Biopsy of cheek
15.8
14.4
23
16
L13.9
ICD-10 Finland
Bullous disorder, unspecified
56.8
14.0
16
*
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.9
12.0
54
168
E000001
ATC
NA
3.2
11.6
73
292
H13.3*L12.9
ICD-10 Finland
Ocular pemphigoid
+∞
11.5
11
*
SBA00
NOMESCO Finland
Microbiological examinations
12.0
10.8
19
17
L12
ICD-10 Finland
Pemphigoid
114.8
10.5
11
*
S99
ICPC
Skin disease other
9.7
9.7
19
21
D07BC01
ATC
betamethasone and antiseptics; topical
3.5
9.6
48
162
D07AB02
ATC
hydrocortisone butyrate; topical
2.5
8.9
87
447
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
6.7
8.2
20
32
D07AB08
ATC
desonide; topical
3.2
8.0
42
147
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.0
7.9
48
185
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
19.1
7.7
11
6
K13.78
ICD-10 Finland
Other change in the oral mucosa
8.3
7.2
15
19
K12.10
ICD-10 Finland
Stomatitis NOS
20.8
7.2
10
5
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
7.1
56
253
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.5
7.0
58
269
L43.8
ICD-10 Finland
Other lichen planus
7.2
6.6
15
22
L12.2
ICD-10 Finland
Chronic bullous disease of childhood
+∞
6.3
6
*
L29.9
ICD-10 Finland
Pruritus, unspecified
6.3
6.1
15
25
R06AE07
ATC
cetirizine; oral
2.0
6.1
102
644
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.3
6.1
66
346
Mortality – FinRegistry
↥Association
Association between endpoint L12_PEMPHIGOID_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGOID_NAS | 1.903 [1.56, 2.32] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.044 |
During the follow-up period (1.1.1998 — 31.12.2019), 546 out of 1148 females with L12_PEMPHIGOID_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGOID_NAS | 2.036 [1.5, 2.76] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 407 out of 732 males with L12_PEMPHIGOID_NAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_PEMPHIGOID_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.148% | 0.367% |
| 5 | 1.004% | 2.224% |
| 10 | 2.413% | 5.341% |
| 15 | 4.364% | 10.53% |
| 20 | 7.81% | 17.358% |
Relationships between endpoints
↥Index endpoint: L12_PEMPHIGOID_NAS – Other and unspecified pemphigoid
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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