phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.
Other acute skin changes due to ultraviolet radiation
DOID EFO Endpoint Browser PheWeb
L12_OTHACUSKINSUN
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
657 |
4. Check minimum number of eventsNone |
657 |
5. Include endpoints |
1325 |
6. Filter based on genotype QC (FinnGen only) |
1325 |
Control definitions (FinnGen only)
- Control exclude
- L12_RADIATIONRELATEDSKIN
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L55-L59
- Name in latin
- Aliae commutationes acutae cutis e radiatione ultraviolacea
Similar endpoints
↥List of similar endpoints to
Other acute skin changes due to ultraviolet radiation
based on the number of shared cases.
Similar with more cases:
- Radiation-related disorders of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12305 | 6288 | 5855 |
| Only index persons | 8709 | 4853 | 3856 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.18 | 0.16 |
| Only index persons | 0.16 | 0.18 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 44.15 | 46.17 | 41.73 |
| Only index persons | 37.54 | 41.00 | 33.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1325 | 715 | 610 |
| Unadjusted period prevalence (%) | 0.26 | 0.24 | 0.27 |
| Median age at first event (years) | 41.04 | 41.23 | 40.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1208
- Matched controls
- 12077
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
69282
ICD-8 Finland
Other eczema and dermatitis, E microbis
+∞
323.0
458
*
L56.4
ICD-10 Finland
Polymorphous light eruption
615.0
258.2
247
5
L56.8
ICD-10 Finland
Other specified acute skin changes due to ultraviolet radiation
2262.0
193.0
182
*
69288
ICD-8 Finland
Other eczema and dermatitis, E causis alii definitis
+∞
87.6
83
*
L57.0
ICD-10 Finland
Actinic keratosis
12.4
85.3
160
147
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.5
83.4
238
440
D07AB08
ATC
desonide; topical
5.3
80.0
275
636
L56.9
ICD-10 Finland
Acute skin change due to ultraviolet radiation, unspecified
401.7
76.7
76
*
D07AC01
ATC
betamethasone; topical
2.9
65.2
564
2764
E0000UV
ATC
NA
2.9
64.3
605
3119
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.6
61.5
336
1175
D07AB02
ATC
hydrocortisone butyrate; topical
2.9
56.0
465
2162
69283
ICD-8 Finland
Other eczema and dermatitis, Dysidroticum (pompholyx)
+∞
54.6
52
*
TQW99
NOMESCO Finland
Other minor procedure on skin
8.2
52.1
121
161
L56.3
ICD-10 Finland
Solar urticaria
+∞
51.4
49
*
E000001
ATC
NA
3.0
51.2
361
1489
D07AC13
ATC
mometasone; topical
2.7
49.2
464
2286
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
14.9
47.8
81
58
L56.2
ICD-10 Finland
Photocontact dermatitis [berloque dermatitis]
162.7
45.1
47
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
4.0
43.8
194
553
D07AA02
ATC
hydrocortisone; topical
3.3
41.0
239
845
R06AE07
ATC
cetirizine; oral
2.3
39.5
581
3499
XQ802
NOMESCO Finland
Epicutan test
5.6
37.1
113
218
ZXC20
NOMESCO Finland
Use of chemical agents
11.5
36.5
69
63
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
22.6
35.9
52
24
69280
ICD-8 Finland
Other eczema and dermatitis, E radiatione solari
+∞
34.5
33
*
H02AB06
ATC
prednisolone; systemic
2.1
32.6
630
4149
E000002
ATC
NA
3.1
31.8
193
695
L57.8
ICD-10 Finland
Other skin changes due to chronic exposure to nonionizing radiation
112.9
30.8
33
*
L20.0
ICD-10 Finland
Besnier prurigo
4.4
29.8
114
280
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.2
28.5
161
550
N05BB01
ATC
hydroxyzine; systemic
3.6
27.1
129
386
L56.0
ICD-10 Finland
Drug phototoxic response
+∞
26.1
25
*
P01BA02
ATC
hydroxychloroquine; oral
3.2
25.8
145
491
D07AD01
ATC
clobetasol; topical
2.4
24.7
234
1089
D07BC01
ATC
betamethasone and antiseptics; topical
2.5
22.2
191
838
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.5
21.5
188
835
69240
ICD-8 Finland
Other eczema and dermatitis, Due to other chemicals
44.2
21.5
26
6
XQ800
NOMESCO Finland
Prick test
3.2
21.1
115
381
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.2
19.9
77
192
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
9.6
19.7
40
43
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
13.0
19.0
33
26
69299
ICD-8 Finland
Other eczema and dermatitis, Due to other and unspecified cause
17.4
18.7
29
17
D07CC01
ATC
betamethasone and antibiotics; topical
2.3
18.7
182
849
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.8
18.5
62
134
E000003
ATC
NA
3.6
18.3
85
249
ZXC50
NOMESCO Finland
Cryotherapy
10.6
18.2
35
34
XQ848
NOMESCO Finland
Dermatological photography
7.0
17.8
44
65
L30.3
ICD-10 Finland
Infective dermatitis
4.0
17.5
71
185
69200
ICD-8 Finland
Other eczema and dermatitis, Due to detergents
42.6
17.3
21
5
TQW80
NOMESCO Finland
Local dermatologic skincare
5.1
17.2
54
109
ZXC10
NOMESCO Finland
Use of laser
5.2
17.0
53
106
R06AX27
ATC
desloratadine; oral
1.9
16.8
304
1832
XQ806
NOMESCO Finland
Minimal Erythema Dose (MED) test
+∞
16.7
16
*
D04.0
ICD-10 Finland
Carcinoma in situ: Skin of lip
172.2
16.5
17
*
D07XC01
ATC
betamethasone, combinations; topical
2.3
16.3
169
812
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
16.1
217
1166
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
8.0
16.1
36
46
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
11.8
16.1
29
25
C44.02
ICD-10 Finland
Spinocellular carcinoma of the lip skin
60.8
15.8
18
*
EAA10
NOMESCO Finland
Excision of lesion of lip
7.1
15.7
38
55
L93.0
ICD-10 Finland
Discoid lupus erythematosus
12.6
14.9
26
21
R06AX22
ATC
ebastine; oral
2.0
14.8
200
1077
6927F
ICD-9 Finland
Contact dermatitis and other eczema, Due to solar radiation[ERUPTIO POLYMORPHICA SOLARIS]
+∞
14.6
14
*
D02AX
ATC
Other emollients and protectives
4.1
14.1
55
139
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
14.0
276
1699
E000007
ATC
NA
2.9
13.9
85
305
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
8.1
13.6
30
38
L56.1
ICD-10 Finland
Drug photoallergic response
+∞
13.6
13
*
6929B
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[ECZEMA INFECTIOSUM]
18.4
13.4
20
11
D11AH01
ATC
tacrolimus; topical
12.3
13.1
23
19
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
7.5
13.0
30
41
ZQZ00
NOMESCO Finland
Treatment of several skin areas
28.7
13.0
17
6
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
12.9
335
2237
R06AE09
ATC
levocetirizine; oral
2.0
12.8
168
889
H02AB07
ATC
prednisone; oral
1.9
12.6
192
1076
69230
ICD-8 Finland
Other eczema and dermatitis, Due to drugs
+∞
12.5
12
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.8
12.4
233
1408
E000006
ATC
NA
2.5
12.3
100
425
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
3.8
12.1
50
134
EAA30
NOMESCO Finland
Partial excision of lower lip
27.0
12.1
16
6
L23.3
ICD-10 Finland
Allergic contact dermatitis due to drugs in contact with skin
11.2
12.0
22
20
D07AC14
ATC
methylprednisolone aceponate; topical
2.9
12.0
71
251
D07XB05
ATC
dexamethasone, combinations; topical
3.9
11.9
49
131
J01DB01
ATC
cefalexin; oral
1.6
11.7
915
7962
L57.9
ICD-10 Finland
Skin changes due to chronic exposure to nonionizing radiation, unspecified
121.0
11.4
12
*
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
5.4
11.4
33
62
68600
ICD-8 Finland
Other local infections of skin and subcutaneous tissue, Pyoderma
35.4
11.3
14
*
D06BX01
ATC
metronidazole; topical
2.1
11.1
125
623
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.1
11.0
60
201
J01DA01
ATC
[U] cefalexin; systemic
1.5
10.9
719
5950
R03AC02
ATC
salbutamol; inhalant
1.5
10.9
578
4558
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
10.9
114
548
T78.4
ICD-10 Finland
Allergy, unspecified
3.0
10.8
61
208
N02AX02
ATC
tramadol; systemic, rectal
1.5
10.7
483
3670
6929X
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[DERMATITITIS ARTEFACTA NUD]
18.0
10.7
16
9
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
8.1
10.6
23
29
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
9.3
10.5
21
23
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
14.3
10.5
17
12
R06.0
ICD-10 Finland
Dyspnoea
1.6
10.4
285
1912
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.3
10.2
98
455
S18
ICPC
Laceration/cut
1.5
10.1
432
3234
11006
ICD-8 Finland
Dermatophytosis, Pedis
40.4
10.0
12
*
J01FF01
ATC
clindamycin; systemic
1.6
9.9
310
2149
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
16.8
9.9
15
9
D05BB02
ATC
acitretin; oral
3.8
9.8
40
107
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.3
9.8
93
430
Z3231
NOMESCO Finland
Registered nurse
1.6
9.8
302
2091
M25.5
ICD-10 Finland
Pain in joint
1.6
9.5
297
2058
L71.8
ICD-10 Finland
Other rosacea
5.7
9.5
26
46
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.0
9.1
111
570
N03AX12
ATC
gabapentin; oral
1.8
8.8
165
986
R96
ICPC
Asthma
2.2
8.7
92
443
J01AA07
ATC
tetracycline; systemic
1.8
8.7
162
967
69009
ICD-8 Finland
Seborrhoeic dermatitis, Unspecified
50.3
8.7
10
*
70908
ICD-8 Finland
Other diseases of skin, Alii definiti
50.3
8.7
10
*
A46
ICD-10 Finland
Erysipelas
1.8
8.6
161
963
ZXC15
NOMESCO Finland
Use of photodynamic technique
11.7
8.6
15
13
L50.3
ICD-10 Finland
Dermatographic urticaria
4.9
8.4
26
54
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
8.4
469
3679
XQ815
NOMESCO Finland
Photoprovocation test
+∞
8.3
8
*
L17
ICPC
Foot/toe symptom/complaint
1.6
8.3
252
1727
R03AC03
ATC
terbutaline; inhalant
1.8
8.2
150
893
S29
ICPC
Skin symptom/complaint other
1.7
8.0
175
1097
L04AX01
ATC
azathioprine; systemic
2.6
8.0
55
216
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
7.9
363
2729
L50.8
ICD-10 Finland
Other urticaria
4.4
7.8
27
63
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
7.8
486
3876
A02BC03
ATC
lansoprazole; oral
1.5
7.7
329
2430
D02BB01
ATC
betacarotene; oral
15.1
7.7
12
8
M54.5
ICD-10 Finland
Low back pain
1.5
7.6
334
2483
L26
ICD-10 Finland
Exfoliative dermatitis
18.5
7.6
11
6
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
5.8
7.5
20
35
N03AX16
ATC
pregabalin; oral
1.5
7.5
248
1730
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.5
7.5
294
2132
J01AA04
ATC
lymecycline; systemic
1.8
7.5
138
822
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
2.4
7.4
59
251
D09AB01
ATC
zinc bandage without supplements; topical
3.5
7.4
32
92
D05AX52
ATC
calcipotriol, combinations; topical
2.4
7.4
63
276
L30.0
ICD-10 Finland
Nummular dermatitis
2.7
7.4
47
176
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
10.9
7.3
13
12
6927X
ICD-9 Finland
Contact dermatitis and other eczema, Due to solar radiation[DERMATITIS PHOTOTOXICA NUD]
+∞
7.3
7
*
C07AB07
ATC
bisoprolol; oral
1.4
7.1
517
4216
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
7.1
220
1512
D02AE01
ATC
carbamide; topical
2.1
7.0
79
395
Z2221
NOMESCO Finland
Medical doctor
1.5
7.0
283
2067
L71.9
ICD-10 Finland
Rosacea, unspecified
3.6
6.9
29
82
S01GX01
ATC
cromoglicic acid; ophthalmic
1.6
6.9
194
1300
G47.3
ICD-10 Finland
Sleep apnoea
1.6
6.9
208
1420
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.7
6.9
45
173
D07AB01
ATC
clobetasone; topical
2.7
6.9
45
173
D11AX14
ATC
[U] tacrolimus; topical
8.3
6.8
14
17
H02AB04
ATC
methylprednisolone; systemic
1.7
6.8
158
1007
D06BB10
ATC
imiquimod; topical
2.9
6.8
39
136
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
5.1
6.8
20
40
R03BA05
ATC
fluticasone; inhalant
1.6
6.8
189
1265
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.3
6.8
60
270
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
6.8
171
1117
N06AX11
ATC
mirtazapine; oral
1.4
6.7
337
2564
R03AK07
ATC
formoterol and budesonide; inhalant
1.6
6.7
196
1326
Z01.2
ICD-10 Finland
Dental examination
1.4
6.6
392
3072
J01AA02
ATC
doxycycline; systemic
1.4
6.6
874
7853
UJF32
NOMESCO Finland
Coloscopy
1.5
6.5
266
1939
R06AX13
ATC
loratadine; oral
1.6
6.5
152
972
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.9
6.4
96
533
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.7
6.4
140
875
8070/3-C44.0
ICD-O-3
Squamous cell carcinoma, NOS, of skin of lip, NOS
70.2
6.4
7
*
J01MA12
ATC
levofloxacin; systemic
1.5
6.4
203
1398
N02BE01
ATC
paracetamol; systemic, rectal
1.4
6.4
952
8709
S87
ICPC
Dermatitis/atopic eczema
3.4
6.3
28
83
C03CA01
ATC
furosemide; systemic
1.4
6.3
330
2523
R03DC03
ATC
montelukast; oral
1.6
6.3
162
1058
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
11.1
6.3
11
10
L16
ICPC
Ankle symptom/complaint
1.8
6.3
99
563
N05BA01
ATC
diazepam; systemic, rectal
1.6
6.3
145
924
D04.2
ICD-10 Finland
Carcinoma in situ: Skin of ear and external auricular canal
18.1
6.3
9
5
WXQ24
NOMESCO Finland
UVB/UVA light therapy
+∞
6.3
6
*
Y1203
ICD-8 Finland
NA
+∞
6.3
6
*
J01FA06
ATC
roxithromycin; oral
1.4
6.2
428
3437
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
6.2
706
6144
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
1.9
6.2
81
431
30300
ICD-8 Finland
Alcoholism, Episodic excessive drinking
4.5
6.2
20
45
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
6.1
154
1005
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
4.1
6.1
22
55
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.6
6.1
140
890
XF400
NOMESCO Finland
ECG with 12 standard connections
1.6
6.0
181
1231
N05CF01
ATC
zopiclone; oral
1.4
6.0
349
2717
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
6.0
326
2507
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
3.5
6.0
26
76
I50.9
ICD-10 Finland
Heart failure, unspecified
1.6
6.0
156
1023
E66.01
ICD-10 Finland
Obesity due to excess calories
2.0
6.0
75
390
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
6.0
394
3131
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHACUSKINSUN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHACUSKINSUN | 0.926 [0.79, 1.09] | 0.361 |
| Birth year | 0.998 [0.99, 1.01] | 0.614 |
During the follow-up period (1.1.1998 — 31.12.2019), 231 out of 2255 females with L12_OTHACUSKINSUN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHACUSKINSUN | 1.147 [0.96, 1.37] | 0.129 |
| Birth year | 0.99 [0.98, 1.0] | 0.046 |
During the follow-up period (1.1.1998 — 31.12.2019), 282 out of 1251 males with L12_OTHACUSKINSUN died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHACUSKINSUN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.099% | 0.216% |
| 5 | 0.486% | 1.37% |
| 10 | 1.451% | 3.59% |
| 15 | 2.824% | 6.989% |
| 20 | 5.077% | 12.099% |
Relationships between endpoints
↥Index endpoint: L12_OTHACUSKINSUN – Other acute skin changes due to ultraviolet radiation
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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