photosensitivity disease: Photosensitivity refers to various symptoms, diseases and conditions caused or aggravated by exposure to sunlight.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
276 |
4. Check minimum number of eventsNone |
276 |
5. Include endpointsNone |
276 |
6. Filter based on genotype QC (FinnGen only) |
276 |
Control definitions (FinnGen only)
- Control exclude
- L12_RADIATIONRELATEDSKIN
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L56
- Name in latin
- Eruptio polymorpha solaris
Similar endpoints
↥List of similar endpoints to
Polymorphous light eruption
based on the number of shared cases.
Similar with more cases:
- Other acute skin changes due to ultraviolet radiation
- Radiation-related disorders of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1773 | 1252 | 515 |
| Only index persons | 1610 | 1179 | 431 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.01 |
| Only index persons | 0.04 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 42.81 | 41.90 | 45.06 |
| Only index persons | 42.03 | 41.75 | 42.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 276 | 227 | 49 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.02 |
| Median age at first event (years) | 44.33 | 42.38 | 53.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 254
- Matched controls
- 2541
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L56.4
ICD-10 Finland
Polymorphous light eruption
+∞
323.0
244
*
XQ802
NOMESCO Finland
Epicutan test
17.8
39.8
64
47
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
9.4
38.2
87
133
L30.9
ICD-10 Finland
Dermatitis, unspecified
6.9
37.8
115
272
D07AB08
ATC
desonide; topical
7.6
32.3
85
158
E0000UV
ATC
NA
4.7
29.4
165
723
D07AB02
ATC
hydrocortisone butyrate; topical
4.6
26.8
127
456
P01BA02
ATC
hydroxychloroquine; oral
7.1
25.6
68
124
D07AC01
ATC
betamethasone; topical
4.1
24.3
138
574
D07AA02
ATC
hydrocortisone; topical
4.7
20.8
81
229
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.2
20.7
53
90
H02AB06
ATC
prednisolone; systemic
3.5
20.0
160
830
E000001
ATC
NA
4.0
20.0
101
363
XQ800
NOMESCO Finland
Prick test
6.3
18.1
51
98
E000002
ATC
NA
4.5
15.9
61
165
D07AC13
ATC
mometasone; topical
3.1
15.4
114
524
R06AE07
ATC
cetirizine; oral
3.0
15.3
156
887
L93.0
ICD-10 Finland
Discoid lupus erythematosus
60.4
15.0
17
*
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
27.0
14.9
20
8
6927F
ICD-9 Finland
Contact dermatitis and other eczema, Due to solar radiation[ERUPTIO POLYMORPHICA SOLARIS]
+∞
14.7
14
*
L20.0
ICD-10 Finland
Besnier prurigo
5.3
14.4
46
102
L56.3
ICD-10 Finland
Solar urticaria
+∞
13.7
13
*
R06AX27
ATC
desloratadine; oral
2.9
13.1
111
543
R06AE09
ATC
levocetirizine; oral
3.6
13.1
67
232
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.1
12.7
53
154
D07AD01
ATC
clobetasol; topical
3.4
10.9
58
202
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
18.8
10.9
16
9
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
6.3
10.0
26
45
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
6.5
9.5
24
40
L57.8
ICD-10 Finland
Other skin changes due to chronic exposure to nonionizing radiation
+∞
9.4
9
*
L56.8
ICD-10 Finland
Other specified acute skin changes due to ultraviolet radiation
+∞
9.4
9
*
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
10.6
9.2
17
17
L30.3
ICD-10 Finland
Infective dermatitis
7.9
9.1
20
27
R06AX22
ATC
ebastine; oral
2.6
8.7
70
321
L56.9
ICD-10 Finland
Acute skin change due to ultraviolet radiation, unspecified
93.0
8.5
9
*
XQ806
NOMESCO Finland
Minimal Erythema Dose (MED) test
93.0
8.5
9
*
L57.0
ICD-10 Finland
Actinic keratosis
10.5
8.1
15
15
J45.9
ICD-10 Finland
Asthma, unspecified
2.7
8.1
59
255
D07BC01
ATC
betamethasone and antiseptics; topical
3.1
7.9
45
165
E000007
ATC
NA
4.2
7.9
29
75
N05BB01
ATC
hydroxyzine; systemic
4.1
7.8
30
81
L50.3
ICD-10 Finland
Dermatographic urticaria
8.1
7.5
16
21
XQ848
NOMESCO Finland
Dermatological photography
8.8
7.4
15
18
TQW80
NOMESCO Finland
Local dermatologic skincare
8.3
7.2
15
19
D02AE01
ATC
carbamide; topical
3.9
7.2
29
82
M25.5
ICD-10 Finland
Pain in joint
2.2
7.0
93
534
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.8
7.0
22
49
F03
ICPC
Eye discharge
4.1
6.9
26
69
L23.3
ICD-10 Finland
Allergic contact dermatitis due to drugs in contact with skin
17.3
6.8
10
6
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.1
6.7
37
133
E000003
ATC
NA
4.1
6.5
24
63
R03AC02
ATC
salbutamol; inhalant
2.0
6.4
146
1036
L71.8
ICD-10 Finland
Other rosacea
11.4
6.4
11
10
D07AC14
ATC
methylprednisolone aceponate; topical
4.0
6.3
24
65
R06AX13
ATC
loratadine; oral
2.4
6.1
57
278
Mortality – FinRegistry
↥Association
Association between endpoint L12_POLYMORPHLIGHTERUPT and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have L12_POLYMORPHLIGHTERUPT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: L12_POLYMORPHLIGHTERUPT – Polymorphous light eruption
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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