phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.
Other and unspecified acute skin changes due to ultraviolet radiation
DOID EFO Endpoint Browser PheWeb
L12_OTHACUSKINSUNNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
954 |
4. Check minimum number of eventsNone |
954 |
5. Include endpointsNone |
954 |
6. Filter based on genotype QC (FinnGen only) |
954 |
Control definitions (FinnGen only)
- Control exclude
- L12_RADIATIONRELATEDSKIN
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified acute skin changes due to ultraviolet radiation
based on the number of shared cases.
Similar with more cases:
- Other acute skin changes due to ultraviolet radiation
- Radiation-related disorders of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9789 | 4557 | 5076 |
| Only index persons | 6433 | 3241 | 3192 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.13 | 0.14 |
| Only index persons | 0.12 | 0.12 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 44.43 | 47.31 | 41.57 |
| Only index persons | 35.57 | 39.46 | 31.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 954 | 426 | 528 |
| Unadjusted period prevalence (%) | 0.19 | 0.15 | 0.23 |
| Median age at first event (years) | 38.16 | 38.10 | 38.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 871
- Matched controls
- 8708
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
69282
ICD-8 Finland
Other eczema and dermatitis, E microbis
+∞
323.0
458
*
L56.8
ICD-10 Finland
Other specified acute skin changes due to ultraviolet radiation
+∞
197.6
182
*
69288
ICD-8 Finland
Other eczema and dermatitis, E causis alii definitis
+∞
88.0
83
*
L57.0
ICD-10 Finland
Actinic keratosis
13.8
79.9
143
122
L56.9
ICD-10 Finland
Acute skin change due to ultraviolet radiation, unspecified
273.0
74.6
75
*
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
32.9
61.5
81
27
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.4
60.0
173
326
69283
ICD-8 Finland
Other eczema and dermatitis, Dysidroticum (pompholyx)
+∞
54.8
52
*
TQW99
NOMESCO Finland
Other minor procedure on skin
10.3
52.8
108
118
D07AB08
ATC
desonide; topical
4.6
46.3
179
463
E0000UV
ATC
NA
2.7
40.4
413
2187
ZXC20
NOMESCO Finland
Use of chemical agents
13.6
38.7
68
54
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
31.1
37.8
50
17
D07AC01
ATC
betamethasone; topical
2.6
37.5
384
2009
D07AB02
ATC
hydrocortisone butyrate; topical
2.7
34.7
316
1529
69280
ICD-8 Finland
Other eczema and dermatitis, E radiatione solari
+∞
34.6
33
*
E000001
ATC
NA
2.8
30.9
239
1035
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.0
30.1
199
777
D07AC13
ATC
mometasone; topical
2.5
30.0
313
1603
L57.8
ICD-10 Finland
Other skin changes due to chronic exposure to nonionizing radiation
257.1
24.8
25
*
ZXC10
NOMESCO Finland
Use of laser
8.6
23.7
52
64
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.4
23.6
125
412
R06AE07
ATC
cetirizine; oral
2.1
22.2
382
2384
L20.0
ICD-10 Finland
Besnier prurigo
5.2
21.6
69
142
L56.4
ICD-10 Finland
Polymorphous light eruption
+∞
20.9
20
*
69240
ICD-8 Finland
Other eczema and dermatitis, Due to other chemicals
38.2
20.9
26
7
N05BB01
ATC
hydroxyzine; systemic
3.7
20.6
93
269
69299
ICD-8 Finland
Other eczema and dermatitis, Due to other and unspecified cause
23.0
20.5
29
13
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.6
19.9
95
288
E000002
ATC
NA
2.9
19.5
128
487
D07AA02
ATC
hydrocortisone; topical
2.6
18.6
145
611
EAA10
NOMESCO Finland
Excision of lesion of lip
10.1
18.3
36
37
D07AD01
ATC
clobetasol; topical
2.5
18.0
161
733
69200
ICD-8 Finland
Other eczema and dermatitis, Due to detergents
53.7
18.0
21
*
D04.0
ICD-10 Finland
Carcinoma in situ: Skin of lip
+∞
17.8
17
*
ZXC50
NOMESCO Finland
Cryotherapy
11.0
17.1
32
30
H02AB06
ATC
prednisolone; systemic
1.9
16.9
423
2942
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
11.4
16.8
31
28
C44.02
ICD-10 Finland
Spinocellular carcinoma of the lip skin
91.8
16.6
18
*
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
13.2
15.7
27
21
EAA30
NOMESCO Finland
Partial excision of lower lip
162.8
15.5
16
*
6929B
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[ECZEMA INFECTIOSUM]
29.2
15.2
20
7
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.5
14.2
122
541
E000003
ATC
NA
3.9
14.1
59
161
XQ802
NOMESCO Finland
Epicutan test
4.6
13.8
48
110
L30.3
ICD-10 Finland
Infective dermatitis
4.2
13.1
49
121
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
8.6
12.3
26
31
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.8
12.3
40
86
68600
ICD-8 Finland
Other local infections of skin and subcutaneous tissue, Pyoderma
47.3
11.9
14
*
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
9.8
11.8
23
24
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.7
11.7
51
145
6929X
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[DERMATITITIS ARTEFACTA NUD]
65.8
11.6
13
*
E000007
ATC
NA
3.3
11.2
57
183
D07XC01
ATC
betamethasone, combinations; topical
2.1
11.2
126
635
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
9.7
10.8
21
22
69230
ICD-8 Finland
Other eczema and dermatitis, Due to drugs
60.7
10.6
12
*
XQ800
NOMESCO Finland
Prick test
3.0
10.6
61
213
H02AB07
ATC
prednisone; oral
2.0
10.6
145
789
J01DB01
ATC
cefalexin; oral
1.7
10.5
653
5565
D11AH01
ATC
tacrolimus; topical
14.4
10.5
17
12
D07BC01
ATC
betamethasone and antiseptics; topical
2.0
10.0
128
679
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
16.9
9.9
15
9
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
26.3
9.8
13
5
D02AX
ATC
Other emollients and protectives
4.2
9.7
36
89
ZQZ00
NOMESCO Finland
Treatment of several skin areas
13.6
9.7
16
12
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.4
9.5
79
344
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
101.1
9.4
10
*
69009
ICD-8 Finland
Seborrhoeic dermatitis, Unspecified
101.1
9.4
10
*
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
17.8
9.4
14
8
11006
ICD-8 Finland
Dermatophytosis, Pedis
30.4
9.4
12
*
D07CC01
ATC
betamethasone and antibiotics; topical
2.0
9.0
122
660
E000006
ATC
NA
2.4
8.5
71
311
70908
ICD-8 Finland
Other diseases of skin, Alii definiti
90.9
8.4
9
*
TQW80
NOMESCO Finland
Local dermatologic skincare
4.1
8.3
31
78
J01FF01
ATC
clindamycin; systemic
1.6
8.2
222
1499
R06.0
ICD-10 Finland
Dyspnoea
1.7
8.2
215
1442
D07XB05
ATC
dexamethasone, combinations; topical
3.9
8.1
32
85
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
2.7
8.0
54
208
J01AA04
ATC
lymecycline; systemic
2.1
8.0
95
489
R03AC03
ATC
terbutaline; inhalant
1.9
7.8
113
628
A46
ICD-10 Finland
Erysipelas
1.8
7.7
135
803
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.8
7.5
46
170
J01AA07
ATC
tetracycline; systemic
1.9
7.5
109
603
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
7.5
142
863
P01BA02
ATC
hydroxychloroquine; oral
2.3
7.5
65
291
R03AC02
ATC
salbutamol; inhalant
1.5
7.3
398
3149
ZXC15
NOMESCO Finland
Use of photodynamic technique
11.0
7.3
13
12
69830
ICD-8 Finland
Pruritus and related conditions, Lichenification and lichen simplex chronicus
+∞
7.3
7
*
6927X
ICD-9 Finland
Contact dermatitis and other eczema, Due to solar radiation[DERMATITIS PHOTOTOXICA NUD]
+∞
7.3
7
*
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.6
7.1
195
1316
Z2221
NOMESCO Finland
Medical doctor
1.6
7.1
214
1481
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
7.1
133
806
D06BX01
ATC
metronidazole; topical
2.1
7.1
84
430
D05BB02
ATC
acitretin; oral
3.7
7.0
29
81
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
7.0
169
1104
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
7.6
6.9
15
20
L40.0
ICD-10 Finland
Psoriasis vulgaris
2.8
6.9
44
165
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
6.8
241
1728
XQ848
NOMESCO Finland
Dermatological photography
4.1
6.8
25
63
N02AX02
ATC
tramadol; systemic, rectal
1.5
6.7
346
2697
J01DA01
ATC
[U] cefalexin; systemic
1.4
6.5
505
4254
D07AC14
ATC
methylprednisolone aceponate; topical
2.6
6.5
46
185
D07AB01
ATC
clobetasone; topical
3.2
6.5
31
98
8070/3-C44.0
ICD-O-3
Squamous cell carcinoma, NOS, of skin of lip, NOS
70.3
6.4
7
*
6929A
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[ECZEMA NUMMULARE]
70.3
6.4
7
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
6.4
150
971
S18
ICPC
Laceration/cut
1.5
6.3
317
2450
T78.4
ICD-10 Finland
Allergy, unspecified
2.8
6.3
37
134
30300
ICD-8 Finland
Alcoholism, Episodic excessive drinking
4.8
6.2
19
40
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
2.0
6.2
78
409
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
5.8
6.2
16
28
L30.0
ICD-10 Finland
Nummular dermatitis
2.9
6.1
35
123
Z3231
NOMESCO Finland
Registered nurse
1.5
6.1
218
1562
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
6.0
60
289
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHACUSKINSUNNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHACUSKINSUNNAS | 0.923 [0.74, 1.15] | 0.471 |
| Birth year | 0.993 [0.98, 1.0] | 0.128 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 829 females with L12_OTHACUSKINSUNNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHACUSKINSUNNAS | 1.121 [0.91, 1.38] | 0.29 |
| Birth year | 0.983 [0.97, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 194 out of 643 males with L12_OTHACUSKINSUNNAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHACUSKINSUNNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.185% |
| 5 | 0.486% | 1.079% |
| 10 | 1.204% | 2.838% |
| 15 | 2.335% | 5.413% |
| 20 | 4.209% | 9.097% |
Relationships between endpoints
↥Index endpoint: L12_OTHACUSKINSUNNAS – Other and unspecified acute skin changes due to ultraviolet radiation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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