obsolete_alopecia:
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
228 |
4. Check minimum number of eventsNone |
228 |
5. Include endpoints |
266 |
6. Filter based on genotype QC (FinnGen only) |
266 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L60-L75
- Name in latin
- Alopecia cicatrisans
Similar endpoints
↥List of similar endpoints to
Cicatricial alopecia [scarring hair loss]
based on the number of shared cases.
Similar with more cases:
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1938 | 1201 | 729 |
| Only index persons | 1789 | 1155 | 634 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.04 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 48.69 | 56.69 | 35.57 |
| Only index persons | 48.37 | 56.89 | 32.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 266 | 199 | 67 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.03 |
| Median age at first event (years) | 54.51 | 58.16 | 43.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 233
- Matched controls
- 2330
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L66.1
ICD-10 Finland
Lichen planopilaris
+∞
96.8
86
*
L66.9
ICD-10 Finland
Cicatricial alopecia, unspecified
+∞
55.5
51
*
D07AD01
ATC
clobetasol; topical
9.7
50.8
129
265
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
11.4
41.3
85
112
70404
ICD-8 Finland
Diseases of hair and hair follicles, Folliculitis NUD
+∞
36.4
34
*
L66.2
ICD-10 Finland
Folliculitis decalvans
+∞
33.1
31
*
L66.8
ICD-10 Finland
Other cicatricial alopecia
+∞
33.1
31
*
P01BA02
ATC
hydroxychloroquine; oral
7.9
29.4
74
129
D07AC01
ATC
betamethasone; topical
4.2
23.5
134
566
L66.0
ICD-10 Finland
Pseudopelade
+∞
19.0
18
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.7
14.1
71
247
D07AC13
ATC
mometasone; topical
3.1
13.8
101
463
L43.8
ICD-10 Finland
Other lichen planus
12.6
13.7
24
21
J01AA04
ATC
lymecycline; systemic
4.4
13.5
52
142
D07XC01
ATC
betamethasone, combinations; topical
4.1
13.1
55
162
E0000UV
ATC
NA
2.8
12.5
123
668
L63.9
ICD-10 Finland
Alopecia areata, unspecified
+∞
11.6
11
*
D10BA01
ATC
isotretinoin; oral
7.1
11.5
28
44
D07AB02
ATC
hydrocortisone butyrate; topical
2.7
10.9
95
468
L66.4
ICD-10 Finland
Folliculitis ulerythematosa reticulata
+∞
10.5
10
*
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
12.1
10.2
18
16
L71.8
ICD-10 Finland
Other rosacea
57.4
9.7
11
*
H04.10
ICD-10 Finland
Dry eye syndrome
3.9
9.6
41
122
XQ848
NOMESCO Finland
Dermatological photography
8.9
9.3
19
23
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
25.2
9.0
12
5
L43.9
ICD-10 Finland
Lichen planus, unspecified
9.6
8.7
17
19
L93.0
ICD-10 Finland
Discoid lupus erythematosus
28.7
8.6
11
*
L71.9
ICD-10 Finland
Rosacea, unspecified
11.4
7.4
13
12
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.7
7.3
20
38
L73.8
ICD-10 Finland
Other specified follicular disorders
+∞
6.3
6
*
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
13.0
6.1
10
8
D05BB02
ATC
acitretin; oral
5.8
6.1
16
29
Mortality – FinRegistry
↥Association
Association between endpoint L12_HAIRLOSSSCAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_HAIRLOSSSCAR | 1.016 [0.78, 1.33] | 0.91 |
| Birth year | 0.996 [0.99, 1.0] | 0.377 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 867 females with L12_HAIRLOSSSCAR died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_HAIRLOSSSCAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | No data |
| 5 | 0.624% | No data |
| 10 | 1.506% | No data |
| 15 | 3.054% | No data |
| 20 | 5.469% | No data |
Relationships between endpoints
↥Index endpoint: L12_HAIRLOSSSCAR – Cicatricial alopecia [scarring hair loss]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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