androgenetic alopecia:
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
84 |
4. Check minimum number of eventsNone |
84 |
5. Include endpointsNone |
84 |
6. Filter based on genotype QC (FinnGen only) |
84 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified cicatricial alopecia
based on the number of shared cases.
Similar with more cases:
- Cicatricial alopecia [scarring hair loss]
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 559 | 452 | 105 |
| Only index persons | 544 | 440 | 104 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.02 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 53.97 | 58.53 | 34.66 |
| Only index persons | 54.40 | 58.89 | 35.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 84 | 76 | 8 |
| Unadjusted period prevalence (%) | 0.02 | 0.03 | 0.00 |
| Median age at first event (years) | 61.58 | 62.58 | 52.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 73
- Matched controls
- 731
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L66.9
ICD-10 Finland
Cicatricial alopecia, unspecified
+∞
59.8
49
*
L66.8
ICD-10 Finland
Other cicatricial alopecia
+∞
34.0
30
*
D07AD01
ATC
clobetasol; topical
17.8
26.2
50
79
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
11.0
14.2
29
41
D07AC01
ATC
betamethasone; topical
6.2
12.2
49
180
P01BA02
ATC
hydroxychloroquine; oral
9.2
11.8
26
41
L66.1
ICD-10 Finland
Lichen planopilaris
+∞
11.8
11
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.1
7.8
27
75
D07XC01
ATC
betamethasone, combinations; topical
5.3
6.5
20
48
L65.9
ICD-10 Finland
Nonscarring hair loss, unspecified
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint L12_HAIRLOSS_SCARNAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have L12_HAIRLOSS_SCARNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: L12_HAIRLOSS_SCARNAS – Other and unspecified cicatricial alopecia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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