Other epidermal thickening

L12_EPIDERMALTHICKOTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L85
  • Cause of death: ICD-10 L85

2 out of 7 registries used, show all original rules.

1573

4. Check minimum number of events

None

1573

5. Include endpoints

1633

6. Filter based on genotype QC (FinnGen only)

1633

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L80-L99
Name in latin
Alia crassificatio epidermidis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11143 5842 5246
Only index persons 10074 5399 4675
Unadjusted period prevalence (%)
Whole population 0.16 0.17 0.15
Only index persons 0.19 0.20 0.18
Median age at first event (years)
Whole population 54.82 55.17 54.43
Only index persons 54.88 55.18 54.53

-FinnGen-

Key figures

All Female Male
Number of individuals 1633 883 750
Unadjusted period prevalence (%) 0.31 0.30 0.33
Median age at first event (years) 58.28 55.01 62.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1465
Matched controls
14648
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L85.9
ICD-10 Finland
Epidermal thickening, unspecified
2189.8
323.0
330
*
L85.3
ICD-10 Finland
Xerosis cutis
268.2
323.0
448
24
L85.89
ICD-10 Finland
Other specified epidermal thickening
2759.8
260.2
244
*
L85.81
ICD-10 Finland
Keratosis pilaris
+∞
211.7
198
*
E0000UV
ATC
NA
5.7
208.5
973
3765
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
9.2
173.3
400
575
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.6
150.9
534
1362
L85.80
ICD-10 Finland
Hudhorn
199.3
140.3
144
8
L85.1
ICD-10 Finland
Acquired keratosis [keratoderma] palmaris et plantaris
1387.8
132.4
127
*
D02AE01
ATC
carbamide; topical
8.4
125.7
301
439
D07XC01
ATC
betamethasone, combinations; topical
5.8
122.6
398
884
D05BB02
ATC
acitretin; oral
18.4
112.8
179
110
D07AC01
ATC
betamethasone; topical
3.4
101.2
709
3151
TQW80
NOMESCO Finland
Local dermatologic skincare
15.9
95.1
159
111
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
14.3
89.2
156
121
L84
ICD-10 Finland
Corns and callosities
13.3
83.8
151
125
E000001
ATC
NA
3.5
80.0
476
1792
D07AD01
ATC
clobetasol; topical
3.8
71.3
355
1142
L57.0
ICD-10 Finland
Actinic keratosis
4.7
66.8
253
628
E000003
ATC
NA
6.9
61.0
161
258
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
24.7
57.7
82
35
R4180
NOMESCO Finland
Podiatric therapy
22.5
56.8
83
39
D07AC13
ATC
mometasone; topical
2.6
53.7
534
2671
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
28.0
52.6
72
27
D07AB08
ATC
desonide; topical
3.7
52.4
252
769
E000006
ATC
NA
4.6
51.5
194
472
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
4.0
51.1
227
646
D07AB02
ATC
hydrocortisone butyrate; topical
2.5
46.5
495
2524
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.2
44.1
264
945
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.1
44.0
273
1002
H02AB06
ATC
prednisolone; systemic
2.2
42.5
743
4735
S18
ICPC
Laceration/cut
2.2
41.6
678
4180
B07.9
ICD-10 Finland
Verruca simplex
6.8
41.4
108
169
D07BC01
ATC
betamethasone and antiseptics; topical
3.1
40.2
247
895
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.4
38.8
399
1965
A46
ICD-10 Finland
Erysipelas
2.8
36.5
264
1058
E000002
ATC
NA
3.1
36.2
226
823
L30.8
ICD-10 Finland
Other specified dermatitis
7.8
36.2
85
114
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
35.6
677
4357
B35.3
ICD-10 Finland
Tinea pedis
5.3
35.0
112
227
L82
ICD-10 Finland
Seborrhoeic keratosis
2.9
34.9
245
962
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.7
34.8
268
1118
L30.4
ICD-10 Finland
Erythema intertrigo
13.2
34.5
61
48
L40.0
ICD-10 Finland
Psoriasis vulgaris
4.9
34.1
117
256
C03CA01
ATC
furosemide; systemic
2.2
34.0
459
2546
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.7
33.7
155
448
RJ411
NOMESCO Finland
NA
41.1
32.2
40
10
SPAT1153
SPAT
Removal of sutures
2.1
31.7
508
3011
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
31.7
467
2675
S97
ICPC
Chronic ulcer skin
4.7
31.6
111
249
L04AA06
ATC
mycophenolic acid; systemic
10.2
31.6
63
64
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
31.5
248
1042
70119
ICD-8 Finland
Other hypertrophic and atrophic conditions of the skin, Keratosis, hyperkeratosis alia sive NUD
+∞
31.4
30
*
XQ848
NOMESCO Finland
Dermatological photography
7.1
31.2
78
115
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.3
30.9
97
192
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
6.5
30.2
80
128
D07AA02
ATC
hydrocortisone; topical
2.6
30.0
249
1076
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.0
29.9
192
709
L30.3
ICD-10 Finland
Infective dermatitis
5.4
29.6
92
180
J01FF01
ATC
clindamycin; systemic
2.1
29.4
423
2383
J01DB01
ATC
cefalexin; oral
2.1
29.3
1196
9933
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.6
29.0
233
986
127
Kela drug reimbursment
Transplant complication
10.0
28.8
58
60
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
42.1
26.8
33
8
E000007
ATC
NA
3.9
26.7
116
318
L85.2
ICD-10 Finland
Keratosis punctata (palmaris et plantaris)
+∞
26.1
25
*
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.9
25.9
87
186
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
25.9
487
3019
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
3.0
25.8
160
575
L04AD01
ATC
ciclosporin; systemic
7.3
25.5
62
88
A12AA04
ATC
calcium carbonate; oral
9.3
25.4
53
59
SPAT1301
SPAT
No procedures
1.9
25.4
496
3112
L04AX01
ATC
azathioprine; systemic
4.3
25.0
97
240
-
ICD-10 Finland
NA
6.0
25.0
70
121
L04AA01
ATC
[U] ciclosporin; systemic
9.4
24.6
51
56
XQ802
NOMESCO Finland
Epicutan test
4.1
24.5
99
255
D05AX02
ATC
calcipotriol; topical
4.0
24.1
99
259
D02AX
ATC
Other emollients and protectives
4.6
23.7
84
190
N02BE01
ATC
paracetamol; systemic, rectal
2.0
23.7
1231
10577
D05AX52
ATC
calcipotriol, combinations; topical
3.4
23.5
119
371
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.2
23.2
63
105
D09AB01
ATC
zinc bandage without supplements; topical
6.9
23.0
58
87
L29.9
ICD-10 Finland
Pruritus, unspecified
5.8
23.0
66
118
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.8
23.0
66
118
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
22.9
593
4053
B35.1
ICD-10 Finland
Tinea unguium
3.4
22.1
111
343
Z94.0
ICD-10 Finland
Kidney transplant status
10.3
21.9
43
43
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
21.6
186
811
E000004
ATC
NA
6.1
21.5
59
100
R23.8
ICD-10 Finland
Other and unspecified skin changes
2.2
21.5
240
1190
D01BA02
ATC
terbinafine; oral; topical
1.9
21.1
368
2186
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.9
21.1
408
2513
L17
ICPC
Foot/toe symptom/complaint
1.9
21.1
374
2237
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
6.8
21.0
53
80
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
21.8
20.8
30
14
RJ421
NOMESCO Finland
NA
37.8
20.8
26
7
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
5.0
20.5
67
140
SPAT1312
SPAT
General health counselling
1.8
20.3
489
3235
TK800
NOMESCO Finland
Hemodialysis
5.5
20.2
60
112
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.1
20.1
116
397
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
13.9
20.1
34
25
R06.0
ICD-10 Finland
Dyspnoea
1.9
20.0
362
2175
L30.0
ICD-10 Finland
Nummular dermatitis
4.4
20.0
74
176
A02BC02
ATC
pantoprazole; systemic
1.7
20.0
902
7149
R06AE07
ATC
cetirizine; oral
1.7
19.7
607
4309
SPAT1263
SPAT
Sampling
1.7
19.5
615
4394
D07CC01
ATC
betamethasone and antibiotics; topical
2.2
19.4
207
1002
J01DA01
ATC
[U] cefalexin; systemic
1.7
19.3
883
6993
A11CC03
ATC
alfacalcidol; systemic
5.3
19.0
58
112
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
18.8
412
2631
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
18.8
504
3425
UJF32
NOMESCO Finland
Coloscopy
1.8
18.8
383
2387
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
18.3
247
1324
N03AX12
ATC
gabapentin; oral
2.1
18.2
226
1168
A10AE04
ATC
insulin glargine; parenteral
2.5
18.1
149
634
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
7.6
18.0
42
57
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
7.8
17.9
41
54
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.5
17.9
87
263
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.9
17.9
113
411
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.6
17.8
132
531
D01AE15
ATC
terbinafine; topical
2.8
17.7
119
447
Q82.82
ICD-10 Finland
Inherited keratosis palmaris et plantaris
+∞
17.7
17
*
L20.0
ICD-10 Finland
Besnier prurigo
2.9
17.6
114
419
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
12.2
17.3
31
26
L91.0
ICD-10 Finland
Hypertrophic scar
24.3
17.3
24
10
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
17.3
550
3904
N02AX02
ATC
tramadol; systemic, rectal
1.6
17.2
579
4171
H02AB04
ATC
methylprednisolone; systemic
2.1
17.1
224
1181
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
5.4
17.0
51
97
ZXC50
NOMESCO Finland
Cryotherapy
4.2
16.9
64
156
R60.0
ICD-10 Finland
Localized oedema
2.3
16.7
168
790
XQ800
NOMESCO Finland
Prick test
2.7
16.6
118
463
RJ420
NOMESCO Finland
NA
27.9
16.5
22
8
137
Kela drug reimbursment
Uraemia requiring dialysis
10.9
16.5
31
29
J01MA02
ATC
ciprofloxacin; systemic
1.6
16.5
530
3759
R50.9
ICD-10 Finland
Fever, unspecified
2.1
16.4
212
1113
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.2
16.4
173
831
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.1
16.3
194
983
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
16.3
313
1902
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
5.1
16.2
51
103
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
16.1
340
2130
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
2.8
16.0
107
404
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.6
16.0
117
466
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
15.9
590
4334
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
15.9
449
3064
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
14.7
15.9
26
18
NH3BG
NOMESCO Finland
MRI of foot
15.9
15.7
25
16
D01AE16
ATC
amorolfine; topical
2.2
15.7
173
847
L89
ICD-10 Finland
Decubitus ulcer and pressure area
17.4
15.6
24
14
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.8
15.6
104
392
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
6.3
15.5
41
67
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.9
15.5
240
1350
D01AC02
ATC
miconazole; topical
2.4
15.4
137
607
RJ410
NOMESCO Finland
NA
23.6
15.1
21
9
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.9
15.0
92
329
J01AA02
ATC
doxycycline; systemic
1.6
14.9
1061
9081
S20
ICPC
Corn/callosity
5.0
14.8
47
96
G47.3
ICD-10 Finland
Sleep apnoea
1.8
14.8
288
1753
C07AB07
ATC
bisoprolol; oral
1.6
14.7
631
4776
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
7.8
14.6
33
43
L85.0
ICD-10 Finland
Acquired ichthyosis
+∞
14.6
14
*
P01AB01
ATC
metronidazole; oral, rectal
1.6
14.6
520
3755
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
12.0
14.6
26
22
J01CE08
ATC
benzathine benzylpenicillin; parenteral
8.2
14.6
32
40
L50.3
ICD-10 Finland
Dermatographic urticaria
5.6
14.6
42
77
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.4
14.5
72
222
J02AC01
ATC
fluconazole; systemic
1.6
14.5
508
3652
NH3CG
NOMESCO Finland
Extensive MRI of foot
15.5
14.4
23
15
A10AA01
ATC
NA
4.4
14.4
52
122
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
3.8
14.4
60
161
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.3
14.4
138
633
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
6.7
14.4
36
55
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.5
14.4
117
495
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.2
14.3
74
236
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.0
14.3
84
293
R03BB04
ATC
tiotropium bromide; inhalant
2.2
14.2
154
749
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
14.1
500
3603
V03AE01
ATC
polystyrene sulfonate; oral
7.3
14.0
33
46
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
14.0
254
1505
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
11.0
14.0
26
24
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.7
13.9
330
2131
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
13.8
177
925
R03AC02
ATC
salbutamol; inhalant
1.5
13.8
703
5512
AA1AD
NOMESCO Finland
CT of head and brain
1.7
13.7
317
2030
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.1
13.7
167
853
RJ190
NOMESCO Finland
NA
34.4
13.5
17
5
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.6
13.5
460
3273
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
6.9
13.5
33
49
SPAT1229
SPAT
Assessment of need for aid
2.4
13.5
119
523
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
13.4
185
993
SPAT1254
SPAT
Administration of medicine
1.9
13.4
220
1261
M79.6
ICD-10 Finland
Pain in limb
1.6
13.3
467
3342
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
13.3
765
6141
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
10.6
13.2
25
24
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
13.9
13.2
22
16
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
13.2
222
1280
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.0
13.2
78
273
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.6
13.2
368
2482
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
13.2
365
2457
RJ511
NOMESCO Finland
NA
40.4
13.2
16
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.2
13.2
140
675
H03AA01
ATC
levothyroxine sodium; systemic
1.7
13.1
304
1945
A10AA02
ATC
NA
3.5
13.1
60
175
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
13.1
330
2165
SPAT1262
SPAT
Handing over of treatment supplies
1.8
13.0
254
1541
SPAT1101
SPAT
Orthostatic test
2.9
12.9
79
281
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
3.5
12.9
59
172
R06AX27
ATC
desloratadine; oral
1.6
12.9
355
2386
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
8.1
12.8
28
35
PD4CC
NOMESCO Finland
Very extensive arterigography of lower extremity with X-ray
11.7
12.8
23
20
J02AC02
ATC
itraconazole; systemic
1.8
12.8
239
1431
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
10.6
12.8
24
23
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
5.0
12.7
40
82
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.7
12.6
311
2026
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.7
12.6
315
2058
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
12.5
210
1211
M25.5
ICD-10 Finland
Pain in joint
1.6
12.5
364
2475
70115
ICD-8 Finland
Other hypertrophic and atrophic conditions of the skin, Ichthyosis
+∞
12.5
12
*
B05DA
ATC
Isotonic solutions
10.1
12.5
24
24
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
9.4
12.5
25
27
SPAT1216
SPAT
Assessment of functional ability
1.8
12.5
211
1221
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.6
12.4
390
2707
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
4.1
12.3
47
117
M54.5
ICD-10 Finland
Low back pain
1.6
12.3
424
3012
A10AE05
ATC
insulin detemir; parenteral
2.6
12.2
90
359
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
2.1
12.1
135
663
103
Kela drug reimbursment
Diabetes, insulin-treated
1.6
12.1
356
2426
ZZA00
NOMESCO Finland
Split skin graft
3.9
12.0
49
130
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
3.9
12.0
49
130
S76
ICPC
Skin infection other
2.7
12.0
84
328
ZX120
NOMESCO Finland
Intravenous
2.1
12.0
134
660
Z49.1
ICD-10 Finland
Extracorporeal dialysis
5.6
12.0
34
62
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
13.5
11.9
20
15
B03XA01
ATC
erythropoietin; parenteral
7.6
11.9
27
36
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.5
11.9
90
368
S29
ICPC
Skin symptom/complaint other
1.8
11.8
229
1382
SPAT1255
SPAT
Intravenous administration of medicine
2.4
11.8
100
432
E66.8
ICD-10 Finland
Other obesity
2.8
11.7
76
281
A41.9
ICD-10 Finland
Sepsis, unspecified
3.3
11.7
59
186
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
3.6
11.6
51
144
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.0
11.6
150
782
RJ422
NOMESCO Finland
NA
65.5
11.6
13
*
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
19.1
11.6
17
9
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
11.2
11.5
21
19
D06BB10
ATC
imiquimod; topical
2.8
11.5
73
269
7011A
ICD-9 Finland
Other hypertrophic and atrophic conditions of skin, Keratoderma, acquired[KERATODERMA PALMARE ET PLANTARE ACQUISITUM]
+∞
11.5
11
*
N03AX16
ATC
pregabalin; oral
1.6
11.5
303
2002
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
11.4
149
782
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
4.7
11.4
38
83
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.9
11.4
46
121
B05DB
ATC
Hypertonic solutions
11.9
11.3
20
17
TQW99
NOMESCO Finland
Other minor procedure on skin
2.7
11.3
75
283
M04AA01
ATC
allopurinol; systemic
1.9
11.3
173
965
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.1
11.2
137
698
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
11.2
124
610
NHQ40
NOMESCO Finland
Amputation of toe
6.9
11.2
27
40
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
11.1
134
683
S21
ICPC
Skin texture symptom/complaint
1.9
11.1
169
941
H3603, E103
ICD-10 Finland
NA
7.1
11.1
26
37
L20.8
ICD-10 Finland
Other atopic dermatitis
7.1
11.1
26
37
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.9
11.0
157
852
C07AB02
ATC
metoprolol; systemic
1.6
11.0
281
1842
A06AD11
ATC
lactulose; oral
1.8
11.0
200
1185
M14.6*E10.6
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic neuropathic
43.6
10.9
13
*
J01FA06
ATC
roxithromycin; oral
1.5
10.9
527
4017
M48.0
ICD-10 Finland
Spinal stenosis
1.9
10.8
169
947
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
15.6
10.8
17
11
SPAT1147
SPAT
Destruction of skin lesion with external methods
4.4
10.8
38
88
SPAT1325
SPAT
Vaccination
1.5
10.8
484
3627
N18.8
ICD-10 Finland
Other chronic renal failure
3.5
10.8
50
148
L73.8
ICD-10 Finland
Other specified follicular disorders
7.2
10.8
25
35
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
9.7
10.8
21
22
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
5.4
10.7
31
58
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
10.7
262
1691
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.5
10.7
49
144
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.3
10.7
101
460
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
13.0
10.7
18
14
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
10.6
202
1211
T89
ICPC
Diabetes insulin dependent
3.1
10.6
57
189
SPAT1310
SPAT
Counselling related to known health issue
1.5
10.6
438
3223
C08CA01
ATC
amlodipine; oral
1.5
10.5
459
3416
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.1
10.5
121
603
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
10.5
239
1513
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
4.3
10.5
38
91
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.0
10.4
141
752
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
10.4
123
623
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
16.2
10.4
16
10
A02BC03
ATC
lansoprazole; oral
1.5
10.3
376
2686
L28.1
ICD-10 Finland
Prurigo nodularis
8.3
10.3
22
27
A02BC05
ATC
esomeprazole; systemic
1.5
10.3
508
3877
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.1
10.3
118
589
C02AC05
ATC
moxonidine; oral
2.7
10.3
69
263
J01MA14
ATC
moxifloxacin; systemic
2.1
10.3
124
631
J45.1
ICD-10 Finland
Nonallergic asthma
2.2
10.3
104
492
B35.4
ICD-10 Finland
Tinea corporis
6.3
10.2
26
42
SPAT1210
SPAT
Application of cast or individual aid
2.7
10.1
67
251
H02AB09
ATC
hydrocortisone; systemic
3.8
10.0
41
110
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.0
10.0
124
639
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.2
10.0
52
169
R03DC03
ATC
montelukast; oral
1.7
10.0
209
1290
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
10.0
540
4196
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
9.9
266
1759
L21.9
ICD-10 Finland
Seborrhoeic dermatitis, unspecified
4.6
9.9
33
73
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
4.6
9.9
33
73
A07AA02
ATC
nystatin; oral
2.3
9.8
91
414
J01CE02
ATC
phenoxymethylpenicillin; oral
1.4
9.8
909
7816
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.7
9.8
226
1435
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
9.8
435
3241
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
4.4
9.7
34
79
N05BA04
ATC
oxazepam; oral
1.6
9.6
313
2175
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
9.6
494
3792
N06AX16
ATC
venlafaxine; oral
1.8
9.5
169
989
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.3
9.5
88
397
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.0
9.5
54
184
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
9.5
124
652
T90
ICPC
Diabetes non-insulin dependent
1.6
9.4
294
2020
QDA10
NOMESCO Finland
Incision of skin of lower limb
7.6
9.4
21
28
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.7
9.4
64
247
RJ412
NOMESCO Finland
NA
30.2
9.4
12
*
L29.8
ICD-10 Finland
Other pruritus
5.6
9.4
26
47
M14.6*A52.1
ICD-10 Finland
Charcot's or tabetic arthropathy
21.8
9.4
13
6
D05AX03
ATC
calcitriol; topical
4.3
9.3
33
78
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.2
9.3
47
150
B03XA02
ATC
darbepoetin alfa; parenteral
4.2
9.3
34
83
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
9.6
9.3
18
19
B01AC04
ATC
clopidogrel; oral
1.7
9.3
201
1253
J01CF05
ATC
flucloxacillin; systemic
2.8
9.3
56
202
D07XB01
ATC
flumetasone, combinations; topical
6.1
9.2
24
40
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.7
9.2
63
244
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
5.8
9.2
25
44
N05AH04
ATC
quetiapine; oral
1.7
9.2
205
1285
196
Kela drug reimbursment
Paricalcitol and cinacalcet
13.8
9.2
15
11
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
9.2
537
4217
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.7
9.2
181
1098
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.4
9.1
496
3838
KA1AE
NOMESCO Finland
Kidney ultrasound examination
3.3
9.1
44
136
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.4
9.1
75
322
L28
ICPC
Limited function/disability (L)
1.7
9.1
190
1173
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.2
9.1
88
408
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
9.0
113
586
K92.1
ICD-10 Finland
Melaena
2.4
9.0
75
324
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
9.0
156
909
M05BA04
ATC
alendronic acid; oral
2.0
9.0
110
564
L40.9
ICD-10 Finland
Psoriasis, unspecified
4.4
8.9
31
72
C44.72
ICD-10 Finland
Spinocellular carcinoma of the skin of the lower extremity including the hip
12.6
8.9
15
12
M54.4
ICD-10 Finland
Lumbago with sciatica
1.7
8.9
196
1230
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.2
8.8
92
442
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
8.8
914
7933
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
8.7
8.8
18
21
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
10.8
8.8
16
15
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.7
8.8
57
215
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.1
8.7
97
478
JAL10
NOMESCO Finland
Laparotomy and removal of foreign body
50.3
8.7
10
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
8.7
220
1432
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
3.1
8.7
45
147
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
8.6
602
4864
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.0
8.6
106
546
M01AC06
ATC
meloxicam; systemic, rectal
1.4
8.6
449
3438
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.7
8.6
203
1296
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
2.6
8.6
59
229
I50.9
ICD-10 Finland
Heart failure, unspecified
1.7
8.6
171
1040
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
3.3
8.6
41
126
134
Kela drug reimbursment
General erythroderma
11.6
8.6
15
13
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
16.4
8.6
13
8
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.8
8.5
34
90
JN3AD
NOMESCO Finland
Abdominal CT examination
2.0
8.5
103
527
SPAT1100
SPAT
Long-term monitoring of blood pressure
2.1
8.5
91
441
SPAT1211
SPAT
Application of soft bandage
1.9
8.5
124
680
P01BA02
ATC
hydroxychloroquine; oral
2.0
8.4
102
521
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
8.4
166
1005
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
8.4
223
1471
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
7.9
8.4
18
23
Z49.2
ICD-10 Finland
Other dialysis
7.9
8.4
18
23
205
Kela drug reimbursment
Chronic hypertension
1.5
8.4
358
2632
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
+∞
8.3
8
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.7
8.3
165
1001
D06BX01
ATC
metronidazole; topical
1.9
8.3
132
744
H04AA01
ATC
glucagon; nasal, parenteral
3.5
8.3
37
108
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
5.5
8.3
23
42
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
10.8
8.3
15
14
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.6
8.3
252
1714
T82
ICPC
Obesity
2.8
8.2
52
191
EBA00
NOMESCO Finland
Extraction of tooth
1.4
8.2
420
3197
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.8
8.2
149
878
A05
ICPC
Feeling ill
2.1
8.2
89
432
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
6.5
8.2
20
31
R05FA02
ATC
opium derivatives and expectorants; systemic
1.4
8.2
508
4013
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
2.7
8.2
53
200
D64.9
ICD-10 Finland
Anaemia, unspecified
1.8
8.2
135
774
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
8.2
475
3706
K02.1
ICD-10 Finland
Caries of dentine
1.4
8.2
712
5966
XQ845
NOMESCO Finland
Dermatoscopy
5.4
8.1
23
43
C09AA02
ATC
enalapril; systemic
1.6
8.1
249
1697
A02BA02
ATC
ranitidine; systemic
1.6
8.1
246
1671
SPAT1260
SPAT
Consultation of another employee
1.6
8.1
223
1482
H02AB07
ATC
prednisone; oral
1.7
8.1
179
1121
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
17.3
8.1
12
7
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.1
8.1
86
417
A07AA09
ATC
vancomycin; oral
4.5
8.1
27
61
L04AA13
ATC
leflunomide; oral
3.1
8.0
41
133
D07AC14
ATC
methylprednisolone aceponate; topical
2.4
8.0
63
266
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
8.0
457
3556
K29.7
ICD-10 Finland
Gastritis, unspecified
2.7
8.0
51
191
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
2.9
7.9
47
168
B01AA03
ATC
warfarin; systemic
1.5
7.9
255
1759
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.6
7.9
55
217
R13
ICD-10 Finland
Dysphagia
2.1
7.9
83
402
D04.4
ICD-10 Finland
Carcinoma in situ: Skin of scalp and neck
7.8
7.9
17
22
B37.2
ICD-10 Finland
Candidiasis of skin and nail
7.8
7.9
17
22
L60.0
ICD-10 Finland
Ingrowing nail
2.4
7.9
64
273
R06.2
ICD-10 Finland
Wheezing
2.5
7.9
61
254
L28.0
ICD-10 Finland
Lichen simplex chronicus
5.2
7.9
23
45
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.6
7.8
57
228
V03AE03
ATC
lanthanum carbonate; oral
10.9
7.8
14
13
K59.09
ICD-10 Finland
Constipation, unspecified
2.1
7.8
86
422
A02BC01
ATC
omeprazole; systemic
1.5
7.8
342
2522
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
2.8
7.7
46
165
M70.6
ICD-10 Finland
Trochanteric bursitis
1.8
7.7
140
827
C03DA01
ATC
spironolactone; oral
1.8
7.7
136
793
ZXD05
NOMESCO Finland
Urgent procedure
1.4
7.7
394
2994
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.8
7.7
49
181
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
5.1
7.7
23
46
ND1AE
NOMESCO Finland
Wrist ultrasound examination
15.1
7.7
12
8
Z94.1
ICD-10 Finland
Heart transplant status
15.1
7.7
12
8
C08CA05
ATC
nifedipine; systemic
2.0
7.7
92
466
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.3
7.7
66
290
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
7.7
572
4650
J01CA04
ATC
amoxicillin; systemic
1.4
7.7
1084
9799
S91.3
ICD-10 Finland
Open wound of other parts of foot
3.4
7.6
35
105
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
2.8
7.6
47
173
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
7.6
374
2817
N03AE01
ATC
clonazepam; systemic
2.2
7.6
78
372
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
4.2
7.6
27
65
A98
ICPC
Health maint/preventive medicine
1.7
7.6
1349
12786
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.9
7.6
110
604
RJ414
NOMESCO Finland
NA
25.1
7.6
10
*
TGC00
NOMESCO Finland
Bronchial lavation
3.1
7.6
39
128
S01
ICPC
Pain/tenderness of skin
2.4
7.5
62
267
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.7
7.5
49
186
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.2
7.5
77
367
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
3.2
7.5
37
118
TQW11
NOMESCO Finland
Vacuum treatment of wound
3.8
7.5
30
81
Q82.88
ICD-10 Finland
Other specified congenital malformations of skin
80.5
7.4
8
*
N02AA05
ATC
oxycodone; systemic
1.6
7.4
177
1131
M13.9
ICD-10 Finland
Arthritis, unspecified
2.0
7.4
98
517
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
7.4
259
1821
S87
ICPC
Dermatitis/atopic eczema
3.4
7.4
34
103
S06
ICPC
Rash localized
2.1
7.4
79
386
C10AX09
ATC
ezetimibe; oral
1.8
7.3
136
807
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
8.4
7.3
15
18
I50.0
ICD-10 Finland
Congestive heart failure
2.0
7.3
92
480
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
3.0
7.3
40
137
R42
ICD-10 Finland
Dizziness and giddiness
1.5
7.3
270
1921
GD1AD
NOMESCO Finland
Thorax CT examination
2.4
7.3
60
257
70110
ICD-8 Finland
Other hypertrophic and atrophic conditions of the skin, Keratoderma acquisitum (Kämmen, jalkapohja) (palmare, plantare)
+∞
7.3
7
*
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.4
7.2
60
259
D06BX02
ATC
ingenol mebutate; topical
4.3
7.2
25
59
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
1.8
7.2
125
729
R01AD09
ATC
mometasone; nasal
1.4
7.2
552
4495
H36.01
ICD-10 Finland
Diabetic maculopathy
4.7
7.2
23
50
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
7.2
633
5268
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
7.3
7.2
16
22
R03AK07
ATC
formoterol and budesonide; inhalant
1.5
7.2
230
1582
R11
ICD-10 Finland
Nausea and vomiting
1.9
7.2
104
569
WYA10
NOMESCO Finland
First aid or other corresponding healthcare contact
1.9
7.2
100
539
L24.8
ICD-10 Finland
Irritant contact dermatitis due to other agents
20.1
7.1
10
5
L92.0
ICD-10 Finland
Granuloma annulare
20.1
7.1
10
5
R06AX22
ATC
ebastine; oral
1.6
7.1
204
1367
WKPAL
NOMESCO Finland
NA
3.3
7.1
34
106
SPAT1234
SPAT
Support of social functional capacity
2.2
7.1
70
330
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.7
7.1
163
1031
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.3
7.1
33
101
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
7.1
659
5532
E66.01
ICD-10 Finland
Obesity due to excess calories
1.9
7.1
96
515
C10AA01
ATC
simvastatin; oral
1.4
7.1
542
4410
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.3
7.1
59
257
ZXD10
NOMESCO Finland
Scheduled procedure
1.4
7.0
484
3868
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
3.1
7.0
36
118
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.0
7.0
40
138
UKC02
NOMESCO Finland
Cystoscopy
1.6
7.0
210
1422
H43.1
ICD-10 Finland
Vitreous haemorrhage
3.0
7.0
37
124
J01FA10
ATC
azithromycin; systemic
1.3
7.0
724
6175
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
2.4
7.0
58
250
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
1.7
7.0
128
760
H3600, E103
ICD-10 Finland
NA
4.9
7.0
21
43
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.2
6.9
64
293
K65.0
ICD-10 Finland
Acute peritonitis
4.3
6.9
24
57
B01AB05
ATC
enoxaparin; parenteral
1.4
6.9
361
2746
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.6
6.9
48
188
L12.0
ICD-10 Finland
Bullous pemphigoid
7.6
6.9
15
20
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
3.6
6.9
29
82
R01AD12
ATC
fluticasone furoate; nasal
1.4
6.9
347
2621
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
6.9
338
2543
L40
ICD-10 Finland
Psoriasis
3.4
6.8
31
93
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
3.4
6.8
31
93
J04AB02
ATC
rifampicin; systemic
4.8
6.8
21
44
TK820
NOMESCO Finland
Peritoneal dialysis
8.3
6.8
14
17
PG1AE
NOMESCO Finland
Ultrasound examination of artery not elsewher classified
9.4
6.8
13
14
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.9
6.8
101
559
A07EC01
ATC
sulfasalazine; oral, rectal
1.9
6.8
101
560
KMAK
NOMESCO Finland
NA
1.3
6.8
637
5344
R5140
NOMESCO Finland
Monitoring the use of the aid
1.7
6.7
124
735
S02
ICPC
Pruritus
2.5
6.7
48
193
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
6.7
255
1820
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
2.2
6.7
62
284
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
3.8
6.7
26
69
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
6.7
809
7046
WX110
NOMESCO Finland
Local anesthesy
1.3
6.6
885
7814
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
5.2
6.6
19
37
C08CA13
ATC
lercanidipine; oral
1.6
6.6
163
1049
G44.2
ICD-10 Finland
Tension-type headache
1.6
6.6
157
1003
R03BA05
ATC
fluticasone; inhalant
1.5
6.6
224
1562
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
3.0
6.6
35
118
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.5
6.6
267
1933
B35.6
ICD-10 Finland
Tinea inguinalis [Tinea cruris]
3.5
6.6
28
80
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
2.5
6.6
47
189
N06AX21
ATC
duloxetine; oral
1.7
6.6
123
735
L85
ICD-10 Finland
Other epidermal thickening
12.3
6.6
11
9
E87.5
ICD-10 Finland
Hyperkalaemia
3.8
6.6
26
70
C01DA14
ATC
isosorbide mononitrate; oral
1.6
6.6
192
1293
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.8
6.5
112
651
QDA99
NOMESCO Finland
Other local destruction of skin of lower limb
10.1
6.5
12
12
H3600, E113
ICD-10 Finland
NA
4.2
6.5
23
56
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
3.3
6.5
30
92
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
5.3
6.5
18
34
H25.1
ICD-10 Finland
Senile nuclear cataract
1.4
6.4
296
2197
L88
ICD-10 Finland
Pyoderma gangrenosum
70.1
6.4
7
*
RJ425
NOMESCO Finland
NA
70.1
6.4
7
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.6
6.4
170
1117
L72.1
ICD-10 Finland
Trichilemmal cyst
2.0
6.4
78
400
C08CA02
ATC
felodipine; oral
1.7
6.4
124
748
WW200
NOMESCO Finland
Immunization
2.7
6.4
41
154
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.7
6.4
134
829
R05
ICD-10 Finland
Cough
1.5
6.3
237
1684
UJF30
NOMESCO Finland
Ileoscopy through colon
1.7
6.3
117
696
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
2.1
6.3
65
314
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
2.2
6.3
62
293
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
11.1
6.3
11
10
AN1
HP
Coronary angiography
1.6
6.3
149
953
PG5AC
NOMESCO Finland
Contrast examination of injection gate to artery or vein
18.1
6.3
9
5
FQA00
NOMESCO Finland
Orthotopic transplantation of heart
+∞
6.3
6
*
M21.5
ICD-10 Finland
Acquired clawhand, clubhand, clawfoot and clubfoot
+∞
6.3
6
*
L85.8
ICD-10 Finland
Other specified epidermal thickening
+∞
6.3
6
*
NF1AA
NOMESCO Finland
Hip X-ray examination
1.8
6.2
104
599
SPAT1240
SPAT
Therapeutic discussion
1.7
6.2
123
747
R22.4
ICD-10 Finland
Localized swelling, mass and lump, lower limb
2.9
6.2
36
127
RJ210
NOMESCO Finland
NA
26.8
6.2
8
*
L93.0
ICD-10 Finland
Discoid lupus erythematosus
26.8
6.2
8
*
CKC15
NOMESCO Finland
Panretinal photocoagulation
4.8
6.2
19
40
XQ899
NOMESCO Finland
Other assessment of skin
7.1
6.2
14
20
M10.9
ICD-10 Finland
Gout, unspecified
1.9
6.2
81
429
SPAT1252
SPAT
Overall medication plan or its review
1.9
6.2
91
504
G04AC01
ATC
NA
2.8
6.2
37
135
C09CA01
ATC
losartan; oral
1.4
6.2
290
2160
S03
ICPC
Warts
3.0
6.2
32
107
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
3.3
6.2
28
85
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
5.8
6.1
16
28
J01MA12
ATC
levofloxacin; systemic
1.5
6.1
217
1525
C44.42
ICD-10 Finland
Spinocellular carcinoma of the skin of the scalp and neck
7.7
6.1
13
17
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.0
6.1
78
408
L43.8
ICD-10 Finland
Other lichen planus
3.2
6.1
29
91
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.4
6.1
275
2030
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.5
6.1
230
1637
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.8
6.1
92
514
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
4.0
6.1
22
55
N18.0
ICD-10 Finland
End-stage renal disease
4.0
6.1
22
55
ZXC15
NOMESCO Finland
Use of photodynamic technique
4.0
6.1
22
55
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
1.9
6.1
82
439
CKD50
NOMESCO Finland
Endodiathermy of retina
12.6
6.1
10
8
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
3.3
6.1
28
86
R01AD08
ATC
fluticasone; nasal
1.4
6.1
336
2578
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
4.9
6.1
18
37
SPAT1146
SPAT
Puncture of abscess or incision of skin
3.4
6.0
27
81
PD4DG
NOMESCO Finland
Very extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
10.1
6.0
11
11
R22.7
ICD-10 Finland
Localized swelling, mass and lump, multiple sites
10.1
6.0
11
11
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
6.0
199
1377
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
6.0
172
1153
Z2446
NOMESCO Finland
Social worker
1.9
6.0
82
443
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.2
6.0
55
252
R06AX13
ATC
loratadine; oral
1.6
6.0
173
1160

Mortality – FinRegistry

Association

Association between endpoint L12_EPIDERMALTHICKOTH and mortality.

Females

Parameter HR [95% CI] p-value
L12_EPIDERMALTHICKOTH 1.335 [1.16, 1.53] < 0.001
Birth year 0.997 [0.99, 1.01] 0.45

During the follow-up period (1.1.1998 — 31.12.2019), 798 out of 4472 females with L12_EPIDERMALTHICKOTH died.

Males

Parameter HR [95% CI] p-value
L12_EPIDERMALTHICKOTH 1.552 [1.33, 1.81] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 899 out of 3883 males with L12_EPIDERMALTHICKOTH died.

Mortality risk

Mortality risk for people of age

years, who have L12_EPIDERMALTHICKOTH.

N-year risk Females Males
1 0.144% 0.271%
5 0.917% 1.62%
10 2.242% 3.923%
15 4.196% 7.346%
20 7.089% 12.323%

Relationships between endpoints

Index endpoint: L12_EPIDERMALTHICKOTH – Other epidermal thickening

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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