Risteys · L12_EPIDERMTHICKNAS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L85.80, L85.81, L85.89, L85.9 Hospital discharge: ICD-9 — 7018G Hospital discharge: ICD-8 — 70119 Cause of death: ICD-10 — L85.80, L85.81, L85.89, L85.9 Cause of death: ICD-9 — 7018G Cause of death: ICD-8 — 70119 2 out of 7 registries used, show all original rules.	991
4. Check minimum number of events None	991
5. Include endpoints None	991
6. Filter based on genotype QC (FinnGen only)	991

	All	Female	Male
Number of individuals
Whole population	7347	3872	3440
Only index persons	6683	3612	3071
Unadjusted period prevalence (%)
Whole population	0.10	0.11	0.10
Only index persons	0.13	0.13	0.12
Median age at first event (years)
Whole population	51.27	51.51	50.95
Only index persons	51.20	51.44	50.92

	All	Female	Male
Number of individuals	991	553	438
Unadjusted period prevalence (%)	0.19	0.19	0.19
Median age at first event (years)	54.34	50.74	58.89

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
904: Matched controls
9040

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L85.9

ICD-10 Finland

Epidermal thickening, unspecified

2588.8

323.0

328

L85.89

ICD-10 Finland

Other specified epidermal thickening

+∞

267.3

243

L85.81

ICD-10 Finland

Keratosis pilaris

2724.3

213.2

198

L85.80

ICD-10 Finland

Hudhorn

284.8

144.8

144

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

10.5

117.2

249

316

E0000UV

ATC

4.6

100.9

562

2372

D07XC01

ATC

betamethasone, combinations; topical

6.4

89.0

269

563

L30.9

ICD-10 Finland

Dermatitis, unspecified

5.1

84.2

321

878

D02AE01

ATC

carbamide; topical

8.5

82.7

195

282

D05BB02

ATC

acitretin; oral

15.9

66.4

111

L84

ICD-10 Finland

Corns and callosities

18.3

65.3

103

D07AC01

ATC

betamethasone; topical

3.1

53.0

404

1850

QXA25

NOMESCO Finland

Destruction of lesion of skin, site unspecified

14.4

51.5

D07AD01

ATC

clobetasol; topical

4.0

48.5

226

698

TQW80

NOMESCO Finland

Local dermatologic skincare

12.9

48.0

R4180

NOMESCO Finland

Podiatric therapy

32.1

47.8

L85.3

ICD-10 Finland

Xerosis cutis

32.6

46.4

E000001

ATC

3.2

43.4

280

1107

L57.0

ICD-10 Finland

Actinic keratosis

4.8

42.7

156

377

E000003

ATC

7.1

41.5

106

165

L98.4

ICD-10 Finland

Chronic ulcer of skin, not elsewhere classified

51.7

41.1

D07AC13

ATC

mometasone; topical

2.6

35.0

329

1614

E000006

ATC

4.8

33.9

120

278

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

21.5

33.4

B07.9

ICD-10 Finland

Verruca simplex

7.3

31.6

115

70119

ICD-8 Finland

Other hypertrophic and atrophic conditions of the skin, Keratosis, hyperkeratosis alia sive NUD

+∞

31.4

L40.0

ICD-10 Finland

Psoriasis vulgaris

5.9

30.8

167

SPAT1148

SPAT

Treatment of chronic ulcer or burn

3.2

27.0

160

574

D07AB08

ATC

desonide; topical

3.4

26.1

142

476

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

3.4

25.7

136

448

D07BC01

ATC

betamethasone and antiseptics; topical

3.1

25.5

156

571

SPAT1225

SPAT

Implementation of podiatry rehabilitation plan

7.5

24.7

A46

ICD-10 Finland

Erysipelas

3.0

24.6

162

619

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

6.7

24.6

102

S18

ICPC

Laceration/cut

2.1

23.7

404

2520

D01AC20

ATC

imidazoles/triazoles in combination with corticosteroids; topical

2.4

23.6

239

1172

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.0

22.0

410

2629

C03CA01

ATC

furosemide; systemic

2.2

21.2

261

1400

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.2

21.2

278

1531

L04AA06

ATC

mycophenolic acid; systemic

11.6

21.1

S97

ICPC

Chronic ulcer skin

5.1

20.9

143

QAE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in head or neck

3.4

20.9

106

337

E000002

ATC

2.9

20.8

138

527

L30.4

ICD-10 Finland

Erythema intertrigo

11.3

20.8

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.7

20.6

152

623

D05AX02

ATC

calcipotriol; topical

4.7

20.0

155

H02AB06

ATC

prednisolone; systemic

1.9

19.9

432

2896

RJ411

NOMESCO Finland

75.2

19.8

B35.3

ICD-10 Finland

Tinea pedis

4.6

19.7

162

A12AA04

ATC

calcium carbonate; oral

14.2

19.6

J01FF01

ATC

clindamycin; systemic

2.1

19.4

262

1453

127

Kela drug reimbursment

Transplant complication

10.7

19.3

D07AA02

ATC

hydrocortisone; topical

2.6

19.2

155

668

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

2.6

19.0

153

655

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

2.6

19.0

153

657

L98.9

ICD-10 Finland

Disorder of skin and subcutaneous tissue, unspecified

35.1

19.0

XQ848

NOMESCO Finland

Dermatological photography

7.5

18.7

D05AX52

ATC

calcipotriol, combinations; topical

3.8

18.6

232

L04AX01

ATC

azathioprine; systemic

4.5

18.5

158

D07AB02

ATC

hydrocortisone butyrate; topical

2.1

18.5

277

1601

L04AA01

ATC

[U] ciclosporin; systemic

9.8

18.0

SPAT1153

SPAT

Removal of sutures

2.0

17.7

301

1821

L04AD01

ATC

ciclosporin; systemic

8.1

17.4

J01DB01

ATC

cefalexin; oral

2.0

17.3

731

6087

D07BA04

ATC

hydrocortisone and antiseptics; topical

2.8

17.3

120

472

SPAT1149

SPAT

Suture or treatment of traumatic wound

2.6

17.2

134

560

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

8.2

17.2

E000007

ATC

3.6

16.8

225

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

7.5

16.6

A11CC03

ATC

alfacalcidol; systemic

7.2

16.5

UJF32

NOMESCO Finland

Coloscopy

2.1

16.4

231

1291

Z01.8

ICD-10 Finland

Other specified special examinations

2.1

16.1

203

1081

SPAT1144

SPAT

Treatment of reopened or infected surgical wound

3.2

16.1

290

Z01.0

ICD-10 Finland

Examination of eyes and vision

2.3

15.5

161

783

L82

ICD-10 Finland

Seborrhoeic keratosis

2.4

15.5

136

610

D09AB01

ATC

zinc bandage without supplements; topical

7.1

15.3

B35.1

ICD-10 Finland

Tinea unguium

3.4

15.2

228

ICD-10 Finland

5.7

15.0

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

2.1

14.8

200

1090

L85.1

ICD-10 Finland

Acquired keratosis [keratoderma] palmaris et plantaris

81.4

14.6

L91.0

ICD-10 Finland

Hypertrophic scar

36.7

14.5

D01AE15

ATC

terbinafine; topical

3.1

14.4

289

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.9

14.4

261

1594

A10AE04

ATC

insulin glargine; parenteral

2.8

14.4

386

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

4.1

14.3

143

R06.0

ICD-10 Finland

Dyspnoea

2.0

14.3

224

1297

J01DA01

ATC

[U] cefalexin; systemic

1.7

14.3

550

4266

A10AC01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)

3.1

14.0

277

E000004

ATC

5.5

13.9

L20.0

ICD-10 Finland

Besnier prurigo

3.1

13.8

273

SPAT1312

SPAT

General health counselling

1.8

13.7

301

1956

QBE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin of trunk

3.2

13.7

241

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.8

13.7

279

1770

D02AX

ATC

Other emollients and protectives

4.3

13.4

118

R23.8

ICD-10 Finland

Other and unspecified skin changes

2.2

13.3

143

704

D01BA02

ATC

terbinafine; oral; topical

1.9

13.2

230

1376

KA2AE

NOMESCO Finland

Ultrasound examination transplanted kidney

19.4

12.9

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

2.8

12.9

310

L30.8

ICD-10 Finland

Other specified dermatitis

5.1

12.9

Z94.0

ICD-10 Finland

Kidney transplant status

10.7

12.8

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.2

12.7

143

719

TK800

NOMESCO Finland

Hemodialysis

6.3

12.7

215

Kela drug reimbursment

Diabetes, non-insulin-treated

1.9

12.7

207

1211

SPAT1249

SPAT

Treatment-related counselling outside office

1.7

12.6

357

2493

L20.9

ICD-10 Finland

Atopic dermatitis, unspecified

4.1

12.6

125

ZXC50

NOMESCO Finland

Cryotherapy

4.7

12.6

RJ420

NOMESCO Finland

32.5

12.6

TNX92

NOMESCO Finland

Supporting bandage or orthosis of lower limb

7.5

12.5

QAA25

NOMESCO Finland

Destruction of lesion of head or neck

5.7

12.5

WXQ12

NOMESCO Finland

Psoralen - Ultraviolet A therapy with local sensitivisation

20.4

12.5

103

Kela drug reimbursment

Diabetes, insulin-treated

1.9

12.4

224

1353

E10.7

ICD-10 Finland

Type 1 diabetes mellitus, With multiple complications

5.8

12.3

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

3.4

12.3

180

TQW99

NOMESCO Finland

Other minor procedure on skin

3.6

12.3

164

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.7

12.2

311

2097

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.8

12.2

251

1584

N08.39*E10.2

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic nephropathy

16.1

12.2

L30.3

ICD-10 Finland

Infective dermatitis

3.9

12.1

130

L17

ICPC

Foot/toe symptom/complaint

1.9

12.1

224

1364

S20

ICPC

Corn/callosity

6.1

12.0

QDE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in lower limb

5.0

12.0

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

2.7

12.0

319

C07AB07

ATC

bisoprolol; oral

1.7

12.0

377

2703

N02AX02

ATC

tramadol; systemic, rectal

1.7

12.0

351

2466

N02BE01

ATC

paracetamol; systemic, rectal

1.8

11.9

745

6488

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

3.1

11.8

224

C44.32

ICD-10 Finland

Spinocellular carcinoma of the skin on another or unspecified part of the face

8.3

11.6

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

2.3

11.6

111

517

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.7

11.6

366

2620

L50.3

ICD-10 Finland

Dermatographic urticaria

6.2

11.4

SPAT1301

SPAT

No procedures

1.7

11.4

289

1938

D07CC01

ATC

betamethasone and antibiotics; topical

2.1

11.3

129

650

R50.9

ICD-10 Finland

Fever, unspecified

2.1

11.3

145

767

QAA05

NOMESCO Finland

Incision for biopsy of skin of head or neck

4.9

11.3

A02BC02

ATC

pantoprazole; systemic

1.6

11.1

533

4249

H03AA01

ATC

levothyroxine sodium; systemic

1.8

11.1

199

1198

A41.9

ICD-10 Finland

Sepsis, unspecified

4.4

11.0

D04.3

ICD-10 Finland

Carcinoma in situ: Skin of other and unspecified parts of face

6.4

11.0

SPAT1263

SPAT

Sampling

1.6

10.9

374

2726

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

2.3

10.8

106

499

C44.51

ICD-10 Finland

Basocellular carcinoma of the skin on the torso

4.5

10.8

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

3.5

10.8

149

J02AC01

ATC

fluconazole; systemic

1.7

10.8

328

2308

C01DA08

ATC

isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal

1.9

10.8

184

1085

KAS10

NOMESCO Finland

Allogenic transplantation of kidney from cadaver donor

10.7

10.8

XQ802

NOMESCO Finland

Epicutan test

3.5

10.7

150

QAA50

NOMESCO Finland

Cryotherapy of skin of head or neck

13.1

10.7

D07CA01

ATC

hydrocortisone and antibiotics; topical

2.1

10.7

125

639

J18.9

ICD-10 Finland

Pneumonia, unspecified

1.8

10.7

197

1192

E11.5

ICD-10 Finland

Type 2 diabetes mellitus, with peripheral circulatory complications

7.1

10.6

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.0

10.6

146

797

B03XA01

ATC

erythropoietin; parenteral

10.2

10.5

R06AE07

ATC

cetirizine; oral

1.6

10.4

377

2775

N03AX12

ATC

gabapentin; oral

2.0

10.4

133

702

L89

ICD-10 Finland

Decubitus ulcer and pressure area

16.2

10.4

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

2.4

10.4

399

137

Kela drug reimbursment

Uraemia requiring dialysis

10.8

10.3

PBL10

NOMESCO Finland

Construction of arteriovenous fistula from radial artery

10.8

10.3

ZZA00

NOMESCO Finland

Split skin graft

4.4

10.3

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

3.6

10.3

134

PD4CC

NOMESCO Finland

Very extensive arterigography of lower extremity with X-ray

13.3

10.2

J01CE08

ATC

benzathine benzylpenicillin; parenteral

8.0

10.1

G47.3

ICD-10 Finland

Sleep apnoea

1.8

10.1

180

1074

J01FA06

ATC

roxithromycin; oral

1.6

10.0

330

2369

SPAT1250

SPAT

Comprehensive monitoring of chronic illness

1.7

9.7

224

1448

D05AX03

ATC

calcitriol; topical

6.2

9.7

D01AC02

ATC

miconazole; topical

2.4

9.7

353

190

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

13.5

9.7

A10AA01

ATC

4.4

9.7

ZX120

NOMESCO Finland

Intravenous

2.3

9.6

409

S76

ICPC

Skin infection other

2.9

9.6

204

J45.9

ICD-10 Finland

Asthma, unspecified

1.9

9.6

149

849

I10

ICD-10 Finland

Essential (primary) hypertension

1.6

9.6

453

3540

A10AE05

ATC

insulin detemir; parenteral

2.9

9.6

214

QCE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in upper limb

4.3

9.6

SPAT1101

SPAT

Orthostatic test

3.4

9.5

137

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

1.9

9.5

148

841

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

3.0

9.5

187

QX2XE

NOMESCO Finland

Ultrsound examination of soft tissue not elsewhere classified

5.0

9.5

XCD10

NOMESCO Finland

Electrophysiological examination of eye

4.4

9.5

L20.8

ICD-10 Finland

Other atopic dermatitis

7.6

9.4

Z3229

NOMESCO Finland

Other healthcare associate professional

2.3

9.4

398

M14.6*E10.6

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic neuropathic

101.0

9.4

Q82.82

ICD-10 Finland

Inherited keratosis palmaris et plantaris

101.0

9.4

NH3CG

NOMESCO Finland

Extensive MRI of foot

17.7

9.4

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

2.1

9.4

107

538

SPAT1325

SPAT

Vaccination

1.6

9.3

296

2094

A41.0

ICD-10 Finland

Sepsis due to Staphylococcus aureus

5.3

9.3

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

2.3

9.3

374

QDA10

NOMESCO Finland

Incision of skin of lower limb

13.8

9.2

AA1AD

NOMESCO Finland

CT of head and brain

1.8

9.1

189

1182

A10AA02

ATC

3.7

9.1

105

XCW99

NOMESCO Finland

Other investigative procedure of eye

2.1

9.1

490

8070/3-C44.9

ICD-O-3

Squamous cell carcinoma, NOS, of skin, NOS

7.1

9.1

NH3BG

NOMESCO Finland

MRI of foot

10.2

9.0

XQ800

NOMESCO Finland

Prick test

2.4

9.0

331

C03EA01

ATC

hydrochlorothiazide and potassium-sparing agents; oral

2.0

9.0

126

691

A06AC01

ATC

ispaghula (psylla seeds); oral

1.7

8.9

196

1247

T90

ICPC

Diabetes non-insulin dependent

1.8

8.9

181

1127

N17.9

ICD-10 Finland

Acute renal failure, unspecified

3.7

8.7

104

R03AC02

ATC

salbutamol; inhalant

1.5

8.7

432

3387

E10.5

ICD-10 Finland

Type 1 diabetes mellitus, With peripheral circulatory complications

50.5

8.7

R03BB04

ATC

tiotropium bromide; inhalant

2.2

8.6

407

205

Kela drug reimbursment

Chronic hypertension

1.7

8.6

212

1396

N05BA04

ATC

oxazepam; oral

1.7

8.6

199

1287

SPAT1033

SPAT

Irrigation or wax removal of outer auditory canal

1.8

8.5

157

947

L30.0

ICD-10 Finland

Nummular dermatitis

3.3

8.5

128

M04AA01

ATC

allopurinol; systemic

2.0

8.5

107

562

A10BA02

ATC

metformin; oral

1.7

8.5

217

1444

SPAT1262

SPAT

Handing over of treatment supplies

1.8

8.5

155

932

A06AD11

ATC

lactulose; oral

1.9

8.5

120

658

L02.4

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle of limb

3.6

8.4

107

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.6

8.4

323

2381

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.8

8.4

161

980

A07AA09

ATC

vancomycin; oral

6.8

8.4

Z49.1

ICD-10 Finland

Extracorporeal dialysis

6.8

8.4

D01AE16

ATC

amorolfine; topical

2.1

8.4

100

513

SPAT1229

SPAT

Assessment of need for aid

2.4

8.4

297

I50.9

ICD-10 Finland

Heart failure, unspecified

2.0

8.3

102

530

L73.8

ICD-10 Finland

Other specified follicular disorders

8.6

8.3

A10AB04

ATC

insulin lispro; parenteral (insulins and analog. for injection, fast-acting)

3.4

8.3

114

H36.09*E10.3

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic retinopathy

9.6

8.3

J01CF05

ATC

flucloxacillin; systemic

3.3

8.3

125

R60.0

ICD-10 Finland

Localized oedema

2.1

8.3

452

N05AH04

ATC

quetiapine; oral

1.8

8.2

143

842

KA2AT

NOMESCO Finland

Biopsy of transplanted kidney with ultrasound guidance

14.6

8.2

V03AE01

ATC

polystyrene sulfonate; oral

8.2

8.1

TPH04

NOMESCO Finland

Cathetrisation of vein

1.7

8.1

169

1059

K92.1

ICD-10 Finland

Melaena

2.8

8.0

191

H02AB09

ATC

hydrocortisone; systemic

3.8

8.0

SFA30

NOMESCO Finland

Filling on tree or more surfaces of tooth

1.5

8.0

317

2346

E10.9

ICD-10 Finland

Type 1 diabetes mellitus, Without complications

2.9

8.0

169

J02AC02

ATC

itraconazole; systemic

1.8

7.9

144

863

M54.5

ICD-10 Finland

Low back pain

1.6

7.9

260

1840

H02AB04

ATC

methylprednisolone; systemic

1.9

7.9

127

731

L04AD02

ATC

tacrolimus; systemic (calcineurin inhibitors)

7.8

7.9

E27.3

ICD-10 Finland

Drug-induced adrenocortical insufficiency

13.2

7.9

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

2.3

7.9

308

J01AA02

ATC

doxycycline; systemic

1.5

7.9

635

5485

C44.31

ICD-10 Finland

Basocellular carcinoma of the skin on another or unspecified part of the face

2.6

7.8

231

E11.00

ICD-10 Finland

Non-insulin dependent diabetes diabetic hypoglycaemic coma

3.6

7.8

A02BC05

ATC

esomeprazole; systemic

1.5

7.8

315

2338

SPAT1222

SPAT

Counselling/guidance promoting independent living

1.9

7.8

119

672

CKD65

NOMESCO Finland

Pars plana or pars plicata vitrectomy

4.9

7.8

R21

ICD-10 Finland

Rash and other nonspecific skin eruption

2.8

7.8

172

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.5

7.8

355

2712

WXQ27

NOMESCO Finland

UVB narrow spectrum light therapy

6.0

7.7

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

1.8

7.7

142

855

346

Kela drug reimbursment

Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)

3.0

7.7

144

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.6

7.7

275

1984

C08CA02

ATC

felodipine; oral

2.2

7.6

367

N08.2

ICD-10 Finland

Glomerular disorders in blood diseases and disorders involving the immune mechanism

18.5

7.6

I15.1

ICD-10 Finland

Hypertension secondary to other renal disorders

6.8

7.6

SPAT1254

SPAT

Administration of medicine

1.8

7.6

126

735

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

1.9

7.5

111

618

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

2.1

7.5

422

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.5

7.5

339

2576

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

2.6

7.5

207

A10AB01

ATC

insulin (human); parenteral (insulins and analog. for injection, fast-acting)

3.2

7.4

119

SPAT1253

SPAT

Initiation, adjustment, discontinuation or repetition of medication

1.5

7.4

265

1909

N03AX16

ATC

pregabalin; oral

1.7

7.4

184

1209

L40.9

ICD-10 Finland

Psoriasis, unspecified

5.3

7.4

N18.8

ICD-10 Finland

Other chronic renal failure

3.9

7.4

SPAT1292

SPAT

Other function in accordance with SHToL (Finnish classification of nursing interventions)

2.2

7.4

380

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

2.1

7.4

418

E11.4

ICD-10 Finland

Type 2 diabetes mellitus, with neurological complications

4.4

7.4

2500B

ICD-9 Finland

Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]

4.4

7.4

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

2.2

7.4

346

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

1.6

7.4

214

1463

J04AB02

ATC

rifampicin; systemic

6.9

7.3

E66.01

ICD-10 Finland

Obesity due to excess calories

2.2

7.3

327

P01AB01

ATC

metronidazole; oral, rectal

1.5

7.2

307

2297

C07AB02

ATC

metoprolol; systemic

1.7

7.2

161

1027

RJ421

NOMESCO Finland

30.3

7.2

8070/3-C44.2

ICD-O-3

Squamous cell carcinoma, NOS, of external ear

30.3

7.2

V03AE02

ATC

sevelamer; oral

30.3

7.2

J45.1

ICD-10 Finland

Nonallergic asthma

2.2

7.1

322

SPAT1234

SPAT

Support of social functional capacity

2.7

7.1

191

B03XA03

ATC

methoxy polyethylene glycol-epoetin beta; parenteral

20.2

7.1

R13

ICD-10 Finland

Dysphagia

2.5

7.1

226

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

3.7

7.1

I83.1

ICD-10 Finland

Varicose veins of lower extremities with inflammation

4.6

7.1

C02AC05

ATC

moxonidine; oral

2.9

7.1

145

E66.00

ICD-10 Finland

Metabolic syndrome

2.8

7.1

168

QDG20

NOMESCO Finland

Operation for chronic ulcer or fistula of skin of lower limb

12.1

7.1

L60.0

ICD-10 Finland

Ingrowing nail

2.7

7.1

169

E66.8

ICD-10 Finland

Other obesity

2.5

7.0

213

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

2.1

7.0

363

R03BA02

ATC

budesonide; inhalant

1.7

7.0

144

895

J45.0

ICD-10 Finland

Predominantly allergic asthma

2.1

6.9

373

G56.0

ICD-10 Finland

Carpal tunnel syndrome

1.9

6.9

106

600

X59

ICD-10 Finland

Exposure to unspecified factor

1.7

6.9

152

965

L40.3

ICD-10 Finland

Pustulosis palmaris et plantaris

4.9

6.9

SPAT1147

SPAT

Destruction of skin lesion with external methods

4.2

6.8

SPAT1210

SPAT

Application of cast or individual aid

2.8

6.8

151

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

2.2

6.8

331

SPAT1310

SPAT

Counselling related to known health issue

1.5

6.8

264

1936

QBA99

NOMESCO Finland

Other local destruction of skin of trunk

16.8

6.8

QDA99

NOMESCO Finland

Other local destruction of skin of lower limb

16.8

6.8

J01.0

ICD-10 Finland

Acute maxillary sinusitis

1.6

6.7

174

1153

K83.0

ICD-10 Finland

Cholangitis

5.0

6.7

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

2.4

6.7

234

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

1.8

6.7

106

606

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

2.0

6.7

429

R03DC03

ATC

montelukast; oral

1.8

6.6

126

762

JN3BD

NOMESCO Finland

Extensive abdominal CT

1.9

6.6

494

SPAT1216

SPAT

Assessment of functional ability

1.8

6.6

119

710

B05DA

ATC

Isotonic solutions

8.8

6.6

N08.2*D89.80

ICD-10 Finland

Immunoglobulin A (IgA) nephropathy

10.1

6.5

S29

ICPC

Skin symptom/complaint other

1.7

6.5

138

864

CKC12

NOMESCO Finland

Photocoagulation of retina

2.8

6.5

149

H36.03

ICD-10 Finland

Proliferative diabetic retinopathy

6.9

6.5

SPAT1255

SPAT

Intravenous administration of medicine

2.3

6.5

251

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

2.4

6.5

223

B01AC04

ATC

clopidogrel; oral

1.8

6.5

120

722

R07.4

ICD-10 Finland

Chest pain, unspecified

1.6

6.5

205

1430

C08CA01

ATC

amlodipine; oral

1.5

6.4

264

1951

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

2.6

6.4

179

D06BB10

ATC

imiquimod; topical

2.6

6.4

179

L94.0

ICD-10 Finland

Localized scleroderma [morphea]

70.3

6.4

E10.2

ICD-10 Finland

Type 1 diabetes mellitus, With renal complications

7.5

6.4

E10.00

ICD-10 Finland

Insulin-dependent diabetes diabetic hypoglycemic coma

7.5

6.4

QDB05

NOMESCO Finland

Revision of wound of skin of lower limb

4.1

6.4

M25.5

ICD-10 Finland

Pain in joint

1.5

6.4

219

1552

C44.72

ICD-10 Finland

Spinocellular carcinoma of the skin of the lower extremity including the hip

14.4

6.4

E11

ICD-10 Finland

Type 2 diabetes mellitus

1.8

6.4

117

701

R03AC03

ATC

terbutaline; inhalant

1.8

6.4

117

701

EBA00

NOMESCO Finland

Extraction of tooth

1.5

6.3

263

1949

L21.9

ICD-10 Finland

Seborrhoeic dermatitis, unspecified

4.2

6.3

A05AA02

ATC

ursodeoxycholic acid; oral

4.2

6.3

SPAT1211

SPAT

Application of soft bandage

2.0

6.3

444

E11.3

ICD-10 Finland

Type 2 diabetes mellitus, with ophthalmic complications

3.6

6.3

E10.6

ICD-10 Finland

Type 1 diabetes mellitus, With other specified complications

9.3

6.3

D48.5

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Skin

2.3

6.3

253

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

2.1

6.3

336

G63.2*E10.4

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic polyneuropathy

18.2

6.3

A49.9

ICD-10 Finland

Bacterial infection, unspecified

1.9

6.3

462

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

1.5

6.3

257

1898

L85.8

ICD-10 Finland

Other specified epidermal thickening

+∞

6.3

L21.8

ICD-10 Finland

Other seborrhoeic dermatitis

4.8

6.2

EP1AE

NOMESCO Finland

Neck ultrasound examination

2.3

6.2

243

CJB10

NOMESCO Finland

Laser discission of secondary cataract

2.2

6.2

302

CKD05

NOMESCO Finland

Puncture of vitreous body with injection of medication

2.7

6.2

159

M14.6*A52.1

ICD-10 Finland

Charcot's or tabetic arthropathy

26.9

6.2

L92.0

ICD-10 Finland

Granuloma annulare

26.9

6.2

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

2.6

6.2

166

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

2.7

6.2

142

N02AC04

ATC

dextropropoxyphene; oral

3.0

6.2

113

J01MA02

ATC

ciprofloxacin; systemic

1.5

6.2

295

2250

T82

ICPC

Obesity

2.9

6.2

122

C09AA02

ATC

enalapril; systemic

1.6

6.1

148

960

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

3.3

6.1

L03.1

ICD-10 Finland

Cellulitis of other parts of limb

3.5

6.1

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

2.2

6.1

259

C10AA01

ATC

simvastatin; oral

1.4

6.1

318

2462

A02BC01

ATC

omeprazole; systemic

1.5

6.1

212

1509

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

2.3

6.1

229

196

Kela drug reimbursment

Paricalcitol and cinacalcet

12.6

6.1

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

2.0

6.1

421

M05BA04

ATC

alendronic acid; oral

2.1

6.1

312

PG1DE

NOMESCO Finland

Other extensive ultrasound examination of artery

2.7

6.0

148

H3603, E103

ICD-10 Finland

6.7

6.0

N08.39

ICD-10 Finland

Glomerular disorders in diabetes mellitus microalbuminuria

10.1

6.0

D06AX01

ATC

fusidic acid; topical (antibiotics for topical use)

1.9

6.0

453

TGC00

NOMESCO Finland

Bronchial lavation

3.6

6.0

D06BX02

ATC

ingenol mebutate; topical

5.2

6.0

A08

ICPC

Swelling

2.7

6.0

139

ZY020

NOMESCO Finland

Telephone, letter or other consultation without direct patient contact

2.2

6.0

279

SFC01

NOMESCO Finland

Adjuvant procedure of filling therapy

1.5

6.0

204

1443

E16.2

ICD-10 Finland

Hypoglycaemia, unspecified

5.6

6.0

NAME	L12_EPIDERMTHICKNAS
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L85[8-9]
HD_ICD_9	7018G
HD_ICD_8	70119
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L85[8-9]
COD_ICD_9	7018G
COD_ICD_8	70119
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
L12_EPIDERMTHICKNAS	1.228 [1.06, 1.42]	0.007
Birth year	0.994 [0.99, 1.0]	0.146

Parameter	HR [95% CI]	p-value
L12_EPIDERMTHICKNAS	1.233 [1.05, 1.44]	0.009
Birth year	0.988 [0.98, 1.0]	0.011

N-year risk	Females	Males
1	0.112%	0.254%
5	0.796%	1.429%
10	1.809%	3.74%
15	3.451%	7.347%
20	6.151%	12.246%

Other and unspecified epidermal thickening

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints