skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.
Acquired keratosis [keratoderma] palmaris et plantaris
DOID EFO Endpoint Browser PheWeb
L12_ACQKERAT
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
155 |
4. Check minimum number of eventsNone |
155 |
5. Include endpointsNone |
155 |
6. Filter based on genotype QC (FinnGen only) |
155 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L85
- Name in latin
- Keratosis (keratoderma) palmaris et plantaris acquisita
Similar endpoints
↥List of similar endpoints to
Acquired keratosis [keratoderma] palmaris et plantaris
based on the number of shared cases.
Similar with more cases:
- Other epidermal thickening
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1124 | 601 | 516 |
| Only index persons | 982 | 536 | 446 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 54.60 | 57.17 | 51.70 |
| Only index persons | 54.36 | 56.87 | 51.33 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 155 | 83 | 72 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 55.64 | 57.10 | 53.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 142
- Matched controls
- 1418
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L85.1
ICD-10 Finland
Acquired keratosis [keratoderma] palmaris et plantaris
7981.1
160.2
123
*
D07XC01
ATC
betamethasone, combinations; topical
19.6
46.8
79
85
D05BB02
ATC
acitretin; oral
72.2
40.5
45
9
E0000UV
ATC
NA
8.9
31.1
105
344
D02AE01
ATC
carbamide; topical
15.8
26.0
44
39
D07AC01
ATC
betamethasone; topical
5.5
20.3
86
308
D07AD01
ATC
clobetasol; topical
6.7
19.2
56
125
L30.9
ICD-10 Finland
Dermatitis, unspecified
6.5
18.4
55
126
D07AC13
ATC
mometasone; topical
4.5
14.9
71
259
XQ802
NOMESCO Finland
Epicutan test
16.9
14.7
23
16
E000003
ATC
NA
12.9
14.2
25
23
D05AX02
ATC
calcipotriol; topical
12.2
12.8
23
22
7011A
ICD-9 Finland
Other hypertrophic and atrophic conditions of skin, Keratoderma, acquired[KERATODERMA PALMARE ET PLANTARE ACQUISITUM]
+∞
11.6
11
*
E000001
ATC
NA
4.3
11.4
49
156
L85.9
ICD-10 Finland
Epidermal thickening, unspecified
+∞
10.5
10
*
L30.8
ICD-10 Finland
Other specified dermatitis
20.7
10.5
15
8
E000006
ATC
NA
7.2
9.9
24
39
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
5.2
9.1
29
67
D07BC01
ATC
betamethasone and antiseptics; topical
4.5
8.7
32
86
TQW80
NOMESCO Finland
Local dermatologic skincare
13.9
8.6
14
11
70110
ICD-8 Finland
Other hypertrophic and atrophic conditions of the skin, Keratoderma acquisitum (Kämmen, jalkapohja) (palmare, plantare)
+∞
7.3
7
*
D07XB01
ATC
flumetasone, combinations; topical
42.1
6.8
8
*
D05AX52
ATC
calcipotriol, combinations; topical
5.7
6.6
18
35
L30.3
ICD-10 Finland
Infective dermatitis
11.8
6.4
11
10
L40.0
ICD-10 Finland
Psoriasis vulgaris
6.8
6.4
15
24
D09AB01
ATC
zinc bandage without supplements; topical
19.0
6.3
9
5
Mortality – FinRegistry
↥Association
Association between endpoint L12_ACQKERAT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACQKERAT | 1.483 [1.05, 2.09] | 0.025 |
| Birth year | 0.991 [0.98, 1.0] | 0.053 |
During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 400 females with L12_ACQKERAT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACQKERAT | 1.494 [1.12, 2.0] | 0.007 |
| Birth year | 0.987 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 297 males with L12_ACQKERAT died.
Mortality risk
Mortality risk for people of age
years, who have L12_ACQKERAT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.085% | 0.303% |
| 5 | 0.719% | 1.604% |
| 10 | 1.966% | 4.021% |
| 15 | 3.781% | 7.835% |
| 20 | 6.415% | 13.288% |
Relationships between endpoints
↥Index endpoint: L12_ACQKERAT – Acquired keratosis [keratoderma] palmaris et plantaris
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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