Acne

L12_ACNE

acne: An inflammatory process of the sebaceous glands which is characterized by comedones, nodules, papules and/or pustules on the skin.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L70
  • Cause of death: ICD-10 L70

2 out of 7 registries used, show all original rules.

4539

4. Check minimum number of events

None

4539

5. Include endpoints

4847

6. Filter based on genotype QC (FinnGen only)

4847

Control definitions (FinnGen only)

Control exclude
L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L60-L75
Name in latin
Acne

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 52364 25973 26178
Only index persons 51216 25574 25642
Unadjusted period prevalence (%)
Whole population 0.74 0.74 0.73
Only index persons 0.96 0.94 0.98
Median age at first event (years)
Whole population 20.29 21.46 19.05
Only index persons 20.23 21.46 19.00

-FinnGen-

Key figures

All Female Male
Number of individuals 4847 3155 1692
Unadjusted period prevalence (%) 0.96 1.08 0.75
Median age at first event (years) 24.40 26.56 20.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
4192
Matched controls
41916
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D10AX03
ATC
azelaic acid; topical
6.2
323.0
1252
2698
L70.0
ICD-10 Finland
Acne vulgaris
130.7
323.0
3094
882
J01AA07
ATC
tetracycline; systemic
8.1
323.0
1943
4019
J01AA04
ATC
lymecycline; systemic
7.4
323.0
1764
3764
L70
ICD-10 Finland
Acne
12.6
323.0
876
860
D10BA01
ATC
isotretinoin; oral
17.2
323.0
2198
2524
L70.9
ICD-10 Finland
Acne, unspecified
26.2
255.0
361
150
G03HB01
ATC
cyproterone and estrogen; systemic
4.2
239.8
1090
3266
L70.1
ICD-10 Finland
Acne conglobata
76.7
222.8
253
35
E0000UV
ATC
NA
2.7
199.4
2176
11935
70610
ICD-8 Finland
Diseases of sebaceous glands, Acne vulgaris
+∞
180.5
172
*
L70.8
ICD-10 Finland
Other acne
53.6
174.0
209
41
E000001
ATC
NA
2.7
144.8
1283
5927
D10AF01
ATC
clindamycin; topical
5.2
144.3
484
1023
L73.2
ICD-10 Finland
Hidradenitis suppurativa
41.7
139.8
176
44
S96
ICPC
Acne
5.7
117.5
358
671
E0001A1
ATC
NA
5.9
112.4
333
602
D06BX01
ATC
metronidazole; topical
3.3
78.6
428
1382
7061A
ICD-9 Finland
Diseases of sebaceous glands, Other acne[ACNE VULGARIS]
+∞
77.3
74
*
L73.8
ICD-10 Finland
Other specified follicular disorders
20.9
73.3
110
54
L71.9
ICD-10 Finland
Rosacea, unspecified
10.5
68.6
137
134
L71.8
ICD-10 Finland
Other rosacea
24.4
65.1
93
39
XQ848
NOMESCO Finland
Dermatological photography
7.2
59.7
150
216
L72.1
ICD-10 Finland
Trichilemmal cyst
4.5
59.6
225
527
L70.2
ICD-10 Finland
Acne varioliformis
17.6
55.5
88
51
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.3
51.5
282
907
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
49.5
1010
6214
L70.5
ICD-10 Finland
Acné excoriée
151.6
42.8
45
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.0
42.6
660
3660
N06AX11
ATC
mirtazapine; oral
1.7
41.9
1064
6951
H02AB06
ATC
prednisolone; systemic
1.6
39.3
1415
10131
D10AD01
ATC
tretinoin; topical
4.3
38.9
148
350
J01FF01
ATC
clindamycin; systemic
1.7
37.8
881
5587
J01DB01
ATC
cefalexin; oral
1.6
36.3
3278
28919
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
35.2
702
4225
C03DA01
ATC
spironolactone; oral
3.0
33.6
206
716
L71.0
ICD-10 Finland
Perioral dermatitis
4.9
33.4
112
233
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.0
32.8
437
2269
D07AB02
ATC
hydrocortisone butyrate; topical
1.6
32.3
992
6752
TQW80
NOMESCO Finland
Local dermatologic skincare
4.3
31.7
121
288
S10
ICPC
Boil/carbuncle
2.7
31.6
232
903
N05BA04
ATC
oxazepam; oral
1.7
30.5
823
5397
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
29.8
574
3404
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.9
29.7
502
2848
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.7
29.6
683
4279
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.2
29.0
79
129
N06AX16
ATC
venlafaxine; oral
1.8
28.6
585
3529
N05AH04
ATC
quetiapine; oral
1.6
28.6
770
5037
J02AC01
ATC
fluconazole; systemic
1.5
28.2
1370
10317
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
27.9
1021
7212
N03AX16
ATC
pregabalin; oral
1.8
27.7
566
3413
D07AC01
ATC
betamethasone; topical
1.5
27.7
1008
7109
Z94.0
ICD-10 Finland
Kidney transplant status
6.5
27.4
72
112
L04AA06
ATC
mycophenolic acid; systemic
4.9
26.6
88
182
A02BC02
ATC
pantoprazole; systemic
1.4
26.5
1767
14129
XQ800
NOMESCO Finland
Prick test
2.0
26.4
386
2071
70612
ICD-8 Finland
Diseases of sebaceous glands, Acne alia sive NUD
+∞
26.1
25
*
N05CF01
ATC
zopiclone; oral
1.6
25.6
705
4626
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.5
25.4
202
823
L71
ICD-10 Finland
Rosacea
5.0
25.1
81
163
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.2
25.1
79
155
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
24.7
656
4261
N02AX02
ATC
tramadol; systemic, rectal
1.5
24.2
991
7142
D07AB08
ATC
desonide; topical
1.8
24.1
416
2368
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.7
24.0
164
612
UJF32
NOMESCO Finland
Coloscopy
1.7
23.9
539
3336
J04BA02
ATC
dapsone; oral
14.4
23.8
40
28
N06AB04
ATC
citalopram; systemic
1.6
23.8
620
4002
N02BE01
ATC
paracetamol; systemic, rectal
1.4
23.8
2948
26173
J01FA01
ATC
erythromycin; systemic
1.6
23.7
710
4750
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
23.4
520
3203
TK800
NOMESCO Finland
Hemodialysis
4.9
23.2
76
156
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.6
23.1
615
3989
137
Kela drug reimbursment
Uraemia requiring dialysis
8.0
22.9
52
66
D07XC01
ATC
betamethasone, combinations; topical
2.0
22.7
308
1608
127
Kela drug reimbursment
Transplant complication
4.7
22.7
78
169
TQW99
NOMESCO Finland
Other minor procedure on skin
3.2
22.6
119
374
L68.0
ICD-10 Finland
Hirsutism
11.8
22.4
41
35
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
8.4
22.3
49
59
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
7.6
22.3
52
69
L04AD01
ATC
ciclosporin; systemic
4.0
22.1
89
225
B03XA02
ATC
darbepoetin alfa; parenteral
6.7
21.9
56
85
380
Kela drug reimbursment
Adalimumab (hidradenitis suppurativa)
+∞
21.9
21
*
XQ802
NOMESCO Finland
Epicutan test
2.5
21.7
175
719
L20.0
ICD-10 Finland
Besnier prurigo
1.7
21.5
457
2778
L73.9
ICD-10 Finland
Follicular disorder, unspecified
11.2
21.4
40
36
S29
ICPC
Skin symptom/complaint other
1.6
21.3
557
3587
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
7.4
21.1
50
68
L04AX01
ATC
azathioprine; systemic
2.3
20.7
197
880
C03CA01
ATC
furosemide; systemic
2.0
20.6
287
1509
R06AE07
ATC
cetirizine; oral
1.4
20.3
1765
14560
D07AD01
ATC
clobetasol; topical
1.8
20.0
377
2207
J01MA02
ATC
ciprofloxacin; systemic
1.5
19.8
941
6951
A06AD11
ATC
lactulose; oral
2.0
19.4
266
1390
J01AA02
ATC
doxycycline; systemic
1.3
19.3
2224
19122
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
2.6
19.3
149
597
D07BA04
ATC
hydrocortisone and antiseptics; topical
1.6
19.2
506
3261
SPAT1301
SPAT
No procedures
1.4
19.2
1110
8507
R53
ICD-10 Finland
Malaise and fatigue
1.5
19.1
673
4660
L04AA01
ATC
[U] ciclosporin; systemic
5.0
19.1
61
123
J01DA01
ATC
[U] cefalexin; systemic
1.3
19.1
2116
18074
L40.0
ICD-10 Finland
Psoriasis vulgaris
2.6
18.9
138
538
A02BC01
ATC
omeprazole; systemic
1.5
18.8
670
4651
N03AX12
ATC
gabapentin; oral
1.8
18.7
364
2150
N06AB06
ATC
sertraline; oral
1.6
18.7
471
2999
N06AB03
ATC
fluoxetine; oral
1.7
18.6
421
2601
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
1.8
18.5
336
1944
A02BC03
ATC
lansoprazole; oral
1.6
18.0
580
3927
L02.0
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of face
3.7
18.0
79
217
L91.0
ICD-10 Finland
Hypertrophic scar
3.4
17.9
88
264
R06.0
ICD-10 Finland
Dyspnoea
1.5
17.8
582
3958
SDA02
NOMESCO Finland
Parodonthologic therapy
1.4
17.5
1272
10111
A12AA04
ATC
calcium carbonate; oral
5.5
17.5
51
93
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
17.4
706
5034
R50.9
ICD-10 Finland
Fever, unspecified
1.6
17.3
505
3336
N06AB10
ATC
escitalopram; oral
1.4
17.3
889
6645
B05DA
ATC
Isotonic solutions
7.3
17.2
41
57
N06AX12
ATC
bupropion; oral
1.8
17.2
328
1925
Z49.2
ICD-10 Finland
Other dialysis
8.1
17.2
38
47
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
17.1
201
987
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
7.1
17.0
41
58
P01AB01
ATC
metronidazole; oral, rectal
1.4
17.0
1167
9182
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.7
17.0
380
2339
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
5.4
16.7
50
94
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
16.6
1307
10507
R03AC02
ATC
salbutamol; inhalant
1.3
16.6
1884
16009
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
16.6
1190
9423
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
5.6
16.6
48
87
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
4.9
16.6
54
112
R4110
NOMESCO Finland
Physiotherapy
1.5
16.5
668
4752
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
16.5
1698
14218
V03AE02
ATC
sevelamer; oral
10.8
16.4
31
29
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
16.3
163
749
N05BA01
ATC
diazepam; systemic, rectal
1.7
16.2
336
2020
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.5
16.2
582
4038
M25.5
ICD-10 Finland
Pain in joint
1.4
16.2
875
6596
Z49.1
ICD-10 Finland
Extracorporeal dialysis
5.7
16.1
46
82
N03AX09
ATC
lamotrigine; oral
1.9
15.9
244
1331
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
1.8
15.9
276
1573
B03XA01
ATC
erythropoietin; parenteral
10.1
15.9
31
31
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
7.1
15.8
38
54
SPAT1260
SPAT
Consultation of another employee
1.5
15.7
586
4093
N05AX08
ATC
risperidone; systemic
1.8
15.7
261
1463
ZX120
NOMESCO Finland
Intravenous
1.9
15.7
240
1310
A02BC05
ATC
esomeprazole; systemic
1.4
15.6
965
7442
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
1.6
15.6
382
2410
N05CD07
ATC
temazepam; oral
2.2
15.5
164
772
B05DB
ATC
Hypertonic solutions
7.4
15.4
36
49
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
2.1
15.4
184
911
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.3
15.4
146
656
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
1.8
15.3
263
1495
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
1.7
15.2
298
1762
WX110
NOMESCO Finland
Local anesthesy
1.3
15.2
2838
25734
J04AB02
ATC
rifampicin; systemic
6.4
15.2
39
61
N06AX21
ATC
duloxetine; oral
1.7
15.2
316
1904
A11CC03
ATC
alfacalcidol; systemic
3.7
15.1
66
182
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.3
15.0
1231
9924
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.6
15.0
452
3005
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.9
14.9
60
154
196
Kela drug reimbursment
Paricalcitol and cinacalcet
9.4
14.9
30
32
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
2.2
14.9
158
747
D05BB02
ATC
acitretin; oral
4.1
14.9
57
140
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.8
14.7
251
1424
C07AB07
ATC
bisoprolol; oral
1.4
14.6
699
5136
L21.9
ICD-10 Finland
Seborrhoeic dermatitis, unspecified
3.5
14.5
67
193
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.3
14.5
72
220
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
14.5
3018
27680
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
1.9
14.4
220
1202
L02
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle
2.2
14.3
141
643
D07AC13
ATC
mometasone; topical
1.4
14.3
822
6242
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.3
14.3
127
550
V03AE01
ATC
polystyrene sulfonate; oral
6.6
14.3
36
55
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
14.3
1331
10922
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
14.3
1793
15341
N18.8
ICD-10 Finland
Other chronic renal failure
4.1
14.3
55
136
S97
ICPC
Chronic ulcer skin
2.7
14.2
96
358
L21.0
ICD-10 Finland
Seborrhoea capitis
4.4
14.2
51
118
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
14.1
490
3369
M79.6
ICD-10 Finland
Pain in limb
1.4
14.0
1020
8056
H3603, E103
ICD-10 Finland
NA
3.8
14.0
59
158
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
8.8
13.9
29
33
Z71.8
ICD-10 Finland
Other specified counselling
1.4
13.7
971
7632
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
1.5
13.5
563
4019
J01MA12
ATC
levofloxacin; systemic
1.6
13.5
357
2299
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
13.5
2970
27277
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
2.0
13.5
161
801
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
2.7
13.4
90
337
E000008
ATC
NA
6.8
13.4
33
49
L30.3
ICD-10 Finland
Infective dermatitis
2.5
13.4
106
435
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
2.1
13.3
142
674
E000002
ATC
NA
1.5
13.3
504
3531
S18
ICPC
Laceration/cut
1.3
13.3
1097
8823
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.7
13.2
91
345
L02.9
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle, unspecified
2.4
13.2
114
489
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
13.2
2224
19691
C07AA05
ATC
propranolol; systemic
1.4
13.1
673
5004
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.7
13.0
276
1674
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.3
13.0
64
195
L04AB04
ATC
adalimumab; parenteral
2.6
13.0
94
368
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1.8
12.9
226
1290
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.5
12.8
99
400
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
12.8
502
3537
A10AE04
ATC
insulin glargine; parenteral
1.8
12.8
221
1257
N18.0
ICD-10 Finland
End-stage renal disease
6.6
12.8
32
49
N05CF02
ATC
zolpidem; oral
1.5
12.7
448
3086
T36
ICD-10 Finland
Poisoning by systemic antibiotics
1.9
12.7
202
1116
E000007
ATC
NA
1.7
12.7
242
1418
M03BC01
ATC
orphenadrine (citrate); systemic
1.4
12.7
720
5444
L90.5
ICD-10 Finland
Scar conditions and fibrosis of skin
4.0
12.7
50
127
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
7.5
12.6
29
39
D02AX
ATC
Other emollients and protectives
2.1
12.6
144
704
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
3.9
12.6
51
133
D02AE01
ATC
carbamide; topical
1.8
12.5
221
1269
H02AB09
ATC
hydrocortisone; systemic
2.5
12.5
98
402
L73.0
ICD-10 Finland
Acne keloid
130.4
12.4
13
*
N06AB05
ATC
paroxetine; oral
1.9
12.4
194
1067
UKC02
NOMESCO Finland
Cystoscopy
1.7
12.4
236
1387
N06AX22
ATC
agomelatine; oral
2.3
12.3
112
495
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
12.3
426
2925
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
1.8
12.3
204
1144
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
3.9
12.3
49
126
N06AA09
ATC
amitriptyline; systemic
2.0
12.3
159
819
XCK10
NOMESCO Finland
Photography of fundus of eye
1.8
12.2
198
1107
K59.1
ICD-10 Finland
Functional diarrhoea
2.1
12.1
144
714
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
8.2
12.0
26
32
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
11.8
465
3279
L02.8
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of other sites
3.0
11.8
68
231
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.9
11.7
69
239
R06AX27
ATC
desloratadine; oral
1.3
11.7
1125
9213
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
2.3
11.7
105
462
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.1
11.6
129
621
H02AB04
ATC
methylprednisolone; systemic
1.6
11.6
303
1945
W78
ICPC
Pregnancy
0.7
11.6
631
8125
M54.5
ICD-10 Finland
Low back pain
1.3
11.5
1032
8369
T89
ICPC
Diabetes insulin dependent
1.9
11.5
171
926
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
1.4
11.5
503
3624
WX002
NOMESCO Finland
Sedation and analgesia
1.5
11.5
406
2797
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.4
11.4
650
4910
WQ031
NOMESCO Finland
NA
120.3
11.4
12
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
11.4
244
1485
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
11.4
255
1570
G44.2
ICD-10 Finland
Tension-type headache
1.5
11.4
447
3152
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
2.2
11.3
108
489
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
6.0
11.3
30
50
M79.1
ICD-10 Finland
Myalgia
1.5
11.3
419
2922
S21
ICPC
Skin texture symptom/complaint
1.5
11.2
361
2435
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
3.8
11.2
46
122
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.2
11.2
58
185
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.5
11.2
394
2714
L63.8
ICD-10 Finland
Other alopecia areata
25.1
11.1
15
6
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
11.1
231
1395
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
11.1
747
5799
WZC30
NOMESCO Finland
Teaching
1.6
11.1
282
1797
J45.9
ICD-10 Finland
Asthma, unspecified
1.4
11.0
483
3480
SPAT1263
SPAT
Sampling
1.3
11.0
1610
13895
N05AH03
ATC
olanzapine; systemic
1.6
10.9
262
1645
SPAT1240
SPAT
Therapeutic discussion
1.4
10.9
604
4538
ZXA10
NOMESCO Finland
Bilateral
1.5
10.9
427
3006
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
1.7
10.9
208
1224
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.3
10.8
1244
10415
N06AA12
ATC
doxepin; systemic
2.4
10.8
90
382
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.5
10.7
354
2400
J01FA06
ATC
roxithromycin; oral
1.3
10.7
1034
8458
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
10.7
1244
10422
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
10.7
215
1283
D07CC01
ATC
betamethasone and antibiotics; topical
1.5
10.7
362
2470
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
1.9
10.6
146
772
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.4
10.6
537
3977
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
1.8
10.6
178
1007
A07AA02
ATC
nystatin; oral
2.1
10.5
112
533
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
8.5
10.5
22
26
V03AE03
ATC
lanthanum carbonate; oral
9.2
10.5
21
23
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
7.3
10.4
24
33
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.6
10.4
274
1762
R11
ICD-10 Finland
Nausea and vomiting
1.6
10.4
280
1810
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.0
10.4
138
719
A10AE05
ATC
insulin detemir; parenteral
1.8
10.4
169
943
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.7
10.4
212
1273
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.4
10.4
574
4313
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
10.3
1938
17168
C08CA01
ATC
amlodipine; oral
1.5
10.3
377
2618
Z49.0
ICD-10 Finland
Preparatory care for dialysis
6.0
10.3
27
45
B07.9
ICD-10 Finland
Verruca simplex
1.9
10.3
147
788
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
10.2
774
6112
L03.0
ICD-10 Finland
Cellulitis of finger and toe
1.6
10.2
233
1446
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.4
10.1
516
3819
H43.1
ICD-10 Finland
Vitreous haemorrhage
3.3
10.1
50
155
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
1.8
10.1
159
879
MA3AE
NOMESCO Finland
Combined first trimester screening
0.6
10.1
133
2254
A10AA02
ATC
NA
2.1
10.0
106
503
N06AX26
ATC
vortioxetine; oral
1.6
10.0
254
1617
H04AA01
ATC
glucagon; nasal, parenteral
1.9
10.0
149
809
N05AA02
ATC
levomepromazine; systemic
2.1
10.0
113
552
SPAT1380
SPAT
Postpartum check-up
0.7
10.0
381
5198
R51.80
ICD-10 Finland
Headache
1.4
10.0
594
4516
N05AX12
ATC
aripiprazole; systemic
1.7
10.0
220
1352
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.7
10.0
189
1110
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.4
9.9
446
3226
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
4.1
9.9
37
91
R21
ICPC
Throat symptom/complaint
1.3
9.9
1202
10111
L72.0
ICD-10 Finland
Epidermal cyst
4.5
9.8
33
73
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
2.2
9.8
94
425
SPAT1379
SPAT
Health check-up of pregnant person
0.7
9.7
484
6335
P01
ICPC
Feeling anxious/nervous/tense
1.3
9.7
733
5782
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
3.9
9.7
38
98
N76.0
ICD-10 Finland
Acute vaginitis
1.5
9.7
321
2181
A10AA01
ATC
NA
2.1
9.7
103
491
L50.3
ICD-10 Finland
Dermatographic urticaria
2.6
9.6
66
253
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
9.6
321
2186
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
9.6
2155
19394
WZA90
NOMESCO Finland
Other doctors statement
1.3
9.6
938
7667
QBA10
NOMESCO Finland
Incision of skin of trunk
3.5
9.6
43
124
F43.1
ICD-10 Finland
Post-traumatic stress disorder
1.9
9.6
147
805
L05.9
ICD-10 Finland
Pilonidal cyst without abscess
2.5
9.6
73
297
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.4
9.6
470
3458
WW200
NOMESCO Finland
Immunization
2.2
9.5
90
407
ZXA05
NOMESCO Finland
Left side
1.4
9.5
463
3399
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
9.4
1820
16107
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.2
9.4
2458
22462
EMB10
NOMESCO Finland
Tonsillectomy
1.5
9.4
354
2474
QBE05
NOMESCO Finland
Excision of sweat glands or sweat gland bearing skin from trunk
30.1
9.4
12
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
1.7
9.4
187
1116
F51.0
ICD-10 Finland
Nonorganic insomnia
1.4
9.4
482
3575
CKD40
NOMESCO Finland
Endophotocoagulation of retina
4.2
9.3
34
82
Z01.9
ICD-10 Finland
Special examination, unspecified
1.9
9.3
133
710
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.9
9.3
137
740
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.3
9.3
840
6790
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
0.6
9.3
142
2318
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
3.5
9.3
41
117
K02.1
ICD-10 Finland
Caries of dentine
1.2
9.3
2460
22495
R42
ICD-10 Finland
Dizziness and giddiness
1.4
9.3
441
3223
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.6
9.2
222
1394
SPAT1310
SPAT
Counselling related to known health issue
1.3
9.2
1199
10150
N03AG01
ATC
valproic acid; systemic, rectal
1.7
9.2
204
1255
N05AN01
ATC
lithium; oral
2.2
9.2
95
447
SPAT1249
SPAT
Treatment-related counselling outside office
1.2
9.2
1494
12969
SPAT1262
SPAT
Handing over of treatment supplies
1.5
9.2
344
2398
F45.8
ICD-10 Finland
Other somatoform disorders
1.5
9.2
324
2231
SPAT1153
SPAT
Removal of sutures
1.3
9.2
716
5671
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
3.4
9.2
43
129
N05BA12
ATC
alprazolam; oral
1.6
9.2
237
1518
R04.0
ICD-10 Finland
Epistaxis
1.9
9.2
124
653
ZXA00
NOMESCO Finland
Right side
1.4
9.1
489
3647
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.4
9.1
520
3923
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.3
9.1
838
6789
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
1.8
9.1
149
837
103
Kela drug reimbursment
Diabetes, insulin-treated
1.4
9.1
394
2831
AA1AD
NOMESCO Finland
CT of head and brain
1.4
9.1
406
2933
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
2.6
9.1
62
238
A05
ICPC
Feeling ill
1.4
9.1
443
3253
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
11.5
9.1
16
14
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
9.0
1126
9479
H05BX01
ATC
cinacalcet; oral
7.0
9.0
21
30
N02AA05
ATC
oxycodone; systemic
1.7
9.0
180
1079
A07EC02
ATC
mesalazine; oral, rectal
1.7
9.0
185
1118
E000006
ATC
NA
1.7
9.0
198
1217
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
3.5
8.9
40
116
D01
ICPC
Abdominal pain/cramps general
1.4
8.9
500
3762
N06AB08
ATC
fluvoxamine; oral
2.5
8.9
65
259
Z30.0
ICD-10 Finland
General counselling and advice on contraception
1.4
8.9
393
2835
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
1.8
8.9
145
812
M01AE02
ATC
naproxen; oral, rectal
1.2
8.9
2133
19271
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
1.5
8.9
287
1943
D10AE01
ATC
benzoyl peroxide; topical
12.5
8.9
15
12
CKC15
NOMESCO Finland
Panretinal photocoagulation
4.4
8.8
30
68
F34.1
ICD-10 Finland
Dysthymia
1.8
8.8
135
743
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
2.5
8.8
67
272
N05AB03
ATC
perphenazine; systemic, rectal
2.1
8.8
97
472
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.5
8.7
264
1761
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.2
8.7
1142
9668
K65.0
ICD-10 Finland
Acute peritonitis
4.2
8.7
31
74
TK820
NOMESCO Finland
Peritoneal dialysis
7.6
8.6
19
25
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
3.0
8.6
46
153
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
4.4
8.5
29
66
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.6
8.5
219
1402
G04BD04
ATC
oxybutynin; oral, transdermal
2.1
8.5
92
442
F33.1
ICD-10 Finland
Recurrent depressive disorder, current episode moderate
1.8
8.5
134
745
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
0.8
8.5
780
9442
K07.60
ICD-10 Finland
Snapping jaw
1.6
8.5
203
1277
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
8.5
688
5475
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
8.5
120
641
Z01.2
ICD-10 Finland
Dental examination
1.2
8.4
1713
15186
205
Kela drug reimbursment
Chronic hypertension
1.6
8.4
223
1442
C09CA06
ATC
candesartan; oral
1.4
8.4
386
2806
A63.0
ICD-10 Finland
Anogenital (venereal) warts
1.6
8.4
215
1377
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
2.2
8.4
82
380
R05
ICPC
Cough
1.3
8.3
761
6155
W90
ICPC
Uncompl labour/delivery livebirth
0.6
8.3
124
2037
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
2.2
8.2
79
363
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
7.1
8.2
19
27
JLE03
NOMESCO Finland
Allogenic total transplantation of pancreas with pancreaticoenterostomy
14.5
8.2
13
9
A46
ICD-10 Finland
Erysipelas
1.6
8.2
220
1425
M03BX02
ATC
tizanidine; oral
1.2
8.1
1830
16364
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
2.8
8.1
50
182
A02BA02
ATC
ranitidine; systemic
1.5
8.1
294
2039
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
1.5
8.1
275
1880
K59.09
ICD-10 Finland
Constipation, unspecified
1.9
8.1
111
587
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
1.5
8.1
313
2203
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
1.6
8.1
194
1223
R02
ICPC
Shortness of breath/dyspnoea
1.5
8.0
311
2184
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
3.1
8.0
42
138
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
1.6
8.0
200
1275
J45.1
ICD-10 Finland
Nonallergic asthma
1.6
8.0
200
1275
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.3
8.0
597
4692
L01
ICPC
Neck symptom/complaint
1.4
8.0
442
3317
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
3.1
8.0
41
133
L03
ICPC
Low back symptom/complaint
1.3
8.0
787
6427
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.4
7.9
377
2755
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
1.4
7.9
390
2866
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.6
7.9
175
1080
L17
ICPC
Foot/toe symptom/complaint
1.3
7.9
746
6056
UJF30
NOMESCO Finland
Ileoscopy through colon
1.5
7.9
228
1502
R01AD08
ATC
fluticasone; nasal
1.3
7.9
907
7546
N03AE01
ATC
clonazepam; systemic
1.8
7.8
134
764
XF404
NOMESCO Finland
Ambulatory ECG
1.7
7.8
167
1018
M05BA04
ATC
alendronic acid; oral
2.4
7.8
64
271
L82
ICD-10 Finland
Seborrhoeic keratosis
1.6
7.8
212
1379
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.9
7.8
45
156
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
1.9
7.8
107
569
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
1.6
7.8
175
1085
H00.00
ICD-10 Finland
Hordeolum
1.8
7.8
135
775
N05AF03
ATC
chlorprothixene; systemic
2.1
7.8
87
427
K51.5
ICD-10 Finland
Left sided colitis
1.9
7.7
104
546
J01EA01
ATC
trimethoprim; systemic
1.3
7.7
676
5433
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.1
7.7
85
416
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
1.6
7.7
174
1081
KMAK
NOMESCO Finland
NA
1.2
7.7
1939
17503
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
2.8
7.7
45
159
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
1.6
7.6
177
1106
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.5
7.6
275
1905
D07AA02
ATC
hydrocortisone; topical
1.3
7.6
575
4523
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.3
7.6
591
4670
C09AA02
ATC
enalapril; systemic
1.6
7.6
210
1371
K03.00
ICD-10 Finland
Approximal wear
1.7
7.6
155
933
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.3
7.6
64
277
UGC12
NOMESCO Finland
Flexible bronchoscopy
1.9
7.6
99
515
NHQ40
NOMESCO Finland
Amputation of toe
4.9
7.6
23
47
A28
ICPC
Limited function/disability NOS
1.7
7.6
139
814
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
8.8
7.5
15
17
R61.0
ICD-10 Finland
Localized hyperhidrosis
3.9
7.5
29
75
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
1.7
7.5
164
1006
R06AE09
ATC
levocetirizine; oral
1.3
7.5
541
4230
D11AH01
ATC
tacrolimus; topical
2.6
7.5
52
201
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
5.7
7.5
20
35
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.3
7.5
729
5938
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
7.5
1974
17867
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.4
7.5
318
2277
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.6
7.5
167
1035
F29
ICD-10 Finland
Unspecified nonorganic psychosis
1.6
7.4
191
1227
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
7.4
476
3656
H26.2
ICD-10 Finland
Complicated cataract
4.0
7.4
28
71
J01FA10
ATC
azithromycin; systemic
1.2
7.4
2468
22816
RS221
NOMESCO Finland
NA
2.5
7.4
55
221
N30.0
ICD-10 Finland
Acute cystitis
1.4
7.4
414
3114
ZXC50
NOMESCO Finland
Cryotherapy
3.1
7.4
38
124
G43.9
ICD-10 Finland
Migraine, unspecified
1.5
7.3
277
1937
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
1.4
7.3
435
3303
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.8
7.3
731
8791
ZQX00
NOMESCO Finland
0-4% of the skin
8.4
7.3
15
18
L60.0
ICD-10 Finland
Ingrowing nail
1.7
7.3
131
761
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
2.2
7.3
67
303
N06AX03
ATC
mianserin; oral
2.0
7.3
86
432
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.2
7.3
936
7877
PG1XE
NOMESCO Finland
Other ultrasound examination of blood vessel not elsewhere classified
6.8
7.3
17
25
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.7
7.3
136
800
K50.8
ICD-10 Finland
Other Crohn disease
2.2
7.3
69
316
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.5
7.3
273
1910
K30
ICD-10 Finland
Functional dyspepsia
1.5
7.2
257
1774
QDH05
NOMESCO Finland
Correction of deformity of toe nail
6.2
7.2
18
29
N05BE01
ATC
buspirone; oral
2.0
7.2
81
399
EBA00
NOMESCO Finland
Extraction of tooth
1.2
7.2
1324
11565
L84
ICD-10 Finland
Corns and callosities
2.2
7.2
66
297
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
5.4
7.2
20
37
XKD00
NOMESCO Finland
Uroflowmetry
1.6
7.2
185
1187
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.7
7.2
156
959
SAA04
NOMESCO Finland
Special inverstigation of mouth
1.5
7.2
258
1788
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.7
7.2
151
922
H02AB07
ATC
prednisone; oral
1.5
7.2
276
1939
TPH07
NOMESCO Finland
Cathetrisation of artery
1.6
7.2
162
1006
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
2.3
7.2
63
279
J01MA14
ATC
moxifloxacin; systemic
1.6
7.1
167
1048
SPAT1312
SPAT
General health counselling
1.2
7.1
1390
12210
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.5
7.1
212
1410
A07EA02
ATC
hydrocortisone; rectal
2.2
7.1
66
300
P29
ICPC
Psychological sympt/compl other
1.4
7.1
317
2289
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
2.7
7.1
46
172
S01GX01
ATC
cromoglicic acid; ophthalmic
1.3
7.1
752
6185
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.5
7.1
204
1344
N04BC05
ATC
pramipexole; oral
1.9
7.1
101
543
F41.09
ICD-10 Finland
UNS Panic Syndrome
1.7
7.1
148
898
TLC00
NOMESCO Finland
Insertion of intrauterine device
1.5
7.1
238
1628
T78.4
ICD-10 Finland
Allergy, unspecified
1.6
7.1
185
1193
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.2
7.1
863
7218
F60.9
ICD-10 Finland
Personality disorder, unspecified
2.2
7.0
67
306
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.4
7.0
285
2023
XPX08
NOMESCO Finland
Intraoperative flow measurement
7.0
7.0
16
23
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.2
7.0
1488
13184
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
0.8
6.9
435
5530
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.2
6.9
2153
19727
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.7
6.9
133
792
R01AD09
ATC
mometasone; nasal
1.2
6.9
1562
13907
K03.64
ICD-10 Finland
Dental calculus supragingival
1.2
6.9
1200
10419
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
1.8
6.9
120
690
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
13.8
6.9
11
8
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.3
6.9
791
6569
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.5
6.8
207
1385
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
2.8
6.8
40
142
H60.9
ICD-10 Finland
Otitis externa, unspecified
1.5
6.8
220
1492
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
2.6
6.8
46
179
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
10.9
6.8
12
11
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
9.3
6.8
13
14
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
0.7
6.8
158
2354
N06AX18
ATC
reboxetine; oral
3.6
6.8
28
78
Z94.4
ICD-10 Finland
Liver transplant status
5.6
6.7
18
32
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.3
6.7
419
3206
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
3.0
6.7
35
116
H10
ICD-10 Finland
Conjunctivitis
1.5
6.7
229
1570
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
1.9
6.7
88
463
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
2.6
6.7
44
168
-1
NOMESCO Finland
NA
1.2
6.7
1592
14232
RJ425
NOMESCO Finland
NA
22.5
6.7
9
*
QAE50
NOMESCO Finland
Dermabrasion of superficial lesion of skin of head or neck
22.5
6.7
9
*
N06AX05
ATC
trazodone; oral
2.0
6.7
75
372
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.6
6.7
152
947
J35.0
ICD-10 Finland
Chronic tonsillitis
1.4
6.6
286
2057
E10
ICD-10 Finland
Type 1 diabetes mellitus
1.9
6.6
87
454
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
6.6
345
2565
J01CE02
ATC
phenoxymethylpenicillin; oral
1.2
6.6
2841
26729
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.4
6.6
380
2867
M79.7
ICD-10 Finland
Fibromyalgia
1.9
6.6
91
484
WX872
NOMESCO Finland
Intensive care
2.0
6.6
81
415
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.4
6.6
322
2368
F41.1
ICD-10 Finland
Generalized anxiety disorder
1.5
6.6
252
1770
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.6
6.6
158
998
Z37.0
ICD-10 Finland
Single live birth
0.7
6.6
254
3465
N94.4
ICD-10 Finland
Primary dysmenorrhoea
1.7
6.6
140
857
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
6.6
619
5015
C07AB02
ATC
metoprolol; systemic
1.5
6.6
229
1580
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
1.5
6.6
229
1580
R05
ICD-10 Finland
Cough
1.3
6.5
501
3950
E000003
ATC
NA
1.6
6.5
146
905
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.1
6.5
69
333
L64.9
ICD-10 Finland
Androgenic alopecia, unspecified
10.0
6.5
12
12
R06AX22
ATC
ebastine; oral
1.3
6.5
487
3828
Q79.6
ICD-10 Finland
Ehlers-Danlos syndrome
4.8
6.5
20
42
N06AG02
ATC
moclobemide; oral
2.0
6.5
82
423
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.5
6.5
199
1335
L93.0
ICD-10 Finland
Discoid lupus erythematosus
6.8
6.5
15
22
K50.9
ICD-10 Finland
Crohn disease, unspecified
2.2
6.5
64
300
S76
ICPC
Skin infection other
1.7
6.5
127
760
F40.1
ICD-10 Finland
Social phobias
1.6
6.5
144
894
L05.0
ICD-10 Finland
Pilonidal cyst with abscess
2.3
6.5
56
248
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
1.9
6.4
92
499
WX290
NOMESCO Finland
Other blockade of nerve
1.2
6.4
2031
18584
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
1.8
6.4
107
611
R52.9
ICD-10 Finland
Pain, unspecified
1.5
6.4
218
1494
R60.9
ICD-10 Finland
Oedema, unspecified
2.0
6.4
81
418
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
1.6
6.4
170
1102
TAB00
NOMESCO Finland
Lumbar puncture
1.7
6.4
133
811
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
1.9
6.4
87
463
R06.5
ICD-10 Finland
Mouth breathing
1.5
6.4
206
1400
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.7
6.4
131
796
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
0.8
6.3
505
6236
W85
ICPC
Gestational diabetes
0.6
6.3
101
1630
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
1.8
6.3
99
554
L65.9
ICD-10 Finland
Nonscarring hair loss, unspecified
5.2
6.3
18
35
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
1.5
6.3
205
1391
TKC20
NOMESCO Finland
Catheterisation of bladder
1.8
6.3
108
623
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
2.0
6.3
74
373
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.2
6.3
57
257
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.4
6.3
289
2105
H60.0
ICD-10 Finland
Abscess of external ear
3.6
6.3
26
73
D07BC01
ATC
betamethasone and antiseptics; topical
1.4
6.3
245
1731
C08CA02
ATC
felodipine; oral
2.0
6.3
74
375
7061E
ICD-9 Finland
Diseases of sebaceous glands, Other acne[ACNE CONGLOBATA]
+∞
6.2
6
*
7061X
ICD-9 Finland
Diseases of sebaceous glands, Other acne[ACNE ALIA DEFINITA]
+∞
6.2
6
*
70600
ICD-8 Finland
Diseases of sebaceous glands, Acne necrotica
+∞
6.2
6
*
H13
ICPC
Plugged feeling ear
1.4
6.2
360
2721
TDM10
NOMESCO Finland
Puncture of maxillary antrum
1.7
6.2
125
754
H00.1
ICD-10 Finland
Chalazion
1.8
6.2
100
564
R4120
NOMESCO Finland
Occupational therapy
1.6
6.2
143
894
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
2.1
6.2
64
304
SDA01
NOMESCO Finland
Simple parodonthologic therapy
1.2
6.2
1138
9909
L02.1
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of neck
3.2
6.2
30
95
H01.0
ICD-10 Finland
Blepharitis
1.6
6.2
168
1096
F33
ICD-10 Finland
Recurrent depressive disorder
1.9
6.2
84
448
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.5
6.2
231
1615
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.4
6.2
301
2210
C02AC05
ATC
moxonidine; oral
2.5
6.2
45
183
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
1.5
6.2
181
1201
R19.5
ICD-10 Finland
Other faecal abnormalities
2.8
6.1
37
135
KA1AE
NOMESCO Finland
Kidney ultrasound examination
2.4
6.1
50
213
N05BA06
ATC
lorazepam; systemic, sublingual
1.9
6.1
89
484
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.4
6.1
284
2068
N05AA01
ATC
chlorpromazine; systemic, rectal
2.9
6.1
33
113
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
2.9
6.1
33
113
C10AA01
ATC
simvastatin; oral
1.4
6.1
342
2572
K08.3
ICD-10 Finland
Retained dental root
1.7
6.1
125
759
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
1.7
6.1
111
650
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.3
6.1
441
3452
A07AA09
ATC
vancomycin; oral
3.2
6.1
29
91
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
2.0
6.1
75
387
H05BX02
ATC
paricalcitol; systemic
12.5
6.1
10
8
M14.6
ICD-10 Finland
Neuropathic arthropathy
12.5
6.1
10
8
L21
ICD-10 Finland
Seborrhoeic dermatitis
2.4
6.1
47
197
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
0.8
6.1
457
5680
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
2.9
6.0
33
114
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
6.0
70
352
D06BB04
ATC
podophyllotoxin; topical
1.4
6.0
242
1719

Mortality – FinRegistry

Association

Association between endpoint L12_ACNE and mortality.

Females

Parameter HR [95% CI] p-value
L12_ACNE 2.128 [1.75, 2.59] < 0.001
Birth year 0.996 [0.99, 1.0] 0.347

During the follow-up period (1.1.1998 — 31.12.2019), 306 out of 13469 females with L12_ACNE died.

Males

Parameter HR [95% CI] p-value
L12_ACNE 1.88 [1.62, 2.18] < 0.001
Birth year 0.991 [0.98, 1.0] 0.055

During the follow-up period (1.1.1998 — 31.12.2019), 599 out of 16909 males with L12_ACNE died.

Mortality risk

Mortality risk for people of age

years, who have L12_ACNE.

N-year risk Females Males
1 0.146% 0.335%
5 1.172% 2.19%
10 3.024% 5.676%
15 6.046% 10.808%
20 10.594% 18.722%

Relationships between endpoints

Index endpoint: L12_ACNE – Acne

GWS hits: 8

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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