No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
205 |
4. Check minimum number of eventsNone |
205 |
5. Include endpointsNone |
205 |
6. Filter based on genotype QC (FinnGen only) |
205 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L70
- Name in latin
- Acne conglobata
Similar endpoints
↥List of similar endpoints to
Acne conglobata
based on the number of shared cases.
Similar with more cases:
- Acne
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2189 | 621 | 1555 |
| Only index persons | 2136 | 611 | 1525 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.02 | 0.04 |
| Only index persons | 0.05 | 0.02 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 21.34 | 25.74 | 19.47 |
| Only index persons | 21.13 | 25.47 | 19.39 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 205 | 92 | 113 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | 28.84 | 30.71 | 27.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 183
- Matched controls
- 1829
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L70.1
ICD-10 Finland
Acne conglobata
+∞
250.5
178
*
D10BA01
ATC
isotretinoin; oral
29.3
78.2
117
104
L70.0
ICD-10 Finland
Acne vulgaris
55.5
64.7
76
23
J01AA07
ATC
tetracycline; systemic
12.8
49.0
105
174
J01AA04
ATC
lymecycline; systemic
7.4
26.9
74
153
L73.2
ICD-10 Finland
Hidradenitis suppurativa
68.4
25.8
29
5
L70.9
ICD-10 Finland
Acne, unspecified
42.0
15.7
19
5
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
11.0
13.8
26
27
L72.1
ICD-10 Finland
Trichilemmal cyst
11.8
13.2
24
23
L70
ICD-10 Finland
Acne
11.3
12.4
23
23
J01FF01
ATC
clindamycin; systemic
3.7
12.4
65
239
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
7.6
10.8
25
37
S10
ICPC
Boil/carbuncle
7.5
10.3
24
36
L70.8
ICD-10 Finland
Other acne
42.6
10.1
12
*
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
16.2
9.7
15
10
L02.9
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle, unspecified
9.5
9.6
19
22
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
11.6
9.5
17
16
D10AX03
ATC
azelaic acid; topical
4.3
9.4
36
99
H02AB06
ATC
prednisolone; systemic
2.6
8.5
83
443
E0001A1
ATC
NA
8.0
7.9
17
23
N05BA04
ATC
oxazepam; oral
3.0
7.8
49
197
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
7.0
7.6
18
28
L02.0
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of face
10.0
7.4
14
15
E0000UV
ATC
NA
2.4
7.3
86
495
J01DB01
ATC
cefalexin; oral
2.9
7.1
155
1207
TQW99
NOMESCO Finland
Other minor procedure on skin
8.3
6.7
14
18
L02.8
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of other sites
12.9
6.7
11
9
S96
ICPC
Acne
7.9
6.5
14
19
L71.0
ICD-10 Finland
Perioral dermatitis
18.8
6.3
9
5
380
Kela drug reimbursment
Adalimumab (hidradenitis suppurativa)
+∞
6.3
6
*
7061E
ICD-9 Finland
Diseases of sebaceous glands, Other acne[ACNE CONGLOBATA]
+∞
6.3
6
*
P01AB01
ATC
metronidazole; oral, rectal
2.3
6.2
67
364
Mortality – FinRegistry
↥Association
Association between endpoint L12_ACNE_CONGLOBLATA and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACNE_CONGLOBLATA | 2.188 [1.59, 3.01] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 1137 males with L12_ACNE_CONGLOBLATA died.
Mortality risk
Mortality risk for people of age
years, who have L12_ACNE_CONGLOBLATA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.376% |
| 5 | No data | 2.552% |
| 10 | No data | 6.73% |
| 15 | No data | 12.466% |
| 20 | No data | 21.196% |
Relationships between endpoints
↥Index endpoint: L12_ACNE_CONGLOBLATA – Acne conglobata
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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