idiopathic pulmonary fibrosis: Idiopathic pulmonary fibrosis (IPF) is a nonneoplastic pulmonary disease that is characterized by the formation of scar tissue within the lungs in the absence of any known cause.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2788 |
4. Check minimum number of eventsNone |
2788 |
5. Include endpointsNone |
2788 |
6. Filter based on genotype QC (FinnGen only) |
2788 |
Control definitions (FinnGen only)
- Control exclude
- ILD_ENDPOINTS
Extra metadata
- First used in FinnGen datafreeze
- DF5
- Parent code in ICD-10
- J84
- Name in latin
- Morbus pulmonum interstitialis cum fibrosi
Similar endpoints
↥List of similar endpoints to
Idiopathic pulmonary fibrosis
based on the number of shared cases.
Similar with more cases:
- Other interstitial pulmonary diseases
- Interstitial lung disease
- Interstitial lung disease endpoints
- Respiratory diseases principally affecting the interstitium, IBD co-morbidites
- Other respiratory diseases principally affecting the interstitium
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18549 | 7438 | 10834 |
| Only index persons | 13181 | 5367 | 7814 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.27 | 0.21 | 0.30 |
| Only index persons | 0.26 | 0.20 | 0.30 |
| Median age at first event (years) | |||
| Whole population | 74.28 | 75.14 | 73.71 |
| Only index persons | 74.01 | 74.46 | 73.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2788 | 946 | 1842 |
| Unadjusted period prevalence (%) | 0.65 | 0.32 | 0.81 |
| Median age at first event (years) | 71.90 | 69.97 | 72.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2495
- Matched controls
- 24947
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
356
Kela drug reimbursment
Nintedanib and pirfenidone
+∞
323.0
384
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
10.8
323.0
907
1257
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
27.3
323.0
882
490
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
25.9
323.0
543
265
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
5490.8
323.0
1043
*
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
+∞
323.0
2495
*
284
Kela drug reimbursment
Nintedanib and pirfenidone
+∞
323.0
461
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
+∞
323.0
373
*
TGC00
NOMESCO Finland
Bronchial lavation
31.4
323.0
526
210
L04AX05
ATC
pirfenidone; oral
+∞
322.0
302
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
7.3
312.8
878
1723
H02AB06
ATC
prednisolone; systemic
4.9
285.4
1803
8699
XG410
NOMESCO Finland
Flow-volume spirometry
11.4
232.7
463
487
L01XE31
ATC
[U] nintedanib; oral
+∞
207.2
196
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.6
191.7
1266
5501
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
5.6
188.7
635
1445
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
13.2
186.1
341
295
R06.0
ICD-10 Finland
Dyspnoea
3.7
183.1
1112
4464
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.4
178.4
1641
9012
J96.1
ICD-10 Finland
Chronic respiratory failure
12.6
178.4
334
302
L04AX01
ATC
azathioprine; systemic
11.2
174.3
346
352
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
7.4
171.8
446
715
R03AC02
ATC
salbutamol; inhalant
3.0
146.4
1521
8540
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
148.0
145.0
153
11
L01EX09
ATC
nintedanib; oral
+∞
135.7
129
*
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
71.3
129.3
148
22
GD1AD
NOMESCO Finland
Thorax CT examination
6.8
117.0
315
517
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.6
109.0
416
1030
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
37.0
108.6
140
40
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.9
106.3
323
618
L04AA06
ATC
mycophenolic acid; systemic
16.2
105.0
174
115
Z94.2
ICD-10 Finland
Lung transplant status
354.7
102.9
103
*
GDG10
NOMESCO Finland
Bilateral transplantation of lung
512.8
100.2
99
*
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
17.1
84.1
136
84
J84.0
ICD-10 Finland
Alveolar and parietoalveolar conditions
+∞
83.8
80
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
82.3
1071
6057
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.6
81.2
309
750
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.2
79.3
472
1675
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
7.0
78.9
205
315
J01MA14
ATC
moxifloxacin; systemic
3.6
76.8
390
1225
GD1BT
NOMESCO Finland
Biopsy of lung with X-ray guidance
771.1
76.7
75
*
R03BB04
ATC
tiotropium bromide; inhalant
3.0
76.2
519
2017
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
65.6
630
2975
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.2
62.7
207
428
M05BA04
ATC
alendronic acid; oral
3.1
59.1
367
1321
R05
ICD-10 Finland
Cough
2.4
58.7
584
2785
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.4
58.4
582
2778
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
11.2
58.0
112
104
C03CA01
ATC
furosemide; systemic
2.0
56.3
1154
7546
J61
ICD-10 Finland
Pneumoconiosis due to asbestos and other mineral fibres
13.0
55.1
99
79
127
Kela drug reimbursment
Transplant complication
10.3
53.1
107
108
XX4BW
NOMESCO Finland
NA
61.4
51.6
60
10
A02BC02
ATC
pantoprazole; systemic
1.9
51.2
1665
12715
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.7
50.3
234
673
P01BA02
ATC
hydroxychloroquine; oral
3.2
49.5
279
932
L04AD01
ATC
ciclosporin; systemic
9.0
49.5
107
123
XG466
NOMESCO Finland
Sleep oxymetry
4.8
48.5
169
370
J43.9
ICD-10 Finland
Emphysema, unspecified
6.9
47.2
122
185
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.1
46.6
629
3414
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
46.2
373
1568
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.2
45.6
147
295
R28
ICPC
Limited function/disability (R)
8.7
43.8
97
116
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.7
43.5
206
600
R4110
NOMESCO Finland
Physiotherapy
2.0
43.4
752
4489
UGC18
NOMESCO Finland
Flexible bronchoscopy with biopsy of lung
14.0
41.1
71
52
J01AA02
ATC
doxycycline; systemic
1.9
41.1
1884
15504
R99
ICPC
Respiratory disease other
7.1
40.6
102
149
J47
ICD-10 Finland
Bronchiectasis
5.9
40.2
117
208
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
40.1
838
5322
J01FA06
ATC
roxithromycin; oral
1.8
40.0
999
6738
WX892
NOMESCO Finland
Monitored bed care
2.7
39.1
297
1198
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.8
38.9
1103
7725
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.2
37.8
448
2268
R03BA08
ATC
ciclesonide; inhalant
3.1
37.2
221
759
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.1
36.3
448
2306
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.8
35.8
756
4777
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
35.5
675
4113
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
34.7
483
2609
5150X
ICD-9 Finland
Postinflammatory pulmonary fibrosis[FIBROSIS PULMONUM E CAUSA IGNOTA]
+∞
34.4
33
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
34.0
489
2677
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
33.9
565
3272
J01MA12
ATC
levofloxacin; systemic
1.9
33.6
584
3436
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.3
33.5
177
560
J45.1
ICD-10 Finland
Nonallergic asthma
2.8
33.1
224
840
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
4.2
32.4
127
313
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.7
32.0
145
406
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.8
31.9
213
793
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
31.6
581
3478
Z3226
NOMESCO Finland
Physiotherapist
1.9
31.5
516
2958
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.9
31.5
205
750
R02
ICPC
Shortness of breath/dyspnoea
2.2
31.0
360
1791
WX721
NOMESCO Finland
Oxygen concentrator therapy
25.7
31.0
43
17
R04.2
ICD-10 Finland
Haemoptysis
3.4
30.8
156
478
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
30.5
596
3631
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
52.1
30.4
36
7
ZX108
NOMESCO Finland
Inhalation
9.4
29.4
61
66
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
4.8
29.4
100
214
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
3.5
28.0
135
398
J84
ICD-10 Finland
Other interstitial pulmonary diseases
284.5
27.8
28
*
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
4.5
27.3
99
226
GD1RA
NOMESCO Finland
Dynamic X-ray examination of respiratory organs with convetional X-ray picture
54.0
27.2
32
6
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
11.3
26.6
50
45
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.6
26.4
830
5797
J94.1
ICD-10 Finland
Fibrothorax
37.1
26.2
33
9
GX1K5
NOMESCO Finland
Diffusion capacity
40.5
25.8
32
8
L04AA13
ATC
leflunomide; oral
4.6
25.7
92
208
WX725
NOMESCO Finland
Noninvasive ventilation
3.1
25.7
147
493
GDA10
NOMESCO Finland
Biopsy of lung
24.3
25.7
36
15
D86.0
ICD-10 Finland
Sarcoidosis of lung
7.8
25.5
59
77
R03AK08
ATC
formoterol and beclometasone; inhalant
3.6
25.0
116
332
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.4
24.9
222
970
F1246
NOMESCO Finland
NA
17.2
24.9
39
23
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
4.9
24.8
83
175
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
5.3
24.7
77
150
A02BC05
ATC
esomeprazole; systemic
1.6
24.5
920
6701
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
22.2
24.3
35
16
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.2
24.3
132
427
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.6
24.2
184
736
XG460
NOMESCO Finland
Short time oxymetry
4.2
23.9
94
233
Z51.5
ICD-10 Finland
Palliative care
2.3
23.8
233
1067
J92.9
ICD-10 Finland
Pleural plaque without asbestos
5.2
23.7
75
149
L01AA01
ATC
cyclophosphamide; systemic
12.2
23.3
42
35
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
7.5
23.2
55
75
R03BA02
ATC
budesonide; inhalant
1.9
23.1
407
2371
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.2
23.1
264
1299
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
24.9
23.0
32
13
R05
ICPC
Cough
1.8
23.0
487
3011
WX872
NOMESCO Finland
Intensive care
2.5
22.8
180
738
XJC10
NOMESCO Finland
Oesophageal pH monitoring
11.5
22.7
42
37
J99.0*M05.1
ICD-10 Finland
Rheumatoid lung disease
232.0
22.6
23
*
J43.8
ICD-10 Finland
Other emphysema
17.7
22.6
35
20
WW200
NOMESCO Finland
Immunization
4.0
22.6
93
241
A07EC01
ATC
sulfasalazine; oral, rectal
2.3
22.6
213
959
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
22.5
995
7492
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
7.3
22.5
54
75
M05BA07
ATC
risedronic acid; oral
3.1
22.1
125
414
5AB14
NOMESCO Finland
NA
52.5
22.1
26
5
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
2.2
21.8
240
1160
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
21.8
325
1776
GX1D5
NOMESCO Finland
Flow volume spirometry
116.0
21.6
23
*
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
5.9
21.5
60
103
RS123
NOMESCO Finland
NA
43.7
21.4
26
6
J01CA04
ATC
amoxicillin; systemic
1.5
21.4
1730
14852
A02BC03
ATC
lansoprazole; oral
1.6
21.0
736
5217
F2680
NOMESCO Finland
NA
15.6
21.0
34
22
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
12.0
21.0
38
32
N02AX02
ATC
tramadol; systemic, rectal
1.5
20.9
1034
7943
H02AB07
ATC
prednisone; oral
1.8
20.8
381
2240
I50.0
ICD-10 Finland
Congestive heart failure
2.0
20.8
308
1679
R5140
NOMESCO Finland
Monitoring the use of the aid
2.0
20.7
276
1443
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.4
20.7
181
781
L04AA01
ATC
[U] ciclosporin; systemic
5.1
20.6
65
129
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
3.6
20.6
93
262
A07AA02
ATC
nystatin; oral
2.3
20.5
194
875
R03AK07
ATC
formoterol and budesonide; inhalant
1.8
20.3
397
2385
A02BC01
ATC
omeprazole; systemic
1.6
20.0
726
5178
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
2.6
19.9
155
628
2AX04
NOMESCO Finland
NA
36.0
19.8
25
7
WX726
NOMESCO Finland
High-flow oxygen therapy
29.2
19.6
26
9
3A006
NOMESCO Finland
NA
201.5
19.6
20
*
XW5WT
NOMESCO Finland
Other blood specimen with radiologicl guidance
19.5
19.5
29
15
R03BA05
ATC
fluticasone; inhalant
1.8
19.4
400
2438
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
7.6
19.4
45
60
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
15.7
19.3
31
20
Z2446
NOMESCO Finland
Social worker
2.4
19.1
165
709
Z2221
NOMESCO Finland
Medical doctor
1.6
18.9
652
4581
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
3.9
18.7
79
210
ZXE40
NOMESCO Finland
More than seven and less than nine hours
3.4
18.7
91
272
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.2
18.3
187
873
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.2
18.1
200
968
C07AB07
ATC
bisoprolol; oral
1.5
18.0
1324
10923
ZXE00
NOMESCO Finland
One hour or less
1.5
17.7
896
6846
J67.9
ICD-10 Finland
Hypersensitivity pneumonitis due to unspecified organic dust
22.9
17.7
25
11
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.5
17.5
137
557
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
3.5
17.3
82
241
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
17.3
488
3249
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.6
17.2
60
134
J01FA10
ATC
azithromycin; systemic
1.5
17.0
1022
8071
Z57.2
ICD-10 Finland
Occupational exposure to dust
9.8
16.6
33
34
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.2
16.5
182
879
XG474
NOMESCO Finland
Exhalation nntrogen oxide
3.8
16.5
71
193
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
40.3
16.3
20
5
Z3231
NOMESCO Finland
Registered nurse
1.5
16.3
673
4904
J96.0
ICD-10 Finland
Acute respiratory failure
3.9
16.2
67
176
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
16.2
301
1772
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
2.9
16.1
98
345
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.2
16.0
173
826
R03BA01
ATC
beclometasone; inhalant
1.7
16.0
327
1984
J80
ICD-10 Finland
Adult respiratory distress syndrome
10.1
15.9
31
31
ZX120
NOMESCO Finland
Intravenous
1.9
15.9
254
1421
WX722
NOMESCO Finland
PEEP
2.3
15.9
147
653
M34.1
ICD-10 Finland
CR(E)ST syndrome
14.6
15.8
26
18
GDB11
NOMESCO Finland
Thoracoscopic wedge resection of lung
8.0
15.8
35
44
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
10.5
15.7
30
29
R50.9
ICD-10 Finland
Fever, unspecified
1.7
15.3
338
2096
N02AA01
ATC
morphine; systemic, rectal
3.7
15.2
66
181
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
15.2
635
4629
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
9.5
14.9
30
32
XX9XE
NOMESCO Finland
Other ultrasound examination
7.2
14.8
35
49
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.8
14.7
274
1611
B01AA03
ATC
warfarin; systemic
1.5
14.7
702
5255
J67.0
ICD-10 Finland
Farmer lung
25.2
14.7
20
8
J43.2
ICD-10 Finland
Centrilobular emphysema
10.5
14.2
27
26
AN1
HP
Coronary angiography
1.6
14.1
395
2611
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.5
14.1
496
3468
XF400
NOMESCO Finland
ECG with 12 standard connections
1.6
14.0
462
3185
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.6
13.8
382
2520
M34.0
ICD-10 Finland
Progressive systemic sclerosis
23.9
13.8
19
8
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
3.1
13.6
74
243
M05BB03
ATC
alendronic acid and colecalciferol; oral
3.1
13.6
75
249
J99.0
ICD-10 Finland
Rheumatoid lung disease
75.5
13.6
15
*
M05.1
ICD-10 Finland
Rheumatoid lung disease
+∞
13.5
13
*
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
34.2
13.5
17
5
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
4.3
13.4
49
116
5BA08
NOMESCO Finland
NA
7.3
13.2
31
43
R81
ICPC
Pneumonia
2.5
13.1
104
429
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.0
13.1
172
894
XG499
NOMESCO Finland
Other fysiological examination of respiatory function
9.4
13.0
26
28
R03AC03
ATC
terbutaline; inhalant
1.7
12.6
280
1735
NH3EA
NOMESCO Finland
Feet X-ray examination with load
3.7
12.6
54
148
1CX01
NOMESCO Finland
NA
15.5
12.6
20
13
GDA97
NOMESCO Finland
Other thoracoscopic incision, excision of lesion or repair of lung
70.2
12.6
14
*
RK320
NOMESCO Finland
NA
4.7
12.6
42
91
J01FA15
ATC
telithromycin; oral
1.9
12.5
187
1023
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.4
12.5
650
4919
R03DC03
ATC
montelukast; oral
1.7
12.4
282
1760
J93.1
ICD-10 Finland
Other spontaneous pneumothorax
4.7
12.3
41
89
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.1
12.1
141
697
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
6.6
12.0
30
46
SPAT1262
SPAT
Handing over of treatment supplies
1.5
12.0
462
3285
RK110
NOMESCO Finland
NA
4.8
11.9
39
83
FXD00
NOMESCO Finland
Use of ECHLA without concurrent surgical procedure
46.9
11.9
14
*
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
3.0
11.8
67
226
A01AB09
ATC
miconazole; local oral
1.8
11.7
213
1245
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.8
11.6
197
1125
GX2C5
NOMESCO Finland
Short-lasting oximetry
19.0
11.6
17
9
D07AB02
ATC
hydrocortisone butyrate; topical
1.4
11.5
578
4337
Z3229
NOMESCO Finland
Other healthcare associate professional
1.7
11.5
223
1326
5163A
ICD-9 Finland
Other alveolar and parietoalveolar pneumopathy, Idiopathic fibrosing alveolitis
+∞
11.5
11
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.4
11.4
868
7002
AK3
HP
BLTX (both lung transplants)
120.5
11.4
12
*
C10AA03
ATC
pravastatin; oral
1.7
11.4
221
1316
WZA10
NOMESCO Finland
Long statement of health and health related matters
4.5
11.3
39
88
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
8.9
11.2
23
26
C01DA14
ATC
isosorbide mononitrate; oral
1.4
11.2
560
4196
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
2.3
11.2
101
449
I73.0
ICD-10 Finland
Raynaud syndrome
4.3
11.2
40
94
XG405
NOMESCO Finland
Education on PEF monitoring
3.8
11.0
46
124
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.2
11.0
57
182
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.4
11.0
704
5511
R03BB01
ATC
ipratropium bromide; inhalant
2.0
10.8
144
751
J20
ICD-10 Finland
Acute bronchitis
1.8
10.8
204
1205
R06AE07
ATC
cetirizine; oral
1.4
10.8
769
6126
GAA31
NOMESCO Finland
Thoracoscopy
8.3
10.8
23
28
WZC30
NOMESCO Finland
Teaching
1.6
10.8
288
1875
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
1.6
10.8
285
1851
D07AC01
ATC
betamethasone; topical
1.4
10.8
729
5758
R4190
NOMESCO Finland
Nutritional therapy
2.8
10.8
68
248
ZX197
NOMESCO Finland
NA
28.1
10.7
14
5
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
5.9
10.7
29
50
H02AB04
ATC
methylprednisolone; systemic
1.6
10.7
320
2144
GX2D5
NOMESCO Finland
Sleep oximetry
12.9
10.6
18
14
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.6
10.6
76
299
E0000UV
ATC
NA
1.4
10.6
785
6288
G47.3
ICD-10 Finland
Sleep apnoea
1.5
10.5
433
3114
J01FF01
ATC
clindamycin; systemic
1.4
10.5
566
4289
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
10.5
573
4353
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
1.7
10.4
204
1219
Z94.3
ICD-10 Finland
Heart and lungs transplant status
110.4
10.4
11
*
J99.1*M35.0
ICD-10 Finland
Respiratory disorders in sicca syndrome [Sjögren]
+∞
10.4
10
*
E84.9
ICD-10 Finland
Cystic fibrosis, unspecified
+∞
10.4
10
*
XX2XT
NOMESCO Finland
Other injection with other radiological guidance
7.7
10.4
23
30
XGX32
NOMESCO Finland
Bronchoscopic ultrasonography
5.0
10.3
32
65
SPAT1325
SPAT
Vaccination
1.3
10.3
860
7014
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
6.4
10.3
26
41
R29
ICPC
Respiratory symptom/complaint other
2.0
10.3
128
654
M33.1
ICD-10 Finland
Other dermatomyositis
18.8
10.3
15
8
M81.4
ICD-10 Finland
Drug-induced osteoporosis
8.5
10.0
21
25
WX740
NOMESCO Finland
Nitrogen oxide therapy
14.6
10.0
16
11
R06.2
ICD-10 Finland
Wheezing
2.2
9.9
97
448
A02BA02
ATC
ranitidine; systemic
1.4
9.9
487
3628
R05FB02
ATC
cough suppressants and expectorants
1.3
9.9
856
7012
J01FA09
ATC
clarithromycin; systemic
1.4
9.8
548
4171
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
9.8
388
2763
4040
NOMESCO Finland
NA
20.1
9.8
14
7
XF402
NOMESCO Finland
ECG with work load test
1.6
9.6
282
1881
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
4.2
9.5
35
85
M33.9
ICD-10 Finland
Dermatopolymyositis, unspecified
15.1
9.5
15
10
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
1.9
9.5
130
690
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.2
9.5
99
470
E84.0
ICD-10 Finland
Cystic fibrosis with pulmonary manifestations
100.4
9.4
10
*
J99.1*M34.8
ICD-10 Finland
Respiratory disorders in systemic: sclerosis
100.4
9.4
10
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.8
9.4
156
887
M33.2
ICD-10 Finland
Polymyositis
12.4
9.3
16
13
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
4.4
9.3
32
73
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
2.5
9.3
70
283
A02BA03
ATC
famotidine; systemic
2.0
9.2
120
625
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
9.2
312
2151
M35.1
ICD-10 Finland
Other overlap syndromes
7.3
9.2
21
29
XX4AW
NOMESCO Finland
NA
13.7
9.2
15
11
318
Kela drug reimbursment
Teriparatide
6.7
9.1
22
33
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.3
9.1
699
5605
WX882
NOMESCO Finland
High dependency care
2.4
9.1
76
327
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.6
9.1
226
1445
XPX04
NOMESCO Finland
Angioscopy
9.1
9.0
18
20
J70.2
ICD-10 Finland
Acute drug-induced interstitial lung disorders
10.1
9.0
17
17
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
3.4
9.0
42
126
A28
ICPC
Limited function/disability NOS
1.4
8.9
446
3323
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
2.8
8.9
54
194
H05AA02
ATC
teriparatide; parenteral
7.5
8.9
20
27
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.1
8.8
101
498
WX720
NOMESCO Finland
Own respiration
2.2
8.8
85
393
JN4BD
NOMESCO Finland
Extensive body CT
1.5
8.7
272
1837
C02KX01
ATC
bosentan; oral
50.1
8.7
10
*
81
HP
Angiography of the heart and coronary arteries
1.6
8.7
231
1502
R03BB07
ATC
umeclidinium bromide; inhalant
4.5
8.6
29
65
XJC00
NOMESCO Finland
Oesophageal manometry
6.6
8.6
21
32
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
1.8
8.6
158
924
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
1.8
8.6
151
874
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
3.1
8.6
44
142
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
8.6
104
528
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.0
8.5
104
529
J98.9
ICD-10 Finland
Respiratory disorder, unspecified
16.3
8.5
13
8
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
1.8
8.5
155
907
L88
ICPC
Rheumatoid/seropositive arthritis
2.2
8.5
80
365
C08CA02
ATC
felodipine; oral
1.5
8.4
273
1861
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.9
8.4
125
686
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
12.8
8.4
14
11
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
8.4
176
1076
5169X
ICD-9 Finland
Other alveolar and parietoalveolar pneumopathy, Unspecified alveolar and parietoalveolar pneumopathy
+∞
8.3
8
*
J01XB01
ATC
colistin; inhalant, parenteral
+∞
8.3
8
*
R05CB13
ATC
dornase alfa (desoxyribonuclease); inhalant
+∞
8.3
8
*
304
Kela drug reimbursment
Dornase alfa
+∞
8.3
8
*
N02BE01
ATC
paracetamol; systemic, rectal
1.3
8.3
1933
17976
RK250
NOMESCO Finland
NA
5.5
8.3
23
42
I27.0
ICD-10 Finland
Primary pulmonary hypertension
9.5
8.3
16
17
R01AD09
ATC
mometasone; nasal
1.3
8.3
735
6009
C09AA05
ATC
ramipril; oral
1.3
8.3
683
5524
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
6.0
8.1
21
35
ZXA10
NOMESCO Finland
Bilateral
1.4
8.1
436
3290
XF600
NOMESCO Finland
Bloodpressure measurement
1.7
8.1
153
906
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
3.6
8.0
34
95
M13.9
ICD-10 Finland
Arthritis, unspecified
1.8
8.0
135
773
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.8
8.0
125
697
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
2.9
8.0
46
160
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
2.1
7.9
86
419
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
2.7
7.8
50
186
J02AC03
ATC
voriconazole; systemic
10.8
7.8
14
13
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
7.8
746
6152
N02AA05
ATC
oxycodone; systemic
1.4
7.7
386
2870
J99.1*M33.2
ICD-10 Finland
Respiratory disorders in polymyositis
45.1
7.7
9
*
L04AB01
ATC
etanercept; parenteral
4.3
7.7
27
64
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.6
7.7
179
1125
RS230
NOMESCO Finland
NA
5.3
7.7
22
42
11
HP
Coronary artery bypass surgery
2.0
7.7
95
487
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.4
7.6
321
2312
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
18.4
7.6
11
6
J15.8
ICD-10 Finland
Other bacterial pneumonia
4.0
7.6
28
70
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
1.9
7.5
106
568
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
2.5
7.5
56
227
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
1.5
7.5
265
1838
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.3
7.5
615
4952
L01BB01
ATC
NA
10.0
7.5
14
14
M06
ICD-10 Finland
Other rheumatoid arthritis
5.4
7.5
21
39
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
3.4
7.5
34
101
M01CB01
ATC
sodium aurothiomalate; parenteral
2.9
7.5
44
156
XX1AW
NOMESCO Finland
Written report from X-ray examination without contrast peformed elsewhere
4.8
7.4
23
48
4038
NOMESCO Finland
NA
80.3
7.4
8
*
FXE00
NOMESCO Finland
Use of ECLA
80.3
7.4
8
*
J67.8
ICD-10 Finland
Hypersensitivity pneumonitis due to other organic dusts
80.3
7.4
8
*
C02KX04
ATC
macitentan; oral
80.3
7.4
8
*
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.6
7.4
181
1152
GX1E5
NOMESCO Finland
Flow volume spirometry and bronchodilation test
13.4
7.4
12
9
I84.1
ICD-10 Finland
Internal hemorrhoids with other complications
2.4
7.3
59
252
WX302
NOMESCO Finland
Thoracal epidural anesthesy
1.8
7.3
118
668
2770A
ICD-9 Finland
Other and unspecified disorders of metabolism, Cystic fibrosis
+∞
7.3
7
*
R03AC12
ATC
salmeterol; inhalant
1.8
7.3
119
674
F03
ICD-10 Finland
Unspecified dementia
0.5
7.2
40
869
J93.8
ICD-10 Finland
Other pneumothorax
5.2
7.2
21
41
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
5.2
7.2
21
41
RK310
NOMESCO Finland
NA
15.8
7.2
11
7
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
7.2
869
7372
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.5
7.2
221
1487
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
3.5
7.2
31
89
XQ800
NOMESCO Finland
Prick test
1.9
7.2
97
515
FXF00
NOMESCO Finland
Decannulation after ECHLA or ECLA
30.1
7.1
9
*
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
2.8
7.1
43
156
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
5.0
7.1
21
42
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.7
7.1
157
974
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
1.8
7.1
121
697
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.4
7.0
288
2062
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.4
7.0
288
2066
R03AC19
ATC
olodaterol; inhalant
5.2
6.9
20
39
L01CB
ATC
Podophyllotoxin derivatives
7.5
6.9
15
20
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
2.7
6.8
42
155
J01DB01
ATC
cefalexin; oral
1.3
6.8
1730
15994
S22.2
ICD-10 Finland
Fracture of sternum
5.3
6.8
19
36
C10AA01
ATC
simvastatin; oral
1.2
6.8
1193
10563
J45.8
ICD-10 Finland
Mixed asthma
2.1
6.8
73
357
R03AK11
ATC
formoterol and fluticasone; inhalant
2.5
6.7
51
210
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.5
6.7
237
1650
I25.2
ICD-10 Finland
Old myocardial infarction
1.5
6.7
234
1623
R01AD12
ATC
fluticasone furoate; nasal
1.4
6.7
399
3058
M05BA06
ATC
ibandronic acid; systemic
2.6
6.7
47
185
I20.99
ICD-10 Finland
Angina pectoris, unspecified
1.5
6.7
205
1382
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
1.6
6.7
158
1001
E000001
ATC
NA
1.4
6.7
391
2985
NG1DA
NOMESCO Finland
X-ray of knees
2.7
6.7
43
161
FN1YT
NOMESCO Finland
Percutaneous insertion of coronary artery stent
1.6
6.6
173
1123
A03
ICPC
Fever
1.5
6.6
219
1502
J12.8
ICD-10 Finland
Other viral pneumonia
3.7
6.6
26
70
L04AA24
ATC
abatacept; parenteral
10.0
6.5
12
12
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
2.6
6.5
46
182
R03AL03
ATC
vilanterol and umeclidinium bromide; inhalant
3.0
6.5
35
119
Z31.5
ICD-10 Finland
Genetic counselling
2.3
6.5
56
248
C61
ICD-10 Finland
Malignant neoplasm of prostate
0.7
6.5
171
2468
R2110
NOMESCO Finland
Giving the first information
1.8
6.5
109
627
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
0.5
6.5
51
984
J17.1*B25.0
ICD-10 Finland
Cytomegaloviral pneumonitis
70.0
6.4
7
*
602
Kela drug reimbursment
Children's severe malnutrition
70.0
6.4
7
*
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
14.3
6.4
10
7
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
2.7
6.4
39
144
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
6.4
777
6577
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
3.0
6.3
33
110
J93.0
ICD-10 Finland
Spontaneous tension pneumothorax
8.2
6.3
13
16
M05BX04
ATC
denosumab; parenteral
1.8
6.3
111
646
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
18.0
6.3
9
5
E84.8
ICD-10 Finland
Cystic fibrosis with other manifestations
+∞
6.2
6
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.6
6.2
153
976
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
4.3
6.2
21
49
N03AX12
ATC
gabapentin; oral
1.4
6.2
280
2043
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
4.8
6.2
19
40
1240
FHL
Bronchoscopy
2.7
6.2
38
141
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
3.8
6.2
24
64
C08CA05
ATC
nifedipine; systemic
1.5
6.1
177
1178
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
0.7
6.1
163
2353
RS220
NOMESCO Finland
NA
3.0
6.1
32
107
ECB20
NOMESCO Finland
Oral alveoplasty
3.3
6.1
28
85
J92
ICD-10 Finland
Pleural plaque
12.5
6.1
10
8
R06AX22
ATC
ebastine; oral
1.4
6.1
243
1734
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.3
6.1
509
4099
B01AC04
ATC
clopidogrel; oral
1.3
6.1
454
3598
XG467
NOMESCO Finland
Nocturnal CO2 monitoring
8.6
6.0
12
14
A01AB04
ATC
amphotericin B; local oral
1.7
6.0
112
663
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
6.7
6.0
14
21
M01CC01
ATC
penicillamine; oral
10.0
6.0
11
11
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
10.0
6.0
11
11
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.4
6.0
285
2098
Mortality – FinRegistry
↥Association
Association between endpoint IPF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| IPF | 3.691 [3.29, 4.14] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.045 |
During the follow-up period (1.1.1998 — 31.12.2019), 3391 out of 5474 females with IPF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| IPF | 3.607 [3.15, 4.13] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 5042 out of 7688 males with IPF died.
Mortality risk
Mortality risk for people of age
years, who have IPF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.269% | 0.673% |
| 5 | 1.736% | 3.833% |
| 10 | 4.577% | 9.627% |
| 15 | 8.667% | 17.651% |
| 20 | 15.51% | 28.109% |
Relationships between endpoints
↥Index endpoint: IPF – Idiopathic pulmonary fibrosis
GWS hits: 13
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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