This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
ILD medications: nintedanib
ILD_NINTENDANIB
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
194 |
4. Check minimum number of events
Min. number of events
3
|
194 |
5. Include endpointsNone |
194 |
6. Filter based on genotype QC (FinnGen only) |
194 |
Control definitions (FinnGen only)
- Control exclude
- ILD_MEDICATIONS
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
ILD medications: nintedanib
based on the number of shared cases.
Similar with more cases:
- L01XE Protein kinase inhibitors
- Idiopathic pulmonary fibrosis
- ILD, hospital admissions 1, main diag only
- ILD, hospital admissions
- Other interstitial pulmonary diseases
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 194 | 58 | 136 |
| Unadjusted period prevalence (%) | 0.05 | 0.02 | 0.06 |
| Median age at first event (years) | 70.52 | 71.20 | 70.22 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 183
- Matched controls
- 1831
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L01XE31
ATC
[U] nintedanib; oral
+∞
264.8
183
*
284
Kela drug reimbursment
Nintedanib and pirfenidone
+∞
264.8
183
*
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
+∞
251.2
183
8
356
Kela drug reimbursment
Nintedanib and pirfenidone
+∞
182.0
143
*
L01EX09
ATC
nintedanib; oral
+∞
116.5
99
*
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
186.5
95.2
93
10
L04AX05
ATC
pirfenidone; oral
+∞
86.5
76
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
58.8
83.6
98
35
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
54.1
62.0
73
22
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
57.8
57.7
67
18
XG410
NOMESCO Finland
Flow-volume spirometry
35.9
47.3
61
25
H02AB06
ATC
prednisolone; systemic
9.2
41.7
129
376
UGC12
NOMESCO Finland
Flexible bronchoscopy
14.2
41.4
77
89
GD1AA
NOMESCO Finland
Thorax X-ray examination
9.6
37.9
153
633
TGC00
NOMESCO Finland
Bronchial lavation
27.2
31.9
44
21
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
14.2
29.8
53
51
R03AC02
ATC
salbutamol; inhalant
6.1
28.2
134
564
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
24.6
25.6
36
18
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
7.5
25.1
67
131
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
18.9
24.6
38
25
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
137.2
23.2
24
*
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
124.3
21.1
22
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
82.6
20.2
22
*
GD1AD
NOMESCO Finland
Thorax CT examination
12.2
19.5
36
36
J96.1
ICD-10 Finland
Chronic respiratory failure
28.7
18.8
25
10
R06.0
ICD-10 Finland
Dyspnoea
4.2
16.9
80
283
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
33.6
16.5
21
7
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.2
15.8
75
262
WX721
NOMESCO Finland
Oxygen concentrator therapy
162.4
14.7
15
*
R03BA08
ATC
ciclesonide; inhalant
8.2
14.5
33
48
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
6.6
14.2
38
70
R05
ICD-10 Finland
Cough
4.1
13.9
63
207
L04AA06
ATC
mycophenolic acid; systemic
+∞
13.7
13
*
Z51.5
ICD-10 Finland
Palliative care
5.9
13.0
38
78
Z94.2
ICD-10 Finland
Lung transplant status
+∞
12.6
12
*
GDG10
NOMESCO Finland
Bilateral transplantation of lung
+∞
12.6
12
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.3
12.1
81
358
R28
ICPC
Limited function/disability (R)
32.4
11.8
15
5
127
Kela drug reimbursment
Transplant complication
+∞
10.5
10
*
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
34.8
10.5
13
*
N02AA01
ATC
morphine; systemic, rectal
21.5
10.0
14
7
J47
ICD-10 Finland
Bronchiectasis
21.5
10.0
14
7
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.0
9.7
72
329
R01AD12
ATC
fluticasone furoate; nasal
3.2
9.5
56
219
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
9.4
71
329
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
5.9
9.4
26
50
R03AK08
ATC
formoterol and beclometasone; inhalant
10.9
9.2
17
17
XG466
NOMESCO Finland
Sleep oxymetry
8.2
9.2
20
27
R03BB04
ATC
tiotropium bromide; inhalant
4.3
9.1
35
96
L04AX01
ATC
azathioprine; systemic
38.8
9.1
11
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
12.4
8.7
15
13
R02
ICPC
Shortness of breath/dyspnoea
3.9
8.5
36
108
UGC18
NOMESCO Finland
Flexible bronchoscopy with biopsy of lung
94.2
8.5
9
*
R05
ICPC
Cough
3.1
8.4
53
215
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
+∞
8.4
8
*
J01FA06
ATC
roxithromycin; oral
2.6
8.4
82
433
J01FA10
ATC
azithromycin; systemic
2.5
8.2
103
625
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.8
7.9
26
61
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
6.1
7.3
19
34
A02BC02
ATC
pantoprazole; systemic
2.4
7.2
131
930
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.3
7.0
36
126
J01CA04
ATC
amoxicillin; systemic
2.6
7.0
146
1103
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
6.6
7.0
17
28
R03BA01
ATC
beclometasone; inhalant
3.5
6.9
32
104
XJC10
NOMESCO Finland
Oesophageal pH monitoring
23.5
6.7
9
*
R4110
NOMESCO Finland
Physiotherapy
2.4
6.6
66
345
R03AK07
ATC
formoterol and budesonide; inhalant
3.1
6.5
37
139
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
5.2
6.4
19
40
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.2
6.4
93
578
L04AD01
ATC
ciclosporin; systemic
+∞
6.3
6
*
XX4BW
NOMESCO Finland
NA
+∞
6.3
6
*
GX2C5
NOMESCO Finland
Short-lasting oximetry
+∞
6.3
6
*
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: ILD_NINTENDANIB – ILD medications: nintedanib
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).