This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Cerebral atherosclerosis
I9_CERATHER
cerebral atherosclerosis: Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
394 |
4. Check minimum number of eventsNone |
394 |
5. Include endpointsNone |
394 |
6. Filter based on genotype QC (FinnGen only) |
379 |
Control definitions (FinnGen only)
- Control exclude
- I9_CEREBVASC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I67
- Name in latin
- Atherosclerosis cerebralis
Similar endpoints
↥List of similar endpoints to
Cerebral atherosclerosis
based on the number of shared cases.
Similar with more cases:
- Cerebral atherosclerosis
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Neurological diseases
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 379 | 133 | 246 |
| Unadjusted period prevalence (%) | 0.10 | 0.05 | 0.12 |
| Median age at first event (years) | 73.36 | 73.57 | 73.25 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 391
- Matched controls
- 3904
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I67.2
ICD-10 Finland
Cerebral atherosclerosis
3926.7
323.0
321
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
687.7
109.3
103
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
187.7
87.0
88
6
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
+∞
43.5
41
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
11.6
42.2
82
87
4370A
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Cerebral atherosclerosis
+∞
40.3
38
*
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
209.0
37.4
38
*
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
366.2
34.4
34
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
6.1
27.4
81
161
AA1AD
NOMESCO Finland
CT of head and brain
3.7
25.7
139
507
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
+∞
23.1
22
*
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
+∞
23.1
22
*
B01AC04
ATC
clopidogrel; oral
3.5
20.7
113
402
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
9.0
20.5
44
54
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
9.2
19.4
41
49
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
+∞
17.8
17
*
43700
ICD-8 Finland
Generalised ischaemic cerebrovascular disease, With hypertension (benign)
+∞
17.8
17
*
B01AC07
ATC
dipyridamole; systemic
4.5
16.1
60
151
5541
FHL
Subclavia and / or carotid endarterectomy, reconstruction or bypass surgery
+∞
15.7
15
*
43799
ICD-8 Finland
Generalised ischaemic cerebrovascular disease, Without mention of hypertension
+∞
15.7
15
*
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
+∞
15.7
15
*
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
58.9
14.9
17
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
+∞
14.7
14
*
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
10.2
13.9
27
28
C10AA05
ATC
atorvastatin; oral
2.3
12.8
169
978
K90
ICPC
Stroke/cerebrovascular accident
22.1
12.1
17
8
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
48.1
11.9
14
*
F01.9
ICD-10 Finland
Vascular dementia, unspecified
7.4
11.2
26
37
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.6
10.9
87
385
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
10.4
10.6
20
20
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
+∞
10.4
10
*
315
Kela drug reimbursment
Clopidogrel
19.4
10.3
15
8
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.1
10.3
150
886
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
24.0
10.3
14
6
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.2
10.2
56
192
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.9
9.5
39
108
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.3
9.4
34
84
C10AA01
ATC
simvastatin; oral
1.9
9.1
206
1424
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
6.0
9.0
24
42
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.5
8.8
72
320
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.9
8.7
53
197
205
Kela drug reimbursment
Chronic hypertension
1.9
8.5
167
1087
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
28.1
8.5
11
*
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
+∞
8.3
8
*
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
8.3
8
*
R42
ICD-10 Finland
Dizziness and giddiness
2.2
8.1
96
512
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.2
7.7
28
70
TAB00
NOMESCO Finland
Lumbar puncture
5.6
7.3
20
37
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
+∞
7.3
7
*
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
+∞
7.3
7
*
PA2YT
NOMESCO Finland
Cerebral artery PTA with stent
+∞
7.3
7
*
R53
ICD-10 Finland
Malaise and fatigue
2.1
7.3
94
517
XA800
NOMESCO Finland
Neuropsychological investigation
7.5
7.2
16
22
R51.80
ICD-10 Finland
Headache
2.9
7.2
42
153
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
7.1
80
416
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.1
6.7
36
125
N06AX16
ATC
venlafaxine; oral
3.0
6.6
37
130
103
Kela drug reimbursment
Diabetes, insulin-treated
1.8
6.5
123
777
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.0
6.5
85
469
G45.3
ICD-10 Finland
Amaurosis fugax
7.6
6.4
14
19
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
70.7
6.4
7
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
6.4
67
337
AN1
HP
Coronary angiography
2.2
6.3
68
343
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.4
6.3
55
253
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.8
6.3
135
886
4331X
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Carotid artery[OCCL/STENOSIS ARTERIAE CAROTIS SINE INFARCTU CEREBR]
+∞
6.3
6
*
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
+∞
6.3
6
*
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
+∞
6.3
6
*
L28
ICPC
Limited function/disability (L)
2.1
6.2
76
408
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
6.2
86
484
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
6.1
85
478
PEF23
NOMESCO Finland
Thrombendarterectomy of femoral artery
6.2
6.0
15
25
I10
ICD-10 Finland
Essential (primary) hypertension
1.7
6.0
236
1843
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: I9_CERATHER – Cerebral atherosclerosis
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).