Cerebral atherosclerosis

I9_CEREBATHER

cerebral atherosclerosis: Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 I67.2
  • Hospital discharge: ICD-9 4370
  • Hospital discharge: ICD-8 437
  • Cause of death: ICD-10 I67.2
  • Cause of death: ICD-9 4370
  • Cause of death: ICD-8 437

2 out of 7 registries used, show all original rules.

450

4. Check minimum number of events

None

450

5. Include endpoints

None

450

6. Filter based on genotype QC (FinnGen only)

450

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I67
Name in latin
Atherosclerosis cerebralis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13448 6688 6394
Only index persons 3338 1814 1524
Unadjusted period prevalence (%)
Whole population 0.19 0.19 0.18
Only index persons 0.06 0.07 0.06
Median age at first event (years)
Whole population 76.04 77.52 74.70
Only index persons 76.30 78.24 74.00

-FinnGen-

Key figures

All Female Male
Number of individuals 450 165 285
Unadjusted period prevalence (%) 0.10 0.06 0.13
Median age at first event (years) 73.48 73.82 73.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
391
Matched controls
3909
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I67.2
ICD-10 Finland
Cerebral atherosclerosis
10427.9
323.0
321
*
4370A
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Cerebral atherosclerosis
+∞
40.3
38
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
4.5
21.0
82
219
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.8
18.7
88
277
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
4.0
18.3
81
241
43700
ICD-8 Finland
Generalised ischaemic cerebrovascular disease, With hypertension (benign)
+∞
17.8
17
*
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
9.7
16.8
34
38
43799
ICD-8 Finland
Generalised ischaemic cerebrovascular disease, Without mention of hypertension
+∞
15.7
15
*
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
7.2
15.7
38
57
AA1AD
NOMESCO Finland
CT of head and brain
2.6
15.4
139
676
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.9
14.4
103
432
B01AC04
ATC
clopidogrel; oral
2.6
12.9
113
532
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
5.0
12.7
41
89
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.4
12.1
44
108
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
9.6
11.1
22
24
5541
FHL
Subclavia and / or carotid endarterectomy, reconstruction or bypass surgery
17.2
9.9
15
9
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.8
9.7
41
117
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.2
9.1
34
87
B01AC07
ATC
dipyridamole; systemic
2.8
8.9
60
239
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
9.8
8.8
17
18
F01.9
ICD-10 Finland
Vascular dementia, unspecified
5.1
8.5
26
54
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
6.9
8.4
20
30
C10AA05
ATC
atorvastatin; oral
1.9
8.4
169
1107
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
8.8
8.4
17
20
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.9
7.8
150
961
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
9.6
7.3
14
15
TAB00
NOMESCO Finland
Lumbar puncture
5.5
7.2
20
38
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
4.3
6.9
24
58
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.5
6.8
53
230
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.9
6.7
39
142
XA800
NOMESCO Finland
Neuropsychological investigation
6.6
6.7
16
25
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.7
6.6
27
76
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.0
6.6
87
481
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.4
6.5
56
254
PA2YT
NOMESCO Finland
Cerebral artery PTA with stent
70.7
6.4
7
*

Mortality – FinRegistry

Association

Association between endpoint I9_CEREBATHER and mortality.

Females

Parameter HR [95% CI] p-value
I9_CEREBATHER 2.047 [1.71, 2.45] < 0.001
Birth year 0.993 [0.98, 1.0] 0.133

During the follow-up period (1.1.1998 — 31.12.2019), 756 out of 1228 females with I9_CEREBATHER died.

Males

Parameter HR [95% CI] p-value
I9_CEREBATHER 2.466 [1.9, 3.21] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 656 out of 1080 males with I9_CEREBATHER died.

Mortality risk

Mortality risk for people of age

years, who have I9_CEREBATHER.

N-year risk Females Males
1 0.185% 0.353%
5 1.028% 2.747%
10 2.745% 6.72%
15 5.394% 11.925%
20 9.426% 19.076%

Relationships between endpoints

Index endpoint: I9_CEREBATHER – Cerebral atherosclerosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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