This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Disorders of lacrimal system and orbit in diseases classified elsewhere
H7_LACRIMALORBITINOTH
eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
912 |
4. Check minimum number of eventsNone |
912 |
5. Include endpointsNone |
912 |
6. Filter based on genotype QC (FinnGen only) |
912 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of lacrimal system and orbit in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Disorders of orbit
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 912 | 747 | 165 |
| Unadjusted period prevalence (%) | 0.22 | 0.25 | 0.07 |
| Median age at first event (years) | 52.25 | 51.81 | 54.22 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 811
- Matched controls
- 8108
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
497.7
323.0
692
92
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
79.6
323.0
417
106
H03BB01
ATC
carbimazole; oral
171.6
323.0
628
158
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
323.0
677
*
H03AA01
ATC
levothyroxine sodium; systemic
20.7
304.3
658
1392
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
276.3
249
*
BAA60
NOMESCO Finland
Total thyroidectomy
50.9
230.7
278
82
H062, E050
ICD-10 Finland
NA
+∞
213.2
195
*
104
Kela drug reimbursment
Thyroid insufficiency
15.1
171.0
310
318
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
58.2
167.2
196
44
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
7.7
149.5
618
2381
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
259.3
111.8
112
5
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
51.1
101.5
122
28
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.9
95.9
477
1837
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
93.6
88
*
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
57.0
92.6
109
22
C07AA05
ATC
propranolol; systemic
5.0
85.2
348
1054
H53.2
ICD-10 Finland
Diplopia
18.4
82.0
130
83
H04.10
ICD-10 Finland
Dry eye syndrome
9.9
71.2
152
185
H50.2
ICD-10 Finland
Vertical strabismus
54.5
66.7
79
16
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
63.4
64.9
75
13
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.3
64.4
190
375
H02AB06
ATC
prednisolone; systemic
3.4
59.1
512
2719
XCK00
NOMESCO Finland
Perimetry
7.8
58.2
143
216
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
+∞
50.5
48
*
H02.3
ICD-10 Finland
Blepharochalasis
49.0
45.7
55
12
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.8
44.0
221
731
ZX120
NOMESCO Finland
Intravenous
4.7
41.5
157
397
ZXA10
NOMESCO Finland
Bilateral
3.3
36.3
218
814
CEC00
NOMESCO Finland
Recession of extraocular muscle
61.5
35.5
41
7
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.5
34.6
109
223
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
34.6
33
*
CAC44
NOMESCO Finland
Combined decompression of orbit
+∞
34.6
33
*
CA1AD
NOMESCO Finland
Orbita CT
66.3
33.3
38
6
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.5
33.2
178
604
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
13.8
32.9
57
44
H50.6
ICD-10 Finland
Mechanical strabismus
+∞
32.5
31
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
11.9
30.3
56
50
H50.0
ICD-10 Finland
Convergent concomitant strabismus
34.0
30.2
39
12
A02BC02
ATC
pantoprazole; systemic
2.5
29.9
590
4220
E03.89
ICD-10 Finland
Other specified hypothyroidism
6.6
29.9
80
133
T85
ICPC
Hyperthyroidism/thyrotoxicosis
46.9
29.9
36
8
H50.8
ICD-10 Finland
Other specified strabismus
155.5
28.8
30
*
WF099
NOMESCO Finland
Other radiotherapy
36.5
27.6
35
10
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
26.8
217
961
CAC20
NOMESCO Finland
Lateral decompression of orbit
+∞
26.2
25
*
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
+∞
26.2
25
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
8.4
25.6
57
72
T86
ICPC
Hypothyroidism/myxoedema
5.5
25.3
78
155
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
+∞
25.1
24
*
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
93.0
24.8
27
*
H02AB07
ATC
prednisone; oral
2.9
23.4
163
653
2AB04
NOMESCO Finland
NA
67.0
22.9
26
*
H02.4
ICD-10 Finland
Ptosis of eyelid
33.3
22.5
29
9
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.3
22.5
124
422
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
12.0
20.9
38
33
XCK10
NOMESCO Finland
Photography of fundus of eye
3.3
20.1
108
360
C07AB07
ATC
bisoprolol; oral
2.0
19.7
391
2569
CEW99
NOMESCO Finland
Other operation on extraocular muscle
204.7
19.6
20
*
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
23.2
19.2
27
12
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
5.2
19.1
61
126
E03
ICD-10 Finland
Other hypothyroidism
3.6
19.1
91
276
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
18.8
328
2038
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
18.6
339
2140
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
18.1
247
1382
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
27.4
17.9
24
9
Z3231
NOMESCO Finland
Registered nurse
2.1
17.7
246
1384
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
97.2
17.6
19
*
E05.5
ICD-10 Finland
Thyroid crisis or storm
183.8
17.6
18
*
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
35.9
16.7
21
6
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
+∞
16.7
16
*
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
173.4
16.6
17
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
16.3
340
2226
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.0
16.0
279
1707
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.2
15.9
50
102
CBB20
NOMESCO Finland
Correction of lax skin of eyelid and resection of herniated fat
+∞
15.7
15
*
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
+∞
15.7
15
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.7
15.6
53
118
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.0
15.0
90
322
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
11.6
14.9
27
24
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
16.9
14.8
23
14
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
152.6
14.5
15
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
3.4
14.0
68
210
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.4
13.9
69
216
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
76.4
13.6
15
*
E05.89
ICD-10 Finland
Other thyrotoxicosis
34.7
13.5
17
5
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
13.1
13.5
23
18
A11CC03
ATC
alfacalcidol; systemic
6.7
13.2
33
51
H57.1
ICD-10 Finland
Ocular pain
5.0
13.2
42
88
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
32.6
12.6
16
5
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
+∞
12.5
12
*
N05CF01
ATC
zopiclone; oral
1.8
12.5
272
1766
H01.0
ICD-10 Finland
Blepharitis
3.8
12.2
51
140
S01GX01
ATC
cromoglicic acid; ophthalmic
2.0
12.0
184
1054
H03BA02
ATC
propylthiouracil; oral
65.9
11.6
13
*
WX002
NOMESCO Finland
Sedation and analgesia
2.0
11.6
161
884
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
6.0
11.6
31
53
CS494
NOMESCO Finland
Other visual field testing
5.3
11.5
34
66
CBB21
NOMESCO Finland
Correction of lax skin and resection of herniated fat in upper eyelid
121.6
11.5
12
*
Z3229
NOMESCO Finland
Other healthcare associate professional
2.7
11.3
77
300
CE2W4
NOMESCO Finland
Eye movement mapping
43.9
10.9
13
*
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
18.1
10.8
16
9
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
28.4
10.7
14
5
WF002
NOMESCO Finland
Radical radiotherapy
3.8
10.7
44
119
CA1BD
NOMESCO Finland
Extensive orbita CT
+∞
10.4
10
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
12.2
10.4
18
15
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
19.1
10.3
15
8
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
4.4
10.2
36
85
1XC02
NOMESCO Finland
NA
10.2
10.0
19
19
E83.51
ICD-10 Finland
Hypocalcemia
26.4
9.8
13
5
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
20.3
9.8
14
7
106
Kela drug reimbursment
Hypoparathyroidism
13.6
9.7
16
12
H40.0
ICD-10 Finland
Glaucoma suspect
2.7
9.4
66
260
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.9
9.3
137
769
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
5.6
9.3
26
48
WX402
NOMESCO Finland
General anaesthesia
1.9
9.2
140
796
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
11.6
9.1
16
14
S01KA02
ATC
hypromellose; ophthalmic
5.0
8.9
27
55
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
8.7
8.8
18
21
CB9S4
NOMESCO Finland
Photography of eyelids and eyebrows
50.5
8.7
10
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
10.2
8.5
16
16
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
27.8
8.5
11
*
H02.1
ICD-10 Finland
Ectropion of eyelid
90.9
8.4
9
*
CD2S4
NOMESCO Finland
Photography of eye
17.4
8.1
12
7
ZXD20
NOMESCO Finland
Day surgery
2.0
8.0
105
564
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.5
7.9
61
257
A11CC02
ATC
dihydrotachysterol; oral
13.2
7.9
13
10
ZXE00
NOMESCO Finland
One hour or less
1.6
7.9
303
2242
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.6
7.9
57
231
H50.1
ICD-10 Finland
Divergent concomitant strabismus
10.9
7.8
14
13
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
6.8
7.6
18
27
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
25.3
7.6
10
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
3.7
7.4
31
87
H02AB09
ATC
hydrocortisone; systemic
4.0
7.4
28
72
ZXA00
NOMESCO Finland
Right side
1.6
7.3
199
1346
H11.1
ICD-10 Finland
Conjunctival degenerations and deposits
11.0
7.3
13
12
CBK99
NOMESCO Finland
Other operation for retraction of eyelid
+∞
7.3
7
*
CBG00
NOMESCO Finland
Epilation of cilia by electrolysis
+∞
7.3
7
*
CAB00
NOMESCO Finland
Anterior orbitotomy with excision of lesion
+∞
7.3
7
*
E50.0
ICD-10 Finland
Vitamin A deficiency with conjunctival xerosis
+∞
7.3
7
*
CBD99
NOMESCO Finland
Other plastic reconstruction of eyelid
+∞
7.3
7
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
7.2
175
1146
Z2221
NOMESCO Finland
Medical doctor
1.6
7.2
218
1516
ZXC95
NOMESCO Finland
Use of surgical navigator
6.1
7.1
18
30
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
7.1
92
490
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
4.7
6.9
22
48
XX3DW
NOMESCO Finland
Time consuming IT work
2.0
6.9
83
429
S01EE01
ATC
latanoprost; ophthalmic
2.6
6.9
46
180
N07BA03
ATC
varenicline; oral
2.6
6.9
48
192
XCH00
NOMESCO Finland
Eye pressure measurement
3.0
6.9
37
127
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
16.8
6.8
10
6
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
16.8
6.8
10
6
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.1
6.5
70
348
H52.2
ICD-10 Finland
Astigmatism
5.8
6.5
17
30
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.1
6.4
75
383
H50.30
ICD-10 Finland
Intermittent esotropy
14.4
6.4
10
7
H01CB02
ATC
octreotide; parenteral
14.4
6.4
10
7
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.5
6.4
48
200
WX140
NOMESCO Finland
Parabulbar anesthesy
2.9
6.3
36
127
H02.8
ICD-10 Finland
Other specified disorders of eyelid
18.2
6.3
9
5
H05.1
ICD-10 Finland
Chronic inflammatory disorders of orbit
+∞
6.3
6
*
G73.0*E05.9
ICD-10 Finland
Myasthenic syndromes in thyrotoxicosis [hyperthyroidism]
+∞
6.3
6
*
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
6.3
6
*
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
26.9
6.2
8
*
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.7
6.2
38
143
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: H7_LACRIMALORBITINOTH – Disorders of lacrimal system and orbit in diseases classified elsewhere
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).