Risteys · G6_POSTVIRFAT

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G93.3 Cause of death: ICD-10 — G93.3 2 out of 7 registries used, show all original rules.	295
4. Check minimum number of events None	295
5. Include endpoints None	295
6. Filter based on genotype QC (FinnGen only)	295

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1622	1089	525
Only index persons	1588	1074	514
Unadjusted period prevalence (%)
Whole population	0.03	0.03	0.01
Only index persons	0.03	0.04	0.02
Median age at first event (years)
Whole population	34.76	35.80	32.61
Only index persons	34.81	35.74	32.86

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	295	236	59
Unadjusted period prevalence (%)	0.07	0.08	0.03
Median age at first event (years)	38.57	38.56	38.60

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
254: Matched controls
2538

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G93.3

ICD-10 Finland

Postviral fatigue syndrome

+∞

323.0

254

R53

ICD-10 Finland

Malaise and fatigue

14.8

78.6

165

282

F48.0

ICD-10 Finland

Neurasthenia

121.5

30.4

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

9.3

29.8

N06AX16

ATC

venlafaxine; oral

5.5

27.4

247

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

12.9

25.9

TAB00

NOMESCO Finland

Lumbar puncture

14.1

25.4

Z01.8

ICD-10 Finland

Other specified special examinations

4.8

24.7

100

302

R68.88

ICD-10 Finland

Other specified general symptoms and signs, not elsewhere classified.

60.1

23.6

N06AX21

ATC

duloxetine; oral

6.4

23.5

138

M79.7

ICD-10 Finland

Fibromyalgia

12.1

23.2

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

9.0

23.1

N04BC09

ATC

rotigotine; transdermal

251.8

23.0

N04BC05

ATC

pramipexole; oral

10.9

23.0

N03AX12

ATC

gabapentin; oral

5.7

22.5

165

R50.9

ICD-10 Finland

Fever, unspecified

5.5

22.4

181

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

4.6

20.9

240

A04

ICPC

Weakness/tiredness general

5.1

20.8

190

XA800

NOMESCO Finland

Neuropsychological investigation

10.4

20.6

R51.80

ICD-10 Finland

Headache

4.3

20.3

276

L28

ICPC

Limited function/disability (L)

6.4

20.1

107

M35.7

ICD-10 Finland

Hypermobility syndrome

15.0

19.9

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

14.4

19.5

N06AX12

ATC

bupropion; oral

5.6

19.5

139

Q79.6

ICD-10 Finland

Ehlers-Danlos syndrome

41.9

18.9

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

11.4

18.6

N03AX16

ATC

pregabalin; oral

4.1

18.2

269

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

6.5

17.3

A02BA02

ATC

ranitidine; systemic

4.5

16.3

172

H03AA01

ATC

levothyroxine sodium; systemic

3.6

16.2

333

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

3.5

15.7

338

H02AB06

ATC

prednisolone; systemic

2.9

15.1

141

755

G47.3

ICD-10 Finland

Sleep apnoea

4.0

15.1

208

R06.0

ICD-10 Finland

Dyspnoea

3.7

14.8

254

Z03.5

ICD-10 Finland

Observation for other suspected cardiovascular diseases

6.7

14.3

A02BC05

ATC

esomeprazole; systemic

2.9

14.0

121

610

N06BA07

ATC

modafinil; oral

79.5

13.7

F33.2

ICD-10 Finland

Recurrent depressive disorder, current episode severe without psychotic symptoms

5.4

13.7

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

19.6

13.6

M79.0

ICD-10 Finland

Rheumatism, unspecified

10.6

13.6

G97.0

ICD-10 Finland

Cerebrospinal fluid leak from spinal puncture

147.6

13.6

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

6.6

13.1

R42

ICD-10 Finland

Dizziness and giddiness

3.7

13.1

214

A28

ICPC

Limited function/disability NOS

6.9

12.8

N04BD01

ATC

selegiline; oral

73.6

12.7

R4110

NOMESCO Finland

Physiotherapy

3.1

12.6

349

N06AX11

ATC

mirtazapine; oral

2.8

12.6

105

508

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.7

12.4

127

693

C07AA05

ATC

propranolol; systemic

3.0

12.4

355

M79.1

ICD-10 Finland

Myalgia

3.6

12.4

204

F33.11

ICD-10 Finland

Recurrent depression, moderate episode of somatic syndrome

8.3

12.3

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

2.8

12.3

103

496

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

6.6

12.1

F33.10

ICD-10 Finland

Recurrent depression, moderate episode without somatic syndrome

4.4

11.9

119

F32.11

ICD-10 Finland

Moderate depressive episode with somatic syndrome

7.4

11.8

R1240

NOMESCO Finland

Social assessment of need and possibilities of rehabilitation

31.7

11.8

N06AB04

ATC

citalopram; systemic

3.0

11.5

312

M54.2

ICD-10 Finland

Cervicalgia

4.9

11.4

Z2445

NOMESCO Finland

Psychologist

5.0

11.1

SHA02

NOMESCO Finland

Correction of physiology of bite - basic therapy visit

4.1

11.0

128

A02BC02

ATC

pantoprazole; systemic

2.5

11.0

160

1032

XF404

NOMESCO Finland

Ambulatory ECG

5.5

10.8

H02AB09

ATC

hydrocortisone; systemic

12.0

10.7

R03AC02

ATC

salbutamol; inhalant

2.5

10.7

164

1078

Z03.80

ICD-10 Finland

Observation for other suspected diseases and conditions

6.6

10.6

ZY010

NOMESCO Finland

Hospital outpatient

4.5

10.6

B03BA03

ATC

hydroxocobalamin; parenteral

8.8

10.6

N06AA09

ATC

amitriptyline; systemic

5.0

10.6

C07AB07

ATC

bisoprolol; oral

2.7

10.5

404

J45.9

ICD-10 Finland

Asthma, unspecified

3.3

10.3

200

K30

ICD-10 Finland

Functional dyspepsia

4.0

10.3

119

H04.10

ICD-10 Finland

Dry eye syndrome

4.5

10.3

UJF30

NOMESCO Finland

Ileoscopy through colon

4.2

10.1

105

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.5

10.1

490

ZXE17

NOMESCO Finland

Procedure duration 150 to 179 minutes

17.6

10.0

E03.9

ICD-10 Finland

Hypothyroidism, unspecified

3.6

9.7

148

N02AX02

ATC

tramadol; systemic, rectal

2.5

9.7

520

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

4.1

9.7

104

J31.0

ICD-10 Finland

Chronic rhinitis

4.0

9.6

110

R52.9

ICD-10 Finland

Pain, unspecified

4.3

9.5

N06BA04

ATC

methylphenidate; oral

6.2

9.5

G44.0

ICD-10 Finland

Cluster headache syndrome

22.7

9.4

R2120

NOMESCO Finland

Counselling and guidance concerning rehabilitation services and social security

+∞

9.4

IDY03

NOMESCO Finland

Systematic individual therapy, cognitive-behavioural

5.6

9.4

G43.9

ICD-10 Finland

Migraine, unspecified

3.6

9.4

135

ZXE13

NOMESCO Finland

Procedure duration 90 to 119 minutes

5.1

9.3

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.5

9.2

148

M03BX01

ATC

baclofen; systemic

12.1

9.2

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

4.2

9.2

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

3.4

9.2

155

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.9

9.1

249

N05BA04

ATC

oxazepam; oral

2.5

9.1

394

G43.0

ICD-10 Finland

Migraine without aura [common migraine]

3.5

9.0

139

M25.5

ICD-10 Finland

Pain in joint

2.4

9.0

504

ZXE06

NOMESCO Finland

Procedure duration 50 to 59 minutes

4.3

9.0

C01CA24

ATC

epinephrine; parenteral

3.7

8.9

118

A01

ICPC

Pain general/multiple sites

4.3

8.9

R5140

NOMESCO Finland

Monitoring the use of the aid

4.5

8.9

R4120

NOMESCO Finland

Occupational therapy

4.9

8.8

N05CF01

ATC

zopiclone; oral

2.6

8.7

362

J01AA02

ATC

doxycycline; systemic

2.4

8.7

193

1445

G44.8

ICD-10 Finland

Other specified headache syndromes

12.2

8.7

G50.1

ICD-10 Finland

Atypical facial pain

17.0

8.6

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

4.4

8.6

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

3.5

8.6

133

F33.9

ICD-10 Finland

Recurrent depressive disorder, unspecified

4.2

8.5

G43.3

ICD-10 Finland

Complicated migraine

6.2

8.5

R1220

NOMESCO Finland

Psychological examination of need and possibilities to rehabilitation

11.3

8.4

Z01.9

ICD-10 Finland

Special examination, unspecified

5.8

8.4

WZC20

NOMESCO Finland

Multidisciplinary treatment meeting

6.1

8.4

K58.0

ICD-10 Finland

Irritable bowel syndrome with diarrhoea

4.1

8.3

Z2446

NOMESCO Finland

Social worker

3.7

8.3

108

L19

ICPC

Muscle symptom/complaint NOS

9.4

8.2

R1210

NOMESCO Finland

Medical assessment of need and possibilities to rehabilitation

17.9

8.2

F32.1

ICD-10 Finland

Moderate depressive episode

3.7

8.1

104

N28

ICPC

Limited function/disability (N)

34.6

8.1

Z71.8

ICD-10 Finland

Other specified counselling

2.3

8.0

472

G03BA03

ATC

testosterone; systemic, rectal, sublingual, transdermal

8.2

8.0

F32.9

ICD-10 Finland

Depressive episode, unspecified

2.6

8.0

271

R52.2

ICD-10 Finland

Other chronic pain

7.4

7.9

R03AK11

ATC

formoterol and fluticasone; inhalant

11.3

7.9

N06AB10

ATC

escitalopram; oral

2.3

7.9

435

R10.1

ICD-10 Finland

Pain localized to upper abdomen

2.7

7.8

244

N03AX11

ATC

topiramate; oral

5.5

7.8

H02AA02

ATC

fludrocortisone; oral

25.9

7.6

N99

ICPC

Neurological disease other

25.9

7.6

J01FA09

ATC

clarithromycin; systemic

2.2

7.6

561

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

3.3

7.6

128

ZXE15

NOMESCO Finland

Procedure duration 120 to 149 minutes

6.3

7.5

F41.2

ICD-10 Finland

Mixed anxiety and depressive disorder

2.8

7.5

203

R03DC03

ATC

montelukast; oral

2.6

7.5

265

R68.81

ICD-10 Finland

A constant or recurrent sensitivity to experience symptoms and signs in relation to common factors in the environment, not elsewhere classified.

+∞

7.3

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

2.8

7.3

192

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

4.4

7.2

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

3.8

7.2

R00.2

ICD-10 Finland

Palpitations

3.6

7.2

I49.9

ICD-10 Finland

Cardiac arrhythmia, unspecified

3.2

7.2

133

R26.8

ICD-10 Finland

Other and unspecified abnormalities of gait and mobility

20.7

7.2

N06AX26

ATC

vortioxetine; oral

3.4

7.2

110

ZXE11

NOMESCO Finland

Procedure duration 60 to 89 minutes

3.4

7.2

110

SPAT1229

SPAT

Assessment of need for aid

5.2

7.2

XF402

NOMESCO Finland

ECG with work load test

4.1

7.1

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.1

7.1

118

749

A03FA01

ATC

metoclopramide; systemic, rectal

2.5

7.1

279

G44.2

ICD-10 Finland

Tension-type headache

2.6

7.1

243

G43.1

ICD-10 Finland

Migraine with aura [classical migraine]

3.0

7.0

147

N05AH04

ATC

quetiapine; oral

2.4

7.0

333

U09.9

ICD-10 Finland

Post COVID-19 condition, unspecified

14.3

7.0

S13.4

ICD-10 Finland

Sprain and strain of cervical spine

4.6

6.9

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

2.0

6.9

163

1188

M54.5

ICD-10 Finland

Low back pain

2.1

6.9

100

601

AA1AD

NOMESCO Finland

CT of head and brain

2.9

6.8

169

N03AE01

ATC

clonazepam; systemic

4.6

6.7

R03BA08

ATC

ciclesonide; inhalant

3.6

6.7

UJF92

NOMESCO Finland

Capsular endoscopy

8.2

6.7

F43.1

ICD-10 Finland

Post-traumatic stress disorder

4.4

6.7

TAB22

NOMESCO Finland

Stoppin epidural fluid escape with coagulated blood

12.7

6.6

N06AX17

ATC

milnacipran; oral

12.7

6.6

F41.1

ICD-10 Finland

Generalized anxiety disorder

3.3

6.6

105

NA2BG

NOMESCO Finland

Thoracal spine MRI examination with high intensity magnet

7.2

6.6

Z71.2

ICD-10 Finland

Person consulting for explanation of investigation findings

2.2

6.6

382

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

3.4

6.5

N17

ICPC

Vertigo/dizziness

3.1

6.5

129

Z3226

NOMESCO Finland

Physiotherapist

2.5

6.5

257

D80.3

ICD-10 Finland

Selective deficiency of immunoglobulin G [IgG] subclasses

71.6

6.5

D80.9

ICD-10 Finland

Immunodeficiency with predominantly antibody defects, unspecified

71.6

6.5

J01MA02

ATC

ciprofloxacin; systemic

2.1

6.4

493

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

2.7

6.4

182

R11

ICD-10 Finland

Nausea and vomiting

3.3

6.4

102

Z02.7

ICD-10 Finland

Issue of medical certificate

3.9

6.4

F34.1

ICD-10 Finland

Dysthymia

4.0

6.4

SPAT1215

SPAT

Assessment of need for medical rehabilitation

5.0

6.4

TPH04

NOMESCO Finland

Cathetrisation of vein

2.5

6.3

239

R51.81

ICD-10 Finland

Facial pain NOS

7.3

6.3

KC1EE

NOMESCO Finland

Ultrasound measurement of residual urine

4.5

6.3

F90.0

ICD-10 Finland

Disturbance of activity and attention

4.3

6.3

G90.8

ICD-10 Finland

Other disorders of autonomic nervous system

+∞

6.3

NXL00

NOMESCO Finland

Biopsy of muscle

27.4

6.3

U08.9

ICD-10 Finland

Personal history of COVID-19, unspecified

27.4

6.3

G43.8

ICD-10 Finland

Other migraine

6.0

6.3

R01AD09

ATC

mometasone; nasal

1.9

6.2

134

929

R39.1

ICD-10 Finland

Other difficulties with micturition

10.4

6.1

N29

ICPC

Neurological sympt/complt other

10.4

6.1

M03BC01

ATC

orphenadrine (citrate); systemic

2.1

6.1

430

N05CF02

ATC

zolpidem; oral

2.4

6.1

243

R20.2

ICD-10 Finland

Paraesthesia of skin

3.5

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint G6_POSTVIRFAT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_POSTVIRFAT.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: G6_POSTVIRFAT – Postviral fatigue syndrome

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	G6_POSTVIRFAT
CONTROL_EXCLUDE	G6_OTHNEU
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G933
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G933
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Postviral fatigue syndrome

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints