No definition available.
Sequelae of inflammatory diseases of the central nervous system
G6_NEUROINFSEQ
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
110 |
4. Check minimum number of eventsNone |
110 |
5. Include endpointsNone |
110 |
6. Filter based on genotype QC (FinnGen only) |
110 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEUINFL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G00-G09
- Name in latin
- Sequelae morborum inflammatoriorum systematis nervosi centralis
Similar endpoints
↥List of similar endpoints to
Sequelae of inflammatory diseases of the central nervous system
based on the number of shared cases.
Similar with more cases:
- Inflammatory diseases of the central nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1421 | 653 | 746 |
| Only index persons | 880 | 437 | 443 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 43.55 | 45.47 | 41.45 |
| Only index persons | 36.06 | 39.65 | 32.52 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 110 | 56 | 54 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 38.41 | 32.54 | 44.49 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 97
- Matched controls
- 969
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G09
ICD-10 Finland
Sequelae of inflammatory diseases of central nervous system
+∞
59.7
51
*
32400
ICD-8 Finland
Late effects of intracranial abscess or pyogenic infection, Hydrocephalus acquisitus
+∞
20.5
19
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
14.1
14.0
24
22
A86
ICD-10 Finland
Unspecified viral encephalitis
+∞
10.6
10
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
30.6
8.7
11
*
N03AF01
ATC
carbamazepine; oral, rectal
8.2
8.6
19
28
XA800
NOMESCO Finland
Neuropsychological investigation
11.5
7.8
14
14
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
27.5
7.7
10
*
TAB00
NOMESCO Finland
Lumbar puncture
10.7
7.6
14
15
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
17.5
7.4
11
7
32401
ICD-8 Finland
Late effects of intracranial abscess or pyogenic infection, Status postencephaliticus
+∞
7.4
7
*
R51.80
ICD-10 Finland
Headache
4.4
6.7
25
71
N03AX14
ATC
levetiracetam; systemic
15.7
6.6
10
7
R4150
NOMESCO Finland
Neuropsychological rehabilitation
74.5
6.5
7
*
G06.0
ICD-10 Finland
Intracranial abscess and granuloma
+∞
6.3
6
*
2133
FHL
Suntin revisio
+∞
6.3
6
*
32408
ICD-8 Finland
Late effects of intracranial abscess or pyogenic infection, Alia definitae
+∞
6.3
6
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.2
6.2
13
18
Mortality – FinRegistry
↥Association
Association between endpoint G6_NEUROINFSEQ and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_NEUROINFSEQ | 2.449 [1.58, 3.79] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.263 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 211 females with G6_NEUROINFSEQ died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have G6_NEUROINFSEQ.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.273% | No data |
| 5 | 1.534% | No data |
| 10 | 3.802% | No data |
| 15 | 6.743% | No data |
| 20 | 11.591% | No data |
Relationships between endpoints
↥Index endpoint: G6_NEUROINFSEQ – Sequelae of inflammatory diseases of the central nervous system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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